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Items: 1 to 50 of 579

1.

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.

Koseki H, Miyata H, Shimo S, Ohno N, Mifune K, Shimano K, Yamamoto K, Nozaki K, Kasuya H, Narumiya S, Aoki T.

Transl Stroke Res. 2019 Feb 8. doi: 10.1007/s12975-019-0690-y. [Epub ahead of print]

PMID:
30737656
2.

The role of prostaglandin E2 receptor EP1 in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced neonatal hydronephrosis in mice.

Aida-Yasuoka K, Nishimura N, Fujisawa N, Endo N, Narumiya S, Tohyama C.

Toxicology. 2019 Mar 1;415:10-17. doi: 10.1016/j.tox.2019.01.006. Epub 2019 Jan 11.

PMID:
30641090
3.

Real-time Imaging of an Experimental Intracranial Aneurysm in Rats.

Miyata H, Shimizu K, Koseki H, Abekura Y, Kataoka H, Miyamoto S, Nozaki K, Narumiya S, Aoki T.

Neurol Med Chir (Tokyo). 2019 Jan 15;59(1):19-26. doi: 10.2176/nmc.oa.2018-0197. Epub 2018 Dec 15.

4.

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.

Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T.

Nat Chem Biol. 2019 Jan;15(1):18-26. doi: 10.1038/s41589-018-0131-3. Epub 2018 Dec 3.

PMID:
30510193
5.

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.

Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T.

Nat Chem Biol. 2019 Jan;15(1):8-10. doi: 10.1038/s41589-018-0171-8. Epub 2018 Dec 3.

PMID:
30510192
6.

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.

Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S.

J Invest Dermatol. 2018 Nov 14. pii: S0022-202X(18)32815-X. doi: 10.1016/j.jid.2018.10.034. [Epub ahead of print]

PMID:
30447238
7.

Prostaglandin-cytokine crosstalk in chronic inflammation.

Yao C, Narumiya S.

Br J Pharmacol. 2019 Feb;176(3):337-354. doi: 10.1111/bph.14530. Epub 2018 Dec 18. Review.

8.

mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.

Sakamoto S, Thumkeo D, Ohta H, Zhang Z, Huang S, Kanchanawong P, Fuu T, Watanabe S, Shimada K, Fujihara Y, Yoshida S, Ikawa M, Watanabe N, Saitou M, Narumiya S.

PLoS Biol. 2018 Sep 26;16(9):e2004874. doi: 10.1371/journal.pbio.2004874. eCollection 2018 Sep.

9.

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.

Nie X, Kitaoka S, Tanaka K, Segi-Nishida E, Imoto Y, Ogawa A, Nakano F, Tomohiro A, Nakayama K, Taniguchi M, Mimori-Kiyosue Y, Kakizuka A, Narumiya S, Furuyashiki T.

Neuron. 2018 Aug 8;99(3):464-479.e7. doi: 10.1016/j.neuron.2018.06.035. Epub 2018 Jul 19.

PMID:
30033154
10.

Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety.

Higashida S, Nagai H, Nakayama K, Shinohara R, Taniguchi M, Nagai M, Hikida T, Yawata S, Ago Y, Kitaoka S, Narumiya S, Furuyashiki T.

Sci Rep. 2018 Jul 11;8(1):10454. doi: 10.1038/s41598-018-28803-1.

11.

T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.

Lee J, Aoki T, Thumkeo D, Siriwach R, Yao C, Narumiya S.

J Allergy Clin Immunol. 2019 Feb;143(2):631-643. doi: 10.1016/j.jaci.2018.05.036. Epub 2018 Jun 20.

12.

Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons.

Sumitomo A, Yukitake H, Hirai K, Horike K, Ueta K, Chung Y, Warabi E, Yanagawa T, Kitaoka S, Furuyashiki T, Narumiya S, Hirano T, Niwa M, Sibille E, Hikida T, Sakurai T, Ishizuka K, Sawa A, Tomoda T.

Hum Mol Genet. 2018 Sep 15;27(18):3165-3176. doi: 10.1093/hmg/ddy219.

PMID:
29893844
13.

Rho signaling research: history, current status and future directions.

Narumiya S, Thumkeo D.

FEBS Lett. 2018 Jun;592(11):1763-1776. doi: 10.1002/1873-3468.13087. Epub 2018 May 24. Review.

14.

Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice.

Ueharaguchi Y, Honda T, Kusuba N, Hanakawa S, Adachi A, Sawada Y, Otsuka A, Kitoh A, Dainichi T, Egawa G, Nakashima C, Nakajima S, Murata T, Ono S, Arita M, Narumiya S, Miyachi Y, Kabashima K.

J Allergy Clin Immunol. 2018 Aug;142(2):680-683.e2. doi: 10.1016/j.jaci.2018.01.054. Epub 2018 Apr 17. No abstract available.

