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Items: 1 to 50 of 63

1.

Antiplasmodial and Cytotoxic Cytochalasins from an Endophytic Fungus, Nemania sp. UM10M, Isolated from a Diseased Torreya taxifolia Leaf.

Kumarihamy M, Ferreira D, Croom EM Jr, Sahu R, Tekwani BL, Duke SO, Khan S, Techen N, Nanayakkara NPD.

Molecules. 2019 Feb 21;24(4). pii: E777. doi: 10.3390/molecules24040777.

2.

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes.

Fasinu PS, Nanayakkara NPD, Wang YH, Chaurasiya ND, Herath HMB, McChesney JD, Avula B, Khan I, Tekwani BL, Walker LA.

Malar J. 2019 Jan 30;18(1):30. doi: 10.1186/s12936-019-2658-5.

3.

A cytochrome P450 CYP71 enzyme expressed in Sorghum bicolor root hair cells participates in the biosynthesis of the benzoquinone allelochemical sorgoleone.

Pan Z, Baerson SR, Wang M, Bajsa-Hirschel J, Rimando AM, Wang X, Nanayakkara NPD, Noonan BP, Fromm ME, Dayan FE, Khan IA, Duke SO.

New Phytol. 2018 Apr;218(2):616-629. doi: 10.1111/nph.15037. Epub 2018 Feb 20.

4.

Isolation and characterization of 2-pyridone alkaloids and alloxazines from Beauveria bassiana.

Andrioli WJ, Lopes AA, Cavalcanti BC, Pessoa C, Nanayakkara NPD, Bastos JK.

Nat Prod Res. 2017 Aug;31(16):1920-1929. doi: 10.1080/14786419.2016.1269091. Epub 2016 Dec 29.

PMID:
28032511
5.

Pathway-specific inhibition of primaquine metabolism by chloroquine/quinine.

Fasinu PS, Tekwani BL, Avula B, Chaurasiya ND, Nanayakkara NP, Wang YH, Khan IA, Walker LA.

Malar J. 2016 Sep 13;15:466. doi: 10.1186/s12936-016-1509-x.

6.

Bioactive Formylated Flavonoids from Eugenia rigida: Isolation, Synthesis, and X-ray Crystallography.

Zaki MA, Nanayakkara NP, Hetta MH, Jacob MR, Khan SI, Mohammed R, Ibrahim MA, Samoylenko V, Coleman C, Fronczek FR, Ferreira D, Muhammad I.

J Nat Prod. 2016 Sep 23;79(9):2341-9. doi: 10.1021/acs.jnatprod.6b00474. Epub 2016 Sep 12.

PMID:
27618204
7.

Methemoglobinemia Hemotoxicity of Some Antimalarial 8-Aminoquinoline Analogues and Their Hydroxylated Derivatives: Density Functional Theory Computation of Ionization Potentials.

Ding Y, Liu H, Tekwani BL, Nanayakkara NP, Khan IA, Walker LA, Doerksen RJ.

Chem Res Toxicol. 2016 Jul 18;29(7):1132-41. doi: 10.1021/acs.chemrestox.6b00063. Epub 2016 Jul 1.

PMID:
27223244
8.

Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.

Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.

9.

Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.

Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13.

10.

Enantioselective pharmacokinetics of primaquine in healthy human volunteers.

Tekwani BL, Avula B, Sahu R, Chaurasiya ND, Khan SI, Jain S, Fasinu PS, Herath HM, Stanford D, Nanayakkara NP, McChesney JD, Yates TW, ElSohly MA, Khan IA, Walker LA.

Drug Metab Dispos. 2015 Apr;43(4):571-7. doi: 10.1124/dmd.114.061127. Epub 2015 Jan 30.

PMID:
25637634
11.

Enantioselective metabolism of primaquine by human CYP2D6.

Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA.

Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.

12.

Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).

Saunders D, Vanachayangkul P, Imerbsin R, Khemawoot P, Siripokasupkul R, Tekwani BL, Sampath A, Nanayakkara NP, Ohrt C, Lanteri C, Gettyacamin M, Teja-Isavadharm P, Walker L.

Antimicrob Agents Chemother. 2014 Dec;58(12):7283-91. doi: 10.1128/AAC.02576-13. Epub 2014 Sep 29.

13.

Novel bioassay for the discovery of inhibitors of the 2-C-methyl-D-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis.

