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Items: 1 to 50 of 396

1.

Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring.

Esteban J, Elabbas LE, Borg D, Herlin M, Åkesson A, Barber X, Hamscher G, Nau H, Bowers WJ, Nakai JS, Viluksela M, Håkansson H.

Toxicol Lett. 2014 Aug 17;229(1):41-51. doi: 10.1016/j.toxlet.2014.04.021. Epub 2014 Jun 2.

PMID:
24887809
2.

In utero and lactational exposure to a mixture of environmental contaminants detected in Canadian Arctic human populations alters retinoid levels in rat offspring with low margins of exposure.

Elabbas LE, Esteban J, Barber X, Hamscher G, Nau H, Bowers WJ, Nakai JS, Herlin M, Åkesson A, Viluksela M, Borg D, Håkansson H.

J Toxicol Environ Health A. 2014;77(5):223-45. doi: 10.1080/15287394.2013.861776.

PMID:
24588224
3.

Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner.

Stempin S, Andres S, Bumke Scheer M, Rode A, Nau H, Seidel A, Lampen A.

Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.

PMID:
23892311
4.

Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.

Ivanova D, Gronemeyer H, Steinberg P, Nau H.

Arch Toxicol. 2013 Feb;87(2):303-10. doi: 10.1007/s00204-012-0930-3. Epub 2012 Sep 26.

PMID:
23010695
5.

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Elphick LM, Pawolleck N, Guschina IA, Chaieb L, Eikel D, Nau H, Harwood JL, Plant NJ, Williams RS.

Dis Model Mech. 2012 Mar;5(2):231-40. doi: 10.1242/dmm.008391. Epub 2011 Oct 14.

6.

The teratogenic potencies of valproic acid derivatives and their effects on biological end-points are related to changes in histone deacetylase and Erk1/2 activities.

Gotfryd K, Hansen M, Kawa A, Ellerbeck U, Nau H, Berezin V, Bock E, Walmod PS.

Basic Clin Pharmacol Toxicol. 2011 Sep;109(3):164-74. doi: 10.1111/j.1742-7843.2011.00702.x. Epub 2011 Apr 18.

7.

The embryonic stem cell test as tool to assess structure-dependent teratogenicity: the case of valproic acid.

Riebeling C, Pirow R, Becker K, Buesen R, Eikel D, Kaltenhäuser J, Meyer F, Nau H, Slawik B, Visan A, Volland J, Spielmann H, Luch A, Seiler A.

Toxicol Sci. 2011 Apr;120(2):360-70. doi: 10.1093/toxsci/kfr001. Epub 2011 Jan 11.

8.

Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity.

de Jong E, Doedée AM, Reis-Fernandes MA, Nau H, Piersma AH.

Reprod Toxicol. 2011 May;31(4):375-82. doi: 10.1016/j.reprotox.2010.11.012. Epub 2010 Nov 27. Review.

PMID:
21115111
9.

CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats.

Fritzsche B, Schuchardt JP, Schmidt A, Nau H, Schweigert FJ, Rühl R.

Reprod Toxicol. 2010 Nov;30(3):446-51. doi: 10.1016/j.reprotox.2010.05.005. Epub 2010 May 16.

PMID:
20580668
10.

Modulation of synaptic transmission and analysis of neuroprotective effects of valproic Acid and derivates in rat embryonic motoneurons.

Ragancokova D, Song Y, Nau H, Dengler R, Krampfl K, Petri S.

Cell Mol Neurobiol. 2010 Aug;30(6):891-900. doi: 10.1007/s10571-010-9518-8. Epub 2010 Apr 27.

PMID:
20422280
12.

Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction.

Leng Y, Marinova Z, Reis-Fernandes MA, Nau H, Chuang DM.

Neurosci Lett. 2010 Jun 7;476(3):127-32. doi: 10.1016/j.neulet.2010.04.013. Epub 2010 Apr 13.

13.

Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.

Hettwer M, Reis-Fernandes MA, Iken M, Ott M, Steinberg P, Nau H.

Reprod Toxicol. 2010 Aug;30(1):113-20. doi: 10.1016/j.reprotox.2010.01.009. Epub 2010 Feb 2.

PMID:
20132877
14.

The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo.

Schuchardt JP, Wahlström D, Rüegg J, Giese N, Stefan M, Hopf H, Pongratz I, Håkansson H, Eichele G, Pettersson K, Nau H.

