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Items: 1 to 50 of 110

1.

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma.

Serrano-Del Valle A, Anel A, Naval J, Marzo I.

Front Cell Dev Biol. 2019 Apr 16;7:50. doi: 10.3389/fcell.2019.00050. eCollection 2019. Review.

2.

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy.

Naval J, de Miguel D, Gallego-Lleyda A, Anel A, Martinez-Lostao L.

Cancers (Basel). 2019 Mar 29;11(4). pii: E444. doi: 10.3390/cancers11040444. Review.

3.

A giant retroperitoneal liposarcoma with renal involvement: A case report and literature review.

Montenegro A, Varas M, Sánchez-Vizcaíno E, Naval J, Loras C, Abad R.

Gastroenterol Hepatol. 2019 Feb 13. pii: S0210-5705(19)30019-6. doi: 10.1016/j.gastrohep.2019.01.003. [Epub ahead of print] English, Spanish. No abstract available.

PMID:
30772091
4.

Role of Exosomes in the Regulation of T-cell Mediated Immune Responses and in Autoimmune Disease.

Anel A, Gallego-Lleyda A, de Miguel D, Naval J, Martínez-Lostao L.

Cells. 2019 Feb 12;8(2). pii: E154. doi: 10.3390/cells8020154. Review.

5.

Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo.

Jarauta V, Jaime P, Gonzalo O, de Miguel D, Ramírez-Labrada A, Martínez-Lostao L, Anel A, Pardo J, Marzo I, Naval J.

Cancer Lett. 2016 Nov 1;382(1):1-10. doi: 10.1016/j.canlet.2016.08.019. Epub 2016 Aug 24.

PMID:
27565383
6.

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.

Bosque A, Dietz L, Gallego-Lleyda A, Sanclemente M, Iturralde M, Naval J, Alava MA, Martínez-Lostao L, Thierse HJ, Anel A.

Oncotarget. 2016 May 17;7(20):29287-305. doi: 10.18632/oncotarget.8678.

7.

In vivo potential of recombinant granulysin against human tumors.

Al-Wasaby S, de Miguel D, Aporta A, Naval J, Conde B, Martínez-Lostao L, Anel A.

Oncoimmunology. 2015 Jul 1;4(9):e1036213. eCollection 2015 Sep.

8.

Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells.

Sánchez-Martínez D, Azaceta G, Muntasell A, Aguiló N, Núñez D, Gálvez EM, Naval J, Anel A, Palomera L, Vilches C, Marzo I, Villalba M, Pardo J.

Oncoimmunology. 2015 Jan 9;4(3):e991613. eCollection 2015 Mar.

9.

MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells.

Catalán E, Charni S, Jaime P, Aguiló JI, Enríquez JA, Naval J, Pardo J, Villalba M, Anel A.

Oncoimmunology. 2015 Feb 3;4(1):e985924. eCollection 2015 Jan.

10.

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments.

Naval J, Alonso V, Herranz MA.

Clin Cosmet Investig Dermatol. 2014 Jul 1;7:207-14. doi: 10.2147/CCID.S55669. eCollection 2014.

11.

Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis.

Ramírez-Labrada A, López-Royuela N, Jarauta V, Galán-Malo P, Azaceta G, Palomera L, Pardo J, Anel A, Marzo I, Naval J.

Clin Transl Oncol. 2015 Feb;17(2):121-32. doi: 10.1007/s12094-014-1201-y. Epub 2014 Jul 19.

PMID:
25037851
12.

Methods for diagnosing perceived age on the basis of an ensemble of phenotypic features.

Coma M, Valls R, Mas JM, Pujol A, Herranz MA, Alonso V, Naval J.

Clin Cosmet Investig Dermatol. 2014 Apr 17;7:133-7. doi: 10.2147/CCID.S52257. eCollection 2014.

13.

IFNα signaling through PKC-θ is essential for antitumor NK cell function.

Comet NR, Aguiló JI, Rathoré MG, Catalán E, Garaude J, Uzé G, Naval J, Pardo J, Villalba M, Anel A.

Oncoimmunology. 2014 Nov 14;3(8):e948705. eCollection 2014.

14.

Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors.

Aporta A, Catalán E, Galán-Malo P, Ramírez-Labrada A, Pérez M, Azaceta G, Palomera L, Naval J, Marzo I, Pardo J, Anel A.

Biochem Pharmacol. 2014 Feb 1;87(3):410-23. doi: 10.1016/j.bcp.2013.11.004. Epub 2013 Nov 22.

PMID:
24269628
15.

Antimitotic drugs in cancer chemotherapy: promises and pitfalls.

Marzo I, Naval J.

Biochem Pharmacol. 2013 Sep 15;86(6):703-10. doi: 10.1016/j.bcp.2013.07.010. Epub 2013 Jul 22. Review.

PMID:
23886991
16.

Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells.

De Miguel D, Basáñez G, Sánchez D, Malo PG, Marzo I, Larrad L, Naval J, Pardo J, Anel A, Martinez-Lostao L.

Mol Pharm. 2013 Mar 4;10(3):893-904. doi: 10.1021/mp300258c. Epub 2013 Feb 6.

