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Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner.

Musa MA, Nakamura R, Hena A, Varikuti S, Nakhasi HL, Goto Y, Satoskar AR, Hamano S.

PLoS Negl Trop Dis. 2019 Nov 18;13(11):e0007865. doi: 10.1371/journal.pntd.0007865. eCollection 2019 Nov.


miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen -/- Immunization.

Gannavaram S, Bhattacharya P, Siddiqui A, Ismail N, Madhavan S, Nakhasi HL.

Front Immunol. 2019 Sep 24;10:2273. doi: 10.3389/fimmu.2019.02273. eCollection 2019.


Innovations for the elimination and control of visceral leishmaniasis.

Selvapandiyan A, Croft SL, Rijal S, Nakhasi HL, Ganguly NK.

PLoS Negl Trop Dis. 2019 Sep 19;13(9):e0007616. doi: 10.1371/journal.pntd.0007616. eCollection 2019 Sep. No abstract available.


International survey on the impact of parasitic infections: frequency of transmission and current mitigation strategies.

Leiby DA, O'Brien SF, Wendel S, Nguyen ML, Delage G, Devare SG, Hardiman A, Nakhasi HL, Sauleda S, Bloch EM; WPTTID Subgroup on Parasites.

Vox Sang. 2019 Jan;114(1):17-27. doi: 10.1111/vox.12727. Epub 2018 Dec 6.


Leptin Functions in Infectious Diseases.

Maurya R, Bhattacharya P, Dey R, Nakhasi HL.

Front Immunol. 2018 Nov 26;9:2741. doi: 10.3389/fimmu.2018.02741. eCollection 2018. Review.


A Leishmania-specific gene upregulated at the amastigote stage is crucial for parasite survival.

Avishek K, Ahuja K, Pradhan D, Gannavaram S, Selvapandiyan A, Nakhasi HL, Salotra P.

Parasitol Res. 2018 Oct;117(10):3215-3228. doi: 10.1007/s00436-018-6020-6. Epub 2018 Aug 14.


Centrin-Deleted Leishmania donovani Parasites Help CD4+ T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200-CD200R Immune Inhibitory Axis.

Singh RK, Gannavaram S, Ismail N, Kaul A, Gedda MR, Nakhasi HL.

Front Immunol. 2018 Jun 4;9:1176. doi: 10.3389/fimmu.2018.01176. eCollection 2018.


Immunization with Live Attenuated Leishmania donovani Centrin-/- Parasites Is Efficacious in Asymptomatic Infection.

Ismail N, Kaul A, Bhattacharya P, Gannavaram S, Nakhasi HL.

Front Immunol. 2017 Dec 12;8:1788. doi: 10.3389/fimmu.2017.01788. eCollection 2017.


Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β.

Dey R, Joshi AB, Oliveira F, Pereira L, Guimarães-Costa AB, Serafim TD, de Castro W, Coutinho-Abreu IV, Bhattacharya P, Townsend S, Aslan H, Perkins A, Karmakar S, Ismail N, Karetnick M, Meneses C, Duncan R, Nakhasi HL, Valenzuela JG, Kamhawi S.

Cell Host Microbe. 2018 Jan 10;23(1):134-143.e6. doi: 10.1016/j.chom.2017.12.002. Epub 2017 Dec 28.


Live Attenuated Leishmania donovani Centrin Gene-Deleted Parasites Induce IL-23-Dependent IL-17-Protective Immune Response against Visceral Leishmaniasis in a Murine Model.

Banerjee A, Bhattacharya P, Dagur PK, Karmakar S, Ismail N, Joshi AB, Akue AD, KuKuruga M, McCoy JP Jr, Dey R, Nakhasi HL.

J Immunol. 2018 Jan 1;200(1):163-176. doi: 10.4049/jimmunol.1700674. Epub 2017 Nov 29.


Dermotropic Leishmania donovani in Sri Lanka: visceralizing potential in clinical and preclinical studies.

Kariyawasam KKGDUL, Selvapandiyan A, Siriwardana HVYD, Dube A, Karunanayake P, Senanayake SASC, Dey R, Gannavaram S, Nakhasi HL, Karunaweera ND.

Parasitology. 2018 Apr;145(4):443-452. doi: 10.1017/S003118201700169X. Epub 2017 Nov 8.


Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization.

Gannavaram S, Torcivia J, Gasparyan L, Kaul A, Ismail N, Simonyan V, Nakhasi HL.

Sci Rep. 2017 Jul 5;7(1):4718. doi: 10.1038/s41598-017-05088-4.


Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs.

