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Kinome Analysis of Honeybee (Apis mellifera L.) Dark-Eyed Pupae Identifies Biomarkers and Mechanisms of Tolerance to Varroa Mite Infestation.

Robertson AJ, Scruten E, Mostajeran M, Robertson T, Denomy C, Hogan D, Roesler A, Rutherford C, Kusalik A, Griebel P, Napper S.

Sci Rep. 2020 Feb 7;10(1):2117. doi: 10.1038/s41598-020-58927-2.


BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential.

Miah S, Banks CAS, Ogunbolude Y, Bagu ET, Berg JM, Saraf A, Tettey TT, Hattem G, Dayebgadoh G, Kempf CG, Sardiu M, Napper S, Florens L, Lukong KE, Washburn MP.

Sci Adv. 2019 Oct 23;5(10):eaaw3113. doi: 10.1126/sciadv.aaw3113. eCollection 2019 Oct.


Ibrutinib as a potential therapeutic option for HER2 overexpressing breast cancer - the role of STAT3 and p21.

Prabaharan CB, Yang AB, Chidambaram D, Rajamanickam K, Napper S, Sakharkar MK.

Invest New Drugs. 2019 Aug 2. doi: 10.1007/s10637-019-00837-w. [Epub ahead of print]


Therapeutic vaccines for amyotrophic lateral sclerosis directed against disease specific epitopes of superoxide dismutase 1.

Zhao B, Marciniuk K, Gibbs E, Yousefi M, Napper S, Cashman NR.

Vaccine. 2019 Aug 14;37(35):4920-4927. doi: 10.1016/j.vaccine.2019.07.044. Epub 2019 Jul 16.


Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment.

Wood ME, Griebel P, Huizenga ML, Lockwood S, Hansen C, Potter A, Cashman N, Mapletoft JW, Napper S.

Vaccine. 2018 Nov 29;36(50):7737-7743. doi: 10.1016/j.vaccine.2018.10.057. Epub 2018 Nov 7.


Conservation of kinase-phosphorylation site pairings: Evidence for an evolutionarily dynamic phosphoproteome.

McDonald M, Trost B, Napper S.

PLoS One. 2018 Aug 14;13(8):e0202036. doi: 10.1371/journal.pone.0202036. eCollection 2018.


Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, Src-related Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal Myristoylation Sites (SRMS).

Goel RK, Paczkowska M, Reimand J, Napper S, Lukong KE.

Mol Cell Proteomics. 2018 May;17(5):925-947. doi: 10.1074/mcp.RA118.000643. Epub 2018 Mar 1.


FRK inhibits breast cancer cell migration and invasion by suppressing epithelial-mesenchymal transition.

Ogunbolude Y, Dai C, Bagu ET, Goel RK, Miah S, MacAusland-Berg J, Ng CY, Chibbar R, Napper S, Raptis L, Vizeacoumar F, Vizeacoumar F, Bonham K, Lukong KE.

Oncotarget. 2017 Dec 6;8(68):113034-113065. doi: 10.18632/oncotarget.22958. eCollection 2017 Dec 22.


Lambda display phage as a mucosal vaccine delivery vehicle for peptide antigens.

González-Cano P, Gamage LNA, Marciniuk K, Hayes C, Napper S, Hayes S, Griebel PJ.

Vaccine. 2017 Dec 19;35(52):7256-7263. doi: 10.1016/j.vaccine.2017.11.010. Epub 2017 Nov 16.


Human papillomavirus infection in females with normal cervical cytology: Genotyping and phylogenetic analysis among women in Punjab, Pakistan.

Aziz H, Iqbal H, Mahmood H, Fatima S, Faheem M, Sattar AA, Tabassum S, Napper S, Batool S, Rasheed N.

Int J Infect Dis. 2018 Jan;66:83-89. doi: 10.1016/j.ijid.2017.11.009. Epub 2017 Nov 11.


Development of a generic wound care assessment minimum data set.

