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A novel therapeutic peptide targeting myocardial reperfusion injury.

Boisguérin P, Covinhes A, Gallot L, Barrère C, Vincent A, Busson M, Piot C, Nargeot J, Lebleu B, Barrère-Lemaire S.

Cardiovasc Res. 2020 Mar 1;116(3):633-644. doi: 10.1093/cvr/cvz145.


[Genesis of cardiac sinus automaticity and therapeutic perspectives].

Mesirca P, Torrente AG, Bidaud I, Baudot M, Nargeot J, Mangoni ME.

Arch Mal Coeur Vaiss Pratique. 2018 Apr;2018(267):35-39. doi: 10.1016/j.amcp.2018.02.007. Epub 2018 Mar 12. French. No abstract available.


The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury.

Prompunt E, Sanit J, Barrère-Lemaire S, Nargeot J, Noordali H, Madhani M, Kumphune S.

Exp Ther Med. 2018 Jun;15(6):5231-5242. doi: 10.3892/etm.2018.6097. Epub 2018 Apr 25.


Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice.

Vincent A, Covinhes A, Barrère C, Gallot L, Thoumala S, Piot C, Heurteaux C, Lazdunski M, Nargeot J, Barrère-Lemaire S.

Sci Rep. 2017 Oct 31;7(1):14701. doi: 10.1038/s41598-017-14822-x.


Cardiac mGluR1 metabotropic receptors in cardioprotection.

Vincent A, Sportouch C, Covinhes A, Barrère C, Gallot L, Delgado-Betancourt V, Lattuca B, Solecki K, Boisguérin P, Piot C, Nargeot J, Barrère-Lemaire S.

Cardiovasc Res. 2017 May 1;113(6):644-655. doi: 10.1093/cvr/cvx024.


G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.


L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity.

Torrente AG, Mesirca P, Neco P, Rizzetto R, Dubel S, Barrere C, Sinegger-Brauns M, Striessnig J, Richard S, Nargeot J, Gomez AM, Mangoni ME.

Cardiovasc Res. 2016 Mar 1;109(3):451-61. doi: 10.1093/cvr/cvw006. Epub 2016 Jan 19.


Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'.

Faucherre A, Kissa K, Nargeot J, Mangoni ME, Jopling C.

Haematologica. 2016 Jan;101(1):e38. doi: 10.3324/haematol.2015.137398. No abstract available.


The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function.

François A, Schüetter N, Laffray S, Sanguesa J, Pizzoccaro A, Dubel S, Mantilleri A, Nargeot J, Noël J, Wood JN, Moqrich A, Pongs O, Bourinet E.

Cell Rep. 2015 Jan 20;10(3):370-382. doi: 10.1016/j.celrep.2014.12.042. Epub 2015 Jan 15.


Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.

Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.


[Antipsychotics-induced acute necrotizing enterocolitis: a case report].

Nargeot J, Langlet C, Merlot A, Buard M, Mondoloni A, Viala A, Vacheron MN.

Therapie. 2014 Mar-Apr;69(2):186-8. doi: 10.2515/therapie/2013070. Epub 2014 Jun 12. French.


[The imminent peril in the law of July the fifth 2011, two years later: the impact on health?].

Mondoloni A, Buard M, Nargeot J, Vacheron MN.

Encephale. 2014 Dec;40(6):468-73. doi: 10.1016/j.encep.2014.01.001. Epub 2014 Apr 3. French.


piezo2b regulates vertebrate light touch response.

Faucherre A, Nargeot J, Mangoni ME, Jopling C.

J Neurosci. 2013 Oct 23;33(43):17089-94. doi: 10.1523/JNEUROSCI.0522-13.2013.


Piezo1 plays a role in erythrocyte volume homeostasis.

Faucherre A, Kissa K, Nargeot J, Mangoni ME, Jopling C.

Haematologica. 2014 Jan;99(1):70-5. doi: 10.3324/haematol.2013.086090. Epub 2013 Jul 19.


The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.

Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME.

J Gen Physiol. 2013 Aug;142(2):113-26. doi: 10.1085/jgp.201310996. Epub 2013 Jul 15.


Delayed postconditioning: not too late?

Barrère-Lemaire S, Nargeot J, Piot C.

Trends Cardiovasc Med. 2012 Oct;22(7):173-9. doi: 10.1016/j.tcm.2012.07.016. Epub 2012 Sep 5. Review.


AKAP79 modulation of L-type channels involves disruption of intramolecular interactions in the CaV1.2 subunit.

Altier C, Dubel SJ, Barrere C, Jarvis SE, Stotz SC, Scott JD, Nargeot J, Zamponi GW, Bourinet E.

Channels (Austin). 2012 May-Jun;6(3):157-65. doi: 10.4161/chan.20865. Epub 2012 May 1.


Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium.

