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Intermittent Hypoxia Mimicking Sleep Apnea Increases Passive Stiffness of Myocardial Extracellular Matrix. A Multiscale Study.

Farré N, Otero J, Falcones B, Torres M, Jorba I, Gozal D, Almendros I, Farré R, Navajas D.

Front Physiol. 2018 Aug 15;9:1143. doi: 10.3389/fphys.2018.01143. eCollection 2018.


Aging Reduces Intermittent Hypoxia-induced Lung Carcinoma Growth in a Mouse Model of Sleep Apnea.

Torres M, Campillo N, Nonaka PN, Montserrat JM, Gozal D, Martínez-García MA, Campos-Rodriguez F, Navajas D, Farré R, Almendros I.

Am J Respir Crit Care Med. 2018 Jul 17. doi: 10.1164/rccm.201805-0892LE. [Epub ahead of print] No abstract available.


A Portable Continuous Positive Airway Pressure Device That Can Perform Optimally Under Strenuous Conditions.

Villanueva JA, Isetta V, Montserrat JM, Navajas D, Farré R.

Am J Respir Crit Care Med. 2018 Jun 13. doi: 10.1164/rccm.201803-0584LE. [Epub ahead of print] No abstract available.


The local microenvironment limits the regenerative potential of the mouse neonatal heart.

Notari M, Ventura-Rubio A, Bedford-Guaus SJ, Jorba I, Mulero L, Navajas D, Martí M, Raya Á.

Sci Adv. 2018 May 2;4(5):eaao5553. doi: 10.1126/sciadv.aao5553. eCollection 2018 May.


Head-to-head comparison of two engineered cardiac grafts for myocardial repair: From scaffold characterization to pre-clinical testing.

Perea-Gil I, Gálvez-Montón C, Prat-Vidal C, Jorba I, Segú-Vergés C, Roura S, Soler-Botija C, Iborra-Egea O, Revuelta-López E, Fernández MA, Farré R, Navajas D, Bayes-Genis A.

Sci Rep. 2018 Apr 30;8(1):6708. doi: 10.1038/s41598-018-25115-2.


Alzheimer's Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea.

Menal MJ, Jorba I, Torres M, Montserrat JM, Gozal D, Colell A, Piñol-Ripoll G, Navajas D, Almendros I, Farré R.

Front Neurol. 2018 Jan 19;9:1. doi: 10.3389/fneur.2018.00001. eCollection 2018.


AFM and Microrheology in the Zebrafish Embryo Yolk Cell.

Marsal M, Jorba I, Rebollo E, Luque T, Navajas D, Martín-Blanco E.

J Vis Exp. 2017 Nov 29;(129). doi: 10.3791/56224.


Force loading explains spatial sensing of ligands by cells.

Oria R, Wiegand T, Escribano J, Elosegui-Artola A, Uriarte JJ, Moreno-Pulido C, Platzman I, Delcanale P, Albertazzi L, Navajas D, Trepat X, García-Aznar JM, Cavalcanti-Adam EA, Roca-Cusachs P.

Nature. 2017 Dec 14;552(7684):219-224. doi: 10.1038/nature24662. Epub 2017 Dec 6.


Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.

Elosegui-Artola A, Andreu I, Beedle AEM, Lezamiz A, Uroz M, Kosmalska AJ, Oria R, Kechagia JZ, Rico-Lastres P, Le Roux AL, Shanahan CM, Trepat X, Navajas D, Garcia-Manyes S, Roca-Cusachs P.

Cell. 2017 Nov 30;171(6):1397-1410.e14. doi: 10.1016/j.cell.2017.10.008. Epub 2017 Oct 26.


Bioengineered Lungs: A Challenge and An Opportunity.

Farré R, Otero J, Almendros I, Navajas D.

Arch Bronconeumol. 2018 Jan;54(1):31-38. doi: 10.1016/j.arbres.2017.09.002. Epub 2017 Nov 1. Review. English, Spanish.


Is Telemedicine a Key Tool for Improving Continuous Positive Airway Pressure Adherence in Patients with Sleep Apnea?

Farré R, Navajas D, Montserrat JM.

Am J Respir Crit Care Med. 2018 Jan 1;197(1):12-14. doi: 10.1164/rccm.201709-1791ED. No abstract available.


Bidirectional mechanobiology between cells and their local extracellular matrix probed by atomic force microscopy.

Alcaraz J, Otero J, Jorba I, Navajas D.

Semin Cell Dev Biol. 2018 Jan;73:71-81. doi: 10.1016/j.semcdb.2017.07.020. Epub 2017 Jul 23. Review.


Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples.

