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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats.

Onwordi EC, Halff EF, Whitehurst T, Mansur A, Cotel MC, Wells L, Creeney H, Bonsall D, Rogdaki M, Shatalina E, Reis Marques T, Rabiner EA, Gunn RN, Natesan S, Vernon AC, Howes OD.

Nat Commun. 2020 Jan 14;11(1):246. doi: 10.1038/s41467-019-14122-0.


Development of Methotrexate and Minocycline Loaded Nanoparticles for the Effective Treatment of Rheumatoid Arthritis.

Janakiraman K, Krishnaswami V, Sethuraman V, Natesan S, Rajendran V, Kandasamy R.

AAPS PharmSciTech. 2019 Dec 23;21(2):34. doi: 10.1208/s12249-019-1581-y.


Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.

Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD.

Lancet Psychiatry. 2020 Jan;7(1):64-77. doi: 10.1016/S2215-0366(19)30416-X. Epub 2019 Dec 17.


Curated Collections for Educators: Five Key Papers on Clinical Teaching.

Quinn A, Gottlieb M, Chan TM, Nickson CP, Mitzman J, Natesan S, Stehman C, Young A, Messman A.

Cureus. 2019 Nov 6;11(11):e6084. doi: 10.7759/cureus.6084.


PEGylated Platelet-Free Blood Plasma-Based Hydrogels for Full-Thickness Wound Regeneration.

Natesan S, Stone R, Coronado RE, Wrice NL, Kowalczewski AC, Zamora DO, Christy RJ.

Adv Wound Care (New Rochelle). 2019 Jul 1;8(7):323-340. doi: 10.1089/wound.2018.0844. Epub 2019 Jul 2.


Curated Collections for Educators: Five Key Papers about Receiving Feedback in Medical Education.

Natesan S, Stehman C, Shaw R, Story D, Krzyzaniak SM, Gottlieb M.

Cureus. 2019 Sep 23;11(9):e5728. doi: 10.7759/cureus.5728.


Design and development of artemisinin and dexamethasone loaded topical nanodispersion for the effective treatment of age-related macular degeneration.

Ponnusamy C, Sugumaran A, Krishnaswami V, Kandasamy R, Natesan S.

IET Nanobiotechnol. 2019 Oct;13(8):868-874. doi: 10.1049/iet-nbt.2019.0130.


Marker-Assisted Selection to Pyramid the Opaque-2 (O2) and β-Carotene (crtRB1) Genes in Maize.

Chandran S, Pukalenthy B, Adhimoolam K, Manickam D, Sampathrajan V, Chocklingam V, Eswaran K, Arunachalam K, Joikumar Meetei L, Rajasekaran R, Muthusamy V, Hossain F, Natesan S.

Front Genet. 2019 Sep 26;10:859. doi: 10.3389/fgene.2019.00859. eCollection 2019.


Combinatorial analysis of quercetin and resveratrol by HPTLC in Sesbania grandiflora/phyto-based nanoformulations.

Sethuraman V, Janakiraman K, Krishnaswami V, Natesan S, Kandasamy R.

Nat Prod Res. 2019 Sep 9:1-6. doi: 10.1080/14786419.2019.1662012. [Epub ahead of print]


Kerala Atrial Fibrillation Registry: a prospective observational study on clinical characteristics, treatment pattern and outcome of atrial fibrillation in Kerala, India, cohort profile.

Charantharayil Gopalan B, Namboodiri N, Abdullakutty J, Lip GY, Koshy AG, Krishnan Nair V, Babu S, Muhammed S, Azariah JL, George R, Nambiar A, Govindan U, Zachariah G, Kumaraswamy N, Chakanalil Govindan S, Natesan S, Roby A, Velayudhan Nair K, Pillai AM, Daniel R; Kerala AF Registry Investigators.

BMJ Open. 2019 Jul 27;9(7):e025901. doi: 10.1136/bmjopen-2018-025901.


Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.

Kaar SJ, Natesan S, McCutcheon R, Howes OD.

Neuropharmacology. 2019 Jul 9:107704. doi: 10.1016/j.neuropharm.2019.107704. [Epub ahead of print] Review.


Finessing Feedback: Recommendations for Effective Feedback in the Emergency Department.

Buckley C, Natesan S, Breslin A, Gottlieb M.