Vincent A, Gahide G, Sportouch-Dukhan C, Covinhes A, Franck-Miclo A, Roubille F, Barrère C, Adda J, Dantec C, Redt-Clouet C, Piot C, Nargeot J, Barrère-Lemaire S.

Cardiovasc Res. 2012 May 1;94(2):351-8. doi: 10.1093/cvr/cvr310. Epub 2011 Nov 21.


The case for the funny current and the calcium clock.

Rosen MR, Nargeot J, Salama G.

Heart Rhythm. 2012 Apr;9(4):616-8. doi: 10.1016/j.hrthm.2011.10.008. Epub 2011 Oct 11. No abstract available.


Delayed postconditioning in the mouse heart in vivo.

Roubille F, Franck-Miclo A, Covinhes A, Lafont C, Cransac F, Combes S, Vincent A, Fontanaud P, Sportouch-Dukhan C, Redt-Clouet C, Nargeot J, Piot C, Barrère-Lemaire S.

Circulation. 2011 Sep 20;124(12):1330-6. doi: 10.1161/CIRCULATIONAHA.111.031864. Epub 2011 Aug 29.


Systemic delivery of BH4 anti-apoptotic peptide using CPPs prevents cardiac ischemia-reperfusion injuries in vivo.

Boisguerin P, Redt-Clouet C, Franck-Miclo A, Licheheb S, Nargeot J, Barrère-Lemaire S, Lebleu B.

J Control Release. 2011 Dec 10;156(2):146-53. doi: 10.1016/j.jconrel.2011.07.037. Epub 2011 Aug 2.


T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome.

Marger F, Gelot A, Alloui A, Matricon J, Ferrer JF, Barrère C, Pizzoccaro A, Muller E, Nargeot J, Snutch TP, Eschalier A, Bourinet E, Ardid D.

Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11268-73. doi: 10.1073/pnas.1100869108. Epub 2011 Jun 20.


Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):251-61. Epub 2011 May 1.


Pacemaker activity and ionic currents in mouse atrioventricular node cells.

Marger L, Mesirca P, Alig J, Torrente A, Dubel S, Engeland B, Kanani S, Fontanaud P, Striessnig J, Shin HS, Isbrandt D, Ehmke H, Nargeot J, Mangoni ME.

Channels (Austin). 2011 May-Jun;5(3):241-50. Epub 2011 May 1.


The NALCN ion channel is a new actor in pancreatic β-cell physiology.

Swayne LA, Mezghrani A, Lory P, Nargeot J, Monteil A.

Islets. 2010 Jan-Feb;2(1):54-6. doi: 10.4161/isl.2.1.10522. Review.


T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

Barbara G, Alloui A, Nargeot J, Lory P, Eschalier A, Bourinet E, Chemin J.

J Neurosci. 2009 Oct 21;29(42):13106-14. doi: 10.1523/JNEUROSCI.2919-09.2009.


Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate.

Gros D, Théveniau-Ruissy M, Bernard M, Calmels T, Kober F, Söhl G, Willecke K, Nargeot J, Jongsma HJ, Mangoni ME.

Cardiovasc Res. 2010 Jan 1;85(1):45-55. doi: 10.1093/cvr/cvp280.


The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.

Swayne LA, Mezghrani A, Varrault A, Chemin J, Bertrand G, Dalle S, Bourinet E, Lory P, Miller RJ, Nargeot J, Monteil A.

EMBO Rep. 2009 Aug;10(8):873-80. doi: 10.1038/embor.2009.125. Epub 2009 Jul 3.


Identification of potential pharmacological targets by analysis of the comprehensive G protein-coupled receptor repertoire in the four cardiac chambers.

Moore-Morris T, Varrault A, Mangoni ME, Le Digarcher A, Negre V, Dantec C, Journot L, Nargeot J, Couette B.

Mol Pharmacol. 2009 May;75(5):1108-16. doi: 10.1124/mol.108.054155. Epub 2009 Feb 19.


Ligand-based virtual screening to identify new T-type calcium channel blockers.

Ijjaali I, Barrere C, Nargeot J, Petitet F, Bourinet E.

Channels (Austin). 2007 Jul-Aug;1(4):300-4. Epub 2007 Sep 7.


Genesis and regulation of the heart automaticity.

Mangoni ME, Nargeot J.

Physiol Rev. 2008 Jul;88(3):919-82. doi: 10.1152/physrev.00018.2007. Review.


A destructive interaction mechanism accounts for dominant-negative effects of misfolded mutants of voltage-gated calcium channels.

Mezghrani A, Monteil A, Watschinger K, Sinnegger-Brauns MJ, Barrère C, Bourinet E, Nargeot J, Striessnig J, Lory P.

J Neurosci. 2008 Apr 23;28(17):4501-11. doi: 10.1523/JNEUROSCI.2844-07.2008.


Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury.

Roubille F, Combes S, Leal-Sanchez J, Barrère C, Cransac F, Sportouch-Dukhan C, Gahide G, Serre I, Kupfer E, Richard S, Hueber AO, Nargeot J, Piot C, Barrère-Lemaire S.

Circulation. 2007 Dec 4;116(23):2709-17. Epub 2007 Nov 19.


Temperature-dependent modulation of CaV3 T-type calcium channels by protein kinases C and A in mammalian cells.

Chemin J, Mezghrani A, Bidaud I, Dupasquier S, Marger F, Barrère C, Nargeot J, Lory P.

J Biol Chem. 2007 Nov 9;282(45):32710-8. Epub 2007 Sep 12.


Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.

Meysen S, Marger L, Hewett KW, Jarry-Guichard T, Agarkova I, Chauvin JP, Perriard JC, Izumo S, Gourdie RG, Mangoni ME, Nargeot J, Gros D, Miquerol L.

Dev Biol. 2007 Mar 15;303(2):740-53. Epub 2006 Dec 23.


Chemical determinants involved in anandamide-induced inhibition of T-type calcium channels.

Chemin J, Nargeot J, Lory P.

J Biol Chem. 2007 Jan 26;282(4):2314-23. Epub 2006 Nov 22.


Subunit-specific modulation of T-type calcium channels by zinc.

Traboulsie A, Chemin J, Chevalier M, Quignard JF, Nargeot J, Lory P.

J Physiol. 2007 Jan 1;578(Pt 1):159-71. Epub 2006 Nov 2.


Ionic channels underlying cardiac automaticity: new insights from genetically-modified mouse strains.

Nargeot J, Mangoni ME.

Arch Mal Coeur Vaiss. 2006 Sep;99(9):856-61. Review.


Physiological and pharmacological insights into the role of ionic channels in cardiac pacemaker activity.

Couette B, Marger L, Nargeot J, Mangoni ME.

Cardiovasc Hematol Disord Drug Targets. 2006 Sep;6(3):169-90. Review.


If current inhibition: cellular basis and physiology.

Mangoni ME, Marger L, Nargeot J.

Adv Cardiol. 2006;43:17-30. doi: 10.1159/000095403. Review.


Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels.

Mangoni ME, Traboulsie A, Leoni AL, Couette B, Marger L, Le Quang K, Kupfer E, Cohen-Solal A, Vilar J, Shin HS, Escande D, Charpentier F, Nargeot J, Lory P.

Circ Res. 2006 Jun 9;98(11):1422-30. Epub 2006 May 11.


Properties and role of voltage-dependent calcium channels during mouse skeletal muscle differentiation.

Bidaud I, Monteil A, Nargeot J, Lory P.

J Muscle Res Cell Motil. 2006;27(1):75-81. Epub 2006 Mar 15.


T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine.

Traboulsie A, Chemin J, Kupfer E, Nargeot J, Lory P.

Mol Pharmacol. 2006 Jun;69(6):1963-8. Epub 2006 Mar 1.


Differentiated rabbit prostatic stromal cells in primary culture display functional alpha1A-adrenoceptors.

Boulbès D, Choquet A, Barrère-Lemaire S, Costa P, Soustelle L, Nargeot J, Bali JP, Hollande F, Magous R.

Neurourol Urodyn. 2006;25(2):168-78.


Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes.

Mangoni ME, Couette B, Marger L, Bourinet E, Striessnig J, Nargeot J.

Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):38-63. Epub 2005 Jun 6. Review.


Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes.

Lalevée N, Rebsamen MC, Barrère-Lemaire S, Perrier E, Nargeot J, Bénitah JP, Rossier MF.

Cardiovasc Res. 2005 Aug 1;67(2):216-24.


Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.

Bourinet E, Alloui A, Monteil A, Barrère C, Couette B, Poirot O, Pages A, McRory J, Snutch TP, Eschalier A, Nargeot J.

EMBO J. 2005 Jan 26;24(2):315-24. Epub 2004 Dec 16.


Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart.

Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S.

J Physiol. 2005 Jan 1;562(Pt 1):223-34. Epub 2004 Oct 21.


Morphine mimics the antiapoptotic effect of preconditioning via an Ins(1,4,5)P3 signaling pathway in rat ventricular myocytes.

Barrère-Lemaire S, Combes N, Sportouch-Dukhan C, Richard S, Nargeot J, Piot C.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H83-8. Epub 2004 Sep 2.


Acetaminophen: a central analgesic drug that involves a spinal tropisetron-sensitive, non-5-HT(3) receptor-mediated effect.

Libert F, Bonnefont J, Bourinet E, Doucet E, Alloui A, Hamon M, Nargeot J, Eschalier A.

Mol Pharmacol. 2004 Sep;66(3):728-34.


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