Corniani N, Velini ED, Silva FM, Nanayakkara NP, Witschel M, Dayan FE.

PLoS One. 2014 Jul 31;9(7):e103704. doi: 10.1371/journal.pone.0103704. eCollection 2014.

14.

Hydroxylated derivatives of NPC1161: theoretical insights into their potential toxicity and the feasibility and regioselectivity of their formation.

Ding Y, Liu H, Nanayakkara NP, Khan IA, Tekwani BL, Walker LA, Doerksen RJ.

J Phys Chem A. 2014 Jul 24;118(29):5501-7. doi: 10.1021/jp502612t. Epub 2014 Jul 11.

15.

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

Nanayakkara NP, Tekwani BL, Herath HM, Sahu R, Gettayacamin M, Tungtaeng A, van Gessel Y, Baresel P, Wickham KS, Bartlett MS, Fronczek FR, Melendez V, Ohrt C, Reichard GA, McChesney JD, Rochford R, Walker LA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4737-44. doi: 10.1128/AAC.02674-13. Epub 2014 Jun 9.

16.

Synthesis of [13C6]primaquine.

Herath HM, McChesney JD, Walker LA, Nanayakkara NP.

J Labelled Comp Radiopharm. 2013 Jun 15;56(7):341-3. doi: 10.1002/jlcr.3039. Epub 2013 Mar 12.

PMID:
24285435
17.

Methemoglobin generation by 8-aminoquinolines: effect of substitution at 5-position of primaquine.

Liu H, Tekwani BL, Nanayakkara NP, Walker LA, Doerksen RJ.

Chem Res Toxicol. 2013 Dec 16;26(12):1801-9. doi: 10.1021/tx400067a. Epub 2013 Nov 13.

PMID:
24224488
18.

Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food supplements in the United States.

Wang YH, Avula B, Nanayakkara NP, Zhao J, Khan IA.

J Agric Food Chem. 2013 May 8;61(18):4470-6. doi: 10.1021/jf4005862. Epub 2013 Apr 29.

PMID:
23627682
19.

In vitro anti-allergic activity of the fungal metabolite pyridovericin.

de Souza Santos M, Jonis Andrioli W, Freire de Morais Del Lama MP, Kenupp Bastos J, Nanayakkara NP, Zumstein Georgetto Naal RM.

Int Immunopharmacol. 2013 Mar;15(3):532-8. doi: 10.1016/j.intimp.2013.01.017. Epub 2013 Feb 9.

20.

Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with 13C stable isotope labeling.

Avula B, Tekwani BL, Chaurasiya ND, Nanayakkara NP, Wang YH, Khan SI, Adelli VR, Sahu R, Elsohly MA, McChesney JD, Khan IA, Walker LA.

J Mass Spectrom. 2013 Feb;48(2):276-85. doi: 10.1002/jms.3122.

PMID:
23378100
21.

In planta mechanism of action of leptospermone: impact of its physico-chemical properties on uptake, translocation, and metabolism.

Owens DK, Nanayakkara NP, Dayan FE.

J Chem Ecol. 2013 Feb;39(2):262-70. doi: 10.1007/s10886-013-0237-8. Epub 2013 Jan 13.

PMID:
23314892
22.

New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens.

Herath HM, Jacob M, Wilson AD, Abbas HK, Nanayakkara NP.

Nat Prod Res. 2013;27(17):1562-8. doi: 10.1080/14786419.2012.738206. Epub 2012 Nov 9.

23.

Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.

Kumarihamy M, Khan SI, Jacob M, Tekwani BL, Duke SO, Ferreira D, Nanayakkara NP.

J Nat Prod. 2012 May 25;75(5):883-9. doi: 10.1021/np200940b. Epub 2012 Apr 24.

24.

Endo-xylanase GH11 activation by the fungal metabolite eugenitin.

Andrioli WJ, Damásio AR, Silva TM, da Silva VB, Maller A, Nanayakkara NP, Silva CH, Polizeli ML, Bastos JK.

Biotechnol Lett. 2012 Aug;34(8):1487-92. doi: 10.1007/s10529-012-0918-3. Epub 2012 Apr 6.

PMID:
22481300
25.

Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs.

Chaurasiya ND, Ganesan S, Nanayakkara NP, Dias LR, Walker LA, Tekwani BL.

