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Items: 1 to 50 of 61

1.

Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase.

Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR 3rd, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD.

Cell. 2020 Jan 13. pii: S0092-8674(19)31374-1. doi: 10.1016/j.cell.2019.12.012. [Epub ahead of print]

PMID:
31955845
2.

HP1 reshapes nucleosome core to promote phase separation of heterochromatin.

Sanulli S, Trnka MJ, Dharmarajan V, Tibble RW, Pascal BD, Burlingame AL, Griffin PR, Gross JD, Narlikar GJ.

Nature. 2019 Nov;575(7782):390-394. doi: 10.1038/s41586-019-1669-2. Epub 2019 Oct 16.

PMID:
31618757
3.

Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.

Armache JP, Gamarra N, Johnson SL, Leonard JD, Wu S, Narlikar GJ, Cheng Y.

Elife. 2019 Jun 18;8. pii: e46057. doi: 10.7554/eLife.46057.

4.

Ion counting demonstrates a high electrostatic field generated by the nucleosome.

Gebala M, Johnson SL, Narlikar GJ, Herschlag D.

Elife. 2019 Jun 11;8. pii: e44993. doi: 10.7554/eLife.44993.

5.

Visualization and Quantitation of Phase-Separated Droplet Formation by Human HP1α.

Keenen MM, Larson AG, Narlikar GJ.

Methods Enzymol. 2018;611:51-66. doi: 10.1016/bs.mie.2018.09.034. Epub 2018 Oct 31.

PMID:
30471698
6.

A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase.

Stoddard CI, Feng S, Campbell MG, Liu W, Wang H, Zhong X, Bernatavichute Y, Cheng Y, Jacobsen SE, Narlikar GJ.

Mol Cell. 2019 Jan 3;73(1):73-83.e6. doi: 10.1016/j.molcel.2018.10.006. Epub 2018 Nov 8.

7.

The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h.

Gamarra N, Johnson SL, Trnka MJ, Burlingame AL, Narlikar GJ.

Elife. 2018 Apr 17;7. pii: e35322. doi: 10.7554/eLife.35322.

8.

The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.

Larson AG, Narlikar GJ.

Biochemistry. 2018 May 1;57(17):2540-2548. doi: 10.1021/acs.biochem.8b00401. Epub 2018 Apr 23. Review.

PMID:
29644850
9.

The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding.

Zhou CY, Johnson SL, Lee LJ, Longhurst AD, Beckwith SL, Johnson MJ, Morrison AJ, Narlikar GJ.

Mol Cell. 2018 Feb 15;69(4):677-688.e9. doi: 10.1016/j.molcel.2018.01.028.

10.

Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.

Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ.

J Mol Biol. 2017 Nov 24;429(23):3666-3677. doi: 10.1016/j.jmb.2017.09.012. Epub 2017 Sep 20.

11.

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.

Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ.

Nature. 2017 Jul 13;547(7662):236-240. doi: 10.1038/nature22822. Epub 2017 Jun 21.

12.

Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.

Zhou CY, Stoddard CI, Johnston JB, Trnka MJ, Echeverria I, Palovcak E, Sali A, Burlingame AL, Cheng Y, Narlikar GJ.

Cell Rep. 2017 Jun 6;19(10):2033-2044. doi: 10.1016/j.celrep.2017.05.029.

13.

Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler.

Sinha KK, Gross JD, Narlikar GJ.

Science. 2017 Jan 20;355(6322). pii: eaaa3761. doi: 10.1126/science.aaa3761.

14.

Mechanisms of ATP-Dependent Chromatin Remodeling Motors.

Zhou CY, Johnson SL, Gamarra NI, Narlikar GJ.

Annu Rev Biophys. 2016 Jul 5;45:153-81. doi: 10.1146/annurev-biophys-051013-022819. Review.

PMID:
27391925
15.

Analysis of Nucleosome Sliding by ATP-Dependent Chromatin Remodeling Enzymes.

