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Items: 16

1.

Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.

Adams RA, Fernandes-Cerqueira C, Notarnicola A, Mertsching E, Xu Z, Lo WS, Ogilvie K, Chiang KP, Ampudia J, Rosengren S, Cubitt A, King DJ, Mendlein JD, Yang XL, Nangle LA, Lundberg IE, Jakobsson PJ, Schimmel P.

Cell Mol Immunol. 2019 Dec 4. doi: 10.1038/s41423-019-0331-0. [Epub ahead of print]

PMID:
31797905
2.

Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.

Xu Z, Lo WS, Beck DB, Schuch LA, Oláhová M, Kopajtich R, Chong YE, Alston CL, Seidl E, Zhai L, Lau CF, Timchak D, LeDuc CA, Borczuk AC, Teich AF, Juusola J, Sofeso C, Müller C, Pierre G, Hilliard T, Turnpenny PD, Wagner M, Kappler M, Brasch F, Bouffard JP, Nangle LA, Yang XL, Zhang M, Taylor RW, Prokisch H, Griese M, Chung WK, Schimmel P.

Am J Hum Genet. 2018 Jul 5;103(1):100-114. doi: 10.1016/j.ajhg.2018.06.006.

3.

Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase.

Wei Z, Xu Z, Liu X, Lo WS, Ye F, Lau CF, Wang F, Zhou JJ, Nangle LA, Yang XL, Zhang M, Schimmel P.

Nucleic Acids Res. 2016 Feb 18;44(3):1247-55. doi: 10.1093/nar/gkw002. Epub 2016 Jan 14.

4.

Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.

Liu Y, Satz JS, Vo MN, Nangle LA, Schimmel P, Ackerman SL.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5. doi: 10.1073/pnas.1420196111. Epub 2014 Nov 24.

5.

Human tRNA synthetase catalytic nulls with diverse functions.

Lo WS, Gardiner E, Xu Z, Lau CF, Wang F, Zhou JJ, Mendlein JD, Nangle LA, Chiang KP, Yang XL, Au KF, Wong WH, Guo M, Zhang M, Schimmel P.

Science. 2014 Jul 18;345(6194):328-32. doi: 10.1126/science.1252943.

6.

Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.

Zhou JJ, Wang F, Xu Z, Lo WS, Lau CF, Chiang KP, Nangle LA, Ashlock MA, Mendlein JD, Yang XL, Zhang M, Schimmel P.

J Biol Chem. 2014 Jul 11;289(28):19269-75. doi: 10.1074/jbc.C114.571026. Epub 2014 Jun 4.

7.

Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases.

Wang F, Xu Z, Zhou J, Lo WS, Lau CF, Nangle LA, Yang XL, Zhang M, Schimmel P.

J Biol Chem. 2013 Oct 11;288(41):29223-8. doi: 10.1074/jbc.C113.490599. Epub 2013 Sep 3.

8.

Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing.

Xu Z, Wei Z, Zhou JJ, Ye F, Lo WS, Wang F, Lau CF, Wu J, Nangle LA, Chiang KP, Yang XL, Zhang M, Schimmel P.

Structure. 2012 Sep 5;20(9):1470-7. doi: 10.1016/j.str.2012.08.001.

9.

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.

Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL.

Nat Struct Mol Biol. 2010 Jan;17(1):57-61. doi: 10.1038/nsmb.1706. Epub 2009 Dec 13.

10.

Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect.

Nangle LA, Zhang W, Xie W, Yang XL, Schimmel P.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11239-44. Epub 2007 Jun 26.

11.

Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase.

Xie W, Nangle LA, Zhang W, Schimmel P, Yang XL.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9976-81. Epub 2007 Jun 1.

12.

Global effects of mistranslation from an editing defect in mammalian cells.

Nangle LA, Motta CM, Schimmel P.

Chem Biol. 2006 Oct;13(10):1091-100.

13.

An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.

Seburn KL, Nangle LA, Cox GA, Schimmel P, Burgess RW.

Neuron. 2006 Sep 21;51(6):715-26.

14.

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.

Lee JW, Beebe K, Nangle LA, Jang J, Longo-Guess CM, Cook SA, Davisson MT, Sundberg JP, Schimmel P, Ackerman SL.

Nature. 2006 Sep 7;443(7107):50-5. Epub 2006 Aug 13.

PMID:
16906134
15.

Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.

Nangle LA, De Crecy Lagard V, Doring V, Schimmel P.

J Biol Chem. 2002 Nov 29;277(48):45729-33. Epub 2002 Sep 18.

16.

Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.

Döring V, Mootz HD, Nangle LA, Hendrickson TL, de Crécy-Lagard V, Schimmel P, Marlière P.

Science. 2001 Apr 20;292(5516):501-4.

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