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Items: 43

1.
2.

Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery.

Naritomi Y, Sanoh S, Ohta S.

Drug Metab Pharmacokinet. 2018 Feb;33(1):31-39. doi: 10.1016/j.dmpk.2017.11.001. Epub 2017 Nov 9. Review.

PMID:
29183653
3.

Efficient delivery of signal-responsive gene carriers for disease-specific gene expression via bubble liposomes and sonoporation.

Tsuchiya A, Kang JH, Mori T, Naritomi Y, Kushio S, Niidome T, Tachibana K, Takahashi Y, Negishi Y, Oda Y, Suzuki R, Maruyama K, Katayama Y.

Colloids Surf B Biointerfaces. 2017 Dec 1;160:60-64. doi: 10.1016/j.colsurfb.2017.09.021. Epub 2017 Sep 9.

PMID:
28917150
4.

Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases.

Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, Naritomi Y, Okazaki K, Nakashima Y, Iwamoto Y, Koyanagi S, Hara H, Nagao T.

Mol Med Rep. 2015 Aug;12(2):2757-64. doi: 10.3892/mmr.2015.3707. Epub 2015 Apr 30.

PMID:
25936373
5.

Prediction of hepatic and intestinal glucuronidation using in vitro-in vivo extrapolation.

Naritomi Y, Nakamori F, Furukawa T, Tabata K.

Drug Metab Pharmacokinet. 2015 Feb;30(1):21-9. doi: 10.1016/j.dmpk.2014.10.001. Epub 2014 Oct 13. Review.

PMID:
25760528
6.

Predictability of plasma concentration-time curves in humans using single-species allometric scaling of chimeric mice with humanized liver.

Sanoh S, Naritomi Y, Fujimoto M, Sato K, Kawamura A, Horiguchi A, Sugihara K, Kotake Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Xenobiotica. 2015;45(7):605-14. doi: 10.3109/00498254.2015.1007112. Epub 2015 Mar 3.

PMID:
25733030
7.

Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.

Sakai T, Sato B, Hara K, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T, Ishibashi T.

Vasc Health Risk Manag. 2014 Oct 17;10:591-7. doi: 10.2147/VHRM.S68844. eCollection 2014.

8.

Future perspectives of predicting human pharmacokinetics.

Naritomi Y.

Drug Metab Pharmacokinet. 2014;29(4):287-8. No abstract available.

9.

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.

Ishibashi T, Sato B, Shibata S, Sakai T, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T.

Int Immunopharmacol. 2014 Aug;21(2):468-73. doi: 10.1016/j.intimp.2014.06.001. Epub 2014 Jun 11.

10.

Comparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal-systemic concentration difference method.

Kadono K, Koakutsu A, Naritomi Y, Terashita S, Tabata K, Teramura T.

Xenobiotica. 2014 Jun;44(6):511-21. doi: 10.3109/00498254.2013.869375. Epub 2013 Dec 12.

PMID:
24329478
11.

Slow dynamics of a protein backbone in molecular dynamics simulation revealed by time-structure based independent component analysis.

Naritomi Y, Fuchigami S.

J Chem Phys. 2013 Dec 7;139(21):215102. doi: 10.1063/1.4834695.

PMID:
24320404
12.

Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys.

Furukawa T, Naritomi Y, Tetsuka K, Nakamori F, Moriguchi H, Yamano K, Terashita S, Tabata K, Teramura T.

Xenobiotica. 2014 Mar;44(3):205-16. doi: 10.3109/00498254.2013.828362. Epub 2013 Aug 20.

PMID:
23962030
13.

Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor.

Watanabe K, Kakefuda A, Yasuda M, Enjo K, Kikuchi A, Furutani T, Naritomi Y, Otsuka Y, Okada M, Ohta M.

Bioorg Med Chem. 2013 Sep 1;21(17):5261-70. doi: 10.1016/j.bmc.2013.06.025. Epub 2013 Jun 19.

PMID:
23845281
14.

Combined ivermectin and topical therapy significantly reduces treatment time in aged scabietic patients.

Ichikawa M, Tanaka M, Naritomi Y, Furue M.

J Dermatol. 2013 Apr;40(4):306-7. doi: 10.1111/1346-8138.12070. Epub 2013 Jan 5. No abstract available.

PMID:
23289854
15.

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.

