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Aberrant regulation of the GSK-3β/NRF2 axis unveils a novel therapy for adrenoleukodystrophy.

Ranea-Robles P, Launay N, Ruiz M, Calingasan NY, Dumont M, Naudí A, Portero-Otín M, Pamplona R, Ferrer I, Beal MF, Fourcade S, Pujol A.

EMBO Mol Med. 2018 Jul 11. pii: e8604. doi: 10.15252/emmm.201708604. [Epub ahead of print]


Essential physiological differences characterise short- and long-lived strains of Drosophila melanogaster.

Gubina N, Naudi A, Stefanatos R, Jove M, Scialo F, Fernandez-Ayala DJ, Rantapero T, Yurkevych I, Portero-Otin M, Nykter M, Lushchak O, Navas P, Pamplona R, Sanz A.

J Gerontol A Biol Sci Med Sci. 2018 Jun 26. doi: 10.1093/gerona/gly143. [Epub ahead of print]


Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome.

Jové M, Pradas I, Naudí A, Rovira-Llopis S, Bañuls C, Rocha M, Portero-Otin M, Hernández-Mijares A, Victor VM, Pamplona R.

Oncotarget. 2017 Dec 17;9(4):4522-4536. doi: 10.18632/oncotarget.23393. eCollection 2018 Jan 12.


Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance.

Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A.

Aging Cell. 2017 Dec;16(6):1404-1413. doi: 10.1111/acel.12682. Epub 2017 Oct 5.


Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages.

Cabré R, Naudí A, Dominguez-Gonzalez M, Jové M, Ayala V, Mota-Martorell N, Pradas I, Nogueras L, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):703-710. doi: 10.1093/gerona/glx164.


Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

Naudí A, Cabré R, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

Biochim Biophys Acta. 2017 May;1862(5):485-495. doi: 10.1016/j.bbalip.2017.02.001. Epub 2017 Feb 7.


Specific Metabolomics Adaptations Define a Differential Regional Vulnerability in the Adult Human Cerebral Cortex.

Cabré R, Jové M, Naudí A, Ayala V, Piñol-Ripoll G, Gil-Villar MP, Dominguez-Gonzalez M, Obis È, Berdun R, Mota-Martorell N, Portero-Otin M, Ferrer I, Pamplona R.

Front Mol Neurosci. 2016 Dec 8;9:138. doi: 10.3389/fnmol.2016.00138. eCollection 2016.


Sixty years old is the breakpoint of human frontal cortex aging.

Cabré R, Naudí A, Dominguez-Gonzalez M, Ayala V, Jové M, Mota-Martorell N, Piñol-Ripoll G, Gil-Villar MP, Rué M, Portero-Otín M, Ferrer I, Pamplona R.

Free Radic Biol Med. 2017 Feb;103:14-22. doi: 10.1016/j.freeradbiomed.2016.12.010. Epub 2016 Dec 13.


Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice.

Martínez-Cisuelo V, Gómez J, García-Junceda I, Naudí A, Cabré R, Mota-Martorell N, López-Torres M, González-Sánchez M, Pamplona R, Barja G.

Exp Gerontol. 2016 Oct;83:130-8. doi: 10.1016/j.exger.2016.08.002. Epub 2016 Aug 4.


A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

Jové M, Naudí A, Gambini J, Borras C, Cabré R, Portero-Otín M, Viña J, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):30-37. Epub 2016 Mar 24.


Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.

Ruiz M, Jové M, Schlüter A, Casasnovas C, Villarroya F, Guilera C, Ortega FJ, Naudí A, Pamplona R, Gimeno R, Fourcade S, Portero-Otín M, Pujol A.

Hum Mol Genet. 2015 Dec 15;24(24):6861-76. doi: 10.1093/hmg/ddv375. Epub 2015 Sep 14.


Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau.

López-González I, Aso E, Carmona M, Armand-Ugon M, Blanco R, Naudí A, Cabré R, Portero-Otin M, Pamplona R, Ferrer I.

J Neuropathol Exp Neurol. 2015 Oct;74(10):975-99. doi: 10.1097/NEN.0000000000000241.


Lipidomics of human brain aging and Alzheimer's disease pathology.

