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Upstream anticoagulation for patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Insights from the TOTAL trial.

Cantor WJ, Lavi S, Džavík V, Cairns J, Cheema AN, Della Siega A, Moreno R, Stankovic G, Kedev S, Natarajan MK, Levi Y, Yuan F, Jolly SS.

Catheter Cardiovasc Interv. 2019 Oct 15. doi: 10.1002/ccd.28540. [Epub ahead of print]


Same-Day Discharge After Elective Percutaneous Coronary Interventions in Ontario, Canada.

Madan M, Bagai A, Overgaard CB, Fang J, Koh M, Cantor WJ, Garg P, Natarajan MK, So DYF, Ko DT.

J Am Heart Assoc. 2019 Jul 2;8(13):e012131. doi: 10.1161/JAHA.119.012131. Epub 2019 Jun 24.


The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transcatheter Aortic Valve Replacement Centers: The 3M TAVR Study.

Wood DA, Lauck SB, Cairns JA, Humphries KH, Cook R, Welsh R, Leipsic J, Genereux P, Moss R, Jue J, Blanke P, Cheung A, Ye J, Dvir D, Umedaly H, Klein R, Rondi K, Poulter R, Stub D, Barbanti M, Fahmy P, Htun N, Murdoch D, Prakash R, Barker M, Nickel K, Thakkar J, Sathananthan J, Tyrell B, Al-Qoofi F, Velianou JL, Natarajan MK, Wijeysundera HC, Radhakrishnan S, Horlick E, Osten M, Buller C, Peterson M, Asgar A, Palisaitis D, Masson JB, Kodali S, Nazif T, Thourani V, Babaliaros VC, Cohen DJ, Park JE, Leon MB, Webb JG.

JACC Cardiovasc Interv. 2019 Mar 11;12(5):459-469. doi: 10.1016/j.jcin.2018.12.020.


Factors associated with door-in to door-out delays among ST-segment elevation myocardial infarction (STEMI) patients transferred for primary percutaneous coronary intervention: a population-based cohort study in Ontario, Canada.

Shi O, Khan AM, Rezai MR, Jackevicius CA, Cox J, Atzema CL, Ko DT, Stukel TA, Lambert LJ, Natarajan MK, Zheng ZJ, Tu JV.

BMC Cardiovasc Disord. 2018 Oct 29;18(1):204. doi: 10.1186/s12872-018-0940-z.


Evolution of Procedural and Clinical Outcomes After Balloon-Expanding Transcatheter Aortic Valve Implantation In Canada (from the Early Canadian Experience and SOURCE XT Registries).

Puri R, Webb JG, Al Qoofi F, Welsh RC, Brown C, Masson JB, Natarajan MK, Peniston C, Cheema AN, Radhakrishnan S, Généreux P, Thoenes M, Côté M, Rodés-Cabau J.

Am J Cardiol. 2018 Aug 1;122(3):461-467. doi: 10.1016/j.amjcard.2018.04.032. Epub 2018 May 4.


Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease.

Thériault S, Lali R, Chong M, Velianou JL, Natarajan MK, Paré G.

Circ Genom Precis Med. 2018 Jan;11(1):e001849. doi: 10.1161/CIRCGEN.117.001849. Epub 2018 Jan 8.


Incidence of thrombosis in perioperative and non-operative myocardial infarction.

Sheth T, Natarajan MK, Hsieh V, Valettas N, Rokoss M, Mehta S, Jolly S, Tandon V, Bezerra H, Devereaux PJ.

Br J Anaesth. 2018 Apr;120(4):725-733. doi: 10.1016/j.bja.2017.11.063. Epub 2017 Nov 21.


Avoiding S3 Valve Over-Sizing by Deployment Balloon Over-Filling: Impact on Rates of Permanent Pacemaker and Other Procedural Complications During TAVR.

Sheth T, Natarajan MK, Kreatsoulas C, Whitlock R, Parry D, Chu V, Smith A, Velianou JL.

J Invasive Cardiol. 2018 Jan;30(1):23-27.


