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Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.


Impact of various foot arches on dynamic balance and speed performance in collegiate short distance runners: A cross-sectional comparative study.

Sudhakar S, Kirthika SV, Padmanabhan K, Kumar GM, Nathan CVS, Gopika R, Samuel AJ.

J Orthop. 2018 Feb 2;15(1):114-117. doi: 10.1016/j.jor.2018.01.050. eCollection 2018 Mar.


A quality improvement project to increase self-administration of medicines in an acute hospital.

Garfield S, Bell H, Nathan C, Randall S, Husson F, Boucher C, Taylor A, Lloyd J, Backhouse A, Ritchie L, Franklin BD.

Int J Qual Health Care. 2018 Jun 1;30(5):396-407. doi: 10.1093/intqhc/mzy035.


Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, Oren DA, Beuming T, Wang H, Wu J, Li H, Rhee KY, Nathan CF, Liu G, Somersan-Karakaya S.

ACS Infect Dis. 2018 May 11;4(5):771-787. doi: 10.1021/acsinfecdis.7b00111. Epub 2018 Feb 21.


Evidence for dispensability of protein kinase R in host control of tuberculosis.

Mundhra S, Bryk R, Hawryluk N, Zhang T, Jiang X, Nathan CF.

Eur J Immunol. 2018 Apr;48(4):612-620. doi: 10.1002/eji.201747180. Epub 2018 Feb 28.


Stem cells enhance reperfusion following ischemia: Validation using laser speckle imaging in predicting tissue repair.

Tang YH, Thompson RW, Nathan CA, Alexander JS, Lian T.

Laryngoscope. 2018 Jun;128(6):E198-E205. doi: 10.1002/lary.27110. Epub 2018 Feb 5.


The new face of JEM.

Nathan C, Nussenzweig M, Pulvirenti T.

J Exp Med. 2017 Dec 4;214(12):3467. doi: 10.1084/jem.20172072.


Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

Forastiere AA, Ismaila N, Lewin JS, Nathan CA, Adelstein DJ, Eisbruch A, Fass G, Fisher SG, Laurie SA, Le QT, O'Malley B, Mendenhall WM, Patel S, Pfister DG, Provenzano AF, Weber R, Weinstein GS, Wolf GT.

J Clin Oncol. 2018 Apr 10;36(11):1143-1169. doi: 10.1200/JCO.2017.75.7385. Epub 2017 Nov 27.


Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.

Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G.

Nat Commun. 2017 Nov 22;8(1):1692. doi: 10.1038/s41467-017-01760-5.


A pilot study of Merkel cell polyomavirus in squamous cell carcinoma of the tongue.

Hamiter M, Asarkar A, Rogers D, Moore-Medlin T, McClure G, Ma X, Vanchiere J, Nathan CO.

Oral Oncol. 2017 Nov;74:111-114. doi: 10.1016/j.oraloncology.2017.09.021. Epub 2017 Oct 4. No abstract available.


Occipital dysembryoplastic neuroepithelial tumor presenting as adult-onset temporal epilepsy.

Patira R, Nathan C, Zubkov S, Gutierrez C, Munyon C, Mukherjee A, Jacobson M.

Epilepsy Behav Case Rep. 2017 Sep 12;8:92-95. doi: 10.1016/j.ebcr.2017.09.001. eCollection 2017.


Survival outcomes based on systemic agent used concurrently with radiation in human-papillomavirus associated oropharyngeal cancer.

Mehta V, Moore-Medlin T, Flores JM, Ma X, Ekshyyan O, Nathan CO.

Oncotarget. 2017 Aug 10;8(41):70907-70915. doi: 10.18632/oncotarget.20197. eCollection 2017 Sep 19.


Introduction of Laurie H. Glimcher, MD.

Nathan CF.

J Clin Invest. 2017 Oct 2;127(10):3575. doi: 10.1172/JCI97404. Epub 2017 Oct 2. No abstract available.


Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.

Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J.

MBio. 2017 Sep 12;8(5). pii: e01183-17. doi: 10.1128/mBio.01183-17.


SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling.

Barzegar M, Ma S, Zhang C, Chen X, Gu Y, Shang C, Jiang X, Yang J, Nathan CA, Yang S, Huang S.

Br J Cancer. 2017 Oct 10;117(8):1154-1163. doi: 10.1038/bjc.2017.298. Epub 2017 Sep 5.


A Better Journey for Patients, a Better Deal for the NHS: The Successful Implementation of an Enhanced Recovery Program After Renal Transplant Surgery.

Halawa A, Rowe S, Roberts F, Nathan C, Hassan A, Kumar A, Suvakov B, Edwards B, Gray C.

Exp Clin Transplant. 2018 Apr;16(2):127-132. doi: 10.6002/ect.2016.0304. Epub 2017 Aug 24.