Schillers H, Rianna C, Schäpe J, Luque T, Doschke H, Wälte M, Uriarte JJ, Campillo N, Michanetzis GPA, Bobrowska J, Dumitru A, Herruzo ET, Bovio S, Parot P, Galluzzi M, Podestà A, Puricelli L, Scheuring S, Missirlis Y, Garcia R, Odorico M, Teulon JM, Lafont F, Lekka M, Rico F, Rigato A, Pellequer JL, Oberleithner H, Navajas D, Radmacher M.

Sci Rep. 2017 Jul 11;7(1):5117. doi: 10.1038/s41598-017-05383-0.


Frequency and magnitude of intermittent hypoxia modulate endothelial wound healing in a cell culture model of sleep apnea.

Campillo N, Falcones B, Montserrat JM, Gozal D, Obeso A, Gallego-Martin T, Navajas D, Almendros I, Farré R.

J Appl Physiol (1985). 2017 Nov 1;123(5):1047-1054. doi: 10.1152/japplphysiol.00077.2017. Epub 2017 Jun 22.


Effects of two different decellularization routes on the mechanical properties of decellularized lungs.

Urbano JJ, da Palma RK, de Lima FM, Fratini P, Guimaraes LL, Uriarte JJ, Alvarenga LH, Miglino MA, Vieira RP, Prates RA, Navajas D, Farrè R, Oliveira LVF.

PLoS One. 2017 Jun 1;12(6):e0178696. doi: 10.1371/journal.pone.0178696. eCollection 2017.


Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea.

Campillo N, Torres M, Vilaseca A, Nonaka PN, Gozal D, Roca-Ferrer J, Picado C, Montserrat JM, Farré R, Navajas D, Almendros I.

Sci Rep. 2017 Mar 16;7:44693. doi: 10.1038/srep44693.


Ageing and chronic intermittent hypoxia mimicking sleep apnea do not modify local brain tissue stiffness in healthy mice.

Jorba I, Menal MJ, Torres M, Gozal D, Piñol-Ripoll G, Colell A, Montserrat JM, Navajas D, Farré R, Almendros I.

J Mech Behav Biomed Mater. 2017 Jul;71:106-113. doi: 10.1016/j.jmbbm.2017.03.001. Epub 2017 Mar 6.


Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ.

Nonaka PN, Uriarte JJ, Campillo N, Oliveira VR, Navajas D, Farré R.

Respir Res. 2016 Nov 28;17(1):161. Review.


Polarized cortical tension drives zebrafish epiboly movements.

Hernández-Vega A, Marsal M, Pouille PA, Tosi S, Colombelli J, Luque T, Navajas D, Pagonabarraga I, Martín-Blanco E.

EMBO J. 2017 Jan 4;36(1):25-41. doi: 10.15252/embj.201694264. Epub 2016 Nov 9.


Technology for noninvasive mechanical ventilation: looking into the black box.

Farré R, Navajas D, Montserrat JM.

ERJ Open Res. 2016 Mar 11;2(1). pii: 00004-2016. eCollection 2016 Jan. Review.


Collective cell durotaxis emerges from long-range intercellular force transmission.

Sunyer R, Conte V, Escribano J, Elosegui-Artola A, Labernadie A, Valon L, Navajas D, García-Aznar JM, Muñoz JJ, Roca-Cusachs P, Trepat X.

Science. 2016 Sep 9;353(6304):1157-61. doi: 10.1126/science.aaf7119.


Elastic properties of hydrogels and decellularized tissue sections used in mechanobiology studies probed by atomic force microscopy.

Giménez A, Uriarte JJ, Vieyra J, Navajas D, Alcaraz J.

Microsc Res Tech. 2017 Jan;80(1):85-96. doi: 10.1002/jemt.22740. Epub 2016 Aug 18. Review.


A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea.

Campillo N, Jorba I, Schaedel L, Casals B, Gozal D, Farré R, Almendros I, Navajas D.

Front Physiol. 2016 Jul 29;7:319. doi: 10.3389/fphys.2016.00319. eCollection 2016.


Forced oscillation: A poorly exploited tool for simply assessing respiratory function in children.

Farré R, Navajas D.

Respirology. 2016 Aug;21(6):982-3. doi: 10.1111/resp.12842. Epub 2016 Jun 30. No abstract available.


Finite element simulation for the mechanical characterization of soft biological materials by atomic force microscopy.

Valero C, Navarro B, Navajas D, García-Aznar JM.

J Mech Behav Biomed Mater. 2016 Sep;62:222-235. doi: 10.1016/j.jmbbm.2016.05.006. Epub 2016 May 11.


