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1998 1
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46 results

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NAT8 Variants, N-Acetylated Amino Acids, and Progression of CKD.
Luo S, Surapaneni A, Zheng Z, Rhee EP, Coresh J, Hung AM, Nadkarni GN, Yu B, Boerwinkle E, Tin A, Arking DE, Steinbrenner I, Schlosser P, Köttgen A, Grams ME. Luo S, et al. Clin J Am Soc Nephrol. 2020 Dec 31;16(1):37-47. doi: 10.2215/CJN.08600520. Clin J Am Soc Nephrol. 2020. PMID: 33380473 Free PMC article.
BACKGROUND AND OBJECTIVES: Genetic variants in NAT8, a liver- and kidney-specific acetyltransferase encoding gene, have been associated with eGFR and CKD in European populations. ...We aimed to expand upon prior studies to investigate associations between rs13538, a missen …
BACKGROUND AND OBJECTIVES: Genetic variants in NAT8, a liver- and kidney-specific acetyltransferase encoding gene, have been associat …
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids.
Veiga-da-Cunha M, Tyteca D, Stroobant V, Courtoy PJ, Opperdoes FR, Van Schaftingen E. Veiga-da-Cunha M, et al. J Biol Chem. 2010 Jun 11;285(24):18888-98. doi: 10.1074/jbc.M110.110924. Epub 2010 Apr 13. J Biol Chem. 2010. PMID: 20392701 Free PMC article.
Confocal microscopy indicated that NAT8 was associated with the endoplasmic reticulum. Neither of the two frequent single nucleotide polymorphisms found in NAT8, E104K nor F143S, changed the enzymatic activity or the expression of the protein by >or=2-fold, where …
Confocal microscopy indicated that NAT8 was associated with the endoplasmic reticulum. Neither of the two frequent single nucleotide …
N-Acetyltransferase 8 Promotes Viral Replication by Increasing the Stability of Enterovirus 71 Nonstructural Proteins.
Zhao X, Yuan H, Yang H, Liu Y, Xun M, Li X, Fan T, Wu B, Guo S, Wang H. Zhao X, et al. J Virol. 2022 Mar 23;96(6):e0011922. doi: 10.1128/jvi.00119-22. Epub 2022 Feb 16. J Virol. 2022. PMID: 35170979 Free PMC article.
NAT8 promoted EV71 replication in an acetyltransferase-activity-dependent manner. ...We further show that NAT8 benefits EV71 replication in an acetyltransferase-activity-dependent manner. ...
NAT8 promoted EV71 replication in an acetyltransferase-activity-dependent manner. ...We further show that NAT8 benefits EV71 r …
The endoplasmic reticulum acetyltransferases ATase1/NAT8B and ATase2/NAT8 are differentially regulated to adjust engagement of the secretory pathway.
Rigby MJ, Ding Y, Farrugia MA, Feig M, Cortese GP, Mitchell H, Burger C, Puglielli L. Rigby MJ, et al. J Neurochem. 2020 Aug;154(4):404-423. doi: 10.1111/jnc.14958. Epub 2020 Jan 27. J Neurochem. 2020. PMID: 31945187 Free PMC article.
The ER acetylation machinery consists of the membrane transporter, acetyl-CoA transporter 1 (AT-1/SLC33A1), and two acetyltransferases, ATase1/NAT8B and ATase2/NAT8. Dysfunctional ER acetylation is associated with severe neurological diseases with duplication of AT-1/SLC33 …
The ER acetylation machinery consists of the membrane transporter, acetyl-CoA transporter 1 (AT-1/SLC33A1), and two acetyltransferases, ATas …
Predicting diagnostic biomarkers associated with immune infiltration in Crohn's disease based on machine learning and bioinformatics.
Bao W, Wang L, Liu X, Li M. Bao W, et al. Eur J Med Res. 2023 Jul 26;28(1):255. doi: 10.1186/s40001-023-01200-9. Eur J Med Res. 2023. PMID: 37496049 Free PMC article.
CXCL1, S100A8, REG3A, and DEFA6 in colon tissue and LCN2 and NAT8 in ileum tissue demonstrated excellent diagnostic value and could be employed as CD gene biomarkers using machine learning methods in conjunction with external dataset validation. ...CONCLUSION: CXCL1, S100A …
CXCL1, S100A8, REG3A, and DEFA6 in colon tissue and LCN2 and NAT8 in ileum tissue demonstrated excellent diagnostic value and could b …
The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats.
Fu J, Zhang H, Zhuang Y, Liu H, Shi Q, Li D, Ju X. Fu J, et al. PLoS One. 2014 Jul 24;9(7):e103355. doi: 10.1371/journal.pone.0103355. eCollection 2014. PLoS One. 2014. PMID: 25057902 Free PMC article.
In addition, we downregulated and upregulated NAT8 expression in L02 cells and induced apoptosis by using H2O2 to study the protective role of NAT8. ...CONCLUSIONS: MSC transplantation provides support to the I/R-injured liver by inhibiting hepatocellular apoptosis …
In addition, we downregulated and upregulated NAT8 expression in L02 cells and induced apoptosis by using H2O2 to study the protectiv …
Genome-wide association studies in nephrology research.
Köttgen A. Köttgen A. Am J Kidney Dis. 2010 Oct;56(4):743-58. doi: 10.1053/j.ajkd.2010.05.018. Epub 2010 Aug 21. Am J Kidney Dis. 2010. PMID: 20728256 Review.
For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk of kidney stone disease; and variants in or near SHROOM3, STC1, LASS2, GCKR, NAT8/ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, FAM122A/PIP5K1B, …
For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk o …
N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study.
Juhanson P, Kepp K, Org E, Veldre G, Kelgo P, Rosenberg M, Viigimaa M, Laan M. Juhanson P, et al. BMC Med Genet. 2008 Apr 10;9:25. doi: 10.1186/1471-2350-9-25. BMC Med Genet. 2008. PMID: 18402670 Free PMC article.
The resequencing (n = 42, random Estonian samples) identified 15 NAT8 polymorphisms, including 6 novel variants. The diversity of NAT8 5' upstream region (pi/bp = 0.00320) exceeded up to 10 times the variation in the NAT8 genic region (pi/bp = 0.00037) as wel …
The resequencing (n = 42, random Estonian samples) identified 15 NAT8 polymorphisms, including 6 novel variants. The diversity of …
A Mechanistic-Based and Non-invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides.
Gonçalves-Dias C, Sequeira CO, Vicente JB, Correia MJ, Coelho NR, Morello J, Antunes AMM, Soto K, Monteiro EC, Pereira SA. Gonçalves-Dias C, et al. Adv Exp Med Biol. 2021;1306:109-120. doi: 10.1007/978-3-030-63908-2_8. Adv Exp Med Biol. 2021. PMID: 33959909
There is scarce information regarding the fate of Cys-disulfides (CysSSX), but evidence shows they might be detoxified in proximal tubular cells by the action of N-acetyltransferase 8 (NAT8). This enzyme promotes the addition of an N-acetyl moiety to cysteine-S-conjugates, …
There is scarce information regarding the fate of Cys-disulfides (CysSSX), but evidence shows they might be detoxified in proximal tubular c …
The mercapturic acid pathway.
Hanna PE, Anders MW. Hanna PE, et al. Crit Rev Toxicol. 2019 Nov;49(10):819-929. doi: 10.1080/10408444.2019.1692191. Epub 2020 Jan 16. Crit Rev Toxicol. 2019. PMID: 31944156
46 results