Ann Emerg Med. 2019 Jul 1. pii: S0196-0644(19)30403-2. doi: 10.1016/j.annemergmed.2019.05.016. [Epub ahead of print] No abstract available.


Delivery of silver sulfadiazine and adipose derived stem cells using fibrin hydrogel improves infected burn wound regeneration.

Banerjee J, Seetharaman S, Wrice NL, Christy RJ, Natesan S.

PLoS One. 2019 Jun 13;14(6):e0217965. doi: 10.1371/journal.pone.0217965. eCollection 2019.


Correction: Regulation of dopaminergic function: An [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2019 Jun 11;9(1):168. doi: 10.1038/s41398-019-0501-y.


Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor.

Fechtner S, Singh AK, Srivastava I, Szlenk CT, Muench TR, Natesan S, Ahmed S.

Front Immunol. 2019 May 8;10:1027. doi: 10.3389/fimmu.2019.01027. eCollection 2019.


Curated Collections for Educators: Eight Key Papers about Feedback in Medical Education.

Natesan SM, Krzyzaniak SM, Stehman C, Shaw R, Story D, Gottlieb M.

Cureus. 2019 Mar 1;11(3):e4164. doi: 10.7759/cureus.4164.


Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review.

Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT.

Vet Q. 2019 Dec;39(1):26-55. Review.


Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?

Szlenk CT, Gc JB, Natesan S.

Mol Pharmacol. 2019 Nov;96(5):527-541. doi: 10.1124/mol.118.115113. Epub 2019 Apr 8.


pH responsive delivery of lumefantrine with calcium phosphate nanoparticles loaded lipidic cubosomes for the site specific treatment of lung cancer.

Sethuraman V, Janakiraman K, Krishnaswami V, Natesan S, Kandasamy R.

Chem Phys Lipids. 2019 Nov;224:104763. doi: 10.1016/j.chemphyslip.2019.03.016. Epub 2019 Apr 2.


Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response.

Pokharel SM, Shil NK, Gc JB, Colburn ZT, Tsai SY, Segovia JA, Chang TH, Bandyopadhyay S, Natesan S, Jones JCR, Bose S.

Nat Commun. 2019 Apr 1;10(1):1482. doi: 10.1038/s41467-019-09453-x.


Health-Related Quality of Life at 30 Days Among Indian Patients With Acute Myocardial Infarction.

Huffman MD, Mohanan PP, Devarajan R, Baldridge AS, Kondal D, Zhao L, Ali M, Spertus JA, Chan PS, Natesan S, Abdullakutty J, Krishnan MN, Tp A, Renga S, Punnoose E, Unni G, Prabhakaran D, Lloyd-Jones DM; ACS QUIK Investigators.

Circ Cardiovasc Qual Outcomes. 2019 Feb;12(2):e004980. doi: 10.1161/CIRCOUTCOMES.118.004980.


Platelet rich plasma hydrogels promote in vitro and in vivo angiogenic potential of adipose-derived stem cells.

Samberg M, Stone R 2nd, Natesan S, Kowalczewski A, Becerra S, Wrice N, Cap A, Christy R.

Acta Biomater. 2019 Mar 15;87:76-87. doi: 10.1016/j.actbio.2019.01.039. Epub 2019 Jan 18.


Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis.

Tian DD, Natesan S, White JR , Jr, Paine MF.

Clin Transl Sci. 2019 Jan;12(1):39-46. doi: 10.1111/cts.12598. Epub 2018 Nov 26.


PEG-Plasma Hydrogels Increase Epithelialization Using a Human Ex Vivo Skin Model.

Stone R II, Wall JT, Natesan S, Christy RJ.

Int J Mol Sci. 2018 Oct 13;19(10). pii: E3156. doi: 10.3390/ijms19103156.


Correction: Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2018 Aug 31;8(1):171. doi: 10.1038/s41398-018-0187-6.


The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Natesan S, Turkheimer F, Stone J, Egerton A, McGuire P, Kapur S, Howes OD.

Biol Psychiatry. 2019 Jan 1;85(1):79-87. doi: 10.1016/j.biopsych.2018.07.003. Epub 2018 Jul 11.


Advancements in Regenerative Strategies Through the Continuum of Burn Care.

Stone Ii R, Natesan S, Kowalczewski CJ, Mangum LH, Clay NE, Clohessy RM, Carlsson AH, Tassin DH, Chan RK, Rizzo JA, Christy RJ.

