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Items: 25


Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness.

Cohen M, Lamparello AJ, Schimunek L, El-Dehaibi F, Namas RA, Xu Y, Kaynar AM, Billiar TR, Vodovotz Y.

Shock. 2019 Jul 30. doi: 10.1097/SHK.0000000000001409. [Epub ahead of print]


An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients.

Lamparello AJ, Namas RA, Schimunek L, Cohen M, El-Dehaibi F, Yin J, Barclay D, Zamora R, Billiar TR, Vodovotz Y.

Shock. 2019 Jul 16. doi: 10.1097/SHK.0000000000001411. [Epub ahead of print]


Elevations in Circulating sST2 Levels Are Associated With In-hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma.

Billiar IM, Guardado J, Abdul-Malak O, Vodovotz Y, Billiar TR, Namas RA.

J Surg Res. 2019 Jul 3;244:23-33. doi: 10.1016/j.jss.2019.05.057. [Epub ahead of print]


Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries.

Almahmoud K, Abboud A, Namas RA, Zamora R, Sperry J, Peitzman AB, Truitt MS, Gaski GE, McKinley TO, Billiar TR, Vodovotz Y.

PLoS One. 2019 Jun 4;14(6):e0217577. doi: 10.1371/journal.pone.0217577. eCollection 2019.


A conceptual time window-based model for the early stratification of trauma patients.

Lamparello AJ, Namas RA, Constantine G, McKinley TO, Elster E, Vodovotz Y, Billiar TR.

J Intern Med. 2019 Jul;286(1):2-15. doi: 10.1111/joim.12874. Epub 2019 Jan 9. Review.


Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury.

Lamparello AJ, Namas RA, Abdul-Malak O, Vodovotz Y, Billiar TR.

J Am Coll Surg. 2019 Feb;228(2):148-160.e7. doi: 10.1016/j.jamcollsurg.2018.10.019. Epub 2018 Nov 16.


An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma.

Schimunek L, Namas RA, Yin J, Liu D, Barclay D, El-Dehaibi F, Abboud A, Lindberg H, Zamora R, Billiar TR, Vodovotz Y.

Shock. 2018 Mar;49(3):259-268. doi: 10.1097/SHK.0000000000000987.


From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients.

Namas RA, Vodovotz Y.

Ann Transl Med. 2016 Dec;4(24):492. doi: 10.21037/atm.2016.11.72. No abstract available.


Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

Abdul-Malak O, Vodovotz Y, Zaaqoq A, Guardado J, Almahmoud K, Yin J, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR, Namas RA.

Mediators Inflamm. 2016;2016:7950374. Epub 2016 Nov 15.


Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

Namas RA, Almahmoud K, Mi Q, Ghuma A, Namas R, Zaaqoq A, Zhu X, Abdul-Malak O, Sperry J, Zamora R, Billiar TR, Vodovotz Y.

J Crit Care. 2016 Dec;36:146-153. doi: 10.1016/j.jcrc.2016.07.002. Epub 2016 Jul 11.


Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality.

Abboud A, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, Azhar N, Zaaqoq A, Namas R, Barclay DA, Yin J, Sperry J, Peitzman A, Zamora R, Simmons RL, Billiar TR, Vodovotz Y.

Crit Care Med. 2016 Nov;44(11):e1074-e1081.


Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation.

Namas RA, Mi Q, Namas R, Almahmoud K, Zaaqoq AM, Abdul-Malak O, Azhar N, Day J, Abboud A, Zamora R, Billiar TR, Vodovotz Y.

Antioxid Redox Signal. 2015 Dec 10;23(17):1370-87. doi: 10.1089/ars.2015.6398. Review.


Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.

Almahmoud K, Namas RA, Abdul-Malak O, Zaaqoq AM, Zamora R, Zuckerbraun BS, Sperry J, Peitzman AB, Billiar TR, Vodovotz Y.