Does Early Coronary Angiography Improve Survival After out-of-Hospital Cardiac Arrest? A Systematic Review With Meta-Analysis.

Welsford M, Bossard M, Shortt C, Pritchard J, Natarajan MK, Belley-Côté EP.

Can J Cardiol. 2018 Feb;34(2):180-194. doi: 10.1016/j.cjca.2017.09.012. Epub 2017 Sep 18. Review.


Barriers to the use of emergency medical services for ST-elevation myocardial infarction: Determining why many patients opt for self-transport.

Mercuri M, Connolly K, Natarajan MK, Welsford M, Schwalm JD.

J Eval Clin Pract. 2018 Apr;24(2):375-379. doi: 10.1111/jep.12858. Epub 2017 Dec 13.


Double-Dose Versus Standard-Dose Clopidogrel According to Smoking Status Among Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention.

Bossard M, Granger CB, Tanguay JF, Montalescot G, Faxon DP, Jolly SS, Widimsky P, Niemela K, Steg PG, Natarajan MK, Gao P, Fox KAA, Yusuf S, Mehta SR.

J Am Heart Assoc. 2017 Nov 3;6(11). pii: e006577. doi: 10.1161/JAHA.117.006577.


MitraClip and Transcatheter Aortic Valve Replacement in a Patient With Recurrent Heart Failure.

Gandhi S, Natarajan MK, Chu V, Dokainish H, Mehta S, Velianou JL.

Circ Cardiovasc Interv. 2017 Sep;10(9). pii: e005312. doi: 10.1161/CIRCINTERVENTIONS.117.005312. No abstract available.


Structural Heart Disease Intervention: The Canadian Landscape.

Asgar AW, Horlick E, McKenzie K, Brass N, Cantor WJ, Chan A, Della Siega A, Gobeil JF, Kassam S, Love MP, Mansour S, Martucci G, Nadeem N, Natarajan MK, Paddock V, Rodés-Cabau J, Traboulsi M, Velianou JL, Welsh RC, Wood D, Webb JG.

Can J Cardiol. 2017 Sep;33(9):1197-1200. doi: 10.1016/j.cjca.2016.12.005. Epub 2016 Dec 13.


Negotiating Tensions Between Theory and Design in the Development of Mailings for People Recovering From Acute Coronary Syndrome.

Witteman HO, Presseau J, Nicholas Angl E, Jokhio I, Schwalm JD, Grimshaw JM, Bosiak B, Natarajan MK, Ivers NM.

JMIR Hum Factors. 2017 Mar 1;4(1):e6. doi: 10.2196/humanfactors.6502.


Comparison of Outcomes of Balloon-Expandable Versus Self-Expandable Transcatheter Heart Valves for Severe Aortic Stenosis.

Wijeysundera HC, Qiu F, Koh M, Prasad TJ, Cantor WJ, Cheema A, Chu MW, Czarnecki A, Feindel C, Fremes SE, Kingsbury KJ, Natarajan MK, Peterson M, Ruel M, Strauss B, Ko DT.

Am J Cardiol. 2017 Apr 1;119(7):1094-1099. doi: 10.1016/j.amjcard.2016.12.016. Epub 2017 Jan 5.


Clinical outcomes after trans-catheter aortic valve replacement in men and women in Ontario, Canada.

Czarnecki A, Qiu F, Koh M, Prasad TJ, Cantor WJ, Cheema AN, Chu MWA, Feindel C, Fremes SE, Kingsbury K, Natarajan MK, Peterson MD, Ruel M, Strauss BH, Wijeysundera HC, Ko DT.

Catheter Cardiovasc Interv. 2017 Sep 1;90(3):486-494. doi: 10.1002/ccd.26906. Epub 2017 Feb 1.


Atrial Fibrillation and PCI - Do We Still Need Aspirin?

Jolly SS, Natarajan MK.

N Engl J Med. 2016 Dec 22;375(25):2490-2492. doi: 10.1056/NEJMe1613474. No abstract available.


Identifying determinants of medication adherence following myocardial infarction using the Theoretical Domains Framework and the Health Action Process Approach.