Bioorg Med Chem Lett. 2012 Feb 15;22(4):1701-4. doi: 10.1016/j.bmcl.2011.12.108. Epub 2012 Jan 3.

PMID:
22264472
26.

Schistosomicidal and trypanocidal structure-activity relationships for (±)-licarin A and its (-)- and (+)-enantiomers.

Pereira AC, Magalhães LG, Gonçalves UO, Luz PP, Moraes AC, Rodrigues V, da Matta Guedes PM, da Silva Filho AA, Cunha WR, Bastos JK, Nanayakkara NP, e Silva ML.

Phytochemistry. 2011 Aug;72(11-12):1424-30. doi: 10.1016/j.phytochem.2011.04.007. Epub 2011 May 11.

PMID:
21570099
27.

Methemoglobinemia caused by 8-aminoquinoline drugs: DFT calculations suggest an analogy to H4B's role in nitric oxide synthase.

Liu H, Walker LA, Nanayakkara NP, Doerksen RJ.

J Am Chem Soc. 2011 Feb 9;133(5):1172-5. doi: 10.1021/ja107472c. Epub 2011 Jan 18.

28.

Analysis of primaquine and its metabolite carboxyprimaquine in biological samples: enantiomeric separation, method validation and quantification.

Avula B, Khan SI, Tekwani BL, Nanayakkara NP, McChesney JD, Walker LA, Khan IA.

Biomed Chromatogr. 2011 Sep;25(9):1010-7. doi: 10.1002/bmc.1557. Epub 2010 Nov 5.

PMID:
21058417
29.

Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.

Kumarihamy M, Fronczek FR, Ferreira D, Jacob M, Khan SI, Nanayakkara NP.

J Nat Prod. 2010 Jul 23;73(7):1250-3. doi: 10.1021/np1000939.

30.

Antiprotozoal, schistosomicidal, and antimicrobial activities of the essential oil from the leaves of Baccharis dracunculifolia.

Parreira NA, Magalhães LG, Morais DR, Caixeta SC, de Sousa JP, Bastos JK, Cunha WR, Silva ML, Nanayakkara NP, Rodrigues V, da Silva Filho AA.

Chem Biodivers. 2010 Apr;7(4):993-1001. doi: 10.1002/cbdv.200900292.

PMID:
20397234
31.

Alkylresorcinol synthases expressed in Sorghum bicolor root hairs play an essential role in the biosynthesis of the allelopathic benzoquinone sorgoleone.

Cook D, Rimando AM, Clemente TE, Schröder J, Dayan FE, Nanayakkara NP, Pan Z, Noonan BP, Fishbein M, Abe I, Duke SO, Baerson SR.

Plant Cell. 2010 Mar;22(3):867-87. doi: 10.1105/tpc.109.072397. Epub 2010 Mar 26.

32.

Biologically active tetranorditerpenoids from the fungus Sclerotinia homoeocarpa causal agent of dollar spot in turfgrass.

Herath HM, Herath WH, Carvalho P, Khan SI, Tekwani BL, Duke SO, Tomaso-Peterson M, Nanayakkara NP.

J Nat Prod. 2009 Dec;72(12):2091-7. doi: 10.1021/np900334k.

33.

Antibacterial activity of synthetic fire ant venom: the solenopsins and isosolenopsins.

Sullivan DC, Flowers H, Rockhold R, Herath HM, Nanayakkara NP.

Am J Med Sci. 2009 Oct;338(4):287-91. doi: 10.1097/MAJ.0b013e3181af8270.

PMID:
19826319
34.

In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).

da Silva Filho AA, Resende DO, Fukui MJ, Santos FF, Pauletti PM, Cunha WR, Silva ML, Gregório LE, Bastos JK, Nanayakkara NP.

Fitoterapia. 2009 Dec;80(8):478-82. doi: 10.1016/j.fitote.2009.06.007. Epub 2009 Jun 18.

PMID:
19540316
35.

Antileishmanial, antimalarial and antimicrobial activities of the extract and isolated compounds from Austroplenckia populnea (Celastraceae).

Andrade SF, da Silva Filho AA, de O Resende D, Silva ML, Cunha WR, Nanayakkara NP, Bastos JK.

Z Naturforsch C. 2008 Jul-Aug;63(7-8):497-502.

PMID:
18810991
36.

