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Items: 8

1.

Detection and quantification of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) from smoker albumin and its potential as a surrogate biomarker of tobacco-specific nitrosamines exposure and bioactivation.

Wang Y, Narayanapillai SC, Hu Q, Fujioka N, Xing C.

Toxicol Lett. 2019 Sep 1;311:11-16. doi: 10.1016/j.toxlet.2019.04.020. Epub 2019 Apr 23.

PMID:
31026483
2.

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications.

Wang Y, Eans SO, Stacy HM, Narayanapillai SC, Sharma A, Fujioka N, Haddad L, McLaughlin J, Avery BA, Xing C.

PLoS One. 2018 May 24;13(5):e0197940. doi: 10.1371/journal.pone.0197940. eCollection 2018.

3.

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice.

Puppala M, Narayanapillai SC, Leitzman P, Sun H, Upadhyaya P, O'Sullivan MG, Hecht SS, Xing C.

J Med Chem. 2017 Sep 28;60(18):7935-7940. doi: 10.1021/acs.jmedchem.7b00921. Epub 2017 Sep 13.

4.
5.

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C.

Drug Metab Dispos. 2016 Mar;44(3):422-7. doi: 10.1124/dmd.115.068387. Epub 2016 Jan 7.

6.

Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice.

Narayanapillai SC, Leitzman P, O'Sullivan MG, Xing C.

Chem Res Toxicol. 2014 Oct 20;27(10):1871-6. doi: 10.1021/tx5003194. Epub 2014 Sep 12.

7.

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.

Narayanapillai SC, Balbo S, Leitzman P, Grill AE, Upadhyaya P, Shaik AA, Zhou B, O'Sullivan MG, Peterson LA, Lu J, Hecht SS, Xing C.

Carcinogenesis. 2014 Oct;35(10):2365-72. doi: 10.1093/carcin/bgu149. Epub 2014 Jul 22.

8.

Kava blocks 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in association with reducing O6-methylguanine DNA adduct in A/J mice.

Leitzman P, Narayanapillai SC, Balbo S, Zhou B, Upadhyaya P, Shaik AA, O'Sullivan MG, Hecht SS, Lu J, Xing C.

Cancer Prev Res (Phila). 2014 Jan;7(1):86-96. doi: 10.1158/1940-6207.CAPR-13-0301.

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