Coleman S, Nelson EA, Vowden P, Vowden K, Adderley U, Sunderland L, Harker J, Conroy T, Fiori S, Bezer N, Holding E, Atkin L, Stables E, Dumville J, Gavelle S, Sandoz H, Moore K, Chambers T, Napper S, Nixon J; Improving Wound Care Project Board, as part of NHS England's Leading Change Adding Value Framework.

J Tissue Viability. 2017 Nov;26(4):226-240. doi: 10.1016/j.jtv.2017.09.007. Epub 2017 Sep 18. Review.


Non-digestible oligosaccharides directly regulate host kinome to modulate host inflammatory responses without alterations in the gut microbiota.

Wu RY, Määttänen P, Napper S, Scruten E, Li B, Koike Y, Johnson-Henry KC, Pierro A, Rossi L, Botts SR, Surette MG, Sherman PM.

Microbiome. 2017 Oct 10;5(1):135. doi: 10.1186/s40168-017-0357-4.


Induction of PrPSc-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease.

Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S.

Prion. 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083.


Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.

Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP.

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700433. Epub 2017 Oct 17.


Molecular characterization of breast cancer cell lines through multiple omic approaches.

Smith SE, Mellor P, Ward AK, Kendall S, McDonald M, Vizeacoumar FS, Vizeacoumar FJ, Napper S, Anderson DH.

Breast Cancer Res. 2017 Jun 5;19(1):65. doi: 10.1186/s13058-017-0855-0.


Technological advances for interrogating the human kinome.

Baharani A, Trost B, Kusalik A, Napper S.

Biochem Soc Trans. 2017 Feb 8;45(1):65-77. doi: 10.1042/BST20160163. Review.


Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function.

Wu RY, Abdullah M, Määttänen P, Pilar AV, Scruten E, Johnson-Henry KC, Napper S, O'Brien C, Jones NL, Sherman PM.

Sci Rep. 2017 Jan 18;7:40820. doi: 10.1038/srep40820.


Induction of functional interferon alpha and gamma responses during acute infection of cattle with non-cytopathic bovine viral diarrhea virus.

Van Wyk B, Snider M, Scruten E, van Drunen Littel-van den Hurk S, Napper S.

Vet Microbiol. 2016 Nov 15;195:104-114. doi: 10.1016/j.vetmic.2016.09.015. Epub 2016 Sep 22.


Investigation of the physiological, behavioral, and biochemical responses of cattle to restraint stress.

Chen Y, Stookey J, Arsenault R, Scruten E, Griebel P, Napper S.

J Anim Sci. 2016 Aug;94(8):3240-3254.


Marked Differences in Mucosal Immune Responses Induced in Ileal versus Jejunal Peyer's Patches to Mycobacterium avium subsp. paratuberculosis Secreted Proteins following Targeted Enteric Infection in Young Calves.

Facciuolo A, Gonzalez-Cano P, Napper S, Griebel PJ, Mutharia LM.

PLoS One. 2016 Jul 7;11(7):e0158747. doi: 10.1371/journal.pone.0158747. eCollection 2016.


DAPPLE 2: a Tool for the Homology-Based Prediction of Post-Translational Modification Sites.

Trost B, Maleki F, Kusalik A, Napper S.

J Proteome Res. 2016 Aug 5;15(8):2760-7. doi: 10.1021/acs.jproteome.6b00304. Epub 2016 Jul 13.


Protective behavioural strategies while drinking: do they protect against sexual victimisation and is this protection gendered?

Daigle LE, Johnson LM, Napper SL, Azimi AM.

Drug Alcohol Rev. 2016 Sep;35(5):573-9. doi: 10.1111/dar.12385. Epub 2016 May 18.


Methods and Protocols for Developing Prion Vaccines.

Marciniuk K, Taschuk R, Napper S.

Methods Mol Biol. 2016;1403:657-80. doi: 10.1007/978-1-4939-3387-7_37.


Computational Analysis of the Predicted Evolutionary Conservation of Human Phosphorylation Sites.

Trost B, Kusalik A, Napper S.