In response to Does mutational analysis influence the management of differentiated thyroid cancers?

Nathan CO, Asarkar A, Shaha M, Shaha A.

Laryngoscope. 2018 Feb;128(2):E85. doi: 10.1002/lary.26842. Epub 2017 Aug 22. No abstract available.


JEM Advisory Editorial Board: Increasing diversity.

Nathan C, Nussenzweig MC, Pulvirenti T.

J Exp Med. 2017 Jul 26. pii: jem.20171220. doi: 10.1084/jem.20171220. [Epub ahead of print] No abstract available.


Kunkel Lecture: Fundamental immunodeficiency and its correction.

Nathan C.

J Exp Med. 2017 Aug 7;214(8):2175-2191. doi: 10.1084/jem.20170637. Epub 2017 Jul 12. Review.


Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR Jr, Nathan CF.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. doi: 10.1073/pnas.1705385114. Epub 2017 May 30.


Does mutational analysis influence the management of differentiated thyroid cancers?

Asarkar A, Shaha M, Shaha A, Nathan CO.

Laryngoscope. 2018 Jan;128(1):1-2. doi: 10.1002/lary.26650. Epub 2017 May 17. Review. No abstract available.


Comparison of Survival Outcomes Following Postsurgical Radioactive Iodine Versus External Beam Radiation in Stage IV Differentiated Thyroid Carcinoma.

Yang Z, Flores J, Katz S, Nathan CA, Mehta V.

Thyroid. 2017 Jul;27(7):944-952. doi: 10.1089/thy.2016.0650. Epub 2017 May 17.


Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

Gold B, Nathan C.

Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.TBTB2-0031-2016. Review.


Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK.

ACS Infect Dis. 2017 Feb 10;3(2):176-181. doi: 10.1021/acsinfecdis.6b00172. Epub 2016 Dec 5.


Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria.

Gold B, Roberts J, Ling Y, Lopez Quezada L, Glasheen J, Ballinger E, Somersan-Karakaya S, Warrier T, Nathan C.

J Vis Exp. 2016 Dec 14;(118). doi: 10.3791/54690.


New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges.

Dartois V, Saito K, Warrier T, Nathan C.

Am J Respir Crit Care Med. 2016 Dec 15;194(12):1448-1451. No abstract available.


Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.

Hsu HC, Singh PK, Fan H, Wang R, Sukenick G, Nathan C, Lin G, Li H.

Biochemistry. 2017 Jan 10;56(1):324-333. doi: 10.1021/acs.biochem.6b01107. Epub 2016 Dec 27.


Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.

Sula Karreci E, Fan H, Uehara M, Mihali AB, Singh PK, Kurdi AT, Solhjou Z, Riella LV, Ghobrial I, Laragione T, Routray S, Assaker JP, Wang R, Sukenick G, Shi L, Barrat FJ, Nathan CF, Lin G, Azzi J.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8425-E8432. doi: 10.1073/pnas.1618548114. Epub 2016 Dec 12.


Incidence of contralateral-bilateral nodes in the human papillomavirus era.

Tritter AG, Mehta V, Samuelson M, deGravelle G, Ma X, Medlin-Moore T, Takalkar A, Caldito G, Nathan CO.

Laryngoscope. 2017 Jun;127(6):1328-1333. doi: 10.1002/lary.26439. Epub 2016 Dec 1.


Rapamycin targets Interleukin 6 (IL-6) expression and suppresses endothelial cell invasion stimulated by tumor cells.

Ekshyyan O, Khandelwal AR, Rong X, Moore-Medlin T, Ma X, Alexander JS, Nathan CO.

Am J Transl Res. 2016 Nov 15;8(11):4822-4830. eCollection 2016.


Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.

Lupoli TJ, Fay A, Adura C, Glickman MS, Nathan CF.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7947-E7956. Epub 2016 Nov 21.


Predicting feeding tube and tracheotomy dependence in laryngeal cancer patients.

Lavo JP, Ludlow D, Morgan M, Caldito G, Nathan CA.

Acta Otolaryngol. 2017 Mar;137(3):326-330. doi: 10.1080/00016489.2016.1245864. Epub 2016 Oct 26.


Macrophages' Choice: Take It In or Keep It Out.

Nathan C.

Immunity. 2016 Oct 18;45(4):710-711. doi: 10.1016/j.immuni.2016.10.002. Review.


Primary payer status, individual patient characteristics, and hospital-level factors affecting length of stay and total cost of hospitalization in total laryngectomy.

Mehta V, Flores JM, Thompson RW, Nathan CA.

Head Neck. 2017 Feb;39(2):311-319. doi: 10.1002/hed.24585. Epub 2016 Sep 21.


Identification of Novel Anti-mycobacterial Compounds by Screening a Pharmaceutical Small-Molecule Library against Nonreplicating Mycobacterium tuberculosis.