PMID:
29678752
15.

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.

Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M.

J Hepatol. 2018 Jul;69(1):110-120. doi: 10.1016/j.jhep.2018.02.009. Epub 2018 Feb 16.

PMID:
29458169
16.

Targeting macrophages to treat intracranial aneurysm.

Aoki T, Yamamoto R, Narumiya S.

Oncotarget. 2017 Sep 28;8(62):104704-104705. doi: 10.18632/oncotarget.21368. eCollection 2017 Dec 1. No abstract available.

17.

Prostaglandin E2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment.

Aoki T, Narumiya S.

Inflamm Regen. 2017 Mar 1;37:4. doi: 10.1186/s41232-017-0036-7. eCollection 2017. Review.

18.

Prostaglandin I2 suppresses the development of diet-induced nonalcoholic steatohepatitis in mice.

Kumei S, Yuhki KI, Kojima F, Kashiwagi H, Imamichi Y, Okumura T, Narumiya S, Ushikubi F.

FASEB J. 2018 May;32(5):2354-2365. doi: 10.1096/fj.201700590R. Epub 2017 Dec 15.

PMID:
29247122
19.

Constitutive Activation of Integrin α9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis.

Emori T, Hirose J, Ise K, Yomoda JI, Kasahara M, Shinkuma T, Yoshitomi H, Ito H, Hashimoto M, Sugahara S, Fujita H, Yamamoto N, Morita Y, Narumiya S, Aramori I.

J Immunol. 2017 Nov 15;199(10):3427-3436. doi: 10.4049/jimmunol.1700941. Epub 2017 Oct 16.

20.

Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice.

Shinohara R, Taniguchi M, Ehrlich AT, Yokogawa K, Deguchi Y, Cherasse Y, Lazarus M, Urade Y, Ogawa A, Kitaoka S, Sawa A, Narumiya S, Furuyashiki T.

Mol Psychiatry. 2018 Aug;23(8):1717-1730. doi: 10.1038/mp.2017.177. Epub 2017 Sep 19.

PMID:
28924188
21.

Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients.

Aoki T, Saito M, Koseki H, Tsuji K, Tsuji A, Murata K, Kasuya H, Morita A, Narumiya S, Nozaki K; MR Macrophage Imaging Study Investigators.

J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2055-2064. doi: 10.1016/j.jstrokecerebrovasdis.2016.10.026. Epub 2017 Jul 31.

PMID:
28774792
22.

EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions.

Ota H, Katanosaka K, Murase S, Furuyashiki T, Narumiya S, Mizumura K.

Scand J Med Sci Sports. 2018 Mar;28(3):826-833. doi: 10.1111/sms.12954. Epub 2017 Aug 11.

PMID:
28759126
23.

Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.

Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5444-E5453. doi: 10.1073/pnas.1704099114. Epub 2017 Jun 19.

24.

An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients.

Takahashi H, Kawaguchi M, Kitamura K, Narumiya S, Kawamura M, Tengan I, Nishimoto S, Hanamure Y, Majima Y, Tsubura S, Teruya K, Shirahata S.

Integr Cancer Ther. 2018 Jun;17(2):282-291. doi: 10.1177/1534735417692097. Epub 2017 Feb 12.

25.

Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C.

J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.

26.

Exacerbation of Aging-Associated and Instability-Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D2 Receptor.

Ouhaddi Y, Nebbaki SS, Habouri L, Afif H, Lussier B, Kapoor M, Narumiya S, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H.

Arthritis Rheumatol. 2017 Sep;69(9):1784-1795. doi: 10.1002/art.40160. Epub 2017 Aug 1.

27.

T cell function is dispensable for intracranial aneurysm formation and progression.

Miyata H, Koseki H, Takizawa K, Kasuya H, Nozaki K, Narumiya S, Aoki T.

PLoS One. 2017 Apr 24;12(4):e0175421. doi: 10.1371/journal.pone.0175421. eCollection 2017.

28.

A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration.

Yamamoto R, Aoki T, Koseki H, Fukuda M, Hirose J, Tsuji K, Takizawa K, Nakamura S, Miyata H, Hamakawa N, Kasuya H, Nozaki K, Hirayama Y, Aramori I, Narumiya S.

Br J Pharmacol. 2017 Jul;174(13):2085-2101. doi: 10.1111/bph.13820. Epub 2017 May 27.

29.

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N.

Cancer Discov. 2017 May;7(5):522-538. doi: 10.1158/2159-8290.CD-16-0932. Epub 2017 Feb 15.

30.

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.

Aoki T, Frȍsen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J, Narumiya S.

Sci Signal. 2017 Feb 7;10(465). pii: eaah6037. doi: 10.1126/scisignal.aah6037.

PMID:
28174280
31.

mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety.