Presseau J, Schwalm JD, Grimshaw JM, Witteman HO, Natarajan MK, Linklater S, Sullivan K, Ivers NM.

Psychol Health. 2017 Oct;32(10):1176-1194. doi: 10.1080/08870446.2016.1260724. Epub 2016 Dec 20.


Impact of Center Experience on Patient Radiation Exposure During Transradial Coronary Angiography and Percutaneous Intervention: A Patient-Level, International, Collaborative, Multi-Center Analysis.

Simard T, Hibbert B, Natarajan MK, Mercuri M, Hetherington SL, Wright R, Delewi R, Piek JJ, Lehmann R, Ruzsa Z, Lange HW, Geijer H, Sandborg M, Kansal V, Bernick J, Di Santo P, Pourdjabbar A, Ramirez FD, Chow BJ, Chong AY, Labinaz M, Le May MR, O'Brien ER, Wells GA, So D.

J Am Heart Assoc. 2016 May 31;5(6). pii: e003333. doi: 10.1161/JAHA.116.003333.


Double Trouble: A Case of Valvular Disease in Pregnancy.

Gandhi S, Ganame J, Whitlock R, Chu V, Natarajan MK, Velianou JL.

Circulation. 2016 May 31;133(22):2206-11. doi: 10.1161/CIRCULATIONAHA.116.021114. No abstract available.


Optical Coherence Tomography-Guided Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction: A Prospective Propensity-Matched Cohort of the Thrombectomy Versus Percutaneous Coronary Intervention Alone Trial.

Sheth TN, Kajander OA, Lavi S, Bhindi R, Cantor WJ, Cheema AN, Stankovic G, Niemelä K, Natarajan MK, Shestakovska O, Tittarelli R, Meeks B, Jolly SS.

Circ Cardiovasc Interv. 2016 Apr;9(4):e003414. doi: 10.1161/CIRCINTERVENTIONS.115.003414.


Medical Therapy and Coronary Revascularization for Patients With Stable Coronary Artery Disease and Unclassified Appropriateness Score.

Shuvy M, Guo H, Wijeysundera HC, Feindel CM, Cohen EA, Austin PC, Kingsbury K, Natarajan MK, Tu JV, Ko DT.

Am J Cardiol. 2015 Dec 15;116(12):1815-21. doi: 10.1016/j.amjcard.2015.09.020. Epub 2015 Oct 3.


Cluster randomized controlled trial of Delayed Educational Reminders for Long-term Medication Adherence in ST-Elevation Myocardial Infarction (DERLA-STEMI).

Schwalm JD, Ivers NM, Natarajan MK, Taljaard M, Rao-Melacini P, Witteman HO, Zwarenstein M, Grimshaw JM.

Am Heart J. 2015 Nov;170(5):903-13. doi: 10.1016/j.ahj.2015.08.014. Epub 2015 Aug 20.


Vascular access and antiplatelet therapies: does one influence the other?

Jolly SS, Natarajan MK.

Eur Heart J. 2016 Apr 7;37(14):1131-2. doi: 10.1093/eurheartj/ehv570. Epub 2015 Nov 3. No abstract available.


Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial.

Jolly SS, Cairns JA, Yusuf S, Rokoss MJ, Gao P, Meeks B, Kedev S, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemela K, Bernat I, Cantor WJ, Cheema AN, Steg PG, Welsh RC, Sheth T, Bertrand OF, Avezum A, Bhindi R, Natarajan MK, Horak D, Leung RC, Kassam S, Rao SV, El-Omar M, Mehta SR, Velianou JL, Pancholy S, Džavík V; TOTAL Investigators.

Lancet. 2016 Jan 9;387(10014):127-35. doi: 10.1016/S0140-6736(15)00448-1. Epub 2015 Oct 22.


Randomized Controlled Trial of Radiation Protection With a Patient Lead Shield and a Novel, Nonlead Surgical Cap for Operators Performing Coronary Angiography or Intervention.

