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Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves.

McGill JL, Kelly SM, Guerra-Maupome M, Winkley E, Henningson J, Narasimhan B, Sacco RE.

Sci Rep. 2019 Oct 22;9(1):15157. doi: 10.1038/s41598-019-51684-x.


"Feeling" your way to the pericardium-A new approach to an old space.

Narasimhan B, Tandri H.

J Cardiovasc Electrophysiol. 2019 Oct 18. doi: 10.1111/jce.14235. [Epub ahead of print] No abstract available.


Single-dose combination nanovaccine induces both rapid and long-lived protection against pneumonic plague.

Wagner DA, Kelly SM, Petersen AC, Peroutka-Bigus N, Darling RJ, Bellaire BH, Wannemuehler MJ, Narasimhan B.

Acta Biomater. 2019 Oct 11. pii: S1742-7061(19)30692-0. doi: 10.1016/j.actbio.2019.10.016. [Epub ahead of print]


Evaluation of CpG-ODN-adjuvanted polyanhydride-based intranasal influenza nanovaccine in pigs.

Dhakal S, Ghimire S, Renu S, Ross KA, Lakshmanappa YS, Hogshead BT, Bernardo P, Lee CW, Wannemuehler MJ, Narasimhan B, Renukaradhya GJ.

Vet Microbiol. 2019 Oct;237:108401. doi: 10.1016/j.vetmic.2019.108401. Epub 2019 Aug 28.


Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives.

Mehta S, Kumar S, Marwaha RK, Narasimhan B, Ramasamy K, Lim SM, Shah SAA, Mani V.

BMC Chem. 2019 Sep 5;13(1):113. doi: 10.1186/s13065-019-0629-0. eCollection 2019 Dec.


Sustained antigen release polyanhydride-based vaccine platform for immunization against bovine brucellosis.

Boggiatto PM, Schaut RG, Kanipe C, Kelly SM, Narasimhan B, Jones DE, Olsen SC.

Heliyon. 2019 Aug 29;5(8):e02370. doi: 10.1016/j.heliyon.2019.e02370. eCollection 2019 Aug.


Stellate Block in Refractory Ventricular Tachycardia: The Calm After the Storm.

Narasimhan B, Tandri H.

Circ Arrhythm Electrophysiol. 2019 Sep;12(9):e007707. doi: 10.1161/CIRCEP.119.007707. Epub 2019 Sep 13. No abstract available.


Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology.

Tanigawa Y, Li J, Justesen JM, Horn H, Aguirre M, DeBoever C, Chang C, Narasimhan B, Lage K, Hastie T, Park CY, Bejerano G, Ingelsson E, Rivas MA.

Nat Commun. 2019 Sep 6;10(1):4064. doi: 10.1038/s41467-019-11953-9.


3D-QSAR and docking study of 2-((pyridin-3-yloxy)methyl) piperazines as α7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.

Purohit D, Saini V, Kumar S, Kumar A, Narasimhan B.

Mini Rev Med Chem. 2019 Sep 4. doi: 10.2174/1389557519666190904151227. [Epub ahead of print]


Pharmacological significance of heterocyclic 1H-benzimidazole scaffolds: a review.

Tahlan S, Kumar S, Narasimhan B.

BMC Chem. 2019 Aug 6;13(1):101. doi: 10.1186/s13065-019-0625-4. eCollection 2019 Dec. Review.


In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents.

Tahlan S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Mani V, Narasimhan B.

BMC Chem. 2019 Jul 11;13(1):90. doi: 10.1186/s13065-019-0608-5. eCollection 2019 Dec.


Antimicrobial, antioxidant and cytotoxic evaluation of diazenyl chalcones along with insights to mechanism of interaction by molecular docking studies.

Kaur H, Singh J, Narasimhan B.

BMC Chem. 2019 Jul 9;13(1):87. doi: 10.1186/s13065-019-0596-5. eCollection 2019 Dec.


Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents.

Kumar S, Kaushik A, Narasimhan B, Shah SAA, Lim SM, Ramasamy K, Mani V.

BMC Chem. 2019 Jul 9;13(1):85. doi: 10.1186/s13065-019-0601-z. eCollection 2019 Dec.


Benzimidazole scaffolds as promising antiproliferative agents: a review.

Tahlan S, Kumar S, Kakkar S, Narasimhan B.

BMC Chem. 2019 May 15;13(1):66. doi: 10.1186/s13065-019-0579-6. eCollection 2019 Dec. Review.


Indole hybridized diazenyl derivatives: synthesis, antimicrobial activity, cytotoxicity evaluation and docking studies.

Kaur H, Singh J, Narasimhan B.

BMC Chem. 2019 May 10;13(1):65. doi: 10.1186/s13065-019-0580-0. eCollection 2019 Dec.


4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile.

Sharma D, Kumar S, Narasimhan B, Ramasamy K, Lim SM, Shah SAA, Mani V.

