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Triterpenoid glycosides from the rhizomes of Allium ascalonicum and their anoctamin-1 inhibitory activity.

Mai NT, Dung DT, Nga TT, Xuan VT, Doan VV, Tai BH, Nhiem NX, Yen PH, Kiem PV, Seo Y, Namkung W, Park S, Kim SH.

Nat Prod Res. 2020 Jan 22:1-9. doi: 10.1080/14786419.2020.1713122. [Epub ahead of print]


Cytotoxic sesquiterpene glucosides from Fissistigma pallens.

Thinh NS, Bich Thu NT, Ngoc TM, Khoi NM, Tai BH, Van Kiem P, Van Minh C, Nhiem NX, Seo Y, Namkung W, Park S, Kim SH.

Phytochemistry. 2020 Jan 11;172:112255. doi: 10.1016/j.phytochem.2019.112255. [Epub ahead of print]


Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells.

Seo Y, Lee JH, Park SH, Namkung W, Kim I.

Eur J Med Chem. 2019 Dec 20;188:111988. doi: 10.1016/j.ejmech.2019.111988. [Epub ahead of print]


Chemical constituents from Schisandra sphenanthera and their cytotoxic activity.

Mai NT, Doan VV, Lan HTT, Anh BTM, Hoang NH, Tai BH, Nhiem NX, Yen PH, Park SJ, Seo Y, Namkung W, Kim SH, Kiem PV.

Nat Prod Res. 2019 Dec 12:1-10. doi: 10.1080/14786419.2019.1700247. [Epub ahead of print]


Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment.

Jung J, Lin H, Koh YI, Ryu K, Lee JS, Rim JH, Choi HJ, Lee HJ, Kim HY, Yu S, Jin H, Lee JH, Lee MG, Namkung W, Choi JY, Gee HY.

Exp Mol Med. 2019 Aug 21;51(8):99. doi: 10.1038/s12276-019-0300-9.


Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma.

Park J, Lee HJ, Song D, Gi M, Jo S, Jeon DK, Seo Y, Kim B, Lee H, Namkung W, Han G, Choi JY.

J Allergy Clin Immunol. 2019 Nov;144(5):1425-1428.e12. doi: 10.1016/j.jaci.2019.07.016. Epub 2019 Jul 27. No abstract available.


Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosis.

Seo JY, Pandey RP, Lee J, Sohng JK, Namkung W, Park YI.

Phytomedicine. 2019 Mar 1;55:40-49. doi: 10.1016/j.phymed.2018.07.011. Epub 2018 Jul 20.


Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors.

Seo Y, Kim J, Chang J, Kim SS, Namkung W, Kim I.

Eur J Med Chem. 2018 Dec 5;160:245-255. doi: 10.1016/j.ejmech.2018.10.002. Epub 2018 Oct 11.


A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations.

Busschaert N, Park SH, Baek KH, Choi YP, Park J, Howe ENW, Hiscock JR, Karagiannidis LE, Marques I, Félix V, Namkung W, Sessler JL, Gale PA, Shin I.

Nat Chem. 2017 Jul;9(7):667-675. doi: 10.1038/nchem.2706. Epub 2017 Jan 30.


Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium.

Kang JW, Lee YH, Kang MJ, Lee HJ, Oh R, Min HJ, Namkung W, Choi JY, Lee SN, Kim CH, Yoon JH, Cho HJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L466-L476. doi: 10.1152/ajplung.00103.2017. Epub 2017 May 25.


Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells.

Seo Y, Ryu K, Park J, Jeon DK, Jo S, Lee HK, Namkung W.

PLoS One. 2017 Mar 31;12(3):e0174935. doi: 10.1371/journal.pone.0174935. eCollection 2017.


Precision Control of the Electron Longitudinal Bunch Shape Using an Emittance-Exchange Beam Line.

Ha G, Cho MH, Namkung W, Power JG, Doran DS, Wisniewski EE, Conde M, Gai W, Liu W, Whiteford C, Gao Q, Kim KJ, Zholents A, Sun YE, Jing C, Piot P.

Phys Rev Lett. 2017 Mar 10;118(10):104801. doi: 10.1103/PhysRevLett.118.104801. Epub 2017 Mar 9.


Enzyme-Responsive Procarriers Capable of Transporting Chloride Ions across Lipid and Cellular Membranes.

Choi YR, Lee B, Park J, Namkung W, Jeong KS.

J Am Chem Soc. 2016 Nov 30;138(47):15319-15322. Epub 2016 Nov 17.