FEBS J. 2009 Jun;276(11):3043-59. doi: 10.1111/j.1742-4658.2009.07023.x. Epub 2009 Apr 22.

15.

Detection of estrogenically active substances in diets for sows by an in vitro bioassay supported by HPLC analysis.

Winter P, Nau H, Lampen A, Kamphues J.

J Anim Physiol Anim Nutr (Berl). 2008 Jun;92(3):337-44. doi: 10.1111/j.1439-0396.2007.00797.x.

PMID:
18477315
16.

Hydroxamic acid and fluorinated derivatives of valproic acid: anticonvulsant activity, neurotoxicity and teratogenicity.

Gravemann U, Volland J, Nau H.

Neurotoxicol Teratol. 2008 Sep-Oct;30(5):390-4. doi: 10.1016/j.ntt.2008.03.060. Epub 2008 Mar 19.

PMID:
18455366
17.

Penetration studies of propoxur and phoxim from eggshell into whole egg after experimental exposure and application in henhouses.

Limsuwan S, Priess B, Tansakul N, Nau H, Kietzmann M, Hamscher G.

J Agric Food Chem. 2007 Jul 25;55(15):6401-5. Epub 2007 Jun 30.

PMID:
17602660
19.

The practical application of three validated in vitro embryotoxicity tests. The report and recommendations of an ECVAM/ZEBET workshop (ECVAM workshop 57).

Spielmann H, Seiler A, Bremer S, Hareng L, Hartung T, Ahr H, Faustman E, Haas U, Moffat GJ, Nau H, Vanparys P, Piersma A, Sintes JR, Stuart J.

Altern Lab Anim. 2006 Oct;34(5):527-38. No abstract available.

PMID:
17121476
20.

Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement.

Gotfryd K, Owczarek S, Hoffmann K, Klementiev B, Nau H, Berezin V, Bock E, Walmod PS.

Neuropharmacology. 2007 Mar;52(3):764-78. Epub 2006 Nov 7.

PMID:
17095022
21.

Induction of the homeotic gene Hoxa1 through valproic acid's teratogenic mechanism of action.

Stodgell CJ, Ingram JL, O'Bara M, Tisdale BK, Nau H, Rodier PM.

Neurotoxicol Teratol. 2006 Sep-Oct;28(5):617-24. Epub 2006 Aug 16.

PMID:
16989981
22.

[Impacts and impact mechanisms of "dioxins" in humans and animals].

Nau H.

Dtsch Tierarztl Wochenschr. 2006 Aug;113(8):292-7. Review. German.

PMID:
16955640
23.

Novel valproic acid derivatives with hemoglobin F inducing activity.

Rönndahl G, Mönkemeyer S, Schulze S, Pekrun A, Eikel D, Nau H, Witt O.

Am J Hematol. 2006 May;81(5):374-6.

24.

Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein.

Ghyselinck NB, Vernet N, Dennefeld C, Giese N, Nau H, Chambon P, Viville S, Mark M.

Dev Dyn. 2006 Jun;235(6):1608-22.

25.

Analysis of reproductive toxicity and classification of glufosinate-ammonium.

Schulte-Hermann R, Wogan GN, Berry C, Brown NA, Czeizel A, Giavini E, Holmes LB, Kroes R, Nau H, Neubert D, Oesch F, Ott T, Pelkonen O, Robert-Gnansia E, Sullivan FM.

Regul Toxicol Pharmacol. 2006 Apr;44(3 Suppl 1):S1-76. Epub 2006 Feb 28.

PMID:
16510221
26.

Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells.

Deubzer H, Busche B, Rönndahl G, Eikel D, Michaelis M, Cinatl J, Schulze S, Nau H, Witt O.

Leuk Res. 2006 Sep;30(9):1167-75. Epub 2006 Feb 28.

PMID:
16510182
28.

Differential teratogenesis of all-trans-retinoic acid administered on gestational day 9.5 to SWV and C57BL/6N mice: emphasis on limb dysmorphology.

Collins MD, Eckhoff C, Weiss R, Resnick E, Nau H, Scott WJ Jr.

Birth Defects Res A Clin Mol Teratol. 2006 Feb;76(2):96-106.

PMID:
16463421
30.

Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age.

Nohynek GJ, Meuling WJ, Vaes WH, Lawrence RS, Shapiro S, Schulte S, Steiling W, Bausch J, Gerber E, Sasa H, Nau H.