Ishibashi T, Sato B, Rikitake M, Seo T, Kurokawa R, Hara Y, Naritomi Y, Hara H, Nagao T.

Med Gas Res. 2012 Oct 2;2(1):27. doi: 10.1186/2045-9912-2-27.

16.

Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.

Nakamori F, Naritomi Y, Hosoya K, Moriguchi H, Tetsuka K, Furukawa T, Kadono K, Yamano K, Terashita S, Teramura T.

Drug Metab Dispos. 2012 Sep;40(9):1771-7. doi: 10.1124/dmd.112.045476. Epub 2012 Jun 8.

PMID:
22685216
17.

Method for predicting human intestinal first-pass metabolism of UGT substrate compounds.

Furukawa T, Yamano K, Naritomi Y, Tanaka K, Terashita S, Teramura T.

Xenobiotica. 2012 Oct;42(10):980-8. doi: 10.3109/00498254.2012.680620. Epub 2012 Apr 27.

PMID:
22540538
18.

Fluorometric detection of protein kinase Cα activity based on phosphorylation-induced dissociation of a polyion complex.

Toita R, Mori T, Naritomi Y, Kang JH, Shiosaki S, Niidome T, Katayama Y.

Anal Biochem. 2012 May 15;424(2):130-6. doi: 10.1016/j.ab.2012.01.036. Epub 2012 Feb 17.

PMID:
22342947
19.

Improvement in the colloidal stability of protein kinase-responsive polyplexes by PEG modification.

Tsuchiya A, Naritomi Y, Kushio S, Kang JH, Murata M, Hashizume M, Mori T, Niidome T, Katayama Y.

J Biomed Mater Res A. 2012 May;100(5):1136-41. doi: 10.1002/jbm.a.34049. Epub 2012 Feb 15.

PMID:
22337618
20.

A practical and direct comparison of intrinsic metabolic clearance of several non-CYP enzyme substrates in freshly isolated and cryopreserved hepatocytes.

Akabane T, Gerst N, Naritomi Y, Masters JN, Tamura K.

Drug Metab Pharmacokinet. 2012;27(2):181-91. Epub 2011 Oct 25.

21.

Quantitative prediction of intestinal glucuronidation of drugs in rats using in vitro metabolic clearance data.

Furukawa T, Nakamori F, Tetsuka K, Naritomi Y, Moriguchi H, Yamano K, Terashita S, Teramura T.

Drug Metab Pharmacokinet. 2012;27(2):171-80. Epub 2011 Oct 4.

22.

Correlation of intrinsic in vitro and in vivo clearance for drugs metabolized by hepatic UDP-glucuronosyltransferases in rats.

Nakamori F, Naritomi Y, Furutani M, Takamura F, Miura H, Murai H, Terashita S, Teramura T.

Drug Metab Pharmacokinet. 2011;26(5):465-73. Epub 2011 Jul 5.

23.

Slow dynamics in protein fluctuations revealed by time-structure based independent component analysis: the case of domain motions.

Naritomi Y, Fuchigami S.

J Chem Phys. 2011 Feb 14;134(6):065101. doi: 10.1063/1.3554380.

PMID:
21322734
24.

[A case of metronomic chemotherapy as an alternative cancer therapy for palliation].

Yamashita K, Nabeshima A, Kondo H, Nagao T, Hara Y, Naritomi Y.

Nihon Ronen Igakkai Zasshi. 2009 May;46(3):264-8. Japanese.

25.

Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.

Ishikawa T, Nishigaki F, Miyata S, Hirayama Y, Minoura K, Imanishi J, Neya M, Mizutani T, Imamura Y, Naritomi Y, Murai H, Ohkubo Y, Kagayama A, Mutoh S.

Br J Pharmacol. 2005 Jan;144(1):133-43.

27.
28.

Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.

Naritomi Y, Terashita S, Kagayama A, Sugiyama Y.

Drug Metab Dispos. 2003 May;31(5):580-8.

PMID:
12695346
29.

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Naritomi Y, Terashita S, Kimura S, Suzuki A, Kagayama A, Sugiyama Y.

Drug Metab Dispos. 2001 Oct;29(10):1316-24.

PMID:
11560875
30.

Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey.

Niwa T, Kaneko H, Naritomi Y, Togawa A, Shiraga T, Iwasaki K, Tozuka Z, Hata T.

