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Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin-; the role of phosphodiesterase 3A.

Berger M, Raslan Z, Aburima A, Magwenzi S, Wraith KS, SPurgeon BEJ, Hindle MS, Law R, Febbraio M, Naseem KM.

Haematologica. 2019 Jul 9. pii: haematol.2018.213348. doi: 10.3324/haematol.2018.213348. [Epub ahead of print]


Platelet Flow Cytometry: Instrument Setup, Controls, and Panel Performance.

Spurgeon BEJ, Naseem KM.

Cytometry B Clin Cytom. 2019 Feb 19. doi: 10.1002/cyto.b.21774. [Epub ahead of print] Review.


Alterations in Platelet Alpha-Granule Secretion and Adhesion on Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3.

Berger M, Lutz DRJ, Lutz J, Khalil JS, Aburima A, Naseem KM, Rivero F.

Cells. 2019 Feb 11;8(2). pii: E149. doi: 10.3390/cells8020149.


Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.

Kearney KJ, Pechlivani N, King R, Tiede C, Phoenix F, Cheah R, Macrae FL, Simmons KJ, Manfield IW, Smith KA, Spurgeon BEJ, Naseem KM, Ariens RAS, McPherson MJ, Tomlinson DC, Ajjan RA.

Blood. 2019 Mar 14;133(11):1233-1244. doi: 10.1182/blood-2018-06-856195. Epub 2018 Dec 13.


Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.

Scully D, Sfyri P, Verpoorten S, Papadopoulos P, Muñoz-Turrillas MC, Mitchell R, Aburima A, Patel K, Gutiérrez L, Naseem KM, Matsakas A.

Acta Physiol (Oxf). 2019 Mar;225(3):e13207. doi: 10.1111/apha.13207. Epub 2018 Nov 14.


High-Throughput Signaling Profiling in Blood Platelets by Multiplexed Phosphoflow Cytometry.

Spurgeon BEJ, Naseem KM.

Methods Mol Biol. 2018;1812:95-111. doi: 10.1007/978-1-4939-8585-2_6.


Glucose metabolism and metabolic flexibility in blood platelets.

Aibibula M, Naseem KM, Sturmey RG.

J Thromb Haemost. 2018 Nov;16(11):2300-2314. doi: 10.1111/jth.14274. Epub 2018 Sep 27.


Corrigendum: The Effect of a Simulated Commercial Flight Environment With Hypoxia and Low Humidity on Clotting, Platelet, and Endothelial Function in Participants With Type 2 Diabetes - A Cross-Over Study.

Konya J, Spurgeon BEJ, Al Qaissi A, Sathyapalan T, Ajjan R, Madden L, Naseem KM, Garrett AT, Kilpatrick E, Atkin SL.

Front Endocrinol (Lausanne). 2018 Jun 7;9:301. doi: 10.3389/fendo.2018.00301. eCollection 2018.


Platelet function following induced hypoglycaemia in type 2 diabetes.

Kahal H, Aburima A, Spurgeon B, Wraith KS, Rigby AS, Sathyapalan T, Kilpatrick ES, Naseem KM, Atkin SL.

Diabetes Metab. 2018 Nov;44(5):431-436. doi: 10.1016/j.diabet.2018.04.004. Epub 2018 May 3.


Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation.

Berger M, Wraith K, Woodward C, Aburima A, Raslan Z, Hindle MS, Moellmann J, Febbraio M, Naseem KM.

Platelets. 2019;30(4):467-472. doi: 10.1080/09537104.2018.1466386. Epub 2018 May 7.


Platelet biology in regenerative medicine of skeletal muscle.

Scully D, Naseem KM, Matsakas A.

Acta Physiol (Oxf). 2018 Jul;223(3):e13071. doi: 10.1111/apha.13071. Epub 2018 Apr 19. Review.


The Effect of a Simulated Commercial Flight Environment with Hypoxia and Low Humidity on Clotting, Platelet, and Endothelial Function in Participants with Type 2 Diabetes - A Cross-over Study.

Konya J, Spurgeon BEJ, Al Qaissi A, Sathyapalan T, Ajjan R, Madden L, Naseem KM, Garrett AT, Kilpatrick E, Atkin SL.

Front Endocrinol (Lausanne). 2018 Feb 13;9:26. doi: 10.3389/fendo.2018.00026. eCollection 2018. Erratum in: Front Endocrinol (Lausanne). 2018 Jun 07;9:301.


Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi.

Atkinson L, Yusuf MZ, Aburima A, Ahmed Y, Thomas SG, Naseem KM, Calaminus SDJ.

Sci Rep. 2018 Feb 14;8(1):3032. doi: 10.1038/s41598-018-21167-6.


Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability.

Yusuf MZ, Raslan Z, Atkinson L, Aburima A, Thomas SG, Naseem KM, Calaminus SDJ.