PLoS One. 2016 Apr 5;11(4):e0152809. doi: 10.1371/journal.pone.0152809. eCollection 2016.


Models and Methods to Investigate Acute Stress Responses in Cattle.

Chen Y, Arsenault R, Napper S, Griebel P.

Animals (Basel). 2015 Dec 3;5(4):1268-95. doi: 10.3390/ani5040411.


In vitro neutralization of prions with PrP(Sc)-specific antibodies.

Taschuk R, Van der Merwe J, Marciniuk K, Potter A, Cashman N, Griebel P, Napper S.

Prion. 2015;9(4):292-303. doi: 10.1080/19336896.2015.1071761.


Induction of tissue- and stressor-specific kinomic responses in chickens exposed to hot and cold stresses.

Napper S, Dadgar S, Arsenault RJ, Trost B, Scruten E, Kusalik A, Shand P.

Poult Sci. 2015 Jun;94(6):1333-45. doi: 10.3382/ps/pev046. Epub 2015 Apr 1.


EpIC: a rational pipeline for epitope immunogenicity characterization.

Marciniuk K, Trost B, Napper S.

Bioinformatics. 2015 Jul 15;31(14):2388-90. doi: 10.1093/bioinformatics/btv136. Epub 2015 Mar 6.


Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis.

Falcinelli S, Gowen BB, Trost B, Napper S, Kusalik A, Johnson RF, Safronetz D, Prescott J, Wahl-Jensen V, Jahrling PB, Kindrachuk J.

Mol Cell Proteomics. 2015 Mar;14(3):646-57. doi: 10.1074/mcp.M114.045443. Epub 2015 Jan 8.


Case study: using sequence homology to identify putative phosphorylation sites in an evolutionarily distant species (honeybee).

Trost B, Napper S, Kusalik A.

Brief Bioinform. 2015 Sep;16(5):820-9. doi: 10.1093/bib/bbu040. Epub 2014 Nov 6.


Ebola virus modulates transforming growth factor β signaling and cellular markers of mesenchyme-like transition in hepatocytes.

Kindrachuk J, Wahl-Jensen V, Safronetz D, Trost B, Hoenen T, Arsenault R, Feldmann F, Traynor D, Postnikova E, Kusalik A, Napper S, Blaney JE, Feldmann H, Jahrling PB.

J Virol. 2014 Sep 1;88(17):9877-92. doi: 10.1128/JVI.01410-14. Epub 2014 Jun 18.


Identification of developmentally-specific kinotypes and mechanisms of Varroa mite resistance through whole-organism, kinome analysis of honeybee.

Robertson AJ, Trost B, Scruten E, Robertson T, Mostajeran M, Connor W, Kusalik A, Griebel P, Napper S.

Front Genet. 2014 May 21;5:139. doi: 10.3389/fgene.2014.00139. eCollection 2014.


From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis.

Arsenault RJ, Maattanen P, Daigle J, Potter A, Griebel P, Napper S.

Vet Res. 2014 May 15;45:54. doi: 10.1186/1297-9716-45-54. Review.


Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation.

Choi KY, Napper S, Mookherjee N.

Immunology. 2014 Sep;143(1):68-80. doi: 10.1111/imm.12291.


Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope.

Taschuk R, Marciniuk K, Määttänen P, Madampage C, Hedlin P, Potter A, Lee J, Cashman NR, Griebel PJ, Napper S.

Prion. 2014 Jan-Feb;8(1):51-9.


Development of a multivalent, PrP(Sc)-specific prion vaccine through rational optimization of three disease-specific epitopes.

Marciniuk K, Määttänen P, Taschuk R, Airey TD, Potter A, Cashman NR, Griebel P, Napper S.

Vaccine. 2014 Apr 7;32(17):1988-97. doi: 10.1016/j.vaccine.2014.01.027. Epub 2014 Jan 29.


Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes.

Madampage CA, Marciniuk K, Määttänen P, Cashman NR, Potter A, Lee JS, Napper S.

Prion. 2013 Nov-Dec;7(6):511-9. Epub 2014 Jan 8.