Probing Micromechanical Properties of the Extracellular Matrix of Soft Tissues by Atomic Force Microscopy.

Jorba I, Uriarte JJ, Campillo N, Farré R, Navajas D.

J Cell Physiol. 2017 Jan;232(1):19-26. doi: 10.1002/jcp.25420. Epub 2016 Jun 2.


Early Impairment of Lung Mechanics in a Murine Model of Marfan Syndrome.

Uriarte JJ, Meirelles T, Gorbenko Del Blanco D, Nonaka PN, Campillo N, Sarri E, Navajas D, Egea G, Farré R.

PLoS One. 2016 Mar 22;11(3):e0152124. doi: 10.1371/journal.pone.0152124. eCollection 2016.


Novel Approach to Simulate Sleep Apnea Patients for Evaluating Positive Pressure Therapy Devices.

Isetta V, Montserrat JM, Santano R, Wimms AJ, Ramanan D, Woehrle H, Navajas D, Farré R.

PLoS One. 2016 Mar 15;11(3):e0151530. doi: 10.1371/journal.pone.0151530. eCollection 2016.


Behavior of vascular resistance undergoing various pressure insufflation and perfusion on decellularized lungs.

da Palma RK, Nonaka PN, Campillo N, Uriarte JJ, Urbano JJ, Navajas D, Farré R, Oliveira LVF.

J Biomech. 2016 May 3;49(7):1230-1232. doi: 10.1016/j.jbiomech.2016.02.043. Epub 2016 Mar 4.


A New mHealth application to support treatment of sleep apnoea patients.

Isetta V, Torres M, González K, Ruiz C, Dalmases M, Embid C, Navajas D, Farré R, Montserrat JM.

J Telemed Telecare. 2017 Jan;23(1):14-18. doi: 10.1177/1357633X15621848. Epub 2016 Jul 8.


Erratum to: Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices.

Vicens-Zygmunt V, Estany S, Colom A, Montes-Worboys A, Machahua C, Sanabria AJ, Llatjos R, Escobar I, Manresa F, Dorca J, Navajas D, Alcaraz J, Molina-Molina M.

Respir Res. 2015 Nov 2;16:136. doi: 10.1186/s12931-015-0277-4. No abstract available.


Comparative assessment of several automatic CPAP devices' responses: a bench test study.

Isetta V, Navajas D, Montserrat JM, Farré R.

ERJ Open Res. 2015 Aug 21;1(1). pii: 00031-2015. eCollection 2015 May.


Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices.

Vicens-Zygmunt V, Estany S, Colom A, Montes-Worboys A, Machahua C, Sanabria AJ, Llatjos R, Escobar I, Manresa F, Dorca J, Navajas D, Alcaraz J, Molina-Molina M.

Respir Res. 2015 Jul 1;16:82. doi: 10.1186/s12931-015-0237-z. Erratum in: Respir Res. 2015;16:136.


Physical principles of membrane remodelling during cell mechanoadaptation.

Kosmalska AJ, Casares L, Elosegui-Artola A, Thottacherry JJ, Moreno-Vicente R, González-Tarragó V, del Pozo MÁ, Mayor S, Arroyo M, Navajas D, Trepat X, Gauthier NC, Roca-Cusachs P.

Nat Commun. 2015 Jun 15;6:7292. doi: 10.1038/ncomms8292.


In vitro comparative study of two decellularization protocols in search of an optimal myocardial scaffold for recellularization.

Perea-Gil I, Uriarte JJ, Prat-Vidal C, Gálvez-Montón C, Roura S, Llucià-Valldeperas A, Soler-Botija C, Farré R, Navajas D, Bayes-Genis A.

Am J Transl Res. 2015 Mar 15;7(3):558-73. eCollection 2015.


Pressure- and flow-controlled media perfusion differently modify vascular mechanics in lung decellularization.

da Palma RK, Campillo N, Uriarte JJ, Oliveira LV, Navajas D, Farré R.

J Mech Behav Biomed Mater. 2015 Sep;49:69-79. doi: 10.1016/j.jmbbm.2015.04.024. Epub 2015 May 7.


Hydraulic fracture during epithelial stretching.

Casares L, Vincent R, Zalvidea D, Campillo N, Navajas D, Arroyo M, Trepat X.

Nat Mater. 2015 Mar;14(3):343-51. doi: 10.1038/nmat4206. Epub 2015 Feb 9.


Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome.

