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Items: 1 to 50 of 331

1.

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.

Morii I, Iwabuchi Y, Mori S, Suekuni M, Natsume T, Yoshida K, Sugimoto N, Kanemaki MT, Fujita M.

Cancer Sci. 2019 Jan 16. doi: 10.1111/cas.13941. [Epub ahead of print]

2.

Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell-cycle progression.

Goto H, Natsume T, Kanemaki MT, Kaito A, Wang S, Gabazza EC, Inagaki M, Mizoguchi A.

J Cell Sci. 2019 Jan 11. pii: jcs.223123. doi: 10.1242/jcs.223123. [Epub ahead of print]

PMID:
30635443
3.

Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.

Yano M, Matsuda A, Natsume T, Ogawa S, Awaga Y, Hayashi I, Hama A, Takamatsu H.

Hum Reprod. 2018 Dec 31. doi: 10.1093/humrep/dey383. [Epub ahead of print]

PMID:
30597044
4.

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.

Okamoto K, Ohishi T, Kuroiwa M, Iemura SI, Natsume T, Seimiya H.

Oncotarget. 2018 Nov 9;9(88):35844-35855. doi: 10.18632/oncotarget.26312. eCollection 2018 Nov 9.

5.

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer.

Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, Hirokawa T, Natsume T, Doi T.

Bioorg Med Chem. 2018 Dec 15;26(23-24):6023-6034. doi: 10.1016/j.bmc.2018.11.001. Epub 2018 Nov 7.

6.

Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.

Hatta T, Iemura SI, Ohishi T, Nakayama H, Seimiya H, Yasuda T, Iizuka K, Fukuda M, Takeda J, Natsume T, Horikawa Y.

Sci Rep. 2018 Nov 13;8(1):16756. doi: 10.1038/s41598-018-35204-x.

7.

Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signaling pathways in rat gastrocnemius muscles.

Natsume T, Yoshihara T, Naito H.

Appl Physiol Nutr Metab. 2018 Nov 6. doi: 10.1139/apnm-2018-0384. [Epub ahead of print]

PMID:
30398900
8.

Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle.

Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H.

J Physiol Sci. 2018 Sep 27. doi: 10.1007/s12576-018-0640-6. [Epub ahead of print]

PMID:
30259391
9.

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI.

iScience. 2018 Jul 27;5:1-18. doi: 10.1016/j.isci.2018.06.006. Epub 2018 Jun 18.

10.

Effects of a progressive walking program on the risk of developing locomotive syndrome in elderly Japanese people: a single-arm trial.

Yoshihara T, Ozaki H, Nakagata T, Natsume T, Kitada T, Ishihara Y, Deng P, Osawa T, Ishibashi M, Ishijima M, Kobayashi H, Machida S, Naito H.

J Phys Ther Sci. 2018 Sep;30(9):1180-1186. doi: 10.1589/jpts.30.1180. Epub 2018 Sep 4.

11.

[Pharmacological profile of a novel nonhuman primate model of knee osteoarthritis].

Ogawa S, Natsume T, Takamatsu H.

Nihon Yakurigaku Zasshi. 2018;152(3):132-138. doi: 10.1254/fpj.152.132. Japanese.

PMID:
30185731
12.

Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression.

Mochizuki Y, Chiba T, Kataoka K, Yamashita S, Sato T, Kato T, Takahashi K, Miyamoto T, Kitazawa M, Hatta T, Natsume T, Takai S, Asahara H.

Dev Cell. 2018 Sep 24;46(6):794-806.e6. doi: 10.1016/j.devcel.2018.07.024. Epub 2018 Aug 23.

PMID:
30146478
13.

Seasonal variation of energy expenditure in Japanese macaques (Macaca fuscata).

Sha JCM, Kurihara Y, Tsuji Y, Take M, He T, Kaneko A, Suda-Hashimoto N, Morimoto M, Natsume T, Zahariev A, Blanc S, Hanya G.

J Therm Biol. 2018 Aug;76:139-146. doi: 10.1016/j.jtherbio.2018.07.009. Epub 2018 Jul 25.

PMID:
30143288
14.

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K.

Biochim Biophys Acta Gen Subj. 2018 Jul 18;1862(10):2271-2280. doi: 10.1016/j.bbagen.2018.07.015. [Epub ahead of print]

PMID:
30031111
15.

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M.

Oncogene. 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9. Epub 2018 Jun 7.

PMID:
29880877
16.

Gaps in Understanding Mechanism and Lack of Treatments: Potential Use of a Nonhuman Primate Model of Oxaliplatin-Induced Neuropathic Pain.

Hama A, Natsume T, Ogawa S, Higo N, Hayashi I, Takamatsu H.