Zhou CY, Narlikar GJ.

Methods Enzymol. 2016;573:119-35. doi: 10.1016/bs.mie.2016.01.015. Epub 2016 Mar 24.

PMID:
27372751
16.

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.

Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R.

Elife. 2016 Apr 28;5. pii: e13450. doi: 10.7554/eLife.13450.

17.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

18.

A nucleotide-driven switch regulates flanking DNA length sensing by a dimeric chromatin remodeler.

Leonard JD, Narlikar GJ.

Mol Cell. 2015 Mar 5;57(5):850-859. doi: 10.1016/j.molcel.2015.01.008. Epub 2015 Feb 12.

19.

Mechanisms of functional promiscuity by HP1 proteins.

Canzio D, Larson A, Narlikar GJ.

Trends Cell Biol. 2014 Jun;24(6):377-86. doi: 10.1016/j.tcb.2014.01.002. Epub 2014 Mar 4. Review.

20.

The histone H4 tail regulates the conformation of the ATP-binding pocket in the SNF2h chromatin remodeling enzyme.

Racki LR, Naber N, Pate E, Leonard JD, Cooke R, Narlikar GJ.

J Mol Biol. 2014 May 15;426(10):2034-44. doi: 10.1016/j.jmb.2014.02.021. Epub 2014 Mar 4.

21.

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes.

Narlikar GJ, Sundaramoorthy R, Owen-Hughes T.

Cell. 2013 Aug 1;154(3):490-503. doi: 10.1016/j.cell.2013.07.011. Review.

22.

Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.

Al-Sady B, Madhani HD, Narlikar GJ.

Mol Cell. 2013 Jul 11;51(1):80-91. doi: 10.1016/j.molcel.2013.06.013.

23.

Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.

Shiau C, Trnka MJ, Bozicevic A, Ortiz Torres I, Al-Sady B, Burlingame AL, Narlikar GJ, Fujimori DG.

Chem Biol. 2013 Apr 18;20(4):494-9. doi: 10.1016/j.chembiol.2013.03.008.

24.

A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly.

Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ.

Nature. 2013 Apr 18;496(7445):377-81. doi: 10.1038/nature12032. Epub 2013 Mar 13.

25.

Ers1 links HP1 to RNAi.

Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11258-63. doi: 10.1073/pnas.1204947109. Epub 2012 Jun 25.

26.

Analysis of changes in nucleosome conformation using fluorescence resonance energy transfer.

Shahian T, Narlikar GJ.

Methods Mol Biol. 2012;833:337-49. doi: 10.1007/978-1-61779-477-3_20.

PMID:
22183603
27.

Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution.

Armache KJ, Garlick JD, Canzio D, Narlikar GJ, Kingston RE.

Science. 2011 Nov 18;334(6058):977-82. doi: 10.1126/science.1210915.

28.

Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress.

Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10620-5. doi: 10.1073/pnas.1019735108. Epub 2011 Jun 14.

29.

Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.

Canzio D, Chang EY, Shankar S, Kuchenbecker KM, Simon MD, Madhani HD, Narlikar GJ, Al-Sady B.

Mol Cell. 2011 Jan 7;41(1):67-81. doi: 10.1016/j.molcel.2010.12.016.

30.

The ATP-dependent remodeler RSC transfers histone dimers and octamers through the rapid formation of an unstable encounter intermediate.

Rowe CE, Narlikar GJ.

Biochemistry. 2010 Nov 16;49(45):9882-90. doi: 10.1021/bi101491u. Epub 2010 Oct 25.

31.

A proposal for kinetic proof reading by ISWI family chromatin remodeling motors.

Narlikar GJ.

Curr Opin Chem Biol. 2010 Oct;14(5):660-5. doi: 10.1016/j.cbpa.2010.08.001. Epub 2010 Sep 15. Review.

32.

