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Items: 1 to 50 of 221

1.

STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.

Darling RJ, Senapati S, Kelly SM, Kohut ML, Narasimhan B, Wannemuehler MJ.

Vaccine. 2019 May 6;37(20):2721-2730. doi: 10.1016/j.vaccine.2019.04.004. Epub 2019 Apr 12.

PMID:
30987850
2.

Data Analytics Approach for Rational Design of Nanomedicines with Programmable Drug Release.

Mullis AS, Broderick SR, Binnebose AM, Peroutka-Bigus N, Bellaire BH, Rajan K, Narasimhan B.

Mol Pharm. 2019 May 6;16(5):1917-1928. doi: 10.1021/acs.molpharmaceut.8b01272. Epub 2019 Apr 26.

PMID:
30973741
3.

Safety and biocompatibility of injectable vaccine adjuvants composed of thermogelling block copolymer gels.

Adams JR, Senapati S, Haughney SL, Wannemuehler MJ, Narasimhan B, Mallapragada SK.

J Biomed Mater Res A. 2019 Aug;107(8):1754-1762. doi: 10.1002/jbm.a.36691. Epub 2019 Apr 29.

PMID:
30972906
4.

Design and synthesis of multivalent α-1,2-trimannose-linked bioerodible microparticles for applications in immune response studies of Leishmania major infection.

Rintelmann CL, Grinnage-Pulley T, Ross K, Kabotso DEK, Toepp A, Cowell A, Petersen C, Narasimhan B, Pohl N.

Beilstein J Org Chem. 2019 Mar 11;15:623-632. doi: 10.3762/bjoc.15.58. eCollection 2019.

5.

Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma.

Espinosa-Cotton M, Rodman Iii SN, Ross KA, Jensen IJ, Sangodeyi-Miller K, McLaren AJ, Dahl RA, Gibson-Corley KN, Koch AT, Fu YX, Badovinac VP, Laux D, Narasimhan B, Simons AL.

J Immunother Cancer. 2019 Mar 19;7(1):79. doi: 10.1186/s40425-019-0550-z.

6.

A scalable discrete-time survival model for neural networks.

Gensheimer MF, Narasimhan B.

PeerJ. 2019 Jan 25;7:e6257. doi: 10.7717/peerj.6257. eCollection 2019.

7.

Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice.

Ross K, Senapati S, Alley J, Darling R, Goodman J, Jefferson M, Uz M, Guo B, Yoon KJ, Verhoeven D, Kohut M, Mallapragada S, Wannemuehler M, Narasimhan B.

Biomater Sci. 2019 Feb 26;7(3):809-821. doi: 10.1039/c8bm01443d.

PMID:
30663733
8.

Nanotherapeutic provides dose sparing and improved antimicrobial activity against Brucella melitensis infections.

Lueth P, Haughney SL, Binnebose AM, Mullis AS, Peroutka-Bigus N, Narasimhan B, Bellaire BH.

J Control Release. 2019 Jan 28;294:288-297. doi: 10.1016/j.jconrel.2018.12.024. Epub 2018 Dec 17.

PMID:
30572034
9.

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues.

Tahlan S, Ramasamy K, Lim SM, Shah SAA, Mani V, Narasimhan B.

Chem Cent J. 2018 Dec 19;12(1):139. doi: 10.1186/s13065-018-0513-3.

10.

Surface engineered polyanhydride-based oral Salmonella subunit nanovaccine for poultry.

Renu S, Markazi AD, Dhakal S, Lakshmanappa YS, Gourapura SR, Shanmugasundaram R, Senapati S, Narasimhan B, Selvaraj RK, Renukaradhya GJ.

Int J Nanomedicine. 2018 Nov 30;13:8195-8215. doi: 10.2147/IJN.S185588. eCollection 2018.

11.

Design, Synthesis and Therapeutic Potential of Some 6, 6'-(1,4- phenylene)bis(4-(4-bromophenyl)pyrimidin-2-amine)analogues.

Kumar S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2019;19(7):609-621. doi: 10.2174/1389557519666181210162413.

PMID:
30526456
12.

Synthesis and biological profile of substituted benzimidazoles.

Vashist N, Sambi SS, Narasimhan B, Kumar S, Lim SM, Shah SAA, Ramasamy K, Mani V.