Pain Res Manag. 2018 May 2;2018:1630709. doi: 10.1155/2018/1630709. eCollection 2018. Review.

17.

Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble.

Okumura M, Natsume T, Kanemaki MT, Kiyomitsu T.

Elife. 2018 May 31;7. pii: e36559. doi: 10.7554/eLife.36559.

18.

Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain.

Hama A, Natsume T, Ogawa SY, Awaga Y, Hayashi I, Matsuda A, Takamatsu H.

CNS Neurol Disord Drug Targets. 2018;17(5):348-360. doi: 10.2174/1871527317666180515121350.

PMID:
29766827
19.

Effects of training intensity in electromyostimulation on human skeletal muscle.

Natsume T, Ozaki H, Kakigi R, Kobayashi H, Naito H.

Eur J Appl Physiol. 2018 Jul;118(7):1339-1347. doi: 10.1007/s00421-018-3866-3. Epub 2018 Apr 20.

PMID:
29679248
20.

Nuclear export of ubiquitinated proteins via the UBIN-POST system.

Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S, Nagata K.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4199-E4208. doi: 10.1073/pnas.1711017115. Epub 2018 Apr 16.

21.

Hepatomegaly in a boy with ARID1B-related Coffin-Siris syndrome.

Natsume T, Takano K, Motobayashi M, Kosho T.

Pediatr Int. 2018 Apr;60(4):378-380. doi: 10.1111/ped.13508. Epub 2018 Mar 4. No abstract available.

PMID:
29504208
22.

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms.

Takagi M, Ono T, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki MT, Hirano T, Imamoto N.

J Cell Sci. 2018 Mar 22;131(6). pii: jcs212092. doi: 10.1242/jcs.212092.

23.

ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.

Noguchi A, Adachi S, Yokota N, Hatta T, Natsume T, Kawahara H.

Biol Open. 2018 Mar 12;7(3). pii: bio031575. doi: 10.1242/bio.031575.

24.

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function.

Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, Natsume T, Kimura A, Komatsu M, Shimizu S, Ito H, Suzuki Y, Penninger JM, Yamamoto T, Imai Y, Kuba K.

Sci Signal. 2018 Feb 6;11(516). pii: eaan3638. doi: 10.1126/scisignal.aan3638.

PMID:
29438013
25.

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.

Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S.

Genes Dev. 2018 Jan 15;32(2):127-139. doi: 10.1101/gad.308528.117. Epub 2018 Feb 8.

26.

Characterization of extracellular matrix components from the desiccation-tolerant cyanobacterium Nostoc commune.

Inoue-Sakamoto K, Tanji Y, Yamaba M, Natsume T, Masaura T, Asano T, Nishiuchi T, Sakamoto T.

J Gen Appl Microbiol. 2018 Mar 27;64(1):15-25. doi: 10.2323/jgam.2017.03.001. Epub 2017 Dec 8.

27.

TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, Naguro I, Kano K, Udagawa T, Natsume T, Aoki J, Inada T, Noguchi T, Ichijo H, Matsuzawa A.

Cell Rep. 2017 Nov 28;21(9):2447-2457. doi: 10.1016/j.celrep.2017.11.007.

28.

Conditional Degrons for Controlling Protein Expression at the Protein Level.

Natsume T, Kanemaki MT.

Annu Rev Genet. 2017 Nov 27;51:83-102. doi: 10.1146/annurev-genet-120116-024656. Review.

PMID:
29178817
29.

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.

Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T.

Nat Commun. 2017 Nov 1;8(1):1246. doi: 10.1038/s41467-017-01255-3.

30.

A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis.

Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, Hirayama S, Shin-Ya K, Shimada I, Doi T, Goshima N, Natsume T, Nagata K.

J Biol Chem. 2017 Dec 8;292(49):20076-20085. doi: 10.1074/jbc.M117.815936. Epub 2017 Oct 12.

31.

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.

Chowdhury AMMA, Katoh H, Hatanaka A, Iwanari H, Nakamura N, Hamakubo T, Natsume T, Waku T, Kobayashi A.

Sci Rep. 2017 Oct 2;7(1):12494. doi: 10.1038/s41598-017-12675-y.

32.

Determination of Rate-Limiting Factor for Formation of Beta-Catenin Destruction Complexes Using Absolute Protein Quantification.

Kitazawa M, Hatta T, Ogawa K, Fukuda E, Goshima N, Natsume T.

J Proteome Res. 2017 Oct 6;16(10):3576-3584. doi: 10.1021/acs.jproteome.7b00305. Epub 2017 Sep 1.

PMID:
28810742
33.