Xenobiotica. 1995 Nov;25(10):1041-9.

PMID:
8578760
31.

Isolation and characterization of an alicyclic amine N-sulfotransferase from female rat liver.

Naritomi Y, Niwa T, Shiraga T, Iwasaki K, Noda K.

Biol Pharm Bull. 1994 Aug;17(8):1008-11.

PMID:
7820098
32.

Effect of repeated injection of somatomedin C on drug metabolizing enzyme activities in rats.

Niwa T, Naritomi Y, Kawano M, Ueda-Shimohira Y, Takeshita K, Shiraga T, Iwasaki K, Noda K.

Res Commun Chem Pathol Pharmacol. 1994 Mar;83(3):341-8.

PMID:
8008983
33.

[11 cases of anaphylaxis caused by grand keyhole limpet (abalone like shellfish)].

Maeda S, Morikawa A, Kato M, Motegi Y, Shigeta M, Tokuyama K, Kuroume T, Naritomi Y, Suehiro K, Kusaba K, et al.

Arerugi. 1991 Nov;40(11):1415-20. Japanese.

PMID:
1763963
34.

Low-dose aclarubicin in blastic transformation of essential thrombocythemia.

Asano Y, Naritomi Y, Kimura H, Maeda Y, Kusaba T, Yoshizawa S, Shiraishi G.

Ann Hematol. 1991 May;62(5):194-5.

PMID:
2049469
35.

[A case of Crigler-Najjar syndrome of type II].

Mori Y, Kimura H, Suehiro K, Naritomi Y, Maeda Y, Kusaba T, Ishibashi D.

Nihon Naika Gakkai Zasshi. 1991 Jan 10;80(1):102-3. Japanese. No abstract available.

PMID:
1902498
36.

Increase of DT-diaphorase activity and atrophy of thymus by organotin compounds.

Ariyoshi T, Naritomi Y, Machida S, Arizono K.

Bull Environ Contam Toxicol. 1991 Jan;46(1):100-7. No abstract available.

PMID:
1900448
37.

A common Chinese beta-thalassemia mutation found in a Japanese family.

Naritomi Y, Nakashima H, Kagimoto M, Naito Y, Yokota E, Imamura T.

Hum Genet. 1990 Apr;84(5):480-2.

PMID:
1969846
38.

A substitution of cytosine for thymine in codon 110 of the human beta-globin gene is a novel cause of beta-thalassemia phenotypes.

Naritomi Y, Naito Y, Nakashima H, Yokota E, Imamura T.

Hum Genet. 1988 Sep;80(1):11-5.

PMID:
3417300
39.

Identification of abnormal hemoglobin (J Lome): beta 59 (E3) lysine----asparagine in a Japanese.

Naritomi Y, Kawaguchi T, Naito Y, Kagimoto M, Yokota E, Hirakawa M, Imamura T.

Nihon Ketsueki Gakkai Zasshi. 1986 Feb;49(1):127-30. No abstract available.

PMID:
3085422
40.

Thalassemia in Japan.

Imamura T, Yokota E, Naito Y, Kagimoto M, Naritomi Y, Kawaguchi T, Sugihara J, Ohta Y.

Nihon Ketsueki Gakkai Zasshi. 1985 Dec;48(8):2029-37. No abstract available.

PMID:
3836560
41.

[A case of ulcerative colitis associated with acute pancreatitis].

Naritomi Y, Hayashida K, Nakamura M, Higuchi N, Hachimine K, Tsuda Y, Ishibashi H, Urae R, Kakizoe K.

Nihon Shokakibyo Gakkai Zasshi. 1985 Nov;82(11):2824-8. Japanese. No abstract available.

PMID:
4087486
42.

Hemoglobin A2 Honai (alpha 2 delta 2(90)(F6)Glu----Val): a new delta chain variant.

Fujita S, Ohta Y, Saito S, Kobayashi Y, Naritomi Y, Kawaguchi T, Imamura T, Wada Y, Hayashi A.

Hemoglobin. 1985;9(6):597-607.

PMID:
2869009
43.

[Case of familial polyposis of thlarge intestine].

Nishimurm, Naritomi Y, Hisatsugu T, Nakayama H, Hayashi H.

Geka Chiryo. 1969 Oct;21(4):488-92. Japanese. No abstract available.

PMID:
5395002

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