Dynamics of nucleosome remodelling by individual ACF complexes.

Blosser TR, Yang JG, Stone MD, Narlikar GJ, Zhuang X.

Nature. 2009 Dec 24;462(7276):1022-7. doi: 10.1038/nature08627.

33.

The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.

Racki LR, Yang JG, Naber N, Partensky PD, Acevedo A, Purcell TJ, Cooke R, Cheng Y, Narlikar GJ.

Nature. 2009 Dec 24;462(7276):1016-21. doi: 10.1038/nature08621.

34.

Chromatin remodelers act globally, sequence positions nucleosomes locally.

Partensky PD, Narlikar GJ.

J Mol Biol. 2009 Aug 7;391(1):12-25. doi: 10.1016/j.jmb.2009.04.085. Epub 2009 May 18.

35.

MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF.

Chang EY, Ferreira H, Somers J, Nusinow DA, Owen-Hughes T, Narlikar GJ.

Biochemistry. 2008 Dec 23;47(51):13726-32. doi: 10.1021/bi8016944.

36.

Epigenomics: a roadmap, but to where?

Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K.

Science. 2008 Oct 3;322(5898):43-4. doi: 10.1126/science.322.5898.43b. No abstract available.

37.

ATP-dependent chromatin remodeling enzymes: two heads are not better, just different.

Racki LR, Narlikar GJ.

Curr Opin Genet Dev. 2008 Apr;18(2):137-44. doi: 10.1016/j.gde.2008.01.007. Epub 2008 Mar 12. Review.

38.

The site-specific installation of methyl-lysine analogs into recombinant histones.

Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM.

Cell. 2007 Mar 9;128(5):1003-12.

39.
40.

The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing.

Yang JG, Madrid TS, Sevastopoulos E, Narlikar GJ.

Nat Struct Mol Biol. 2006 Dec;13(12):1078-83. Epub 2006 Nov 12.

PMID:
17099699
41.

Human ACF1 alters the remodeling strategy of SNF2h.

He X, Fan HY, Narlikar GJ, Kingston RE.

J Biol Chem. 2006 Sep 29;281(39):28636-47. Epub 2006 Jul 29.

42.

Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.

Mahajan MC, Narlikar GJ, Boyapaty G, Kingston RE, Weissman SM.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15012-7. Epub 2005 Oct 10.

43.

Noncovalent modification of chromatin: different remodeled products with different ATPase domains.

Fan HY, Narlikar GJ, Kingston RE.

Cold Spring Harb Symp Quant Biol. 2004;69:183-92. Review. No abstract available.

PMID:
16117648
44.

Distinct strategies to make nucleosomal DNA accessible.

Fan HY, He X, Kingston RE, Narlikar GJ.

Mol Cell. 2003 May;11(5):1311-22.

45.

Cooperation between complexes that regulate chromatin structure and transcription.

Narlikar GJ, Fan HY, Kingston RE.

Cell. 2002 Feb 22;108(4):475-87. Review.

46.
47.

Functional differences between the human ATP-dependent nucleosome remodeling proteins BRG1 and SNF2H.

Aalfs JD, Narlikar GJ, Kingston RE.

J Biol Chem. 2001 Sep 7;276(36):34270-8. Epub 2001 Jul 2.

48.

Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes.

Jónsson ZO, Dhar SK, Narlikar GJ, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A.

J Biol Chem. 2001 May 11;276(19):16279-88. Epub 2001 Feb 5.

49.

Stability of a human SWI-SNF remodeled nucleosomal array.

Guyon JR, Narlikar GJ, Sullivan EK, Kingston RE.

Mol Cell Biol. 2001 Feb;21(4):1132-44.

50.

Use of duplex rigidity for stability and specificity in RNA tertiary structure.

Narlikar GJ, Bartley LE, Herschlag D.

Biochemistry. 2000 May 23;39(20):6183-9.

PMID:
10821693

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