Toxicol Lett. 2006 May 5;163(1):65-76. Epub 2005 Oct 21.

PMID:
16243460
31.

Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells.

Michaelis M, Suhan T, Michaelis UR, Beek K, Rothweiler F, Tausch L, Werz O, Eikel D, Zörnig M, Nau H, Fleming I, Doerr HW, Cinatl J Jr.

Cell Death Differ. 2006 Mar;13(3):446-53.

32.

Increased replication of human cytomegalovirus in retinal pigment epithelial cells by valproic acid depends on histone deacetylase inhibition.

Michaelis M, Suhan T, Reinisch A, Reisenauer A, Fleckenstein C, Eikel D, Gümbel H, Doerr HW, Nau H, Cinatl J Jr.

Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3451-7.

PMID:
16123451
33.

Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms.

Hoegberg P, Schmidt CK, Fletcher N, Nilsson CB, Trossvik C, Gerlienke Schuur A, Brouwer A, Nau H, Ghyselinck NB, Chambon P, Håkansson H.

Chem Biol Interact. 2005 Sep 10;156(1):25-39.

PMID:
16109390
34.

Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: effects on proliferation, differentiation, and gene expression.

Lampen A, Leifheit M, Voss J, Nau H.

Biochim Biophys Acta. 2005 Jun 15;1735(1):30-40. Epub 2005 Feb 16.

PMID:
15935729
35.

Altered retinoid metabolism in female Long-Evans and Han/Wistar rats following long-term 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treatment.

Fletcher N, Giese N, Schmidt C, Stern N, Lind PM, Viluksela M, Tuomisto JT, Tuomisto J, Nau H, Håkansson H.

Toxicol Sci. 2005 Aug;86(2):264-72. Epub 2005 Apr 27.

PMID:
15858224
36.

Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure.

Hamscher G, Pawelzick HT, Höper H, Nau H.

Environ Toxicol Chem. 2005 Apr;24(4):861-8.

PMID:
15839560
39.

Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development.

Matt N, Schmidt CK, Dupé V, Dennefeld C, Nau H, Chambon P, Mark M, Ghyselinck NB.

Dev Dyn. 2005 May;233(1):167-76.

40.
41.

Identification of 14-hydroxy-retro-retinol and 4-hydroxy-retinol as endogenous retinoids in rats throughout neonatal development.

Rühl R, Hamscher G, Garcia AL, Nau H, Schweigert FJ.

Life Sci. 2005 Feb 18;76(14):1613-22. Epub 2004 Dec 18.

PMID:
15680170
42.
43.
44.

[Safety of food products updated in perspective--an introduction to the following scientific articles].

Nau H.

Dtsch Tierarztl Wochenschr. 2004 Jul;111(7):272. German. No abstract available.

PMID:
15366285
45.

Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid.

Michaelis M, Köhler N, Reinisch A, Eikel D, Gravemann U, Doerr HW, Nau H, Cinatl J Jr.

Biochem Pharmacol. 2004 Aug 1;68(3):531-8.

PMID:
15242819
46.

Discriminative power of an assay for automated in vitro screening of teratogens.

Walmod PS, Gravemann U, Nau H, Berezin V, Bock E.

Toxicol In Vitro. 2004 Aug;18(4):511-25.

PMID:
15130609
47.

Valproic acid inhibits angiogenesis in vitro and in vivo.

Michaelis M, Michaelis UR, Fleming I, Suhan T, Cinatl J, Blaheta RA, Hoffmann K, Kotchetkov R, Busse R, Nau H, Cinatl J Jr.

Mol Pharmacol. 2004 Mar;65(3):520-7.

48.

Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture.

Santos-Guzmán J, Arnhold T, Nau H, Wagner C, Fahr SH, Mao GE, Caudill MA, Wang JC, Henning SM, Swendseid ME, Collins MD.

J Nutr. 2003 Nov;133(11):3561-70.

PMID:
14608074
49.

[Effects of animal housing facilities on residues and contaminants in food].

Hamscher G, Nau H.

Dtsch Tierarztl Wochenschr. 2003 Aug;110(8):316-9. German.

PMID:
14535059
50.

Antibiotics in dust originating from a pig-fattening farm: a new source of health hazard for farmers?

Hamscher G, Pawelzick HT, Sczesny S, Nau H, Hartung J.

Environ Health Perspect. 2003 Oct;111(13):1590-4.

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