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Items: 1 to 50 of 214


Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy.

Lázár-Molnár E, Scandiuzzi L, Basu I, Quinn T, Sylvestre E, Palmieri E, Ramagopal UA, Nathenson SG, Guha C, Almo SC.

EBioMedicine. 2017 Mar;17:30-44. doi: 10.1016/j.ebiom.2017.02.004. Epub 2017 Feb 6.


Increased Heterologous Protein Expression in Drosophila S2 Cells for Massive Production of Immune Ligands/Receptors and Structural Analysis of Human HVEM.

Liu W, Vigdorovich V, Zhan C, Patskovsky Y, Bonanno JB, Nathenson SG, Almo SC.

Mol Biotechnol. 2015 Oct;57(10):914-22. doi: 10.1007/s12033-015-9881-2.


Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.

Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC.

Structure. 2014 Sep 2;22(9):1252-1262. doi: 10.1016/j.str.2014.06.013. Epub 2014 Jul 31.


Tissue-expressed B7-H1 critically controls intestinal inflammation.

Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X.

Cell Rep. 2014 Feb 27;6(4):625-32. doi: 10.1016/j.celrep.2014.01.020. Epub 2014 Feb 13.


Structure and T cell inhibition properties of B7 family member, B7-H3.

Vigdorovich V, Ramagopal UA, Lázár-Molnár E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC.

Structure. 2013 May 7;21(5):707-17. doi: 10.1016/j.str.2013.03.003. Epub 2013 Apr 11.


Functional classification of immune regulatory proteins.

Rubinstein R, Ramagopal UA, Nathenson SG, Almo SC, Fiser A.

Structure. 2013 May 7;21(5):766-76. doi: 10.1016/j.str.2013.02.022. Epub 2013 Apr 11.


Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.

Samanta D, Ramagopal UA, Rubinstein R, Vigdorovich V, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14836-40. doi: 10.1073/pnas.1212912109. Epub 2012 Aug 27.


Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells.

Samanta D, Mukherjee G, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13682-7. doi: 10.1073/pnas.1110971108. Epub 2011 Aug 8.


Decoy strategies: the structure of TL1A:DcR3 complex.

Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC.

Structure. 2011 Feb 9;19(2):162-71. doi: 10.1016/j.str.2010.12.004.


Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis.

Lázár-Molnár E, Chen B, Sweeney KA, Wang EJ, Liu W, Lin J, Porcelli SA, Almo SC, Nathenson SG, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13402-7. doi: 10.1073/pnas.1007394107. Epub 2010 Jul 12.


Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.

Brims DR, Qian J, Jarchum I, Mikesh L, Palmieri E, Ramagopal UA, Malashkevich VN, Chaparro RJ, Lund T, Hattori M, Shabanowitz J, Hunt DF, Nathenson SG, Almo SC, Dilorenzo TP.

Int Immunol. 2010 Mar;22(3):191-203. doi: 10.1093/intimm/dxp127. Epub 2010 Jan 21.


Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation.

Bhatia S, Sun K, Almo SC, Nathenson SG, Hodes RJ.

J Immunol. 2010 Feb 15;184(4):1821-8. doi: 10.4049/jimmunol.0902869. Epub 2010 Jan 11.


Biochemical and structural characterization of the human TL1A ectodomain.

Zhan C, Yan Q, Patskovsky Y, Li Z, Toro R, Meyer A, Cheng H, Brenowitz M, Nathenson SG, Almo SC.

Biochemistry. 2009 Aug 18;48(32):7636-45. doi: 10.1021/bi900031w.


Sequence, structure, function, immunity: structural genomics of costimulation.

Chattopadhyay K, Lazar-Molnar E, Yan Q, Rubinstein R, Zhan C, Vigdorovich V, Ramagopal UA, Bonanno J, Nathenson SG, Almo SC.

Immunol Rev. 2009 May;229(1):356-86. doi: 10.1111/j.1600-065X.2009.00778.x. Review.


1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.

Chattopadhyay K, Ramagopal UA, Nathenson SG, Almo SC.

Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):434-9. doi: 10.1107/S0907444909005721. Epub 2009 Apr 18.


Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.

Lázár-Molnár E, Yan Q, Cao E, Ramagopal U, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10483-8. doi: 10.1073/pnas.0804453105. Epub 2008 Jul 18.


The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum.

Lázár-Molnár E, Gácser A, Freeman GJ, Almo SC, Nathenson SG, Nosanchuk JD.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.


Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.

Chattopadhyay K, Ramagopal UA, Brenowitz M, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):635-40. doi: 10.1073/pnas.0710529105. Epub 2008 Jan 8.


Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.

Chattopadhyay K, Ramagopal UA, Mukhopadhaya A, Malashkevich VN, Dilorenzo TP, Brenowitz M, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19452-7. Epub 2007 Nov 26.


Structure of CD84 provides insight into SLAM family function.

Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10583-8. Epub 2007 Jun 11.