BMC Chem. 2019 Apr 23;13(1):60. doi: 10.1186/s13065-019-0575-x. eCollection 2019 Dec.


Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents.

Tahlan S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Mani V, Pathania R, Narasimhan B.

BMC Chem. 2019 Apr 3;13(1):50. doi: 10.1186/s13065-019-0567-x. eCollection 2019 Dec.


Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents.

Sharma D, Kumar S, Narasimhan B, Ramasamy K, Lim SM, Shah SAA, Mani V.

BMC Chem. 2019 Apr 1;13(1):46. doi: 10.1186/s13065-019-0564-0. eCollection 2019 Dec.


Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review.

Tahlan S, Kumar S, Narasimhan B.

BMC Chem. 2019 Feb 4;13(1):18. doi: 10.1186/s13065-019-0521-y. eCollection 2019 Dec. Review.


A comprehensive review on biological activities of oxazole derivatives.

Kakkar S, Narasimhan B.

BMC Chem. 2019 Feb 4;13(1):16. doi: 10.1186/s13065-019-0531-9. eCollection 2019 Dec. Review.


4-(2-(1H-Benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamides: design, synthesis and biological evaluation.

Tahlan S, Ramasamy K, Lim SM, Shah SAA, Mani V, Narasimhan B.

BMC Chem. 2019 Feb 2;13(1):12. doi: 10.1186/s13065-019-0533-7. eCollection 2019 Dec.


Computational approaches: discovery of GTPase HRas as prospective drug target for 1,3-diazine scaffolds.

Kumar S, Sharma D, Narasimhan B, Ramasamy K, Shah SAA, Lim SM, Mani V.

BMC Chem. 2019 Jul 24;13(1):96. doi: 10.1186/s13065-019-0613-8. eCollection 2019 Dec.


Pentaerythritol-based lipid A bolsters the antitumor efficacy of a polyanhydride particle-based cancer vaccine.

Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B, Salem AK.

Nanomedicine. 2019 Oct;21:102055. doi: 10.1016/j.nano.2019.102055. Epub 2019 Jul 15.


Effective mosaic-based nanovaccines against avian influenza in poultry.

Kingstad-Bakke BA, Chandrasekar SS, Phanse Y, Ross KA, Hatta M, Suresh M, Kawaoka Y, Osorio JE, Narasimhan B, Talaat AM.

Vaccine. 2019 Aug 14;37(35):5051-5058. doi: 10.1016/j.vaccine.2019.06.077. Epub 2019 Jul 9.


Amphiphilic polyanhydride-based recombinant MUC4β-nanovaccine activates dendritic cells.

Banerjee K, Gautam SK, Kshirsagar P, Ross KA, Spagnol G, Sorgen P, Wannemuehler MJ, Narasimhan B, Solheim JC, Kumar S, Batra SK, Jain M.

Genes Cancer. 2019 May;10(3-4):52-62. doi: 10.18632/genesandcancer.189.


Molecular docking study of active diazenyl scaffolds as inhibitors of essential targets towards antimicrobial drug discovery.

Kaur H, Gahlawat S, Singh J, Narasimhan B.

Curr Drug Targets. 2019 Jun 18. doi: 10.2174/1389450120666190618122359. [Epub ahead of print]


Role of diabetes and insulin use in the risk of stroke and acute myocardial infarction in patients with atrial fibrillation: A Medicare analysis.

Mentias A, Shantha G, Adeola O, Barnes GD, Narasimhan B, Siontis KC, Levine DA, Sah R, Giudici MC, Vaughan Sarrazin M.

Am Heart J. 2019 Aug;214:158-166. doi: 10.1016/j.ahj.2019.05.003. Epub 2019 May 10.


STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.

Darling RJ, Senapati S, Kelly SM, Kohut ML, Narasimhan B, Wannemuehler MJ.

Vaccine. 2019 May 6;37(20):2721-2730. doi: 10.1016/j.vaccine.2019.04.004. Epub 2019 Apr 12.


Data Analytics Approach for Rational Design of Nanomedicines with Programmable Drug Release.

Mullis AS, Broderick SR, Binnebose AM, Peroutka-Bigus N, Bellaire BH, Rajan K, Narasimhan B.

Mol Pharm. 2019 May 6;16(5):1917-1928. doi: 10.1021/acs.molpharmaceut.8b01272. Epub 2019 Apr 26.


Safety and biocompatibility of injectable vaccine adjuvants composed of thermogelling block copolymer gels.

Adams JR, Senapati S, Haughney SL, Wannemuehler MJ, Narasimhan B, Mallapragada SK.

J Biomed Mater Res A. 2019 Aug;107(8):1754-1762. doi: 10.1002/jbm.a.36691. Epub 2019 Apr 29.


Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection.