Alazzoni A, Gordon CL, Syed J, Natarajan MK, Rokoss M, Schwalm JD, Mehta SR, Sheth T, Valettas N, Velianou J, Pandie S, Al Khdair D, Tsang M, Meeks B, Colbran K, Waller E, Fu Lee S, Marsden T, Jolly SS.

Circ Cardiovasc Interv. 2015 Aug;8(8):e002384. doi: 10.1161/CIRCINTERVENTIONS.115.002384.


Comparison of Dual-antiplatelet Therapy to Mono-antiplatelet Therapy After Transcatheter Aortic Valve Implantation: Systematic Review and Meta-analysis.

Gandhi S, Schwalm JD, Velianou JL, Natarajan MK, Farkouh ME.

Can J Cardiol. 2015 Jun;31(6):775-84. doi: 10.1016/j.cjca.2015.01.014. Epub 2015 Jan 24. Review.


Reperfusion Times for Radial Versus Femoral Access in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Observations From the Cardiac Care Network Provincial Primary PCI Registry.

Cantor WJ, Ko DT, Natarajan MK, Džavík V, Wijeysundera HC, Wang JT, Kingsbury KJ, Velianou JL, Cohen EA, Le May MR, Tu JV.

Circ Cardiovasc Interv. 2015 May;8(5). pii: e002097. doi: 10.1161/CIRCINTERVENTIONS.114.002097.


Randomized trial of primary PCI with or without routine manual thrombectomy.

Jolly SS, Cairns JA, Yusuf S, Meeks B, Pogue J, Rokoss MJ, Kedev S, Thabane L, Stankovic G, Moreno R, Gershlick A, Chowdhary S, Lavi S, Niemelä K, Steg PG, Bernat I, Xu Y, Cantor WJ, Overgaard CB, Naber CK, Cheema AN, Welsh RC, Bertrand OF, Avezum A, Bhindi R, Pancholy S, Rao SV, Natarajan MK, ten Berg JM, Shestakovska O, Gao P, Widimsky P, Džavík V; TOTAL Investigators.

N Engl J Med. 2015 Apr 9;372(15):1389-98. doi: 10.1056/NEJMoa1415098. Epub 2015 Mar 16.


Providing optimal regional care for ST-segment elevation myocardial infarction: a prospective cohort study of patients in the Hamilton Niagara Haldimand Brant Local Health Integration Network.

Mercuri M, Welsford M, Schwalm JD, Mehta SR, Rao-Melacini P; Nicholas Valettas MD MASc, Sheth T, Rokoss M, Jolly SS, Velianou JL, Natarajan MK.

CMAJ Open. 2015 Jan 13;3(1):E1-7. doi: 10.9778/cmajo.20140035. eCollection 2015 Jan-Mar.


Adherence to process of care quality indicators after percutaneous coronary intervention in Ontario, Canada: a retrospective observational cohort study.

Czarnecki A, Prasad TJ, Wang J, Wijeysundera HC, Cheema AN, Dz̆avík V, Natarajan MK, Simpson CS, So DY, Syed J, Tu JV, Ko DT.

Open Heart. 2015 Feb 14;2(1):e000200. doi: 10.1136/openhrt-2014-000200. eCollection 2015.


Increased uptake of guideline-recommended oral antiplatelet therapy: insights from the Canadian acute coronary syndrome reflective.

Gandhi S, Zile B, Tan MK, Saranu J, Bucci C, Yan AT, Robertson P, Quantz MA, Letovsky E, Tanguay JF, Dery JP, Fitchett D, Madan M, Cantor WJ, Heffernan M, Natarajan MK, Wong GC, Welsh RC, Goodman SG; Canadian ACS Reflective Group.

Can J Cardiol. 2014 Dec;30(12):1725-31. doi: 10.1016/j.cjca.2014.09.011. Epub 2014 Sep 20.


Impact of system and physician factors on the detection of obstructive coronary disease with diagnostic angiography in stable ischemic heart disease.

Wijeysundera HC, Qiu F, Bennell MC, Natarajan MK, Cantor WJ, Smith S, Kingsbury KJ, Ko DT.