Front Pharmacol. 2018 Jul 9;9:672. doi: 10.3389/fphar.2018.00672. eCollection 2018. Review.


Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue.

Calevro A, Cotel MC, Natesan S, Modo M, Vernon AC, Mondelli V.

Psychoneuroendocrinology. 2018 Sep;95:28-33. doi: 10.1016/j.psyneuen.2018.05.021. Epub 2018 May 16.


Assessment of Ablative Fractional CO2 Laser and Er:YAG Laser to Treat Hypertrophic Scars in a Red Duroc Pig Model.

Rodriguez-Menocal L, Davis SS, Becerra S, Salgado M, Gill J, Valdes J, Candanedo A, Natesan S, Solis M, Guzman W, Higa A, Schulman CI, Christy RJ, Waibel J, Badiavas EV.

J Burn Care Res. 2018 Oct 23;39(6):954-962. doi: 10.1093/jbcr/iry012.


Curated Collections for Educators: Five Key Papers about Residents as Teachers Curriculum Development.

Krzyzaniak SM, Cherney A, Messman A, Natesan S, Overbeck M, Schnapp B, Boysen-Osborn M.

Cureus. 2018 Feb 4;10(2):e2154. doi: 10.7759/cureus.2154. Review.


Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns.

Burmeister DM, Stone R 2nd, Wrice N, Laborde A, Becerra SC, Natesan S, Christy RJ.

Stem Cells Transl Med. 2018 Apr;7(4):360-372. doi: 10.1002/sctm.17-0160. Epub 2018 Feb 18.


Effect of a Quality Improvement Intervention on Clinical Outcomes in Patients in India With Acute Myocardial Infarction: The ACS QUIK Randomized Clinical Trial.

Huffman MD, Mohanan PP, Devarajan R, Baldridge AS, Kondal D, Zhao L, Ali M, Krishnan MN, Natesan S, Gopinath R, Viswanathan S, Stigi J, Joseph J, Chozhakkat S, Lloyd-Jones DM, Prabhakaran D; Acute Coronary Syndrome Quality Improvement in Kerala (ACS QUIK) Investigators.

JAMA. 2018 Feb 13;319(6):567-578. doi: 10.1001/jama.2017.21906.


Nepafenac loaded silica nanoparticles dispersed in-situ gel systems: Development and characterization.

Paulsamy M, Ponnusamy C, Palanisami M, Nackeeran G, Paramasivam S, Sugumaran A, Kandasamy R, Natesan S, Palanichamy R.

Int J Biol Macromol. 2018 Apr 15;110:336-345. doi: 10.1016/j.ijbiomac.2018.01.123. Epub 2018 Jan 31.


Decellularization and Solubilization of Porcine Liver for Use as a Substrate for Porcine Hepatocyte Culture: Method Optimization and Comparison.

Coronado RE, Somaraki-Cormier M, Natesan S, Christy RJ, Ong JL, Halff GA.

Cell Transplant. 2017 Dec;26(12):1840-1854. doi: 10.1177/0963689717742157.


Biological macromolecules for ophthalmic drug delivery to treat ocular diseases.

Krishnaswami V, Kandasamy R, Alagarsamy S, Palanisamy R, Natesan S.

Int J Biol Macromol. 2018 Apr 15;110:7-16. doi: 10.1016/j.ijbiomac.2018.01.120. Epub 2018 Jan 31. Review.


Tissue Source and Cell Expansion Condition Influence Phenotypic Changes of Adipose-Derived Stem Cells.

Mangum LH, Natesan S, Stone R 2nd, Wrice NL, Larson DA, Florell KF, Christy BA, Herzig MC, Cap AP, Christy RJ.

Stem Cells Int. 2017;2017:7108458. doi: 10.1155/2017/7108458. Epub 2017 Aug 23.


A PEGylated platelet free plasma hydrogel based composite scaffold enables stable vascularization and targeted cell delivery for volumetric muscle loss.

Aurora A, Wrice N, Walters TJ, Christy RJ, Natesan S.

Acta Biomater. 2018 Jan;65:150-162. doi: 10.1016/j.actbio.2017.11.019. Epub 2017 Nov 8.


Determination of alternative ceftolozane/tazobactam dosing regimens for patients with infections due to Pseudomonas aeruginosa with MIC values between 4 and 32 mg/L.