Crosas-Molist E, Meirelles T, López-Luque J, Serra-Peinado C, Selva J, Caja L, Gorbenko Del Blanco D, Uriarte JJ, Bertran E, Mendizábal Y, Hernández V, García-Calero C, Busnadiego O, Condom E, Toral D, Castellà M, Forteza A, Navajas D, Sarri E, Rodríguez-Pascual F, Dietz HC, Fabregat I, Egea G.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):960-72. doi: 10.1161/ATVBAHA.114.304412. Epub 2015 Jan 15.


Increased upper airway collapsibility in a mouse model of Marfan syndrome.

da Palma RK, Farré R, Montserrat JM, Gorbenko Del Blanco D, Egea G, de Oliveira LV, Navajas D, Almendros I.

Respir Physiol Neurobiol. 2015 Feb 1;207:58-60. doi: 10.1016/j.resp.2014.12.013. Epub 2014 Dec 23.


Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea.

Moreno-Indias I, Torres M, Montserrat JM, Sanchez-Alcoholado L, Cardona F, Tinahones FJ, Gozal D, Poroyko VA, Navajas D, Queipo-Ortuño MI, Farré R.

Eur Respir J. 2015 Apr;45(4):1055-65. doi: 10.1183/09031936.00184314. Epub 2014 Dec 23.


Snail1-expressing fibroblasts in the tumor microenvironment display mechanical properties that support metastasis.

Stanisavljevic J, Loubat-Casanovas J, Herrera M, Luque T, Peña R, Lluch A, Albanell J, Bonilla F, Rovira A, Peña C, Navajas D, Rojo F, García de Herreros A, Baulida J.

Cancer Res. 2015 Jan 15;75(2):284-95. doi: 10.1158/0008-5472.CAN-14-1903. Epub 2014 Dec 8.


Parabiotic model for differentiating local and systemic effects of continuous and intermittent hypoxia.

Torres M, Rojas M, Campillo N, Cardenes N, Montserrat JM, Navajas D, Farré R.

J Appl Physiol (1985). 2015 Jan 1;118(1):42-7. doi: 10.1152/japplphysiol.00858.2014. Epub 2014 Nov 6.


Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice.

Torres M, Laguna-Barraza R, Dalmases M, Calle A, Pericuesta E, Montserrat JM, Navajas D, Gutierrez-Adan A, Farré R.

Sleep. 2014 Nov 1;37(11):1757-65. doi: 10.5665/sleep.4166.


Low oxygen tension enhances the generation of lung progenitor cells from mouse embryonic and induced pluripotent stem cells.

Garreta E, Melo E, Navajas D, Farré R.

Physiol Rep. 2014 Jul 16;2(7). pii: e12075. doi: 10.14814/phy2.12075.


Mechanical properties of acellular mouse lungs after sterilization by gamma irradiation.

Uriarte JJ, Nonaka PN, Campillo N, Palma RK, Melo E, de Oliveira LVF, Navajas D, Farré R.

J Mech Behav Biomed Mater. 2014 Dec;40:168-177. doi: 10.1016/j.jmbbm.2014.08.017. Epub 2014 Aug 28.


Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats.

Dalmases M, Torres M, Márquez-Kisinousky L, Almendros I, Planas AM, Embid C, Martínez-Garcia MÁ, Navajas D, Farré R, Montserrat JM.

Sleep. 2014 Jul 1;37(7):1249-56. doi: 10.5665/sleep.3848.


Inhomogeneity of local stiffness in the extracellular matrix scaffold of fibrotic mouse lungs.

Melo E, Cárdenes N, Garreta E, Luque T, Rojas M, Navajas D, Farré R.

J Mech Behav Biomed Mater. 2014 Sep;37:186-95. doi: 10.1016/j.jmbbm.2014.05.019. Epub 2014 Jun 2.


Mechanical properties of mouse lungs along organ decellularization by sodium dodecyl sulfate.

Nonaka PN, Uriarte JJ, Campillo N, Melo E, Navajas D, Farré R, Oliveira LV.

Respir Physiol Neurobiol. 2014 Aug 15;200:1-5. doi: 10.1016/j.resp.2014.04.008. Epub 2014 May 14.


Heterogeneous micromechanical properties of the extracellular matrix in healthy and infarcted hearts.

Andreu I, Luque T, Sancho A, Pelacho B, Iglesias-García O, Melo E, Farré R, Prósper F, Elizalde MR, Navajas D.

Acta Biomater. 2014 Jul;10(7):3235-42. doi: 10.1016/j.actbio.2014.03.034. Epub 2014 Apr 6.


Telemedicine-based approach for obstructive sleep apnea management: building evidence.

Isetta V, León C, Torres M, Embid C, Roca J, Navajas D, Farré R, Montserrat JM.

Interact J Med Res. 2014 Feb 19;3(1):e6. doi: 10.2196/ijmr.3060.

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