Generation of ΔF508-CFTR T84 cell lines by CRISPR/Cas9-mediated genome editing.

Chung WY, Song M, Park J, Namkung W, Lee J, Kim H, Lee MG, Kim JY.

Biotechnol Lett. 2016 Dec;38(12):2023-2034. Epub 2016 Aug 29.


Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2.

Seo Y, Lee HK, Park J, Jeon DK, Jo S, Jo M, Namkung W.

PLoS One. 2016 May 24;11(5):e0155771. doi: 10.1371/journal.pone.0155771. eCollection 2016.


Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines.

Park J, Khloya P, Seo Y, Kumar S, Lee HK, Jeon DK, Jo S, Sharma PK, Namkung W.

PLoS One. 2016 Feb 10;11(2):e0149131. doi: 10.1371/journal.pone.0149131. eCollection 2016.


Synthetic aminopyrrolic receptors have apoptosis inducing activity.

Park SH, Choi YP, Park J, Share A, Francesconi O, Nativi C, Namkung W, Sessler JL, Roelens S, Shin I.

Chem Sci. 2015 Dec 1;6(12):7284-7292. doi: 10.1039/c5sc03200h. Epub 2015 Oct 2.


Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia.

Lee HJ, Yoo JE, Namkung W, Cho HJ, Kim K, Kang JW, Yoon JH, Choi JY.

Physiol Rep. 2015 Aug;3(8). pii: e12480. doi: 10.14814/phy2.12480.


Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines.

Seo Y, Park J, Kim M, Lee HK, Kim JH, Jeong JH, Namkung W.

PLoS One. 2015 Jul 21;10(7):e0133656. doi: 10.1371/journal.pone.0133656. eCollection 2015.


Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP.

Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS.

Mol Pharmacol. 2015 Oct;88(4):689-96. doi: 10.1124/mol.115.098368. Epub 2015 Jul 14.


Azobenzene-based chloride transporters with light-controllable activities.

Choi YR, Kim GC, Jeon HG, Park J, Namkung W, Jeong KS.

Chem Commun (Camb). 2014 Dec 18;50(97):15305-8. doi: 10.1039/c4cc07560a. Epub 2014 Oct 28.


Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells.

Ko SK, Kim SK, Share A, Lynch VM, Park J, Namkung W, Van Rossom W, Busschaert N, Gale PA, Sessler JL, Shin I.

Nat Chem. 2014 Oct;6(10):885-92. doi: 10.1038/nchem.2021. Epub 2014 Aug 11.


Imidazole-based small molecules that promote neurogenesis in pluripotent cells.

Kim GH, Halder D, Park J, Namkung W, Shin I.

Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4. doi: 10.1002/anie.201404871. Epub 2014 Jul 9.


Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops.

Kim BG, Kim JY, Kim HN, Bok J, Namkung W, Choi JY, Kim SH.

PLoS One. 2014 Apr 21;9(4):e95730. doi: 10.1371/journal.pone.0095730. eCollection 2014.


Shank2 mutant mice display a hypersecretory response to cholera toxin.

Jung ES, Park J, Gee HY, Jung J, Noh SH, Lee JS, Richter W, Namkung W, Lee MG.

J Physiol. 2014 Apr 15;592(8):1809-21. doi: 10.1113/jphysiol.2013.268631. Epub 2014 Jan 20.


Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.

Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W.

FASEB J. 2014 Feb;28(2):791-801. doi: 10.1096/fj.13-240861. Epub 2013 Nov 7.


A comparison of Ypet and firefly luciferase as reporter proteins for high-throughput screening.

Yoon SM, Namkung W, Lee J.

Biosci Biotechnol Biochem. 2013;77(11):2328-30. Epub 2013 Nov 7.


Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice.

Ko EA, Jin BJ, Namkung W, Ma T, Thiagarajah JR, Verkman AS.

Gut. 2014 Jul;63(7):1120-9. doi: 10.1136/gutjnl-2013-305663. Epub 2013 Sep 19.


Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compounds.

Jin BJ, Ko EA, Namkung W, Verkman AS.

Lab Chip. 2013 Oct 7;13(19):3862-7. doi: 10.1039/c3lc50821h.


Novel 5-substituted benzyloxy-2-arylbenzofuran-3-carboxylic acids as calcium activated chloride channel inhibitors.

Kumar S, Namkung W, Verkman AS, Sharma PK.

Bioorg Med Chem. 2012 Jul 15;20(14):4237-44. doi: 10.1016/j.bmc.2012.05.074. Epub 2012 Jun 6.


Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A.

Yao Z, Namkung W, Ko EA, Park J, Tradtrantip L, Verkman AS.

