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Items: 31


APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M.

EMBO Mol Med. 2019 Jan;11(1). pii: e9582. doi: 10.15252/emmm.201809582.


The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.

Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ.

Elife. 2018 Dec 13;7. pii: e40009. doi: 10.7554/eLife.40009.


Hypermobility and sports injury.

Nathan JA, Davies K, Swaine I.

BMJ Open Sport Exerc Med. 2018 Oct 18;4(1):e000366. doi: 10.1136/bmjsem-2018-000366. eCollection 2018.


Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation.

Bailey PSJ, Hiltunen JK, Dieckmann CL, Kastaniotis AJ, Nathan JA.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7458-E7459. doi: 10.1073/pnas.1804041115. Epub 2018 Jul 24. No abstract available.


Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron.

Bailey PSJ, Nathan JA.

Biomedicines. 2018 May 17;6(2). pii: E60. doi: 10.3390/biomedicines6020060. Review.


MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA.

EMBO Rep. 2018 May;19(5). pii: e45603. doi: 10.15252/embr.201745603. Epub 2018 Mar 8.


Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.

Kruppa AJ, Kishi-Itakura C, Masters TA, Rorbach JE, Grice GL, Kendrick-Jones J, Nathan JA, Minczuk M, Buss F.

Dev Cell. 2018 Feb 26;44(4):484-499.e6. doi: 10.1016/j.devcel.2018.01.007. Epub 2018 Feb 1.


Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.


Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.

Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.


Aggressive nasopalatine duct cyst with complete destruction of palatine bone.

Sankar D, Muthusubramanian V, Nathan JA, Nutalapati RS, Jose YM, Kumar YN.

J Pharm Bioallied Sci. 2016 Oct;8(Suppl 1):S185-S188.


Retrospective evaluation of airway management with blind awake intubation in temporomandibular joint ankylosis patients: A review of 48 cases.

Sankar D, Krishnan R, Veerabahu M, Vikraman BP, Nathan JA.

Ann Maxillofac Surg. 2016 Jan-Jun;6(1):54-7. doi: 10.4103/2231-0746.186126.


The recognition of ubiquitinated proteins by the proteasome.

Grice GL, Nathan JA.

Cell Mol Life Sci. 2016 Sep;73(18):3497-506. doi: 10.1007/s00018-016-2255-5. Epub 2016 May 2. Review.


FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT.

PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan.


The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains.

Grice GL, Lobb IT, Weekes MP, Gygi SP, Antrobus R, Nathan JA.

Cell Rep. 2015 Jul 28;12(4):545-53. doi: 10.1016/j.celrep.2015.06.061. Epub 2015 Jul 16.


Muscle wasting in disease: molecular mechanisms and promising therapies.

Cohen S, Nathan JA, Goldberg AL.

Nat Rev Drug Discov. 2015 Jan;14(1):58-74. doi: 10.1038/nrd4467. Review.


TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16.


Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

Boname JM, Bloor S, Wandel MP, Nathan JA, Antrobus R, Dingwell KS, Thurston TL, Smith DL, Smith JC, Randow F, Lehner PJ.

J Cell Biol. 2014 Jun 23;205(6):847-62. doi: 10.1083/jcb.201312009.


The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

Peth A, Nathan JA, Goldberg AL.

J Biol Chem. 2013 Oct 4;288(40):29215-22. doi: 10.1074/jbc.M113.482570. Epub 2013 Aug 21.


Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.

Nathan JA, Spinnenhirn V, Schmidtke G, Basler M, Groettrup M, Goldberg AL.

Cell. 2013 Feb 28;152(5):1184-94. doi: 10.1016/j.cell.2013.01.037.


Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

Nathan JA, Kim HT, Ting L, Gygi SP, Goldberg AL.

EMBO J. 2013 Feb 20;32(4):552-65. doi: 10.1038/emboj.2012.354. Epub 2013 Jan 11.


Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.

Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ.

EMBO J. 2011 Jul 8;30(15):3065-77. doi: 10.1038/emboj.2011.224.


Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression.

Duncan LM, Nathan JA, Lehner PJ.

J Immunol. 2010 Jun 15;184(12):6978-85. doi: 10.4049/jimmunol.0904154. Epub 2010 May 12.


The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases.

Nathan JA, Lehner PJ.

Exp Cell Res. 2009 May 15;315(9):1593-600. doi: 10.1016/j.yexcr.2008.10.026. Epub 2008 Nov 5. Review.


The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.

Nathan JA, Sengupta S, Wood SA, Admon A, Markson G, Sanderson C, Lehner PJ.

Traffic. 2008 Jul;9(7):1130-45. doi: 10.1111/j.1600-0854.2008.00747.x. Epub 2008 Apr 11.


A randomized controlled trial of follow-up of patients discharged from the hospital following acute asthma: best performed by specialist nurse or doctor?

Nathan JA, Pearce L, Field C, Dotesio-Eyres N, Sharples LD, Cafferty F, Laroche CM.

Chest. 2006 Jul;130(1):51-7.


The outcomes of lung transplantation in patients with bronchiectasis and antibody deficiency.

Nathan JA, Sharples LD, Exley AR, Sivasothy P, Wallwork J.

J Heart Lung Transplant. 2005 Oct;24(10):1517-21.


The Polls-Trends: American Ambivalence toward China.

Tien C, Nathan JA.

Public Opin Q. 2001 Spring;65(1):124-38. No abstract available.


Investing in our future.

Nathan JA, Kraus MB.

Trustee. 1993 Jun;46(6):12-3. No abstract available.


Substance abuse treatment modalities in the age of HIV spectrum disease.

Nathan JA, Karan LD.

J Psychoactive Drugs. 1989 Oct-Dec;21(4):423-9.


Clinical and legal aspects of nonphysician prescription of vitamins, amino acids and other nutritional supplements.

Clark HW, Sees KL, Nathan JA.

J Psychoactive Drugs. 1988 Jul-Sep;20(3):355-74. Review. No abstract available.


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