Naudí A, Cabré R, Jové M, Ayala V, Gonzalo H, Portero-Otín M, Ferrer I, Pamplona R.

Int Rev Neurobiol. 2015;122:133-89. doi: 10.1016/bs.irn.2015.05.008. Epub 2015 Jun 19. Review.


Long lifespans have evolved with long and monounsaturated fatty acids in birds.

Galván I, Naudí A, Erritzøe J, Møller AP, Barja G, Pamplona R.

Evolution. 2015 Oct;69(10):2776-84. doi: 10.1111/evo.12754. Epub 2015 Sep 24.


Target of rapamycin activation predicts lifespan in fruit flies.

Scialò F, Sriram A, Naudí A, Ayala V, Jové M, Pamplona R, Sanz A.

Cell Cycle. 2015;14(18):2949-58. doi: 10.1080/15384101.2015.1071745.


Human Aging Is a Metabolome-related Matter of Gender.

Jové M, Maté I, Naudí A, Mota-Martorell N, Portero-Otín M, De la Fuente M, Pamplona R.

J Gerontol A Biol Sci Med Sci. 2016 May;71(5):578-85. doi: 10.1093/gerona/glv074. Epub 2015 May 26.


Activation of sirtuin 1 as therapy for the peroxisomal disease adrenoleukodystrophy.

Morató L, Ruiz M, Boada J, Calingasan NY, Galino J, Guilera C, Jové M, Naudí A, Ferrer I, Pamplona R, Serrano M, Portero-Otín M, Beal MF, Fourcade S, Pujol A.

Cell Death Differ. 2015 Nov;22(11):1742-53. doi: 10.1038/cdd.2015.20. Epub 2015 Mar 27.


Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction.

Gomez A, Gomez J, Lopez Torres M, Naudi A, Mota-Martorell N, Pamplona R, Barja G.

J Bioenerg Biomembr. 2015 Jun;47(3):199-208. doi: 10.1007/s10863-015-9608-x. Epub 2015 Mar 15.


Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.

Jové M, Naudí A, Portero-Otin M, Cabré R, Rovira-Llopis S, Bañuls C, Rocha M, Hernández-Mijares A, Victor VM, Pamplona R.

FASEB J. 2014 Dec;28(12):5163-71. doi: 10.1096/fj.14-253187. Epub 2014 Aug 28.


Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice.

Jové M, Naudí A, Ramírez-Núñez O, Portero-Otín M, Selman C, Withers DJ, Pamplona R.

Aging Cell. 2014 Oct;13(5):828-37. doi: 10.1111/acel.12241. Epub 2014 Jul 23.


Metabolomics of human brain aging and age-related neurodegenerative diseases.

Jové M, Portero-Otín M, Naudí A, Ferrer I, Pamplona R.

J Neuropathol Exp Neurol. 2014 Jul;73(7):640-57. doi: 10.1097/NEN.0000000000000091. Review.


Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.

Granados-Principal S, El-Azem N, Pamplona R, Ramirez-Tortosa C, Pulido-Moran M, Vera-Ramirez L, Quiles JL, Sanchez-Rovira P, Naudí A, Portero-Otin M, Perez-Lopez P, Ramirez-Tortosa M.

Biochem Pharmacol. 2014 Jul 1;90(1):25-33. doi: 10.1016/j.bcp.2014.04.001. Epub 2014 Apr 12.


Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity.

Gómez A, Sánchez-Roman I, Gomez J, Cruces J, Mate I, Lopez-Torres M, Naudi A, Portero-Otin M, Pamplona R, De la Fuente M, Barja G.

Aging Cell. 2014 Jun;13(3):551-60. doi: 10.1111/acel.12205. Epub 2014 Feb 26.


Membrane lipid unsaturation as physiological adaptation to animal longevity.

Naudí A, Jové M, Ayala V, Portero-Otín M, Barja G, Pamplona R.

Front Physiol. 2013 Dec 17;4:372. doi: 10.3389/fphys.2013.00372. Review.


Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

Sanchez-Roman I, Gomez A, Naudí A, Jove M, Gómez J, Lopez-Torres M, Pamplona R, Barja G.