Avishek K, Kaushal H, Gannavaram S, Dey R, Selvapandiyan A, Ramesh V, Negi NS, Dubey US, Nakhasi HL, Salotra P.

Sci Rep. 2016 Sep 14;6:33059. doi: 10.1038/srep33059.


Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis.

Bhattacharya P, Dey R, Dagur PK, Joshi AB, Ismail N, Gannavaram S, Debrabant A, Akue AD, KuKuruga MA, Selvapandiyan A, McCoy JP Jr, Nakhasi HL.

PLoS Negl Trop Dis. 2016 Aug 31;10(8):e0004963. doi: 10.1371/journal.pntd.0004963. eCollection 2016 Aug.


Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines.

Banerjee A, Bhattacharya P, Joshi AB, Ismail N, Dey R, Nakhasi HL.

Cell Immunol. 2016 Nov;309:37-41. doi: 10.1016/j.cellimm.2016.07.004. Epub 2016 Jul 11. Review.


Screening of Blood Donations for Zika Virus Infection - Puerto Rico, April 3-June 11, 2016.

Kuehnert MJ, Basavaraju SV, Moseley RR, Pate LL, Galel SA, Williamson PC, Busch MP, Alsina JO, Climent-Peris C, Marks PW, Epstein JS, Nakhasi HL, Hobson JP, Leiby DA, Akolkar PN, Petersen LR, Rivera-Garcia B.

MMWR Morb Mortal Wkly Rep. 2016 Jun 24;65(24):627-8. doi: 10.15585/mmwr.mm6524e2.


Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules.

Gannavaram S, Bhattacharya P, Ismail N, Kaul A, Singh R, Nakhasi HL.

Front Immunol. 2016 May 13;7:187. doi: 10.3389/fimmu.2016.00187. eCollection 2016. Review.


Application of rapid in vitro co-culture system of macrophages and T-cell subsets to assess the immunogenicity of dogs vaccinated with live attenuated Leishmania donovani centrin deleted parasites (LdCen-/-).

Viana KF, Fiuza JA, Gannavaram S, Dey R, Selvapandiyan A, Bartholomeu DC, da Silveira-Lemos D, Bueno LL, Dutra WO, Fujiwara RT, Nakhasi HL, Giunchetti RC.

Parasit Vectors. 2016 Apr 30;9:250. doi: 10.1186/s13071-016-1528-z.


Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice.

Maurya R, Bhattacharya P, Ismail N, Dagur PK, Joshi AB, Razdan K, McCoy JP, Ascher J, Dey R, Nakhasi HL.

Am J Trop Med Hyg. 2016 Jul 6;95(1):109-119. doi: 10.4269/ajtmh.15-0804. Epub 2016 Apr 25.


Methods to Evaluate the Preclinical Safety and Immunogenicity of Genetically Modified Live-Attenuated Leishmania Parasite Vaccines.

Gannavaram S, Bhattacharya P, Dey R, Ismail N, Avishek K, Salotra P, Selvapandiyan A, Satoskar A, Nakhasi HL.

Methods Mol Biol. 2016;1403:623-38. doi: 10.1007/978-1-4939-3387-7_35.


Multiplex detection and identification of viral, bacterial, and protozoan pathogens in human blood and plasma using a high-density resequencing pathogen microarray platform.

Kourout M, Fisher C, Purkayastha A, Tibbetts C, Winkelman V, Williamson P, Nakhasi HL, Duncan R.

Transfusion. 2016 Jun;56(6 Pt 2):1537-47. doi: 10.1111/trf.13524. Epub 2016 Mar 2.


Standardized methods to generate mock (spiked) clinical specimens by spiking blood or plasma with cultured pathogens.

Dong M, Fisher C, Añez G, Rios M, Nakhasi HL, Hobson JP, Beanan M, Hockman D, Grigorenko E, Duncan R.

J Appl Microbiol. 2016 Apr;120(4):1119-29. doi: 10.1111/jam.13082. Epub 2016 Mar 7.


Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters.

Fiuza JA, Dey R, Davenport D, Abdeladhim M, Meneses C, Oliveira F, Kamhawi S, Valenzuela JG, Gannavaram S, Nakhasi HL.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004322. doi: 10.1371/journal.pntd.0004322. eCollection 2016 Jan.


TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection.

Allman WR, Dey R, Liu L, Siddiqui S, Coleman AS, Bhattacharya P, Yano M, Uslu K, Takeda K, Nakhasi HL, Akkoyunlu M.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4094-103. doi: 10.1073/pnas.1421580112. Epub 2015 Jul 13.


Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice.