Shock. 2015 Aug;44(2):101-9. doi: 10.1097/SHK.0000000000000395.


Trauma in silico: Individual-specific mathematical models and virtual clinical populations.

Brown D, Namas RA, Almahmoud K, Zaaqoq A, Sarkar J, Barclay DA, Yin J, Ghuma A, Abboud A, Constantine G, Nieman G, Zamora R, Chang SC, Billiar TR, Vodovotz Y.

Sci Transl Med. 2015 Apr 29;7(285):285ra61. doi: 10.1126/scitranslmed.aaa3636.


Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans.

Almahmoud K, Namas RA, Zaaqoq AM, Abdul-Malak O, Namas R, Zamora R, Sperry J, Billiar TR, Vodovotz Y.

Crit Care Med. 2015 Jul;43(7):1395-404. doi: 10.1097/CCM.0000000000000964.


Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

Namas RA, Vodovotz Y, Almahmoud K, Abdul-Malak O, Zaaqoq A, Namas R, Mi Q, Barclay D, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR.

Ann Surg. 2016 Jan;263(1):191-8. doi: 10.1097/SLA.0000000000001001.


Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies.

Ziraldo C, Vodovotz Y, Namas RA, Almahmoud K, Tapias V, Mi Q, Barclay D, Jefferson BS, Chen G, Billiar TR, Zamora R.

PLoS One. 2013 Dec 3;8(12):e79804. doi: 10.1371/journal.pone.0079804. eCollection 2013.


Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice.

Namas RA, Bartels J, Hoffman R, Barclay D, Billiar TR, Zamora R, Vodovotz Y.

PLoS One. 2013 Jul 2;8(7):e67419. doi: 10.1371/journal.pone.0067419. Print 2013.


Sepsis: from pattern to mechanism and back.

An G, Namas RA, Vodovotz Y.

Crit Rev Biomed Eng. 2012;40(4):341-51. Review.


Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies.

Zamora R, Azhar N, Namas R, Metukuri MR, Clermont T, Gladstone C, Namas RA, Hermus L, Megas C, Constantine G, Billiar TR, Fink MP, Vodovotz Y.

J Biol Chem. 2012 Sep 7;287(37):31003-14. doi: 10.1074/jbc.M112.344309. Epub 2012 Jul 24.


Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies.

Namas RA, Namas R, Lagoa C, Barclay D, Mi Q, Zamora R, Peng Z, Wen X, Fedorchak MV, Valenti IE, Federspiel WJ, Kellum JA, Vodovotz Y.

Mol Med. 2012 Dec 20;18:1366-74. doi: 10.2119/molmed.2012.00106.


A Biohybrid Device for the Systemic Control of Acute Inflammation.

Namas RA, Mikheev M, Yin J, Over P, Young M, Constantine GM, Zamora R, Gerlach J, Vodovotz Y.

Disrupt Sci Technol. 2012 May 14;1(1). doi: 10.1089/dst.2012.0001.


Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1α in mouse hepatocytes.

Namas RA, Metukuri MR, Dhupar R, Velosa C, Jefferson BS, Myer E, Constantine GM, Billiar TR, Vodovotz Y, Zamora R.

Shock. 2011 Aug;36(2):196-202. doi: 10.1097/SHK.0b013e3182205e07.


Very low frequency variability in the peripheral circulation: the possibility of plethysmographic quantification.

Zenker S, Polanco PM, Torres A, Clermont G, Kim HK, Vodovotz Y, Pinsky MR, Namas RA, Puyana JC.

Eur J Anaesthesiol. 2009 Jun;26(6):522-4; author reply 524. doi: 10.1097/EJA.0b013e3283297539. No abstract available.


Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.

Metukuri MR, Beer-Stolz D, Namas RA, Dhupar R, Torres A, Loughran PA, Jefferson BS, Tsung A, Billiar TR, Vodovotz Y, Zamora R.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G499-509. doi: 10.1152/ajpgi.90526.2008. Epub 2009 Jan 15.

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