In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae).

da Silva Filho AA, Costa ES, Cunha WR, e Silva ML, Nanayakkara NP, Bastos JK.

Phytother Res. 2008 Oct;22(10):1307-10. doi: 10.1002/ptr.2486.

PMID:
18688887
37.

In vitro and in vivo antileishmanial activities of a Brazilian green propolis extract.

Pontin K, Da Silva Filho AA, Santos FF, Silva ML, Cunha WR, Nanayakkara NP, Bastos JK, de Albuquerque S.

Parasitol Res. 2008 Aug;103(3):487-92. doi: 10.1007/s00436-008-0970-z. Epub 2008 May 20.

PMID:
18491139
38.

Antimicrobial activity of the extract and isolated compounds from Baccharis dracunculifolia D. C. (Asteraceae).

da Silva Filho AA, de Sousa JP, Soares S, Furtado NA, Andrade e Silva ML, Cunha WR, Gregório LE, Nanayakkara NP, Bastos JK.

Z Naturforsch C. 2008 Jan-Feb;63(1-2):40-6.

PMID:
18386486
39.

Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline succinate.

Nanayakkara NP, Ager AL Jr, Bartlett MS, Yardley V, Croft SL, Khan IA, McChesney JD, Walker LA.

Antimicrob Agents Chemother. 2008 Jun;52(6):2130-7. doi: 10.1128/AAC.00645-07. Epub 2008 Mar 31.

40.

Synthesis of water-soluble 9,10-anthraquinone analogues with potent cyanobactericidal activity toward the musty-odor cyanobacterium Oscillatoria perornata.

Nanayakkara NP, Schrader KK.

J Agric Food Chem. 2008 Feb 13;56(3):1002-7. doi: 10.1021/jf072836s. Epub 2008 Jan 19.

PMID:
18205309
41.

A functional genomics investigation of allelochemical biosynthesis in Sorghum bicolor root hairs.

Baerson SR, Dayan FE, Rimando AM, Nanayakkara NP, Liu CJ, Schröder J, Fishbein M, Pan Z, Kagan IA, Pratt LH, Cordonnier-Pratt MM, Duke SO.

J Biol Chem. 2008 Feb 8;283(6):3231-47. Epub 2007 Nov 12.

42.

Biosynthesis of lipid resorcinols and benzoquinones in isolated secretory plant root hairs.

Dayan FE, Watson SB, Nanayakkara NP.

J Exp Bot. 2007;58(12):3263-72. Epub 2007 Oct 10.

PMID:
17928374
43.

In vitro propagation of Podophyllum peltatum.

Moraes-Cerdeira RM, Burandt CL Jr, Bastos JK, Nanayakkara NP, McChesney JD.

Planta Med. 1998 Feb;64(1):42-5.

PMID:
17253216
44.

N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.

Jayasinghe L, Abbas HK, Jacob MR, Herath WH, Nanayakkara NP.

J Nat Prod. 2006 Mar;69(3):439-42.

45.

Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts.

Perazzo FF, Souza GH, Lopes W, Cardoso LG, Carvalho JC, Nanayakkara NP, Bastos JK.

J Ethnopharmacol. 2005 Jun 3;99(2):215-20. Epub 2005 Apr 12.

PMID:
15894130
46.

Cardiodepressant and neurologic actions of Solenopsis invicta (imported fire ant) venom alkaloids.

Howell G, Butler J, Deshazo RD, Farley JM, Liu HL, Nanayakkara NP, Yates A, Yi GB, Rockhold RW.

Ann Allergy Asthma Immunol. 2005 Mar;94(3):380-6.

PMID:
15801250
47.

Novel derivatives of 9,10-anthraquinone are selective algicides against the musty-odor cyanobacterium Oscillatoria perornata.

Schrader KK, Nanayakkara NP, Tucker CS, Rimando AM, Ganzera M, Schaneberg BT.

Appl Environ Microbiol. 2003 Sep;69(9):5319-27.

48.

Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure.

Feltenstein MW, Lambdin LC, Ganzera M, Ranjith H, Dharmaratne W, Nanayakkara NP, Khan IA, Sufka KJ.

Phytother Res. 2003 Mar;17(3):210-6.

PMID:
12672148
49.
50.

(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis.

Dharmaratne HR, Nanayakkara NP, Khan IA.

Planta Med. 2002 Jul;68(7):661-2.

PMID:
12143008

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