Bhattacharya P, Dey R, Dagur PK, Kruhlak M, Ismail N, Debrabant A, Joshi AB, Akue A, Kukuruga M, Takeda K, Selvapandiyan A, McCoy JP Jr, Nakhasi HL.

Infect Immun. 2015 Oct;83(10):3800-15. doi: 10.1128/IAI.00184-15. Epub 2015 Jul 13.


Targeted Immunology for Prevention and Cure of VL.

Ali N, Nakhasi HL, Valenzuela JG, Reis AB.

Front Immunol. 2014 Dec 19;5:660. doi: 10.3389/fimmu.2014.00660. eCollection 2014. No abstract available.


Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum.

Fiuza JA, Gannavaram S, Santiago Hda C, Selvapandiyan A, Souza DM, Passos LS, de Mendonça LZ, Lemos-Giunchetti Dda S, Ricci ND, Bartholomeu DC, Giunchetti RC, Bueno LL, Correa-Oliveira R, Nakhasi HL, Fujiwara RT.

Vaccine. 2015 Jan 3;33(2):280-8. doi: 10.1016/j.vaccine.2014.11.039. Epub 2014 Dec 1.


Characterization of cross-protection by genetically modified live-attenuated Leishmania donovani parasites against Leishmania mexicana.

Dey R, Natarajan G, Bhattacharya P, Cummings H, Dagur PK, Terrazas C, Selvapandiyan A, McCoy JP Jr, Duncan R, Satoskar AR, Nakhasi HL.

J Immunol. 2014 Oct 1;193(7):3513-27. doi: 10.4049/jimmunol.1303145. Epub 2014 Aug 25.


Biomarkers of safety and immune protection for genetically modified live attenuated leishmania vaccines against visceral leishmaniasis - discovery and implications.

Gannavaram S, Dey R, Avishek K, Selvapandiyan A, Salotra P, Nakhasi HL.

Front Immunol. 2014 May 23;5:241. doi: 10.3389/fimmu.2014.00241. eCollection 2014. Review.


Generation of growth arrested Leishmania amastigotes: a tool to develop live attenuated vaccine candidates against visceral leishmaniasis.

Selvapandiyan A, Dey R, Gannavaram S, Solanki S, Salotra P, Nakhasi HL.

Vaccine. 2014 Jun 30;32(31):3895-901. doi: 10.1016/j.vaccine.2014.05.009. Epub 2014 May 14. Review.


Deletion of ubiquitin fold modifier protein Ufm1 processing peptidase Ufsp in L. donovani abolishes Ufm1 processing and alters pathogenesis.

Gannavaram S, Davey S, Lakhal-Naouar I, Duncan R, Nakhasi HL.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2707. doi: 10.1371/journal.pntd.0002707. eCollection 2014 Feb.


Multiplex screening for blood-borne viral, bacterial, and protozoan parasites using an OpenArray platform.

Grigorenko E, Fisher C, Patel S, Chancey C, Rios M, Nakhasi HL, Duncan RC.

J Mol Diagn. 2014 Jan;16(1):136-44. doi: 10.1016/j.jmoldx.2013.08.002. Epub 2013 Oct 30.


Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs.

Fiuza JA, Santiago Hda C, Selvapandiyan A, Gannavaram S, Ricci ND, Bueno LL, Bartholomeu DC, Correa-Oliveira R, Nakhasi HL, Fujiwara RT.

Vaccine. 2013 Apr 3;31(14):1785-92. doi: 10.1016/j.vaccine.2013.01.048. Epub 2013 Feb 8.


Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB/c mice.

Dey R, Dagur PK, Selvapandiyan A, McCoy JP, Salotra P, Duncan R, Nakhasi HL.

J Immunol. 2013 Mar 1;190(5):2138-49. doi: 10.4049/jimmunol.1202801. Epub 2013 Jan 21.


A new model of progressive visceral leishmaniasis in hamsters by natural transmission via bites of vector sand flies.

Aslan H, Dey R, Meneses C, Castrovinci P, Jeronimo SM, Oliva G, Fischer L, Duncan RC, Nakhasi HL, Valenzuela JG, Kamhawi S.

J Infect Dis. 2013 Apr 15;207(8):1328-38. doi: 10.1093/infdis/jis932. Epub 2013 Jan 3.


Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis.

Lakhal-Naouar I, Jardim A, Strasser R, Luo S, Kozakai Y, Nakhasi HL, Duncan RC.

PLoS Negl Trop Dis. 2012;6(10):e1849. doi: 10.1371/journal.pntd.0001849. Epub 2012 Oct 18.


Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma brucei.

Selvapandiyan A, Kumar P, Salisbury JL, Wang CC, Nakhasi HL.