Circ Cardiovasc Qual Outcomes. 2014 Sep;7(5):648-55. doi: 10.1161/CIRCOUTCOMES.114.001098. Epub 2014 Sep 2.


Influence of coronary anatomy and SYNTAX Score on the variations in revascularization strategies for patients with multivessel disease.

Schwalm JD, Wijeysundera HC, Tu JV, Guo H, Kingsbury KJ, Natarajan MK.

Can J Cardiol. 2014 Oct;30(10):1155-61. doi: 10.1016/j.cjca.2014.04.006. Epub 2014 Apr 12.


Advanced chronic kidney disease in patients undergoing transcatheter aortic valve implantation: insights on clinical outcomes and prognostic markers from a large cohort of patients.

Allende R, Webb JG, Munoz-Garcia AJ, de Jaegere P, Tamburino C, Dager AE, Cheema A, Serra V, Amat-Santos I, Velianou JL, Barbanti M, Dvir D, Alonso-Briales JH, Nuis RJ, Faqiri E, Imme S, Benitez LM, Cucalon AM, Al Lawati H, Garcia del Blanco B, Lopez J, Natarajan MK, DeLarochellière R, Urena M, Ribeiro HB, Dumont E, Nombela-Franco L, Rodés-Cabau J.

Eur Heart J. 2014 Oct 7;35(38):2685-96. doi: 10.1093/eurheartj/ehu175. Epub 2014 May 5.


Predictors of normal coronary arteries at coronary angiography.

Levitt K, Guo H, Wijeysundera HC, Ko DT, Natarajan MK, Feindel CM, Kingsbury K, Cohen EA, Tu JV.

Am Heart J. 2013 Oct;166(4):694-700. doi: 10.1016/j.ahj.2013.07.030. Epub 2013 Sep 17.


Canadian Cardiovascular Society position statement on radiation exposure from cardiac imaging and interventional procedures.

Natarajan MK, Paul N, Mercuri M, Waller EJ, Leipsic J, Traboulsi M, Banijamali HS, Benson L, Sheth TN; Secondary Panel:, Simpson CS, Brydie A, Love MP, Gallo R; Canadian Cardiovascular Society.

Can J Cardiol. 2013 Nov;29(11):1361-8. doi: 10.1016/j.cjca.2013.06.002. Epub 2013 Sep 10.


Treatment assignment of high-risk symptomatic severe aortic stenosis patients referred for transcatheter AorticValve implantation.

Bainey KR, Natarajan MK, Mercuri M, Lai T, Teoh K, Chu V, Whitlock RP, Velianou JL.

Am J Cardiol. 2013 Jul 1;112(1):100-3. doi: 10.1016/j.amjcard.2013.02.062. Epub 2013 Apr 2.


Effect of radial versus femoral access on radiation dose and the importance of procedural volume: a substudy of the multicenter randomized RIVAL trial.

Jolly SS, Cairns J, Niemela K, Steg PG, Natarajan MK, Cheema AN, Rao SV, Cantor WJ, Džavík V, Budaj A, Sheth T, Valentin V, Fung A, Widimsky P, Ferrari E, Gao P, Jedrzejowski B, Mehta SR; RIVAL Investigators.

JACC Cardiovasc Interv. 2013 Mar;6(3):258-66. doi: 10.1016/j.jcin.2012.10.016.


An international survey of clinical practice during primary percutaneous coronary intervention for ST-elevation myocardial infarction with a focus on aspiration thrombectomy.

Russo JJ, Dzavík V, Cairns JA, Rao SV, Niemelä KO, Natarajan MK, Bertrand OF, Eskola M, Welsh R, Maciejewski P, Cheema AN, Fung A, Cantor WJ, Lavi S, Widimsky P, Jolly SS.

EuroIntervention. 2013 Feb 22;8(10):1143-8. doi: 10.4244/EIJV8I10A177.


Long-term outcomes after transcatheter aortic valve implantation: insights on prognostic factors and valve durability from the Canadian multicenter experience.

