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Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

Popow O, Paulo JA, Tatham MH, Volk MS, Rojas-Fernandez A, Loyer N, Newton IP, Januschke J, Haigis KM, Näthke I.

Mol Cancer Res. 2019 Sep;17(9):1828-1841. doi: 10.1158/1541-7786.MCR-18-1154. Epub 2019 Jun 3.


Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

Carroll TD, Newton IP, Chen Y, Blow JJ, Näthke I.

J Cell Biol. 2018 May 7;217(5):1667-1685. doi: 10.1083/jcb.201708023. Epub 2018 Mar 29.


Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.

Langlands AJ, Carroll TD, Chen Y, Näthke I.

Cell Death Dis. 2018 Feb 15;9(3):255. doi: 10.1038/s41419-017-0199-9.


A Multicellular Model of Intestinal Crypt Buckling and Fission.

Almet AA, Hughes BD, Landman KA, Näthke IS, Osborne JM.

Bull Math Biol. 2018 Feb;80(2):335-359. doi: 10.1007/s11538-017-0377-z. Epub 2017 Dec 12.


Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.

Lawler M, Alsina D, Adams RA, Anderson AS, Brown G, Fearnhead NS, Fenwick SW, Halloran SP, Hochhauser D, Hull MA, Koelzer VH, McNair AGK, Monahan KJ, Näthke I, Norton C, Novelli MR, Steele RJC, Thomas AL, Wilde LM, Wilson RH, Tomlinson I; Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative.

Gut. 2018 Jan;67(1):179-193. doi: 10.1136/gutjnl-2017-315333. Review.


SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo.

Zhang L, Jablonski AM, Mojsilovic-Petrovic J, Ding H, Seeholzer S, Newton IP, Nathke I, Neve R, Zhai J, Shang Y, Zhang M, Kalb RG.

eNeuro. 2017 Dec 6;4(6). pii: ENEURO.0175-17.2017. doi: 10.1523/ENEURO.0175-17.2017. eCollection 2017 Nov-Dec.


Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.

Carroll TD, Langlands AJ, Osborne JM, Newton IP, Appleton PL, Näthke I.

J Cell Sci. 2017 Nov 15;130(22):3862-3877. doi: 10.1242/jcs.211656. Epub 2017 Oct 5.


Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions.

Näthke I.

Curr Biol. 2017 Aug 21;27(16):R805-R807. doi: 10.1016/j.cub.2017.07.028.


Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy.

Stewart FR, Qiu Y, Lay HS, Newton IP, Cox BF, Al-Rawhani MA, Beeley J, Liu Y, Huang Z, Cumming DRS, Näthke I, Cochran S.

Sensors (Basel). 2017 Jul 3;17(7). pii: E1553. doi: 10.3390/s17071553.


Ultrasound capsule endoscopy: sounding out the future.

Cox BF, Stewart F, Lay H, Cummins G, Newton IP, Desmulliez MPY, Steele RJC, Näthke I, Cochran S.

Ann Transl Med. 2017 May;5(9):201. doi: 10.21037/atm.2017.04.21.


Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

Fatehullah A, Sharma S, Newton IP, Langlands AJ, Lay H, Nelson SA, McMahon RK, McIlvenny N, Appleton PL, Cochran S, Näthke IS.

Sci Rep. 2016 Jul 13;6:29570. doi: 10.1038/srep29570.


Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Langlands AJ, Almet AA, Appleton PL, Newton IP, Osborne JM, Näthke IS.

PLoS Biol. 2016 Jun 27;14(6):e1002491. doi: 10.1371/journal.pbio.1002491. eCollection 2016 Jun.


Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts.

Dunn SJ, Osborne JM, Appleton PL, Näthke I.

Mol Biol Cell. 2016 Jun 1;27(11):1863-74. doi: 10.1091/mbc.E15-12-0854. Epub 2016 Apr 6.


Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling.

Boccitto M, Doshi S, Newton IP, Nathke I, Neve R, Dong F, Mao Y, Zhai J, Zhang L, Kalb R.

Neuroscience. 2016 Jun 21;326:22-30. doi: 10.1016/j.neuroscience.2016.03.048. Epub 2016 Mar 26.


Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

Gupta KK, Alberico EO, Näthke IS, Goodson HV.

Bioessays. 2014 Sep;36(9):818-26. doi: 10.1002/bies.201400029. Epub 2014 Jun 18.


Stem cell decisions: a twist of fate or a niche market?

Januschke J, Näthke I.

Semin Cell Dev Biol. 2014 Oct;34:116-23. doi: 10.1016/j.semcdb.2014.02.014. Epub 2014 Mar 5. Review.


Changes in cell and tissue organization in cancer of the breast and colon.

Hinck L, Näthke I.

Curr Opin Cell Biol. 2014 Feb;26:87-95. doi: 10.1016/ Epub 2013 Dec 5. Review.


High-energy particle-induced tumorigenesis throughout the gastrointestinal tract.

Trani D, Nelson SA, Moon BH, Swedlow JJ, Williams EM, Strawn SJ, Appleton PL, Kallakury B, Näthke I, Fornace AJ Jr.

Radiat Res. 2014 Feb;181(2):162-71. doi: 10.1667/RR13502.1. Epub 2014 Feb 10.


Computational models reveal a passive mechanism for cell migration in the crypt.

Dunn SJ, Näthke IS, Osborne JM.

PLoS One. 2013 Nov 18;8(11):e80516. doi: 10.1371/journal.pone.0080516. eCollection 2013.


Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost.

Fatehullah A, Appleton PL, Näthke IS.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130014. doi: 10.1098/rstb.2013.0014. Print 2013.


Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.