Deguchi Y, Harada M, Shinohara R, Lazarus M, Cherasse Y, Urade Y, Yamada D, Sekiguchi M, Watanabe D, Furuyashiki T, Narumiya S.

Cell Rep. 2016 Nov 22;17(9):2405-2417. doi: 10.1016/j.celrep.2016.10.088.

32.

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.

Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y.

Blood. 2017 Feb 2;129(5):587-597. doi: 10.1182/blood-2016-07-725754. Epub 2016 Nov 8.

33.

Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice.

Hosono K, Isonaka R, Kawakami T, Narumiya S, Majima M.

PLoS One. 2016 Oct 6;11(10):e0162532. doi: 10.1371/journal.pone.0162532. eCollection 2016.

34.

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, Yanagita M.

JCI Insight. 2016 Jul 21;1(11):e87680. doi: 10.1172/jci.insight.87680.

35.

Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia.

Amano H, Nakamura M, Ito Y, Kakutani H, Eshima K, Kitasato H, Narumiya S, Majima M.

J Surg Res. 2016 Jul;204(1):153-63. doi: 10.1016/j.jss.2016.04.011. Epub 2016 Apr 22.

PMID:
27451882
36.

Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma.

Ikezoe K, Oga T, Honda T, Hara-Chikuma M, Ma X, Tsuruyama T, Uno K, Fuchikami J, Tanizawa K, Handa T, Taguchi Y, Verkman AS, Narumiya S, Mishima M, Chin K.

Sci Rep. 2016 May 11;6:25781. doi: 10.1038/srep25781.

37.

Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm.

Aoki T, Yamamoto K, Fukuda M, Shimogonya Y, Fukuda S, Narumiya S.

Acta Neuropathol Commun. 2016 May 9;4(1):48. doi: 10.1186/s40478-016-0318-3.

38.

Roles of hepatic stellate cells in liver inflammation: a new perspective.

Fujita T, Narumiya S.

Inflamm Regen. 2016 Apr 25;36:1. doi: 10.1186/s41232-016-0005-6. eCollection 2016. Review.

39.

Thromboxane A2 is Involved in Itch-associated Responses in Mice with Atopic Dermatitis-like Skin Lesions.

Andoh T, Yamamoto A, Haza S, Yuhki KI, Ushikubi F, Narumiya S, Kuraishi Y.

Acta Derm Venereol. 2016 Nov 2;96(7):899-904. doi: 10.2340/00015555-2437.

40.

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.

41.

In Memoriam: Osamu Hayaishi (1920 – 2015).

Narumiya S, Shimizu T, Yamamoto S.

J Lipid Res. 2016 Apr;57(4):517-22. No abstract available.

42.

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.

Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C.

J Biol Chem. 2015 Dec 11;290(50):29781-93. doi: 10.1074/jbc.M115.669481. Epub 2015 Oct 16.

43.

Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.

Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S.

Hepatology. 2016 Apr;63(4):1325-39. doi: 10.1002/hep.28112. Epub 2015 Sep 30.

44.

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways.

Ma X, Aoki T, Narumiya S.

Cell Mol Immunol. 2016 Mar;13(2):240-50. doi: 10.1038/cmi.2015.70. Epub 2015 Jul 20.

45.

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.

Ma X, Aoki T, Tsuruyama T, Narumiya S.

Cancer Res. 2015 Jul 15;75(14):2822-32. doi: 10.1158/0008-5472.CAN-15-0125. Epub 2015 May 27.

46.

Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions.

Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M.

Cardiovasc Res. 2015 Sep 1;107(4):509-21. doi: 10.1093/cvr/cvv139. Epub 2015 May 1.

PMID:
25935870
47.

Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.

Minamino T, Ito Y, Ohkubo H, Shimuzu Y, Kojo K, Nishizwa N, Amano H, Narumiya S, Koizumi W, Majima M.

Life Sci. 2015 Jul 1;132:85-92. doi: 10.1016/j.lfs.2015.03.015. Epub 2015 Apr 25.

PMID:
25921763
48.

The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice.

Kashiwagi H, Yuhki K, Kojima F, Kumei S, Takahata O, Sakai Y, Narumiya S, Ushikubi F.

J Pharmacol Exp Ther. 2015 May;353(2):269-78. doi: 10.1124/jpet.115.222612. Epub 2015 Mar 4.

PMID:
25740898
49.

CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease.

Ko CY, Chu YY, Narumiya S, Chi JY, Furuyashiki T, Aoki T, Wang SM, Chang WC, Wang JM.

Neurobiol Aging. 2015 Mar;36(3):1356-68. doi: 10.1016/j.neurobiolaging.2014.11.020. Epub 2014 Dec 4.

PMID:
25554493
50.

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions.

Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV.

J Exp Med. 2014 Dec 15;211(13):2507-17. doi: 10.1084/jem.20140137. Epub 2014 Dec 8.

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