Natesan S, Pai MP, Lodise TP.

J Antimicrob Chemother. 2017 Oct 1;72(10):2813-2816. doi: 10.1093/jac/dkx221.


Development of copolymeric nanoparticles of hypocrellin B: Enhanced phototoxic effect and ocular distribution.

Krishnaswami V, Ponnusamy C, Sankareswaran S, Paulsamy M, Madiyalakan R, Palanichamy R, Kandasamy R, Natesan S.

Eur J Pharm Sci. 2018 Apr 30;116:26-36. doi: 10.1016/j.ejps.2017.10.023. Epub 2017 Oct 18.


Development and evaluation of camptothecin loaded polymer stabilized nanoemulsion: Targeting potential in 4T1-breast tumour xenograft model.

Sugumaran A, Ponnusamy C, Kandasamy P, Krishnaswami V, Palanichamy R, Kandasamy R, Lakshmanan M, Natesan S.

Eur J Pharm Sci. 2018 Apr 30;116:15-25. doi: 10.1016/j.ejps.2017.10.005. Epub 2017 Oct 5.


Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes.

Kanna RM, Shanmuganathan R, Rajagopalan VR, Natesan S, Muthuraja R, Cheung KMC, Chan D, Kao PYP, Yee A, Shetty AP.

Asian Spine J. 2017 Aug;11(4):594-600. doi: 10.4184/asj.2017.11.4.594. Epub 2017 Aug 7.


Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery.

Antoniraj MG, Ayyavu M, Henry LJK, Nageshwar Rao G, Natesan S, Sundar DS, Kandasamy R.

Drug Dev Ind Pharm. 2018 Mar;44(3):365-376. doi: 10.1080/03639045.2017.1371741. Epub 2017 Dec 5.


A PEGylated fibrin hydrogel-based antimicrobial wound dressing controls infection without impeding wound healing.

Gil J, Natesan S, Li J, Valdes J, Harding A, Solis M, Davis SC, Christy RJ.

Int Wound J. 2017 Dec;14(6):1248-1257. doi: 10.1111/iwj.12791. Epub 2017 Aug 2.


Tannic acid attenuates TGF-β1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-β signaling in lung epithelial cells.

Pattarayan D, Sivanantham A, Krishnaswami V, Loganathan L, Palanichamy R, Natesan S, Muthusamy K, Rajasekaran S.

J Cell Physiol. 2018 Mar;233(3):2513-2525. doi: 10.1002/jcp.26127. Epub 2017 Aug 30.


In Situ Delivery of Fibrin-Based Hydrogels Prevents Contraction and Reduces Inflammation.

Burmeister DM, Roy DC, Becerra SC, Natesan S, Christy RJ.

J Burn Care Res. 2018 Jan 1;39(1):40-53. doi: 10.1097/BCR.0000000000000576.


Chitosan stabilized camptothecin nanoemulsions: Development, evaluation and biodistribution in preclinical breast cancer animal mode.

Natesan S, Sugumaran A, Ponnusamy C, Thiagarajan V, Palanichamy R, Kandasamy R.

Int J Biol Macromol. 2017 Nov;104(Pt B):1846-1852. doi: 10.1016/j.ijbiomac.2017.05.127. Epub 2017 May 22.


Hypocrellin B and nano silver loaded polymeric nanoparticles: Enhanced generation of singlet oxygen for improved photodynamic therapy.

Natesan S, Krishnaswami V, Ponnusamy C, Madiyalakan M, Woo T, Palanisamy R.

Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:935-946. doi: 10.1016/j.msec.2017.03.179. Epub 2017 Apr 4.


RES-loaded pegylated CS NPs: for efficient ocular delivery.

Pandian S, Jeevanesan V, Ponnusamy C, Natesan S.

IET Nanobiotechnol. 2017 Feb;11(1):32-39. doi: 10.1049/iet-nbt.2016.0069.


Co-encapsulated resveratrol and quercetin in chitosan and peg modified chitosan nanoparticles: For efficient intra ocular pressure reduction.

Natesan S, Pandian S, Ponnusamy C, Palanichamy R, Muthusamy S, Kandasamy R.

Int J Biol Macromol. 2017 Nov;104(Pt B):1837-1845. doi: 10.1016/j.ijbiomac.2017.04.117. Epub 2017 May 1.


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