PMID:
23331277
17.

Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation.

Vela L, Gonzalo O, Naval J, Marzo I.

J Biol Chem. 2013 Feb 15;288(7):4935-46. doi: 10.1074/jbc.M112.422204. Epub 2013 Jan 2.

18.

Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer.

Martinez-Lostao L, Marzo I, Anel A, Naval J.

Biochem Pharmacol. 2012 Jun 1;83(11):1475-83. doi: 10.1016/j.bcp.2011.12.036. Epub 2012 Jan 2. Review.

PMID:
22230480
19.

Cell fate after mitotic arrest in different tumor cells is determined by the balance between slippage and apoptotic threshold.

Galán-Malo P, Vela L, Gonzalo O, Calvo-Sanjuán R, Gracia-Fleta L, Naval J, Marzo I.

Toxicol Appl Pharmacol. 2012 Feb 1;258(3):384-93. doi: 10.1016/j.taap.2011.11.021. Epub 2011 Dec 9.

PMID:
22178383
20.

Bortezomib resistance in a myeloma cell line is associated to PSMβ5 overexpression and polyploidy.

Balsas P, Galán-Malo P, Marzo I, Naval J.

Leuk Res. 2012 Feb;36(2):212-8. doi: 10.1016/j.leukres.2011.09.011. Epub 2011 Oct 5.

PMID:
21978467
21.

Revealing the molecular relationship between type 2 diabetes and the metabolic changes induced by a very-low-carbohydrate low-fat ketogenic diet.

Farrés J, Pujol A, Coma M, Ruiz JL, Naval J, Mas JM, Molins A, Fondevila J, Aloy P.

Nutr Metab (Lond). 2010 Dec 9;7:88. doi: 10.1186/1743-7075-7-88.

22.

Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis.

Martinez-Lostao L, García-Alvarez F, Basáñez G, Alegre-Aguarón E, Desportes P, Larrad L, Naval J, Martínez-Lorenzo MJ, Anel A.

Arthritis Rheum. 2010 Aug;62(8):2272-82. doi: 10.1002/art.27501.

23.

Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells.

López-Royuela N, Pérez-Galán P, Galán-Malo P, Yuste VJ, Anel A, Susín SA, Naval J, Marzo I.

Biochem Pharmacol. 2010 Jun 15;79(12):1746-58. doi: 10.1016/j.bcp.2010.02.010. Epub 2010 Feb 24.

PMID:
20188077
24.

Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.

Aguiló JI, Anel A, Catalán E, Sebastián A, Acín-Pérez R, Naval J, Wallich R, Simon MM, Pardo J.

Immunol Cell Biol. 2010 Jul;88(5):545-54. doi: 10.1038/icb.2010.5. Epub 2010 Feb 2.

PMID:
20125115
25.

Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells.

López-Royuela N, Balsas P, Galán-Malo P, Anel A, Marzo I, Naval J.

Biochim Biophys Acta. 2010 Feb;1803(2):311-22. doi: 10.1016/j.bbamcr.2009.11.004. Epub 2009 Nov 13.

26.

Cooperation between Apo2L/TRAIL and bortezomib in multiple myeloma apoptosis.

Balsas P, López-Royuela N, Galán-Malo P, Anel A, Marzo I, Naval J.

Biochem Pharmacol. 2009 Mar 1;77(5):804-12. doi: 10.1016/j.bcp.2008.11.024. Epub 2008 Dec 3.

PMID:
19100720
27.

Bcl-2 family members as molecular targets in cancer therapy.

Marzo I, Naval J.

Biochem Pharmacol. 2008 Oct 15;76(8):939-46. doi: 10.1016/j.bcp.2008.06.009. Epub 2008 Jun 28.

PMID:
18638457
28.

Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes.

Bosque A, Aguiló JI, del Rey M, Paz-Artal E, Allende LM, Naval J, Anel A.

J Leukoc Biol. 2008 Aug;84(2):488-98. doi: 10.1189/jlb.0108043. Epub 2008 May 15.

PMID:
18483205
29.

What Do Spanish physicians believe and expect about telemedicine? Results of a Delphi-based survey.

Segura J, Roldán C, Galera J, Naval J.

Telemed J E Health. 2008 Jan-Feb;14(1):42-8. doi: 10.1089/tmj.2007.0018.

PMID:
18328024
30.

Towards a molecular characterisation of pathological pathways.

Pache RA, Zanzoni A, Naval J, Mas JM, Aloy P.

FEBS Lett. 2008 Apr 9;582(8):1259-65. doi: 10.1016/j.febslet.2008.02.014. Epub 2008 Feb 20. Review.

31.

Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL.

Gómez-Benito M, Martinez-Lorenzo MJ, Anel A, Marzo I, Naval J.

Exp Cell Res. 2007 Jul 1;313(11):2378-88. Epub 2007 Mar 30.

PMID:
17462628
32.

Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin.

Gómez-Benito M, Balsas P, Carvajal-Vergara X, Pandiella A, Anel A, Marzo I, Naval J.