Warrier T, Martinez-Hoyos M, Marin-Amieva M, Colmenarejo G, Porras-De Francisco E, Alvarez-Pedraglio AI, Fraile-Gabaldon MT, Torres-Gomez PA, Lopez-Quezada L, Gold B, Roberts J, Ling Y, Somersan-Karakaya S, Little D, Cammack N, Nathan C, Mendoza-Losana A.

ACS Infect Dis. 2015 Dec 11;1(12):580-5. doi: 10.1021/acsinfecdis.5b00025. Epub 2015 Jun 22.


Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.

Singh PK, Fan H, Jiang X, Shi L, Nathan CF, Lin G.

ChemMedChem. 2016 Oct 6;11(19):2127-2131. doi: 10.1002/cmdc.201600384. Epub 2016 Aug 25.


Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.


N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18.


Tongue Blade Bite Test Predicts Mandible Fractures.

Neiner J, Free R, Caldito G, Moore-Medlin T, Nathan CA.

Craniomaxillofac Trauma Reconstr. 2016 Jun;9(2):121-4. doi: 10.1055/s-0035-1567812. Epub 2015 Nov 9.


Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.

Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezada L, Somersan S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson P, Mitscher LA, Porubsky P, Rogers S, Schoenen FJ, Nathan C, Aubé J.

J Med Chem. 2016 Jul 14;59(13):6027-44. doi: 10.1021/acs.jmedchem.5b01833. Epub 2016 Jun 17.


Biomarker and Pathologic Predictors of Cutaneous Squamous Cell Carcinoma Aggressiveness.

Khandelwal AR, Ma X, Egan P, Kaskas NM, Moore-Medlin T, Caldito G, Abreo F, Gu X, Aubrey L, Milligan E, Nathan CA.

Otolaryngol Head Neck Surg. 2016 Aug;155(2):281-8. doi: 10.1177/0194599816641913. Epub 2016 Apr 19.


Human studies at JEM: Immunology and beyond.

Casanova JL, Nathan CF, Nussenzweig MC; Editors.

J Exp Med. 2016 Apr 4;213(4):467-8. doi: 10.1084/jem.20160211. Epub 2016 Mar 14. No abstract available.


2016 Oral, Head and Neck Cancer Awareness Week: April 10-16.

Nathan CA, Stern W.

Ear Nose Throat J. 2016 Feb;95(2):52-5. No abstract available.


Photopreventive Effect and Mechanism of AZD4547 and Curcumin C3 Complex on UVB-Induced Epidermal Hyperplasia.

Khandelwal AR, Rong X, Moore-Medlin T, Ekshyyan O, Abreo F, Gu X, Nathan CA.

Cancer Prev Res (Phila). 2016 Apr;9(4):296-304. doi: 10.1158/1940-6207.CAPR-15-0366. Epub 2016 Feb 9.


Use of modified barium swallow study to measure posterior airway space in obstructive sleep apnea.

Crosby T, Phillips J, Carbo A, Babcock K, Nathan CA.

Acta Otolaryngol. 2016 Jun;136(6):592-7. doi: 10.3109/00016489.2015.1136431. Epub 2016 Feb 6.


Effect of Payer Status on Relative Survival of Patients with Laryngeal Cancer.

Mehta V, Shi Z, Mills GM, Nathan CA, Shi R.

Anticancer Res. 2016 Jan;36(1):327-33.


Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation.

Latimer B, Ekshyyan O, Nathan N, Moore-Medlin T, Rong X, Ma X, Khandelwal A, Christy HT, Abreo F, McClure G, Vanchiere JA, Caldito G, Dugas T, McMartin K, Lian T, Mehta V, Nathan CA.

Anticancer Res. 2015 Dec;35(12):6411-8.


EBV and not HPV sensitizes tobacco-associated head and neck cancer cell line FaDu to radiotherapy.

Anandharaj A, Ekshyyan O, Jia Y, Rong X, Harrison L, Shi R, Scott RS, Nathan CA.

Acta Otolaryngol. 2016;136(4):354-62. doi: 10.3109/00016489.2015.1114182. Epub 2015 Dec 4.


Molecular profiling of head and neck squamous cell carcinoma.

Feldman R, Gatalica Z, Knezetic J, Reddy S, Nathan CA, Javadi N, Teknos T.

Head Neck. 2016 Apr;38 Suppl 1:E1625-38. doi: 10.1002/hed.24290. Epub 2015 Nov 28.


Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

Maksymiuk C, Ioerger T, Balakrishnan A, Bryk R, Rhee K, Sacchettini J, Nathan C.

Tuberculosis (Edinb). 2015 Dec;95(6):689-694. doi: 10.1016/ Epub 2015 Oct 19.

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