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Fujimori T, Suno R, Iemura SI, Natsume T, Wada I, Hosokawa N.

Genes Cells. 2017 Aug;22(8):684-698. doi: 10.1111/gtc.12506. Epub 2017 Jun 9.

34.

Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.

Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.

Nat Commun. 2017 Jun 7;8:15500. doi: 10.1038/ncomms15500.

35.

Effects of drop sets with resistance training on increases in muscle CSA, strength, and endurance: a pilot study.

Ozaki H, Kubota A, Natsume T, Loenneke JP, Abe T, Machida S, Naito H.

J Sports Sci. 2018 Mar;36(6):691-696. doi: 10.1080/02640414.2017.1331042. Epub 2017 May 22.

PMID:
28532248
36.

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson ID, Kanemaki MT.

Genes Dev. 2017 Apr 15;31(8):816-829. doi: 10.1101/gad.297663.117. Epub 2017 May 9.

37.

Robotic crowd biology with Maholo LabDroids.

Yachie N; Robotic Biology Consortium, Natsume T.

Nat Biotechnol. 2017 Apr 11;35(4):310-312. doi: 10.1038/nbt.3758. No abstract available.

PMID:
28398329
38.

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K.

Sci Rep. 2017 Mar 9;7:44293. doi: 10.1038/srep44293.

39.

A large-scale targeted proteomics assay resource based on an in vitro human proteome.

Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI.

Nat Methods. 2017 Mar;14(3):251-258. doi: 10.1038/nmeth.4116. Epub 2016 Dec 26.

PMID:
28267743
40.

Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion.

Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H.

Cancer Res. 2017 May 1;77(9):2328-2338. doi: 10.1158/0008-5472.CAN-16-1846. Epub 2017 Feb 15.

41.

Patients with benign hand tumors are indicated for surgery according to patient-rated outcome measures.

Yamamoto M, Natsume T, Kurimoto S, Iwatsuki K, Nishizuka T, Nolte MT, Hirata H.

J Plast Reconstr Aesthet Surg. 2017 Apr;70(4):487-494. doi: 10.1016/j.bjps.2016.12.010. Epub 2017 Jan 9.

PMID:
28153429
42.

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):522-528. doi: 10.1016/j.bbrc.2017.01.101. Epub 2017 Jan 23.

PMID:
28126338
43.

TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S.

J Biol Chem. 2017 Mar 10;292(10):4099-4112. doi: 10.1074/jbc.M116.769109. Epub 2017 Jan 23.

44.

A crosslinker-based identification of redox relay targets.

Araki K, Ushioda R, Kusano H, Tanaka R, Hatta T, Fukui K, Nagata K, Natsume T.

Anal Biochem. 2017 Mar 1;520:22-26. doi: 10.1016/j.ab.2016.12.025. Epub 2016 Dec 31.

PMID:
28048978
45.

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.

Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00347-16. doi: 10.1128/MCB.00347-16. Print 2017 Feb 15.

46.

Functional profiling of asymmetrically-organized human CCT/TRiC chaperonin.

Araki K, Suenaga A, Kusano H, Tanaka R, Hatta T, Natsume T, Fukui K.

Biochem Biophys Res Commun. 2016 Dec 9;481(3-4):232-238. doi: 10.1016/j.bbrc.2016.10.120. Epub 2016 Oct 30.

PMID:
27806916
47.

Perichromosomal protein Ki67 supports mitotic chromosome architecture.

Takagi M, Natsume T, Kanemaki MT, Imamoto N.

Genes Cells. 2016 Oct;21(10):1113-1124. doi: 10.1111/gtc.12420. Epub 2016 Sep 9.

48.

Clinical effects of internal fixation for ulnar styloid fractures associated with distal radius fractures: A matched case-control study.

Sawada H, Shinohara T, Natsume T, Hirata H.

J Orthop Sci. 2016 Nov;21(6):745-748. doi: 10.1016/j.jos.2016.06.010. Epub 2016 Aug 7.

PMID:
27511887
49.

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression.

Fukagai K, Waku T, Chowdhury AMMA, Kubo K, Matsumoto M, Kato H, Natsume T, Tsuruta F, Chiba T, Taniguchi H, Kobayashi A.

Biochem Biophys Res Commun. 2016 Sep 9;478(1):363-370. doi: 10.1016/j.bbrc.2016.07.045. Epub 2016 Jul 11.

PMID:
27416755
50.

Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress.

Araki K, Kusano H, Sasaki N, Tanaka R, Hatta T, Fukui K, Natsume T.

J Proteome Res. 2016 Aug 5;15(8):2548-59. doi: 10.1021/acs.jproteome.6b00087. Epub 2016 Jul 15.

PMID:
27350002

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