The interchain disulfide linkage is not a prerequisite but enhances CD28 costimulatory function.

Lazar-Molnar E, Almo SC, Nathenson SG.

Cell Immunol. 2006 Dec;244(2):125-9. Epub 2007 Apr 30.


T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface.

Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC.

Immunity. 2007 Mar;26(3):311-21.


The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge.

Carreño LJ, Bueno SM, Bull P, Nathenson SG, Kalergis AM.

Immunology. 2007 Jun;121(2):227-37. Epub 2007 Feb 20.


NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family.

Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC.

Immunity. 2006 Oct;25(4):559-70.


B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties.

Bhatia S, Edidin M, Almo SC, Nathenson SG.

Immunol Lett. 2006 Apr 15;104(1-2):70-5. Epub 2005 Dec 13. Review.


Different cell surface oligomeric states of B7-1 and B7-2: implications for signaling.

Bhatia S, Edidin M, Almo SC, Nathenson SG.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15569-74. Epub 2005 Oct 12.


T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

González PA, Carreño LJ, Coombs D, Mora JE, Palmieri E, Goldstein B, Nathenson SG, Kalergis AM.

Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4824-9. Epub 2005 Mar 16.


Structural and functional analysis of the costimulatory receptor programmed death-1.

Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC.

Immunity. 2004 Mar;20(3):337-47. Erratum in: Immunity. 2004 May;20(5):651.


Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

Lieberman SM, Evans AM, Han B, Takaki T, Vinnitskaya Y, Caldwell JA, Serreze DV, Shabanowitz J, Hunt DF, Nathenson SG, Santamaria P, DiLorenzo TP.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8384-8. Epub 2003 Jun 18.


Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.

Zhang X, Schwartz JC, Almo SC, Nathenson SG.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2586-91. Epub 2003 Feb 26.


During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.

DiLorenzo TP, Lieberman SM, Takaki T, Honda S, Chapman HD, Santamaria P, Serreze DV, Nathenson SG.

Clin Immunol. 2002 Dec;105(3):332-41.


Activated TCRs remain marked for internalization after dissociation from pMHC.

Coombs D, Kalergis AM, Nathenson SG, Wofsy C, Goldstein B.

Nat Immunol. 2002 Oct;3(10):926-31. Epub 2002 Sep 9. Erratum in: Nat Immunol 2002 Nov;3(11):1109.


Structural mechanisms of costimulation.

Schwartz JC, Zhang X, Nathenson SG, Almo SC.

Nat Immunol. 2002 May;3(5):427-34. Review.


How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.

Ostrov DA, Roden MM, Shi W, Palmieri E, Christianson GJ, Mendoza L, Villaflor G, Tilley D, Shastri N, Grey H, Almo SC, Roopenian D, Nathenson SG.

J Immunol. 2002 Jan 1;168(1):283-9.


Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3alpha and an antigenic peptide bound to MHC class I.

Zhang W, Honda S, Wang F, DiLorenzo TP, Kalergis AM, Ostrov DA, Nathenson SG.

J Immunol. 2001 Oct 15;167(8):4396-404.


Hapten addition to an MHC class I-binding peptide causes substantial adjustments of the TCR structure of the responding CD8(+) T cells.

Honda S, Zhang W, Kalergis AM, DiLorenzo TP, Wang F, Nathenson SG.

J Immunol. 2001 Oct 15;167(8):4276-85.


Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.

Serreze DV, Johnson EA, Chapman HD, Graser RT, Marron MP, DiLorenzo TP, Silveira P, Yoshimura Y, Nathenson SG, Joyce S.

Diabetes. 2001 Sep;50(9):1992-2000.


Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2.

Zhang X, Schwartz JC, Nathenson SG, Almo SC.

Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):898-9. Epub 2001 May 25.


The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation.

Reddy B, Gupta S, Chuzhin Y, Kalergis AM, Budhai L, Zhang M, Droguett G, Horwitz MS, Chowdhury JR, Nathenson SG, Davidson A.

Transplantation. 2001 Mar 27;71(6):801-11.


Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.

Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC.

Nature. 2001 Mar 29;410(6828):604-8.


Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex.

Kalergis AM, Boucheron N, Doucey MA, Palmieri E, Goyarts EC, Vegh Z, Luescher IF, Nathenson SG.

Nat Immunol. 2001 Mar;2(3):229-34.


Structure of murine CTLA-4 and its role in modulating T cell responsiveness.

Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG.

Science. 2000 Oct 27;290(5492):816-9.


Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs.

Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA.

J Immunol. 2000 Oct 15;165(8):4494-504.


Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.

Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV.

J Immunol. 2000 Apr 1;164(7):3913-8.


A simplified procedure for the preparation of MHC/peptide tetramers: chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I.

Kalergis AM, Goyarts EC, Palmieri E, Honda S, Zhang W, Nathenson SG.

J Immunol Methods. 2000 Feb 3;234(1-2):61-70.


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