PLoS One. 2012;7(9):e45288. doi: 10.1371/journal.pone.0045288. Epub 2012 Sep 21.


Development of an aptamer-based concentration method for the detection of Trypanosoma cruzi in blood.

Nagarkatti R, Bist V, Sun S, Fortes de Araujo F, Nakhasi HL, Debrabant A.

PLoS One. 2012;7(8):e43533. doi: 10.1371/journal.pone.0043533. Epub 2012 Aug 22.


Deletion of mitochondrial associated ubiquitin fold modifier protein Ufm1 in Leishmania donovani results in loss of β-oxidation of fatty acids and blocks cell division in the amastigote stage.

Gannavaram S, Connelly PS, Daniels MP, Duncan R, Salotra P, Nakhasi HL.

Mol Microbiol. 2012 Oct;86(1):187-98. doi: 10.1111/j.1365-2958.2012.08183.x. Epub 2012 Aug 16.


Identification and characterization of genes involved in leishmania pathogenesis: the potential for drug target selection.

Duncan R, Gannavaram S, Dey R, Debrabant A, Lakhal-Naouar I, Nakhasi HL.

Mol Biol Int. 2011;2011:428486. doi: 10.4061/2011/428486. Epub 2011 Jun 26.


Downregulation of mitogen-activated protein kinase 1 of Leishmania donovani field isolates is associated with antimony resistance.

Ashutosh, Garg M, Sundar S, Duncan R, Nakhasi HL, Goyal N.

Antimicrob Agents Chemother. 2012 Jan;56(1):518-25. doi: 10.1128/AAC.00736-11. Epub 2011 Nov 7.


Immunity to visceral leishmaniasis using genetically defined live-attenuated parasites.

Selvapandiyan A, Dey R, Gannavaram S, Lakhal-Naouar I, Duncan R, Salotra P, Nakhasi HL.

J Trop Med. 2012;2012:631460. doi: 10.1155/2012/631460. Epub 2011 Sep 6.


Mitochondrial associated ubiquitin fold modifier-1 mediated protein conjugation in Leishmania donovani.

Gannavaram S, Sharma P, Duncan RC, Salotra P, Nakhasi HL.

PLoS One. 2011 Jan 14;6(1):e16156. doi: 10.1371/journal.pone.0016156.


Multiple antigen peptide vaccines against Plasmodium falciparum malaria.

Mahajan B, Berzofsky JA, Boykins RA, Majam V, Zheng H, Chattopadhyay R, de la Vega P, Moch JK, Haynes JD, Belyakov IM, Nakhasi HL, Kumar S.

Infect Immun. 2010 Nov;78(11):4613-24. doi: 10.1128/IAI.00533-10. Epub 2010 Sep 7.


Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence.

Dey R, Meneses C, Salotra P, Kamhawi S, Nakhasi HL, Duncan R.

Mol Microbiol. 2010 Jul;77(2):399-414. doi: 10.1111/j.1365-2958.2010.07214.x. Epub 2010 May 24.


Overexpression of histone H2A modulates drug susceptibility in Leishmania parasites.

Singh R, Kumar D, Duncan RC, Nakhasi HL, Salotra P.

Int J Antimicrob Agents. 2010 Jul;36(1):50-7. doi: 10.1016/j.ijantimicag.2010.03.012. Epub 2010 Apr 27.


Comparative in vivo expression of amastigote up regulated Leishmania genes in three different forms of Leishmaniasis.

Sharma P, Gurumurthy S, Duncan R, Nakhasi HL, Salotra P.

Parasitol Int. 2010 Jun;59(2):262-4. doi: 10.1016/j.parint.2009.11.003. Epub 2009 Dec 4.


Transfusion-transmitted babesiosis in the United States: summary of a workshop.

Gubernot DM, Nakhasi HL, Mied PA, Asher DM, Epstein JS, Kumar S.

Transfusion. 2009 Dec;49(12):2759-71. doi: 10.1111/j.1537-2995.2009.02429.x. Epub 2009 Oct 10.


Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis.

Selvapandiyan A, Dey R, Nylen S, Duncan R, Sacks D, Nakhasi HL.

J Immunol. 2009 Aug 1;183(3):1813-20. doi: 10.4049/jimmunol.0900276. Epub 2009 Jul 10.


Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum.

Mahajan B, Selvapandiyan A, Gerald NJ, Majam V, Zheng H, Wickramarachchi T, Tiwari J, Fujioka H, Moch JK, Kumar N, Aravind L, Nakhasi HL, Kumar S.

J Biol Chem. 2008 Nov 14;283(46):31871-83. doi: 10.1074/jbc.M800028200. Epub 2008 Aug 8.

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