Cell Signal. 2007 Apr;19(4):844-54. Epub 2006 Dec 8.

PMID:
17158029
33.

Apo2L/TRAIL and immune regulation.

Anel A, Bosque A, Naval J, Pineiro A, Larrad L, Alava MA, Martinez-Lorenzo MJ.

Front Biosci. 2007 Jan 1;12:2074-84. Review.

PMID:
17127445
34.

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.

Bosque A, Aguiló JI, Alava MA, Paz-Artal E, Naval J, Allende LM, Anel A.

Blood. 2007 Feb 15;109(4):1627-35. Epub 2006 Oct 24.

35.

Generation of rabbit antibodies against death ligands by cDNA immunization.

Diestre C, Martínez-Lorenzo MJ, Bosque A, Naval J, Larrad L, Anel A.

J Immunol Methods. 2006 Dec 20;317(1-2):12-20. Epub 2006 Oct 2.

PMID:
17045605
36.
37.

Apo2L/TRAIL is an indirect mediator of apoptosis induced by interferon-alpha in human myeloma cells.

Gómez-Benito M, Balsas P, Bosque A, Anel A, Marzo I, Naval J.

FEBS Lett. 2005 Nov 7;579(27):6217-22. Epub 2005 Oct 17.

38.

Characterization of the lipolytic pathways that mediate free fatty acid release during Fas/CD95-induced apoptosis.

Iturralde M, Pardo J, Lacasa E, Barrio G, Alava MA, Piñeiro A, Naval J, Anel A.

Apoptosis. 2005 Dec;10(6):1369-81.

PMID:
16215685
39.

Human CD8+ T cell blasts are more sensitive than CD4+ T cell blasts to regulation by APO2L/TRAIL.

Bosque A, Pardo J, Martínez-Lorenzo MJ, Lasierra P, Larrad L, Marzo I, Naval J, Anel A.

Eur J Immunol. 2005 Jun;35(6):1812-21.

40.

Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA up-regulation, Bax and Bak activation, and Mcl-1 elimination.

Gómez-Benito M, Marzo I, Anel A, Naval J.

Mol Pharmacol. 2005 Jun;67(6):1991-8. Epub 2005 Feb 28.

PMID:
15738311
41.

Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression.

Bosque A, Pardo J, Martínez-Lorenzo MJ, Iturralde M, Marzo I, Piñeiro A, Alava MA, Naval J, Anel A.

J Leukoc Biol. 2005 Apr;77(4):568-78. Epub 2005 Jan 14.

PMID:
15653751
42.

[Effectiveness of an intervention to provide information to patients with hypertension as short text messages and reminders sent to their mobile phone (HTA-Alert)].

Márquez Contreras E, de la Figuera von Wichmann M, Gil Guillén V, Ylla-Catalá A, Figueras M, Balaña M, Naval J.

Aten Primaria. 2004 Nov 15;34(8):399-405. Spanish.

43.

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.

Pardo J, Bosque A, Brehm R, Wallich R, Naval J, Müllbacher A, Anel A, Simon MM.

J Cell Biol. 2004 Nov 8;167(3):457-68.

44.

Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells.

Marzo I, Pérez-Galán P, Giraldo P, López-Royuela N, Gómez-Benito M, Larrad L, Lasierra P, Rubio-Félix D, Anel A, Naval J.

Leukemia. 2004 Oct;18(10):1599-604.

PMID:
15356656
45.

Intrauterine growth retardation: study of placental apoptosis.

Barrio E, Calvo MT, Romo A, Alvarez R, Gutiérrez JI, Naval J, Ferrández Longás A.

J Pediatr Endocrinol Metab. 2004 Mar;17 Suppl 3:451-6.

PMID:
15134306
46.

The human melanoma cell line MelJuSo secretes bioactive FasL and APO2L/TRAIL on the surface of microvesicles. Possible contribution to tumor counterattack.

Martínez-Lorenzo MJ, Anel A, Alava MA, Piñeiro A, Naval J, Lasierra P, Larrad L.

Exp Cell Res. 2004 May 1;295(2):315-29.

PMID:
15093732
47.

Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.

Pardo J, Buferne M, Martínez-Lorenzo MJ, Naval J, Schmitt-Verhulst AM, Boyer C, Anel A.

Int Immunol. 2003 Dec;15(12):1441-50.

PMID:
14645153
48.

Saturated free fatty acid release and intracellular ceramide generation during apoptosis induction are closely related processes.

Iturralde M, Gamen S, Pardo J, Bosque A, Piñeiro A, Alava MA, Naval J, Anel A.

Biochim Biophys Acta. 2003 Oct 20;1634(1-2):40-51.

PMID:
14563412
49.

Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa.

Borruel N, Casellas F, Antolín M, Llopis M, Carol M, Espíin E, Naval J, Guarner F, Malagelada JR.

Am J Gastroenterol. 2003 Apr;98(4):865-70.

PMID:
12738469
50.

Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria.

Borruel N, Carol M, Casellas F, Antolín M, de Lara F, Espín E, Naval J, Guarner F, Malagelada JR.

Gut. 2002 Nov;51(5):659-64.

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