Chem Cent J. 2018 Dec 1;12(1):125. doi: 10.1186/s13065-018-0498-y.

13.

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives.

Kakkar S, Kumar S, Lim SM, Ramasamy K, Mani V, Shah SAA, Narasimhan B.

Chem Cent J. 2018 Dec 4;12(1):130. doi: 10.1186/s13065-018-0499-x.

14.

Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base.

Kashyap S, Kumar S, Ramasamy K, Lim SM, Shah SAA, Om H, Narasimhan B.

Chem Cent J. 2018 Nov 20;12(1):117. doi: 10.1186/s13065-018-0487-1.

15.

Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases.

Carter P, Narasimhan B, Wang Q.

Int J Pharm. 2019 Jan 30;555:49-62. doi: 10.1016/j.ijpharm.2018.11.032. Epub 2018 Nov 15. Review.

PMID:
30448309
16.

Biodegradable polyanhydride-based nanomedicines for blood to brain drug delivery.

Brenza TM, Schlichtmann BW, Bhargavan B, Vela Ramirez JE, Nelson RD, Panthani MG, McMillan JM, Kalyanaraman B, Gendelman HE, Anantharam V, Kanthasamy AG, Mallapragada SK, Narasimhan B, Kanmogne GD.

J Biomed Mater Res A. 2018 Nov;106(11):2881-2890. doi: 10.1002/jbm.a.36477. Epub 2018 Oct 26.

PMID:
30369055
17.

Estrogen alpha receptor antagonists for the treatment of breast cancer: a review.

Sharma D, Kumar S, Narasimhan B.

Chem Cent J. 2018 Oct 25;12(1):107. doi: 10.1186/s13065-018-0472-8. Review.

18.

Single dose of polyanhydride particle-based vaccine generates potent antigen-specific antitumor immune responses.

Wafa EI, Geary SM, Ross KA, Goodman JT, Narasimhan B, Salem AK.

J Pharmacol Exp Ther. 2018 Oct 25. pii: jpet.118.252809. doi: 10.1124/jpet.118.252809. [Epub ahead of print]

19.

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.

Kumar S, Singh J, Narasimhan B, Shah SAA, Lim SM, Ramasamy K, Mani V.

Chem Cent J. 2018 Oct 22;12(1):106. doi: 10.1186/s13065-018-0475-5.

20.

2-Mercaptobenzimidazole Schiff Bases: Design, Synthesis, Antimicrobial Studies and Anticancer Activity on HCT-116 Cell Line.

Tahlan S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2018 Oct 9. doi: 10.2174/1389557518666181009151008. [Epub ahead of print]

PMID:
30306865
21.

Design, Synthesis and Biological Potential of 5-(2-Amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol Scaffolds as Promising Antimicrobial and Anticancer agents.

Kumar S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2018 Oct 9. doi: 10.2174/1389557518666181009141924. [Epub ahead of print]

PMID:
30306864
22.

Polyanhydride Nanovaccine Induces Robust Pulmonary B and T Cell Immunity and Confers Protection Against Homologous and Heterologous Influenza A Virus Infections.

Zacharias ZR, Ross KA, Hornick EE, Goodman JT, Narasimhan B, Waldschmidt TJ, Legge KL.

Front Immunol. 2018 Aug 28;9:1953. doi: 10.3389/fimmu.2018.01953. eCollection 2018.

23.

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents.

Kakkar S, Kumar S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Chem Cent J. 2018 Sep 19;12(1):96. doi: 10.1186/s13065-018-0464-8.

24.

Treatment of neurodegenerative disorders through the blood-brain barrier using nanocarriers.

Poovaiah N, Davoudi Z, Peng H, Schlichtmann B, Mallapragada S, Narasimhan B, Wang Q.

Nanoscale. 2018 Sep 20;10(36):16962-16983. doi: 10.1039/c8nr04073g. Review.

PMID:
30182106
25.

Design, Synthesis, SAR Study, Antimicrobial and Anticancer Evaluation of Novel 2-Mercaptobenzimidazole Azomethine Derivatives.

Tahlan S, Narasimhan B, Lim SM, Ramasamy K, Mani V, Shah SAA.

