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Items: 23


Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, Including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory.

Zhang CL, Huang QL, Chen J, Zhang WJ, Jin HX, Wang HB, Naman CB, Cao ZY.

J Nat Prod. 2019 Oct 10. doi: 10.1021/acs.jnatprod.9b00247. [Epub ahead of print]


A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors.

Li T, Wang N, Zhang T, Zhang B, Sajeevan TP, Joseph V, Armstrong L, He S, Yan X, Naman CB.

Mar Drugs. 2019 Aug 23;17(9). pii: E493. doi: 10.3390/md17090493. Review.


Schekwanglupaside C, a new lupane saponin from Schefflera kwangsiensis, is a potent activator of sarcoplasmic reticulum Ca2+-ATPase.

Yang G, Wang Y, Yu Y, Zheng J, Chen J, Li S, Chen R, Zhang C, Naman CB, Yu D, Cao Z.

Fitoterapia. 2019 Sep;137:104150. doi: 10.1016/j.fitote.2019.04.005. Epub 2019 Apr 14.


25C-NBOMe, a Novel Designer Psychedelic, Induces Neurotoxicity 50 Times More Potent Than Methamphetamine In Vitro.

Xu P, Qiu Q, Li H, Yan S, Yang M, Naman CB, Wang Y, Zhou W, Shen H, Cui W.

Neurotox Res. 2019 May;35(4):993-998. doi: 10.1007/s12640-019-0012-x. Epub 2019 Feb 26.


9-Methylfascaplysin Is a More Potent Aβ Aggregation Inhibitor than the Marine-Derived Alkaloid, Fascaplysin, and Produces Nanomolar Neuroprotective Effects in SH-SY5Y Cells.

Sun Q, Liu F, Sang J, Lin M, Ma J, Xiao X, Yan S, Naman CB, Wang N, He S, Yan X, Cui W, Liang H.

Mar Drugs. 2019 Feb 18;17(2). pii: E121. doi: 10.3390/md17020121.


DNA Binding and Molecular Dynamic Studies of Polycyclic Tetramate Macrolactams (PTM) with Potential Anticancer Activity Isolated from a Sponge-Associated Streptomyces zhaozhouensis subsp. mycale subsp. nov.

Dhaneesha M, Hasin O, Sivakumar KC, Ravinesh R, Naman CB, Carmeli S, Sajeevan TP.

Mar Biotechnol (NY). 2019 Feb;21(1):124-137. doi: 10.1007/s10126-018-9866-9. Epub 2018 Dec 13.


Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice.

Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak S, Carlier PR, Cui W, Han Y.

Front Cell Neurosci. 2018 Nov 7;12:396. doi: 10.3389/fncel.2018.00396. eCollection 2018.


Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.

Almaliti J, Miller B, Pietraszkiewicz H, Glukhov E, Naman CB, Kline T, Hanson J, Li X, Zhou S, Valeriote FA, Gerwick WH.

Eur J Med Chem. 2019 Jan 1;161:416-432. doi: 10.1016/j.ejmech.2018.10.024. Epub 2018 Oct 15.


Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States.

Benatrehina PA, Pan L, Naman CB, Li J, Kinghorn AD.

J Tradit Complement Med. 2018 Mar 2;8(2):267-277. doi: 10.1016/j.jtcme.2018.01.006. eCollection 2018 Apr. Review.


Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β.

Wang J, Zheng J, Huang C, Zhao J, Lin J, Zhou X, Naman CB, Wang N, Gerwick WH, Wang Q, Yan X, Cui W, He S.

ACS Chem Neurosci. 2018 Jun 20;9(6):1349-1356. doi: 10.1021/acschemneuro.7b00527. Epub 2018 Apr 10.


5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro.

Zhao J, Liu F, Huang C, Shentu J, Wang M, Sun C, Chen L, Yan S, Fang F, Wang Y, Xu S, Naman CB, Wang Q, He S, Cui W.

Molecules. 2017 Oct 1;22(10). pii: E1651. doi: 10.3390/molecules22101651.


Bioassay-Guided Isolation of Antioxidant and Cytoprotective Constituents from a Maqui Berry (Aristotelia chilensis) Dietary Supplement Ingredient As Markers for Qualitative and Quantitative Analysis.

Li J, Yuan C, Pan L, Benatrehina PA, Chai H, Keller WJ, Naman CB, Kinghorn AD.

J Agric Food Chem. 2017 Oct 4;65(39):8634-8642. doi: 10.1021/acs.jafc.7b03261. Epub 2017 Sep 26.


5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

Fang F, Zhao J, Ding L, Huang C, Naman CB, He S, Wu B, Zhu P, Luo Q, Gerwick WH, Yan X, Wang Q, Zhang Z, Cui W.

Mar Drugs. 2017 Aug 19;15(8). pii: E260. doi: 10.3390/md15080260.


Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species.

Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH.

J Nat Prod. 2017 Aug 25;80(8):2328-2334. doi: 10.1021/acs.jnatprod.7b00367. Epub 2017 Aug 7.


Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata.

Zhang C, Naman CB, Engene N, Gerwick WH.

Mar Drugs. 2017 Apr 14;15(4). pii: E121. doi: 10.3390/md15040121.


Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium.

Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH.

J Nat Prod. 2017 Mar 24;80(3):625-633. doi: 10.1021/acs.jnatprod.6b00907. Epub 2017 Jan 5.


A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.


Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.

Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD.

J Nat Prod. 2016 Mar 25;79(3):598-606. doi: 10.1021/acs.jnatprod.5b01131. Epub 2016 Feb 23.


Computer-Assisted Structure Elucidation of Black Chokeberry (Aronia melanocarpa) Fruit Juice Isolates with a New Fused Pentacyclic Flavonoid Skeleton.

Naman CB, Li J, Moser A, Hendrycks JM, Benatrehina PA, Chai H, Yuan C, Keller WJ, Kinghorn AD.

Org Lett. 2015 Jun 19;17(12):2988-91. doi: 10.1021/acs.orglett.5b01284. Epub 2015 Jun 1.


Northalrugosidine is a bisbenzyltetrahydroisoquinoline alkaloid from Thalictrum alpinum with in vivo antileishmanial activity.

Naman CB, Gupta G, Varikuti S, Chai H, Doskotch RW, Satoskar AR, Kinghorn AD.

J Nat Prod. 2015 Mar 27;78(3):552-6. doi: 10.1021/np501028u. Epub 2015 Jan 28.


Investigation of Vietnamese plants for potential anticancer agents.

Pérez LB, Still PC, Naman CB, Ren Y, Pan L, Chai HB, Carcache de Blanco EJ, Ninh TN, Van Thanh B, Swanson SM, Soejarto DD, Kinghorn AD.

Phytochem Rev. 2014 Dec;13(4):727-739.


Pyrrole alkaloids with potential cancer chemopreventive activity isolated from a goji berry-contaminated commercial sample of African mango.

Li J, Pan L, Naman CB, Deng Y, Chai H, Keller WJ, Kinghorn AD.

J Agric Food Chem. 2014 Jun 4;62(22):5054-60. doi: 10.1021/jf500802x. Epub 2014 May 27.

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