PLoS One. 2012;7(5):e38030. doi: 10.1371/journal.pone.0038030. Epub 2012 May 30.


Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.

Namkung W, Yao Z, Finkbeiner WE, Verkman AS.

FASEB J. 2011 Nov;25(11):4048-62. doi: 10.1096/fj.11-191627. Epub 2011 Aug 11.


Polarity effect of pulsed corona discharge for the oxidation of gaseous elemental mercury.

Byun Y, Koh DJ, Shin DN, Cho M, Namkung W.

Chemosphere. 2011 Aug;84(9):1285-9. doi: 10.1016/j.chemosphere.2011.05.044. Epub 2011 Jun 22.


Hydrogen recovery from the thermal plasma gasification of solid waste.

Byun Y, Cho M, Chung JW, Namkung W, Lee HD, Jang SD, Kim YS, Lee JH, Lee CR, Hwang SM.

J Hazard Mater. 2011 Jun 15;190(1-3):317-23. doi: 10.1016/j.jhazmat.2011.03.052. Epub 2011 Mar 22.


Radiography simulation on single-shot dual-spectrum X-ray for cargo inspection system.

Gil Y, Oh Y, Cho M, Namkung W.

Appl Radiat Isot. 2011 Feb;69(2):389-93. doi: 10.1016/j.apradiso.2010.11.011. Epub 2010 Nov 21.


TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.

Namkung W, Phuan PW, Verkman AS.

J Biol Chem. 2011 Jan 21;286(3):2365-74. doi: 10.1074/jbc.M110.175109. Epub 2010 Nov 17.


Demonstration of thermal plasma gasification/vitrification for municipal solid waste treatment.

Byun Y, Namkung W, Cho M, Chung JW, Kim YS, Lee JH, Lee CR, Hwang SM.

Environ Sci Technol. 2010 Sep 1;44(17):6680-4. doi: 10.1021/es101244u.


Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea.

Namkung W, Thiagarajah JR, Phuan PW, Verkman AS.

FASEB J. 2010 Nov;24(11):4178-86. doi: 10.1096/fj.10-160648. Epub 2010 Jun 25.


CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.

Namkung W, Finkbeiner WE, Verkman AS.

Mol Biol Cell. 2010 Aug 1;21(15):2639-48. doi: 10.1091/mbc.E09-12-1004. Epub 2010 Jun 16.


Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion.

Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee JS, Kim KS, Venglovecz V, Gray MA, Kim KH, Lee MG.

Gastroenterology. 2010 Aug;139(2):620-31. doi: 10.1053/j.gastro.2010.04.004. Epub 2010 Apr 14.


Insight into the unique oxidation chemistry of elemental mercury by chlorine-containing species: experiment and simulation.

Byun Y, Cho M, Namkung W, Lee K, Koh DJ, Shin DN.

Environ Sci Technol. 2010 Mar 1;44(5):1624-9. doi: 10.1021/es902358u.


Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function.

Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1131-40. doi: 10.1152/ajplung.00085.2009. Epub 2009 Oct 9.


Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels.

Tradtrantip L, Namkung W, Verkman AS.

Mol Pharmacol. 2010 Jan;77(1):69-78. doi: 10.1124/mol.109.061051. Epub 2009 Oct 6.


Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.

Tradtrantip L, Sonawane ND, Namkung W, Verkman AS.

J Med Chem. 2009 Oct 22;52(20):6447-55. doi: 10.1021/jm9009873.


Reaction pathways of NO oxidation by sodium chlorite powder.

Byun Y, Ko KB, Cho M, Namkung W, Lee K, Shin DN, Koh DJ.

Environ Sci Technol. 2009 Jul 1;43(13):5054-9.


Synaptic scaffolding molecule binds to and regulates vasoactive intestinal polypeptide type-1 receptor in epithelial cells.

Gee HY, Kim YW, Jo MJ, Namkung W, Kim JY, Park HW, Kim KS, Kim H, Baba A, Yang J, Kim E, Kim KH, Lee MG.

Gastroenterology. 2009 Aug;137(2):607-17, 617.e1-4.


The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth.

Kim J, Namkung W, Yoon JS, Jo MJ, Lee SH, Kim KH, Kim JY, Lee MG.

Lab Invest. 2009 Aug;89(8):867-74. doi: 10.1038/labinvest.2009.53. Epub 2009 Jun 8.


In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.

Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS.

J Biol Chem. 2009 Jun 5;284(23):15916-26. doi: 10.1074/jbc.M808021200. Epub 2009 Apr 13.

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