Rintelmann CL, Grinnage-Pulley T, Ross K, Kabotso DEK, Toepp A, Cowell A, Petersen C, Narasimhan B, Pohl N.

Beilstein J Org Chem. 2019 Mar 11;15:623-632. doi: 10.3762/bjoc.15.58. eCollection 2019.


Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.

Espinosa-Cotton M, Rodman Iii SN, Ross KA, Jensen IJ, Sangodeyi-Miller K, McLaren AJ, Dahl RA, Gibson-Corley KN, Koch AT, Fu YX, Badovinac VP, Laux D, Narasimhan B, Simons AL.

J Immunother Cancer. 2019 Mar 19;7(1):79. doi: 10.1186/s40425-019-0550-z.


A scalable discrete-time survival model for neural networks.

Gensheimer MF, Narasimhan B.

PeerJ. 2019 Jan 25;7:e6257. doi: 10.7717/peerj.6257. eCollection 2019.


Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice.

Ross K, Senapati S, Alley J, Darling R, Goodman J, Jefferson M, Uz M, Guo B, Yoon KJ, Verhoeven D, Kohut M, Mallapragada S, Wannemuehler M, Narasimhan B.

Biomater Sci. 2019 Feb 26;7(3):809-821. doi: 10.1039/c8bm01443d.


Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections.

Lueth P, Haughney SL, Binnebose AM, Mullis AS, Peroutka-Bigus N, Narasimhan B, Bellaire BH.

J Control Release. 2019 Jan 28;294:288-297. doi: 10.1016/j.jconrel.2018.12.024. Epub 2018 Dec 17.


Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues.

Tahlan S, Ramasamy K, Lim SM, Shah SAA, Mani V, Narasimhan B.

Chem Cent J. 2018 Dec 19;12(1):139. doi: 10.1186/s13065-018-0513-3.


Surface engineered polyanhydride-based oral Salmonella subunit nanovaccine for poultry.

Renu S, Markazi AD, Dhakal S, Lakshmanappa YS, Gourapura SR, Shanmugasundaram R, Senapati S, Narasimhan B, Selvaraj RK, Renukaradhya GJ.

Int J Nanomedicine. 2018 Nov 30;13:8195-8215. doi: 10.2147/IJN.S185588. eCollection 2018.


Design, Synthesis and Therapeutic Potential of Some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues.

Kumar S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2019;19(7):609-621. doi: 10.2174/1389557519666181210162413.


Synthesis and biological profile of substituted benzimidazoles.

Vashist N, Sambi SS, Narasimhan B, Kumar S, Lim SM, Shah SAA, Ramasamy K, Mani V.

Chem Cent J. 2018 Dec 1;12(1):125. doi: 10.1186/s13065-018-0498-y.


Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Kakkar S, Kumar S, Lim SM, Ramasamy K, Mani V, Shah SAA, Narasimhan B.

Chem Cent J. 2018 Dec 4;12(1):130. doi: 10.1186/s13065-018-0499-x.


Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base.

Kashyap S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Om H, Narasimhan B.

Chem Cent J. 2018 Nov 20;12(1):117. doi: 10.1186/s13065-018-0487-1.


Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases.

Carter P, Narasimhan B, Wang Q.

Int J Pharm. 2019 Jan 30;555:49-62. doi: 10.1016/j.ijpharm.2018.11.032. Epub 2018 Nov 15. Review.


Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.

J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. doi: 10.1002/jbm.a.36477. Epub 2018 Oct 26.


Estrogen alpha receptor antagonists for the treatment of breast cancer: a review.

Sharma D, Kumar S, Narasimhan B.

Chem Cent J. 2018 Oct 25;12(1):107. doi: 10.1186/s13065-018-0472-8. Review.


Single Dose of a Polyanhydride Particle-Based Vaccine Generates Potent Antigen-Specific Antitumor Immune Responses.

Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B, Salem AK.

J Pharmacol Exp Ther. 2019 Sep;370(3):855-863. doi: 10.1124/jpet.118.252809. Epub 2018 Oct 25.


Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.

Kumar S, Singh J, Narasimhan B, Shah SAA, Lim SM, Ramasamy K, Mani V.

Chem Cent J. 2018 Oct 22;12(1):106. doi: 10.1186/s13065-018-0475-5.


2-Mercaptobenzimidazole Schiff Bases: Design, Synthesis, Antimicrobial Studies and Anticancer Activity on HCT-116 Cell Line.

Tahlan S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2019;19(13):1080-1092. doi: 10.2174/1389557518666181009151008.


Design, Synthesis and Biological Potential of 5-(2-Amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol Scaffolds as Promising Antimicrobial and Anticancer Agents.

Kumar S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2019;19(10):851-864. doi: 10.2174/1389557518666181009141924.


Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections.

Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B, Waldschmidt TJ, Legge KL.

Front Immunol. 2018 Aug 28;9:1953. doi: 10.3389/fimmu.2018.01953. eCollection 2018.

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