Peptide Arrays for Kinome Analysis of Livestock Species.

Daigle J, Van Wyk B, Trost B, Scruten E, Arsenault R, Kusalik A, Griebel PJ, Napper S.

Front Vet Sci. 2014 Oct 14;1:4. doi: 10.3389/fvets.2014.00004. eCollection 2014. Review.


Kinotypes: stable species- and individual-specific profiles of cellular kinase activity.

Trost B, Kindrachuk J, Scruten E, Griebel P, Kusalik A, Napper S.

BMC Genomics. 2013 Dec 5;14:854. doi: 10.1186/1471-2164-14-854.


PIIKA 2: an expanded, web-based platform for analysis of kinome microarray data.

Trost B, Kindrachuk J, Määttänen P, Napper S, Kusalik A.

PLoS One. 2013 Nov 29;8(11):e80837. doi: 10.1371/journal.pone.0080837. eCollection 2013.


Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapy.

Marciniuk K, Taschuk R, Napper S.

Clin Dev Immunol. 2013;2013:473706. doi: 10.1155/2013/473706. Epub 2013 Oct 20. Review.


In vitro infection of bovine monocytes with Mycoplasma bovis delays apoptosis and suppresses production of gamma interferon and tumor necrosis factor alpha but not interleukin-10.

Mulongo M, Prysliak T, Scruten E, Napper S, Perez-Casal J.

Infect Immun. 2014 Jan;82(1):62-71. doi: 10.1128/IAI.00961-13. Epub 2013 Oct 14.


PrP(Sc)-specific antibodies do not induce prion disease or misfolding of PrP(C) in highly susceptible Tga20 mice.

Määttänen P, Taschuk R, Ross L, Marciniuk K, Bertram L, Potter A, Cashman NR, Napper S.

Prion. 2013 Sep-Oct;7(5):434-9. doi: 10.4161/pri.26639. Epub 2013 Oct 8.


Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases.

Madampage CA, Määttänen P, Marciniuk K, Brownlie R, Andrievskaia O, Potter A, Cashman NR, Lee JS, Napper S.

Prion. 2013 Jul-Aug;7(4):301-11. doi: 10.4161/pri.25148. Epub 2013 May 31.


Divergent immune responses to Mycobacterium avium subsp. paratuberculosis infection correlate with kinome responses at the site of intestinal infection.

Määttänen P, Trost B, Scruten E, Potter A, Kusalik A, Griebel P, Napper S.

Infect Immun. 2013 Aug;81(8):2861-72. doi: 10.1128/IAI.00339-13. Epub 2013 May 28.


DAPPLE: a pipeline for the homology-based prediction of phosphorylation sites.

Trost B, Arsenault R, Griebel P, Napper S, Kusalik A.

Bioinformatics. 2013 Jul 1;29(13):1693-5. doi: 10.1093/bioinformatics/btt265. Epub 2013 May 8.


Host responses to persistent Mycobacterium avium subspecies paratuberculosis infection in surgically isolated bovine ileal segments.

Charavaryamath C, Gonzalez-Cano P, Fries P, Gomis S, Doig K, Scruten E, Potter A, Napper S, Griebel PJ.

Clin Vaccine Immunol. 2013 Feb;20(2):156-65. doi: 10.1128/CVI.00496-12. Epub 2012 Dec 5.


Altered Toll-like receptor 9 signaling in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes reveals potential therapeutic targets.

Arsenault RJ, Li Y, Maattanen P, Scruten E, Doig K, Potter A, Griebel P, Kusalik A, Napper S.

Infect Immun. 2013 Jan;81(1):226-37. doi: 10.1128/IAI.00785-12. Epub 2012 Oct 31.


Induction of ligand-specific PrP (C) signaling in human neuronal cells.

Arsenault RJ, Li Y, Potter A, Griebel PJ, Kusalik A, Napper S.

Prion. 2012 Nov-Dec;6(5):477-88. doi: 10.4161/pri.21914. Epub 2012 Aug 23.

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