Sci Rep. 2017 Jul 17;7(1):5582. doi: 10.1038/s41598-017-05817-9.


cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.

Aburima A, Walladbegi K, Wake JD, Naseem KM.

J Thromb Haemost. 2017 Aug;15(8):1668-1678. doi: 10.1111/jth.13738. Epub 2017 Jul 18.


The Spatiotemporal Regulation of cAMP Signaling in Blood Platelets-Old Friends and New Players.

Raslan Z, Aburima A, Naseem KM.

Front Pharmacol. 2015 Nov 10;6:266. doi: 10.3389/fphar.2015.00266. eCollection 2015.


Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway.

Raslan Z, Magwenzi S, Aburima A, Taskén K, Naseem KM.

J Thromb Haemost. 2015 Sep;13(9):1721-34. doi: 10.1111/jth.13042. Epub 2015 Aug 12.


The effects of treatment with liraglutide on atherothrombotic risk in obese young women with polycystic ovary syndrome and controls.

Kahal H, Aburima A, Ungvari T, Rigby AS, Coady AM, Vince RV, Ajjan RA, Kilpatrick ES, Naseem KM, Atkin SL.

BMC Endocr Disord. 2015 Apr 2;15:14. doi: 10.1186/s12902-015-0005-6.


Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade.

Magwenzi S, Woodward C, Wraith KS, Aburima A, Raslan Z, Jones H, McNeil C, Wheatcroft S, Yuldasheva N, Febbriao M, Kearney M, Naseem KM.

Blood. 2015 Apr 23;125(17):2693-703. doi: 10.1182/blood-2014-05-574491. Epub 2015 Feb 20.


Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor.

Crooks MG, Fahim A, Naseem KM, Morice AH, Hart SP.

PLoS One. 2014 Oct 22;9(10):e111347. doi: 10.1371/journal.pone.0111347. eCollection 2014.


Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets.

Spurgeon BE, Aburima A, Oberprieler NG, Taskén K, Naseem KM.

J Thromb Haemost. 2014 Oct;12(10):1733-43. doi: 10.1111/jth.12670. Epub 2014 Sep 18.


Compartmentalisation of cAMP-dependent signalling in blood platelets: The role of lipid rafts and actin polymerisation.

Raslan Z, Naseem KM.

Platelets. 2015;26(4):349-57. doi: 10.3109/09537104.2014.916792. Epub 2014 May 15.


The control of blood platelets by cAMP signalling.

Raslan Z, Naseem KM.

Biochem Soc Trans. 2014 Apr;42(2):289-94. doi: 10.1042/BST20130278. Review.


Platelet myosin light chain phosphatase: keeping it together.

Aburima A, Naseem KM.

Biochem Soc Trans. 2014 Apr;42(2):279-83. doi: 10.1042/BST20130277. Review.


Acute hypertriglyceridemia induces platelet hyperactivity that is not attenuated by insulin in polycystic ovary syndrome.

Aye MM, Kilpatrick ES, Aburima A, Wraith KS, Magwenzi S, Spurgeon B, Rigby AS, Sandeman D, Naseem KM, Atkin SL.

J Am Heart Assoc. 2014 Feb 28;3(1):e000706. doi: 10.1161/JAHA.113.000706.


cAMP signaling regulates platelet myosin light chain (MLC) phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway.

Aburima A, Wraith KS, Raslan Z, Law R, Magwenzi S, Naseem KM.

Blood. 2013 Nov 14;122(20):3533-45. doi: 10.1182/blood-2013-03-487850. Epub 2013 Oct 7.


Oxidized low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase-signaling pathways.

Wraith KS, Magwenzi S, Aburima A, Wen Y, Leake D, Naseem KM.

Blood. 2013 Jul 25;122(4):580-9. doi: 10.1182/blood-2013-04-491688. Epub 2013 May 22.


Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity.

Kahal H, Aburima A, Ungvari T, Rigby AS, Dawson AJ, Coady AM, Vince RV, Ajjan RA, Kilpatrick ES, Naseem KM, Atkin SL.

Clin Endocrinol (Oxf). 2013 Aug;79(2):252-8. doi: 10.1111/cen.12137. Epub 2013 May 11.


Prednisolone exerts exquisite inhibitory properties on platelet functions.

Liverani E, Banerjee S, Roberts W, Naseem KM, Perretti M.

Biochem Pharmacol. 2012 May 15;83(10):1364-73. doi: 10.1016/j.bcp.2012.02.006. Epub 2012 Feb 16.


Factor XIII supports platelet activation and enhances thrombus formation by matrix proteins under flow conditions.

Magwenzi SG, Ajjan RA, Standeven KF, Parapia LA, Naseem KM.

J Thromb Haemost. 2011 Apr;9(4):820-33. doi: 10.1111/j.1538-7836.2011.04234.x.


