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Items: 28


Methods to Monitor the Trafficking of β-Arrestin/G Protein-Coupled Receptor Complexes Using Enhanced Bystander BRET.

Cao Y, Namkung Y, Laporte SA.

Methods Mol Biol. 2019;1957:59-68. doi: 10.1007/978-1-4939-9158-7_3.


FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C.

Sci Signal. 2018 Dec 4;11(559). pii: eaar5536. doi: 10.1126/scisignal.aar5536.


Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.


Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.

Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR.

Front Synaptic Neurosci. 2018 Feb 21;10:2. doi: 10.3389/fnsyn.2018.00002. eCollection 2018.


A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M.

Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.


Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRET.

Namkung Y, Le Gouill C, Lukashova V, Kobayashi H, Hogue M, Khoury E, Song M, Bouvier M, Laporte SA.

Nat Commun. 2016 Jul 11;7:12178. doi: 10.1038/ncomms12178.


β-Arrestin-mediated Angiotensin II Signaling Controls the Activation of ARF6 Protein and Endocytosis in Migration of Vascular Smooth Muscle Cells.

Charles R, Namkung Y, Cotton M, Laporte SA, Claing A.

J Biol Chem. 2016 Feb 19;291(8):3967-81. doi: 10.1074/jbc.M115.684357. Epub 2015 Dec 24.


The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.


Quantifying biased signaling in GPCRs using BRET-based biosensors.

Namkung Y, Radresa O, Armando S, Devost D, Beautrait A, Le Gouill C, Laporte SA.

Methods. 2016 Jan 1;92:5-10. doi: 10.1016/j.ymeth.2015.04.010. Epub 2015 Apr 15.


Differential regulation of endosomal GPCR/β-arrestin complexes and trafficking by MAPK.

Khoury E, Nikolajev L, Simaan M, Namkung Y, Laporte SA.

J Biol Chem. 2014 Aug 22;289(34):23302-17. doi: 10.1074/jbc.M114.568147. Epub 2014 Jul 11.


G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.

Namkung Y, Dipace C, Urizar E, Javitch JA, Sibley DR.

J Biol Chem. 2009 Dec 4;284(49):34103-15. doi: 10.1074/jbc.M109.055707. Epub 2009 Oct 8.


G protein-coupled receptor kinase-mediated phosphorylation regulates post-endocytic trafficking of the D2 dopamine receptor.

Namkung Y, Dipace C, Javitch JA, Sibley DR.

J Biol Chem. 2009 May 29;284(22):15038-51. doi: 10.1074/jbc.M900388200. Epub 2009 Mar 30.


Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors.

Skinbjerg M, Namkung Y, Halldin C, Innis RB, Sibley DR.

Synapse. 2009 Jun;63(6):462-75. doi: 10.1002/syn.20626.


Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.

Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, Hague C.

J Biol Chem. 2008 Nov 7;283(45):31068-78. doi: 10.1074/jbc.M805251200. Epub 2008 Sep 4.


D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP.

Kim OJ, Ariano MA, Namkung Y, Marinec P, Kim E, Han J, Sibley DR.

J Neurochem. 2008 Jul;106(1):83-95. doi: 10.1111/j.1471-4159.2008.05348.x. Epub 2008 Jul 1.


Clients' safe food-handling knowledge and risk behavior in a home-delivered meal program.

Almanza BA, Namkung Y, Ismail JA, Nelson DC.

J Am Diet Assoc. 2007 May;107(5):816-21.


D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin.

Free RB, Hazelwood LA, Cabrera DM, Spalding HN, Namkung Y, Rankin ML, Sibley DR.

J Biol Chem. 2007 Jul 20;282(29):21285-300. Epub 2007 Mar 29.


Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons.

Kim YT, Namkung YL, Kwak J, Suh CK.

Neuroscience. 2007 Apr 25;146(1):170-7. Epub 2007 Mar 8.


Mitigating the risk of food handling in the home-delivered meal program.

Namkung Y, Ismail JA, Almanza BA, Nelson DC.

J Am Diet Assoc. 2007 Feb;107(2):316-20.


Analysis of governmental Web sites on food safety issues: a global perspective.

Namkung Y, Almanza BA.

J Environ Health. 2006 Oct;69(3):10-5; quiz 25-6.


Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice.

Dou H, Vazquez AE, Namkung Y, Chu H, Cardell EL, Nie L, Parson S, Shin HS, Yamoah EN.

J Assoc Res Otolaryngol. 2004 Jun;5(2):215-26.


Protein kinase C mediates phosphorylation, desensitization, and trafficking of the D2 dopamine receptor.

Namkung Y, Sibley DR.

J Biol Chem. 2004 Nov 19;279(47):49533-41. Epub 2004 Sep 3.


Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice.

Zhang Z, Xu Y, Song H, Rodriguez J, Tuteja D, Namkung Y, Shin HS, Chiamvimonvat N.

Circ Res. 2002 May 17;90(9):981-7.


Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation.

Namkung Y, Skrypnyk N, Jeong MJ, Lee T, Lee MS, Kim HL, Chin H, Suh PG, Kim SS, Shin HS.

J Clin Invest. 2001 Oct;108(7):1015-22.


Identity of mouse IA-2 and PTP35 genes of the tyrosine phosphatase family, and their expression in neuroendocrine tissues.

Suk K, Hwang DY, Kim S, Kim YH, Kim KA, Seo YS, Suh Y, Lee SB, Namkung Y, Shin HS, Lee MS.

Diabetes Res Clin Pract. 2000 Sep;50(1):17-26.


Neuronal voltage-activated calcium channels: on the roles of the alpha 1E and beta 3 subunits.

Smith SM, Piedras-Renterà ES, Namkung Y, Shin HS, Tsien RW.

Ann N Y Acad Sci. 1999 Apr 30;868:175-98.


Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons.

Namkung Y, Smith SM, Lee SB, Skrypnyk NV, Kim HL, Chin H, Scheller RH, Tsien RW, Shin HS.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12010-5.

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