Mini Rev Med Chem. 2018 Sep 3. doi: 10.2174/1389557518666180903151849. [Epub ahead of print]

PMID:
30179132
26.

Morpholine Based Diazenyl Chalcones: Synthesis, Antimicrobial Screening and Cytotoxicity Study.

Kaur H, Desai SD, Singh J, Narasimhan B.

Anticancer Agents Med Chem. 2018;18(15):2193-2205. doi: 10.2174/1871520618666180830152701.

PMID:
30173651
27.

Correction to "pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles".

Sharpe LA, Vela Ramirez JE, Haddadin OM, Ross KA, Narasimhan B, Peppas NA.

Biomacromolecules. 2018 Sep 10;19(9):3904. doi: 10.1021/acs.biomac.8b01240. Epub 2018 Aug 24. No abstract available.

PMID:
30141322
28.

Synthesis, biological evaluation and docking study of N-(2-(3,4,5-trimethoxybenzyl)benzoxazole-5-yl) benzamide derivatives as selective COX-2 inhibitor and anti-inflammatory agents.

Kaur A, Pathak DP, Sharma V, Narasimhan B, Sharma P, Mathur R, Wakode S.

Bioorg Chem. 2018 Dec;81:191-202. doi: 10.1016/j.bioorg.2018.07.007. Epub 2018 Jul 7.

PMID:
30138907
29.

Benzoxazole derivatives: design, synthesis and biological evaluation.

Kakkar S, Tahlan S, Lim SM, Ramasamy K, Mani V, Shah SAA, Narasimhan B.

Chem Cent J. 2018 Aug 12;12(1):92. doi: 10.1186/s13065-018-0459-5.

30.

Synthesis, Characterization, Antimicrobial and Antioxidant Potential of Diazenyl Chalcones.

Kaur H, Narasimhan B.

Curr Top Med Chem. 2018;18(10):844-856. doi: 10.2174/1568026618666180626095714.

PMID:
29943703
31.

Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4'-(1,4-phenylene)bis(pyrimidin-2-amine) derivatives.

Kumar S, Lim SM, Ramasamy K, Mani V, Shah SAA, Narasimhan B.

Chem Cent J. 2018 Jun 25;12(1):73. doi: 10.1186/s13065-018-0440-3.

32.

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides.

Yadav S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Mathur A, Narasimhan B.

Chem Cent J. 2018 May 26;12(1):66. doi: 10.1186/s13065-018-0432-3.

33.

Intranasal delivery of influenza antigen by nanoparticles, but not NKT-cell adjuvant differentially induces the expression of B-cell activation factors in mice and swine.

Renu S, Dhakal S, Kim E, Goodman J, Lakshmanappa YS, Wannemuehler MJ, Narasimhan B, Boyaka PN, Renukaradhya GJ.

Cell Immunol. 2018 Jul;329:27-30. doi: 10.1016/j.cellimm.2018.04.005. Epub 2018 Apr 11.

PMID:
29665972
34.

Therapeutic potential of heterocyclic pyrimidine scaffolds.

Kumar S, Narasimhan B.

Chem Cent J. 2018 Apr 4;12(1):38. doi: 10.1186/s13065-018-0406-5. Review.

35.

Automated High-Throughput Synthesis of Protein-Loaded Polyanhydride Nanoparticle Libraries.

Goodman JT, Mullis AS, Dunshee L, Mitra A, Narasimhan B.

ACS Comb Sci. 2018 May 14;20(5):298-307. doi: 10.1021/acscombsci.8b00008. Epub 2018 Apr 10.

PMID:
29617113
36.

Room Temperature Stable PspA-Based Nanovaccine Induces Protective Immunity.

Wagner-Muñiz DA, Haughney SL, Kelly SM, Wannemuehler MJ, Narasimhan B.

Front Immunol. 2018 Mar 2;9:325. doi: 10.3389/fimmu.2018.00325. eCollection 2018.

37.

Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf.

McGill JL, Kelly SM, Kumar P, Speckhart S, Haughney SL, Henningson J, Narasimhan B, Sacco RE.

Sci Rep. 2018 Feb 14;8(1):3021. doi: 10.1038/s41598-018-21292-2.

38.

pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles.

Sharpe LA, Vela Ramirez JE, Haddadin OM, Ross KA, Narasimhan B, Peppas NA.