Nelson S, Näthke IS.

J Cell Sci. 2013 Feb 15;126(Pt 4):873-7. doi: 10.1242/jcs.100479. Review. No abstract available.


DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.

Davis EJ, Lachaud C, Appleton P, Macartney TJ, Näthke I, Rouse J.

Nat Struct Mol Biol. 2012 Nov;19(11):1093-100. doi: 10.1038/nsmb.2394. Epub 2012 Oct 7.


The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin.

Dikovskaya D, Khoudoli G, Newton IP, Chadha GS, Klotz D, Visvanathan A, Lamond A, Swedlow JR, Näthke IS.

PLoS One. 2012;7(6):e38102. doi: 10.1371/journal.pone.0038102. Epub 2012 Jun 13.


A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath.

Dunn SJ, Appleton PL, Nelson SA, Näthke IS, Gavaghan DJ, Osborne JM.

PLoS Comput Biol. 2012;8(5):e1002515. doi: 10.1371/journal.pcbi.1002515. Epub 2012 May 24.


Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems.

Nelson SA, Li Z, Newton IP, Fraser D, Milne RE, Martin DM, Schiffmann D, Yang X, Dormann D, Weijer CJ, Appleton PL, Näthke IS.

Dis Model Mech. 2012 Nov;5(6):940-7. doi: 10.1242/dmm.008607. Epub 2012 Apr 5.


The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively.

Klotz DM, Nelson SA, Kroboth K, Newton IP, Radulescu S, Ridgway RA, Sansom OJ, Appleton PL, Näthke IS.

J Cell Sci. 2012 Feb 15;125(Pt 4):887-95. doi: 10.1242/jcs.091843. Epub 2012 Mar 7.


The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium.

Marshall TW, Lloyd IE, Delalande JM, Näthke I, Rosenblatt J.

Mol Biol Cell. 2011 Nov;22(21):3962-70. doi: 10.1091/mbc.E11-05-0469. Epub 2011 Sep 7.


Antagonistic crosstalk between APC and HIF-1α.

Näthke I, Rocha S.

Cell Cycle. 2011 May 15;10(10):1545-7. Epub 2011 May 15.


Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection.

Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S.

Mol Biol Cell. 2010 Nov 1;21(21):3630-8. doi: 10.1091/mbc.E10-04-0312. Epub 2010 Sep 15.


Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

Radulescu S, Ridgway RA, Appleton P, Kroboth K, Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ.

Oncogene. 2010 Dec 9;29(49):6418-27. doi: 10.1038/onc.2010.373. Epub 2010 Aug 23.


Inke Nathke: The ABCs of APC. Interview by Caitlin Sedwick.

Nathke I.

J Cell Biol. 2010 May 31;189(5):774-5. doi: 10.1083/jcb.1895pi. No abstract available.


Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

Dikovskaya D, Li Z, Newton IP, Davidson I, Hutchins JR, Kalab P, Clarke PR, Näthke IS.

J Cell Sci. 2010 Mar 1;123(Pt 5):736-46. doi: 10.1242/jcs.060806. Epub 2010 Feb 9.


Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS.

Cell Stem Cell. 2010 Feb 5;6(2):175-81. doi: 10.1016/j.stem.2009.12.007.


Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.


APC proteins. Preface.

Näthke IS, McCartney BM.

Adv Exp Med Biol. 2009;656:vii-x. No abstract available.


Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy.

Appleton PL, Quyn AJ, Swift S, Näthke I.

J Microsc. 2009 May;234(2):196-204. doi: 10.1111/j.1365-2818.2009.03163.x.


Prognostic and therapeutic implications of Apc mutations in colorectal cancer.

Quyn AJ, Steele RJ, Carey FA, Näthke IS.

Surgeon. 2008 Dec;6(6):350-6. Review.


Novel self-association of the APC molecule affects APC clusters and cell migration.

Li Z, Kroboth K, Newton IP, Näthke IS.

J Cell Sci. 2008 Jun 1;121(11):1916-25. doi: 10.1242/jcs.029470. Epub 2008 May 13.


Cell regulation by the Apc protein Apc as master regulator of epithelia.

McCartney BM, Näthke IS.

Curr Opin Cell Biol. 2008 Apr;20(2):186-93. doi: 10.1016/ Epub 2008 Mar 24. Review.


Cell polarity in development and cancer.

Wodarz A, Näthke I.

Nat Cell Biol. 2007 Sep;9(9):1016-24. Review.


Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS.

J Cell Biol. 2007 Jan 15;176(2):183-95. Erratum in: J Cell Biol. 2007 Jan 29;176(3):369.


Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.

Kroboth K, Newton IP, Kita K, Dikovskaya D, Zumbrunn J, Waterman-Storer CM, Näthke IS.

Mol Biol Cell. 2007 Mar;18(3):910-8. Epub 2006 Dec 27.


Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

Näthke I.

Nat Rev Cancer. 2006 Dec;6(12):967-74. Epub 2006 Nov 9. Review.


Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis.

Schiffmann DA, Dikovskaya D, Appleton PL, Newton IP, Creager DA, Allan C, Näthke IS, Goldberg IG.

Biotechniques. 2006 Aug;41(2):199-208.


Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

Kita K, Wittmann T, Näthke IS, Waterman-Storer CM.

Mol Biol Cell. 2006 May;17(5):2331-45. Epub 2006 Mar 8.


The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions.

Penman GA, Leung L, Näthke IS.

J Cell Sci. 2005 Oct 15;118(Pt 20):4741-50. Epub 2005 Sep 27.


The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.

Näthke IS.

Annu Rev Cell Dev Biol. 2004;20:337-66. Review.


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