J Bioenerg Biomembr. 2014 Jun;46(3):159-72. doi: 10.1007/s10863-013-9535-7. Epub 2013 Dec 8.


Plasma long-chain free fatty acids predict mammalian longevity.

Jové M, Naudí A, Aledo JC, Cabré R, Ayala V, Portero-Otin M, Barja G, Pamplona R.

Sci Rep. 2013 Nov 28;3:3346. doi: 10.1038/srep03346.


[A study of selective neuronal vulnerability in the human central nervous system].

Naudí A, Jové M, Ayala V, Cabré R, Portero-Otin M, Ferrer I, Pamplona R.

Rev Esp Geriatr Gerontol. 2013 Sep-Oct;48(5):216-23. doi: 10.1016/j.regg.2013.04.005. Epub 2013 Sep 5. Spanish.


Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophy.

Morató L, Galino J, Ruiz M, Calingasan NY, Starkov AA, Dumont M, Naudí A, Martínez JJ, Aubourg P, Portero-Otín M, Pamplona R, Galea E, Beal MF, Ferrer I, Fourcade S, Pujol A.

Brain. 2013 Aug;136(Pt 8):2432-43. doi: 10.1093/brain/awt143. Epub 2013 Jun 22.


Specific lipidome signatures in central nervous system from methionine-restricted mice.

Jové M, Ayala V, Ramírez-Núñez O, Naudí A, Cabré R, Spickett CM, Portero-Otín M, Pamplona R.

J Proteome Res. 2013 Jun 7;12(6):2679-89. doi: 10.1021/pr400064a. Epub 2013 Apr 30.


Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.

Naudí A, Jové M, Ayala V, Cabré R, Portero-Otín M, Pamplona R.

Int J Mol Sci. 2013 Feb 5;14(2):3285-313. doi: 10.3390/ijms14023285.


Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications.

Soler-Cantero A, Jové M, Cacabelos D, Boada J, Naudí A, Romero MP, Cassanyé A, Serrano JC, Arola L, Valls J, Bellmunt MJ, Prat J, Pamplona R, Portero-Otin M, Motilva MJ.

PLoS One. 2012;7(8):e43308. doi: 10.1371/journal.pone.0043308. Epub 2012 Aug 29.


Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

Naudí A, Jové M, Cacabelos D, Ayala V, Cabre R, Caro P, Gomez J, Portero-Otín M, Barja G, Pamplona R.

Amino Acids. 2013 Feb;44(2):361-71. doi: 10.1007/s00726-012-1339-2. Epub 2012 Jun 22.


Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria.

Sanchez-Roman I, Gómez A, Pérez I, Sanchez C, Suarez H, Naudí A, Jové M, Lopez-Torres M, Pamplona R, Barja G.

Biogerontology. 2012 Aug;13(4):399-411. doi: 10.1007/s10522-012-9384-5. Epub 2012 May 13.


Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

Arranz L, Naudí A, De la Fuente M, Pamplona R.

Age (Dordr). 2013 Jun;35(3):621-35. doi: 10.1007/s11357-012-9391-0. Epub 2012 Feb 25.


Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.

Naudi A, Jove M, Ayala V, Cassanye A, Serrano J, Gonzalo H, Boada J, Prat J, Portero-Otin M, Pamplona R.

Exp Diabetes Res. 2012;2012:696215. doi: 10.1155/2012/696215. Epub 2012 Jan 2. Review.


Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart.

Sanchez-Roman I, Gomez A, Gomez J, Suarez H, Sanchez C, Naudi A, Ayala V, Portero-Otin M, Lopez-Torres M, Pamplona R, Barja G.

J Bioenerg Biomembr. 2011 Dec;43(6):699-708. doi: 10.1007/s10863-011-9389-9. Epub 2011 Oct 18.


Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

López-Erauskin J, Fourcade S, Galino J, Ruiz M, Schlüter A, Naudi A, Jove M, Portero-Otin M, Pamplona R, Ferrer I, Pujol A.

Ann Neurol. 2011 Jul;70(1):84-92. doi: 10.1002/ana.22363.


Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

Ayala V, Granado-Serrano AB, Cacabelos D, Naudí A, Ilieva EV, Boada J, Caraballo-Miralles V, Lladó J, Ferrer I, Pamplona R, Portero-Otin M.

Acta Neuropathol. 2011 Sep;122(3):259-70. doi: 10.1007/s00401-011-0850-y. Epub 2011 Jun 25.


Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.

Galino J, Ruiz M, Fourcade S, Schlüter A, López-Erauskin J, Guilera C, Jove M, Naudi A, García-Arumí E, Andreu AL, Starkov AA, Pamplona R, Ferrer I, Portero-Otin M, Pujol A.

Antioxid Redox Signal. 2011 Oct 15;15(8):2095-107. doi: 10.1089/ars.2010.3877. Epub 2011 Jun 8.


Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.

Ilieva EV, Kichev A, Naudí A, Ferrer I, Pamplona R, Portero-Otín M.

J Neuropathol Exp Neurol. 2011 Apr;70(4):253-63. doi: 10.1097/NEN.0b013e31820f8765.


Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.

Ochoa JJ, Pamplona R, Ramirez-Tortosa MC, Granados-Principal S, Perez-Lopez P, Naudí A, Portero-Otin M, López-Frías M, Battino M, Quiles JL.

Free Radic Biol Med. 2011 May 1;50(9):1053-64. doi: 10.1016/j.freeradbiomed.2011.02.004. Epub 2011 Feb 16.


Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle.

Saborido A, Naudí A, Portero-Otín M, Pamplona R, Megías A.

J Appl Physiol (1985). 2011 Mar;110(3):661-9. doi: 10.1152/japplphysiol.00790.2010. Epub 2010 Dec 16.


The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

Sanchez-Roman I, Gomez J, Naudi A, Ayala V, Portero-Otín M, Lopez-Torres M, Pamplona R, Barja G.

Rejuvenation Res. 2010 Dec;13(6):683-93. doi: 10.1089/rej.2010.1062. Epub 2010 Sep 6.


Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.

Sanz A, Soikkeli M, Portero-Otín M, Wilson A, Kemppainen E, McIlroy G, Ellilä S, Kemppainen KK, Tuomela T, Lakanmaa M, Kiviranta E, Stefanatos R, Dufour E, Hutz B, Naudí A, Jové M, Zeb A, Vartiainen S, Matsuno-Yagi A, Yagi T, Rustin P, Pamplona R, Jacobs HT.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9105-10. doi: 10.1073/pnas.0911539107. Epub 2010 Apr 30.


[Glycation of mitochondrial proteins, oxidative stress and aging].

Naudí A, Jové M, Ayala V, Portero-Otín M, Pamplona R.

Rev Esp Geriatr Gerontol. 2010 May-Jun;45(3):156-66. doi: 10.1016/j.regg.2010.02.001. Epub 2010 Mar 26. Spanish.


Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.

Fourcade S, Ruiz M, Guilera C, Hahnen E, Brichta L, Naudi A, Portero-Otín M, Dacremont G, Cartier N, Wanders R, Kemp S, Mandel JL, Wirth B, Pamplona R, Aubourg P, Pujol A.

Hum Mol Genet. 2010 May 15;19(10):2005-14. doi: 10.1093/hmg/ddq082. Epub 2010 Feb 23.


Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease.

Ilieva EV, Naudí A, Kichev A, Ferrer I, Pamplona R, Portero-Otín M.

Free Radic Biol Med. 2010 May 15;48(10):1302-10. doi: 10.1016/j.freeradbiomed.2010.02.006. Epub 2010 Feb 20.


Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.

Fernandez LL, Carmona M, Portero-Otin M, Naudi A, Pamplona R, Schröder N, Ferrer I.

J Alzheimers Dis. 2010;19(3):1069-80. doi: 10.3233/JAD-2010-1304.


Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart.

Quiles JL, Pamplona R, Ramirez-Tortosa MC, Naudí A, Portero-Otin M, Araujo-Nepomuceno E, López-Frías M, Battino M, Ochoa JJ.

Mech Ageing Dev. 2010 Jan;131(1):38-47. doi: 10.1016/j.mad.2009.11.004. Epub 2009 Dec 3.


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