Rodés-Cabau J, Webb JG, Cheung A, Ye J, Dumont E, Osten M, Feindel CM, Natarajan MK, Velianou JL, Martucci G, DeVarennes B, Chisholm R, Peterson M, Thompson CR, Wood D, Toggweiler S, Gurvitch R, Lichtenstein SV, Doyle D, DeLarochellière R, Teoh K, Chu V, Bainey K, Lachapelle K, Cheema A, Latter D, Dumesnil JG, Pibarot P, Horlick E.

J Am Coll Cardiol. 2012 Nov 6;60(19):1864-75. doi: 10.1016/j.jacc.2012.08.960. Epub 2012 Oct 10.


Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease.

Ko DT, Guo H, Wijeysundera HC, Natarajan MK, Nagpal AD, Feindel CM, Kingsbury K, Cohen EA, Tu JV; Cardiac Care Network (CCN) of Ontario Variations in Revascularization Practice in Ontario (VRPO) Working Group.

J Am Coll Cardiol. 2012 Nov 6;60(19):1876-84. doi: 10.1016/j.jacc.2012.06.056. Epub 2012 Oct 10.


Delayed educational reminders for long-term medication adherence in ST-elevation myocardial infarction (DERLA-STEMI): protocol for a pragmatic, cluster-randomized controlled trial.

Ivers NM, Schwalm JD, Grimshaw JM, Witteman H, Taljaard M, Zwarenstein M, Natarajan MK.

Implement Sci. 2012 Jun 9;7:54. doi: 10.1186/1748-5908-7-54.


Need for permanent pacemaker as a complication of transcatheter aortic valve implantation and surgical aortic valve replacement in elderly patients with severe aortic stenosis and similar baseline electrocardiographic findings.

Bagur R, Rodés-Cabau J, Gurvitch R, Dumont É, Velianou JL, Manazzoni J, Toggweiler S, Cheung A, Ye J, Natarajan MK, Bainey KR, DeLarochellière R, Doyle D, Pibarot P, Voisine P, Côté M, Philippon F, Webb JG.

JACC Cardiovasc Interv. 2012 May;5(5):540-551. doi: 10.1016/j.jcin.2012.03.004.


ST-elevation myocardial infarction: is there time for Q waves?

Mercuri M, Natarajan MK, Velianou JL.

CMAJ. 2012 Jul 10;184(10):1125-6. doi: 10.1503/cmaj.120624. Epub 2012 Apr 30. No abstract available.


Radial artery versus femoral artery access options in coronary angiogram procedures: randomized controlled trial of a patient-decision aid.

Schwalm JD, Stacey D, Pericak D, Natarajan MK.

Circ Cardiovasc Qual Outcomes. 2012 May;5(3):260-6. doi: 10.1161/CIRCOUTCOMES.111.962837. Epub 2012 Apr 10.


Reperfusion for STEMI in current Canadian practice: Are we closing the care gap?

Kotowycz MA, Yung D, Afzal R, Pal Syal R, Natarajan MK.

Mcgill J Med. 2011 Jun;13(1):6. No abstract available.


Randomized trial of insulin versus usual care in reducing restenosis after coronary intervention in patients with diabetes. the STent Restenosis And Metabolism (STREAM) study.

Natarajan MK, Strauss BH, Rokoss M, Buller CE, Mancini GB, Xie C, Sheth TN, Goodhart D, Cohen EA, Seidelin P, Harper W, Gerstein HC.

Cardiovasc Revasc Med. 2012 Mar-Apr;13(2):95-100. doi: 10.1016/j.carrev.2011.12.001. Epub 2012 Jan 30.


Determinants of variations in coronary revascularization practices.

Tu JV, Ko DT, Guo H, Richards JA, Walton N, Natarajan MK, Wijeysundera HC, So D, Latter DA, Feindel CM, Kingsbury K, Cohen EA; Cardiac Care Network of Ontario’s Variations in Revascularization Practice in Ontario Working Group.

CMAJ. 2012 Feb 7;184(2):179-86. doi: 10.1503/cmaj.111072. Epub 2011 Dec 12.

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