Nitric oxide at a glance.

Naseem KM, Roberts W.

Platelets. 2011;22(2):148-52. doi: 10.3109/09537104.2010.522629. Epub 2010 Nov 4. Review. Erratum in: Platelets. 2011;22(2):152.


Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade.

Roberts W, Magwenzi S, Aburima A, Naseem KM.

Blood. 2010 Nov 18;116(20):4297-306. doi: 10.1182/blood-2010-01-265561. Epub 2010 Jul 27.


Peroxynitrite causes phosphorylation of vasodilator-stimulated phosphoprotein through a PKC dependent mechanism.

Aburima A, Riba R, Naseem KM.

Platelets. 2010;21(6):421-8. doi: 10.3109/09537104.2010.483296.


Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation.

Irwin C, Roberts W, Naseem KM.

Platelets. 2009 Nov;20(7):478-86. doi: 10.3109/09537100903159375.


Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin alpha(IIb)beta(3) and myosin light chain.

Roberts W, Michno A, Aburima A, Naseem KM.

J Thromb Haemost. 2009 Dec;7(12):2106-15. doi: 10.1111/j.1538-7836.2009.03619.x. Epub 2009 Sep 18.


Globular adiponectin increases cGMP formation in blood platelets independently of nitric oxide.

Riba R, Patel B, Aburima A, Naseem KM.

J Thromb Haemost. 2008 Dec;6(12):2121-31. doi: 10.1111/j.1538-7836.2008.03179.x. Epub 2008 Oct 1.


Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen.

Roberts W, Riba R, Homer-Vanniasinkam S, Farndale RW, Naseem KM.

J Thromb Haemost. 2008 Dec;6(12):2175-85. doi: 10.1111/j.1538-7836.2008.03190.x. Epub 2008 Oct 11.


The nitration of platelet vasodilator stimulated phosphoprotein following exposure to low concentrations of hydrogen peroxide.

Sabetkar M, Low SY, Bradley NJ, Jacobs M, Naseem KM, Richard Bruckdorfer K.

Platelets. 2008 Jun;19(4):282-92. doi: 10.1080/09537100801915142.


eNOS, iNOS or no NOS, that is the question!

Naseem KM.

J Thromb Haemost. 2008 Aug;6(8):1373-5. doi: 10.1111/j.1538-7836.2008.03035.x. Epub 2008 May 22. No abstract available.


Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.

Riba R, Hughes CE, Graham A, Watson SP, Naseem KM.

J Thromb Haemost. 2008 Jun;6(6):1012-20. doi: 10.1111/j.1538-7836.2008.02982.x. Epub 2008 Apr 16.


Unresolved roles of platelet nitric oxide synthase.

Naseem KM, Riba R.

J Thromb Haemost. 2008 Jan;6(1):10-9. Epub 2007 Oct 15. Review.


cGMP-independent inhibition of integrin alphaIIbbeta3-mediated platelet adhesion and outside-in signalling by nitric oxide.

Oberprieler NG, Roberts W, Riba R, Graham AM, Homer-Vanniasinkam S, Naseem KM.

FEBS Lett. 2007 Apr 3;581(7):1529-34. Epub 2007 Mar 7. Erratum in: FEBS Lett. 2007 May 29;581(13):2574. Riba, Rocio [added].


Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms.

Oberprieler NG, Roberts W, Graham AM, Homer-Vanniasinkam S, Naseem KM.

Biochem Pharmacol. 2007 May 15;73(10):1593-601. Epub 2007 Jan 14.


Nitric oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease.

Elahi MM, Naseem KM, Matata BM.

FEBS J. 2007 Feb;274(4):906-23. Epub 2007 Jan 22. Review.


Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP-1 phosphatase.

Patel B, Sharifi M, Milward AD, Oberprieler NG, Gibbins JM, Parkin S, Naseem KM.

J Thromb Haemost. 2006 Nov;4(11):2423-32. Epub 2006 Aug 8.


Sodium orthovanadate induced tyrosine phosphorylation of platelet nitric oxide synthase negatively regulates enzyme activity.

Milward AD, Riba R, Patel B, Oberprieler NG, Naseem KM.

Biochim Biophys Acta. 2006 Sep;1760(9):1411-7. Epub 2006 Jun 17.


The influence of organic peroxides on platelet aggregation and sensitivity to nitric oxide.

Naseem KM, Bruckdorfer KR.

Platelets. 1999;10(2-3):146-52.


Platelet membrane CD154 and sCD154 in progressive peripheral arterial disease: a pilot study.

Young RS, Naseem KM, Pasupathy S, Ahilathirunayagam S, Chaparala RP, Homer-Vanniasinkam S.

Atherosclerosis. 2007 Feb;190(2):452-8. Epub 2006 Jun 13.


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