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Items: 30


A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities.

Kounatidou E, Nakjang S, McCracken SRC, Dehm SM, Robson CN, Jones D, Gaughan L.

Nucleic Acids Res. 2019 Jun 20;47(11):5634-5647. doi: 10.1093/nar/gkz286.


The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2019 Apr 15;35(4):705. doi: 10.1016/j.ccell.2019.03.012. No abstract available.


The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer.

Chaytor L, Simcock M, Nakjang S, Heath R, Walker L, Robson C, Jones D, Gaughan L.

Mol Cancer Res. 2019 Jun;17(6):1264-1278. doi: 10.1158/1541-7786.MCR-18-1231. Epub 2019 Mar 4.


The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2018 Oct 8;34(4):626-642.e8. doi: 10.1016/j.ccell.2018.08.015. Erratum in: Cancer Cell. 2019 Apr 15;35(4):705.


The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.

McClurg UL, Azizyan M, Dransfield DT, Namdev N, Chit NCTH, Nakjang S, Robson CN.

Oncotarget. 2018 May 18;9(38):24992-25007. doi: 10.18632/oncotarget.25167. eCollection 2018 May 18.


Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.

McClurg UL, Chit NCTH, Azizyan M, Edwards J, Nabbi A, Riabowol KT, Nakjang S, McCracken SR, Robson CN.

Oncogene. 2018 Aug;37(34):4679-4691. doi: 10.1038/s41388-018-0283-3. Epub 2018 May 14.


Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites.

Dean P, Sendra KM, Williams TA, Watson AK, Major P, Nakjang S, Kozhevnikova E, Goldberg AV, Kunji ERS, Hirt RP, Embley TM.

Nat Commun. 2018 Apr 27;9(1):1709. doi: 10.1038/s41467-018-03923-4.


Differential regulation of the androgen receptor by protein phosphatase regulatory subunits.

Grey J, Jones D, Wilson L, Nakjang S, Clayton J, Temperley R, Clark E, Gaughan L, Robson C.

Oncotarget. 2017 Dec 4;9(3):3922-3935. doi: 10.18632/oncotarget.22883. eCollection 2018 Jan 9.


Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.

Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC.

Lancet Oncol. 2017 Jul;18(7):958-971. doi: 10.1016/S1470-2045(17)30243-7. Epub 2017 May 22.


Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.

Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR.

Haematologica. 2017 Jul;102(7):1247-1257. doi: 10.3324/haematol.2016.163030. Epub 2017 Apr 6.


Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis.

Freibert SA, Goldberg AV, Hacker C, Molik S, Dean P, Williams TA, Nakjang S, Long S, Sendra K, Bill E, Heinz E, Hirt RP, Lucocq JM, Embley TM, Lill R.

Nat Commun. 2017 Jan 4;8:13932. doi: 10.1038/ncomms13932.


Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

Russell LJ, Jones L, Enshaei A, Tonin S, Ryan SL, Eswaran J, Nakjang S, Papaemmanuil E, Tubio JM, Fielding AK, Vora A, Campbell PJ, Moorman AV, Harrison CJ.

Genes Chromosomes Cancer. 2017 May;56(5):363-372. doi: 10.1002/gcc.22439. Epub 2017 Jan 18.


Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity.

McClurg UL, Cork DMW, Darby S, Ryan-Munden CA, Nakjang S, Mendes Côrtes L, Treumann A, Gaughan L, Robson CN.

Nucleic Acids Res. 2017 Feb 28;45(4):1793-1804. doi: 10.1093/nar/gkw1162.


A Recent Whole-Genome Duplication Divides Populations of a Globally Distributed Microsporidian.

Williams TA, Nakjang S, Campbell SE, Freeman MA, Eydal M, Moore K, Hirt RP, Embley TM, Williams BA.

Mol Biol Evol. 2016 Aug;33(8):2002-15. doi: 10.1093/molbev/msw083. Epub 2016 Apr 27.


Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.

Esfandiari A, Hawthorne TA, Nakjang S, Lunec J.

Mol Cancer Ther. 2016 Mar;15(3):379-91. doi: 10.1158/1535-7163.MCT-15-0651. Epub 2016 Feb 1.


FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer.

Jones D, Wade M, Nakjang S, Chaytor L, Grey J, Robson CN, Gaughan L.

Oncotarget. 2015 Oct 6;6(30):29782-94. doi: 10.18632/oncotarget.4927.


Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy.

O'Neill D, Jones D, Wade M, Grey J, Nakjang S, Guo W, Cork D, Davies BR, Wedge SR, Robson CN, Gaughan L.

Oncotarget. 2015 Sep 22;6(28):26029-40. doi: 10.18632/oncotarget.4347.


Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia.

Gabriel AS, Lafta FM, Schwalbe EC, Nakjang S, Cockell SJ, Iliasova A, Enshaei A, Schwab C, Rand V, Clifford SC, Kinsey SE, Mitchell CD, Vora A, Harrison CJ, Moorman AV, Strathdee G.

Epigenetics. 2015;10(8):717-26. doi: 10.1080/15592294.2015.1061174.


Plasma membrane-located purine nucleotide transport proteins are key components for host exploitation by microsporidian intracellular parasites.

Heinz E, Hacker C, Dean P, Mifsud J, Goldberg AV, Williams TA, Nakjang S, Gregory A, Hirt RP, Lucocq JM, Kunji ER, Embley TM.

PLoS Pathog. 2014 Dec 4;10(12):e1004547. doi: 10.1371/journal.ppat.1004547. eCollection 2014 Dec.


A distributed computational search strategy for the identification of diagnostics targets: application to finding aptamer targets for methicillin-resistant staphylococci.

Flanagan K, Cockell S, Harwood C, Hallinan J, Nakjang S, Lawry B, Wipat A.

J Integr Bioinform. 2014 Jun 30;11(2):242. doi: 10.2390/biecoll-jib-2014-242.


Transport proteins of parasitic protists and their role in nutrient salvage.

Dean P, Major P, Nakjang S, Hirt RP, Embley TM.

Front Plant Sci. 2014 Apr 29;5:153. doi: 10.3389/fpls.2014.00153. eCollection 2014. Review.


Reduction and expansion in microsporidian genome evolution: new insights from comparative genomics.

Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG, Sendra KM, Heaps SE, Hirt RP, Martin Embley T.

Genome Biol Evol. 2013;5(12):2285-303. doi: 10.1093/gbe/evt184.


Patterns of prokaryotic lateral gene transfers affecting parasitic microbial eukaryotes.

Alsmark C, Foster PG, Sicheritz-Ponten T, Nakjang S, Martin Embley T, Hirt RP.

Genome Biol. 2013 Feb 25;14(2):R19. doi: 10.1186/gb-2013-14-2-r19.


The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.

Heinz E, Williams TA, Nakjang S, Noël CJ, Swan DC, Goldberg AV, Harris SR, Weinmaier T, Markert S, Becher D, Bernhardt J, Dagan T, Hacker C, Lucocq JM, Schweder T, Rattei T, Hall N, Hirt RP, Embley TM.

PLoS Pathog. 2012;8(10):e1002979. doi: 10.1371/journal.ppat.1002979. Epub 2012 Oct 25.


Microbase2.0: a generic framework for computationally intensive bioinformatics workflows in the cloud.

Flanagan K, Nakjang S, Hallinan J, Harwood C, Hirt RP, Pocock MR, Wipat A.

J Integr Bioinform. 2012 Sep 24;9(2):212. doi: 10.2390/biecoll-jib-2012-212.


Data mining the human gut microbiota for therapeutic targets.

Collison M, Hirt RP, Wipat A, Nakjang S, Sanseau P, Brown JR.

Brief Bioinform. 2012 Nov;13(6):751-68. doi: 10.1093/bib/bbs002. Epub 2012 Mar 24. Review.


A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes.

Nakjang S, Ndeh DA, Wipat A, Bolam DN, Hirt RP.

PLoS One. 2012;7(1):e30287. doi: 10.1371/journal.pone.0030287. Epub 2012 Jan 27.


Trichomonas vaginalis pathobiology new insights from the genome sequence.

Hirt RP, de Miguel N, Nakjang S, Dessi D, Liu YC, Diaz N, Rappelli P, Acosta-Serrano A, Fiori PL, Mottram JC.

Adv Parasitol. 2011;77:87-140. doi: 10.1016/B978-0-12-391429-3.00006-X. Review.


Automatic extraction of microorganisms and their habitats from free text using text mining workflows.

Kolluru B, Nakjang S, Hirt RP, Wipat A, Ananiadou S.

J Integr Bioinform. 2011 Oct 10;8(2):184. doi: 10.2390/biecoll-jib-2011-184.


Evidence suggesting a genetic contribution to kidney stone in northeastern Thai population.

Sritippayawan S, Borvornpadungkitti S, Paemanee A, Predanon C, Susaengrat W, Chuawattana D, Sawasdee N, Nakjang S, Pongtepaditep S, Nettuwakul C, Rungroj N, Vasuvattakul S, Malasit P, Yenchitsomanus PT.

Urol Res. 2009 Jun;37(3):141-6. doi: 10.1007/s00240-009-0189-1. Epub 2009 Apr 22.


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