Biomacromolecules. 2018 Mar 12;19(3):793-802. doi: 10.1021/acs.biomac.7b01590. Epub 2018 Feb 21. Erratum in: Biomacromolecules. 2018 Sep 10;19(9):3904.

39.

A polyanhydride-based implantable single dose vaccine platform for long-term immunity.

Schaut RG, Brewer MT, Mendoza K, Jackman J, Narasimhan B, Jones DE.

Vaccine. 2018 Feb 8;36(7):1024-1025. doi: 10.1016/j.vaccine.2017.11.067. No abstract available.

PMID:
29413093
40.

A single dose polyanhydride-based vaccine platform promotes and maintains anti-GnRH antibody titers.

Schaut RG, Brewer MT, Hostetter JM, Mendoza K, Vela-Ramirez JE, Kelly SM, Jackman JK, Dell'Anna G, Howard JM, Narasimhan B, Zhou W, Jones DE.

Vaccine. 2018 Feb 8;36(7):1016-1023. doi: 10.1016/j.vaccine.2017.12.050.

PMID:
29413092
41.

Antimicrobial Activity of Diazenyl Derivatives: An Update.

Kaur H, Narasimhan B.

Curr Top Med Chem. 2018;18(1):3-21. doi: 10.2174/1568026618666180206093107. Review.

PMID:
29412106
42.

Ligand-cascading nano-delivery devices to enable multiscale targeting of anti-neurodegenerative therapeutics.

Mullis AS, Schlichtmann BW, Narasimhan B, Cademartiri R, Mallapragada SK.

Biomed Mater. 2018 Feb 21;13(3):034102. doi: 10.1088/1748-605X/aaa778. Review.

PMID:
29332842
43.

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides.

Yadav S, Narasimhan B, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Selvaraj M.

Chem Cent J. 2017 Dec 22;11(1):137. doi: 10.1186/s13065-017-0361-6.

44.

Emerging trends in the immunotherapy of pancreatic cancer.

Banerjee K, Kumar S, Ross KA, Gautam S, Poelaert B, Nasser MW, Aithal A, Bhatia R, Wannemuehler MJ, Narasimhan B, Solheim JC, Batra SK, Jain M.

Cancer Lett. 2018 Mar 28;417:35-46. doi: 10.1016/j.canlet.2017.12.012. Epub 2017 Dec 12. Review.

45.

Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases.

Davoudi Z, Peroutka-Bigus N, Bellaire B, Wannemuehler M, Barrett TA, Narasimhan B, Wang Q.

J Biomed Mater Res A. 2018 Apr;106(4):876-886. doi: 10.1002/jbm.a.36305. Epub 2017 Dec 21.

46.

Bis-pyrimidine acetamides: design, synthesis and biological evaluation.

Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Narasimhan B.

Chem Cent J. 2017 Aug 8;11(1):80. doi: 10.1186/s13065-017-0312-2.

47.

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives.

Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Selvaraj M, Narasimhan B.

Chem Cent J. 2017 Sep 18;11(1):89. doi: 10.1186/s13065-017-0322-0.

48.

Big data modeling to predict platelet usage and minimize wastage in a tertiary care system.

Guan L, Tian X, Gombar S, Zemek AJ, Krishnan G, Scott R, Narasimhan B, Tibshirani RJ, Pham TD.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11368-11373. doi: 10.1073/pnas.1714097114. Epub 2017 Oct 9.

49.

Three surface freeform aplanatic systems.

Narasimhan B, Benitez P, Miñano JC, Nikolic M, Grabovickic D.

Opt Express. 2017 May 15;25(10):10710-10715. doi: 10.1364/OE.25.010710.

PMID:
28788760
50.

Functionalization promotes pathogen-mimicking characteristics of polyanhydride nanoparticle adjuvants.

Phanse Y, Carrillo-Conde BR, Ramer-Tait AE, Roychoudhury R, Broderick S, Pohl N, Rajan K, Narasimhan B, Wannemuehler MJ, Bellaire BH.

J Biomed Mater Res A. 2017 Oct;105(10):2762-2771. doi: 10.1002/jbm.a.36128. Epub 2017 Jul 6.

PMID:
28556563

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