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Items: 1 to 50 of 320

1.

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment.

Takii R, Fujimoto M, Matsumoto M, Srivastava P, Katiyar A, Nakayama KI, Nakai A.

EMBO J. 2019 Oct 28:e102566. doi: 10.15252/embj.2019102566. [Epub ahead of print]

PMID:
31657478
2.

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases.

Honda H, Matsumoto M, Shijo M, Hamasaki H, Sadashima S, Suzuki SO, Aishima S, Kai K, Nakayama KI, Sasagasako N, Iwaki T.

J Neuropathol Exp Neurol. 2019 Oct 1;78(10):922-929. doi: 10.1093/jnen/nlz075.

PMID:
31504701
3.

A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients.

Shimizu H, Nakayama KI.

EBioMedicine. 2019 Aug;46:150-159. doi: 10.1016/j.ebiom.2019.07.046. Epub 2019 Jul 26.

4.

Potentials of C-C motif chemokine 2-C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents.

Yumimoto K, Sugiyama S, Mimori K, Nakayama KI.

Cancer Sci. 2019 Jul;110(7):2090-2099. doi: 10.1111/cas.14075. Epub 2019 Jun 10. Review.

5.

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.

Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI.

J Exp Med. 2019 Apr 1;216(4):950-965. doi: 10.1084/jem.20180900. Epub 2019 Mar 15.

6.

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation.

Sugiyama S, Yumimoto K, Inoue I, Nakayama KI.

Genes Cells. 2019 May;24(5):354-365. doi: 10.1111/gtc.12680. Epub 2019 Mar 20.

7.

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells.

Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI.

JCI Insight. 2019 Feb 21;4(4). pii: 125138. doi: 10.1172/jci.insight.125138. eCollection 2019 Feb 21.

8.

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825.

Shinkai Y, Koyasu S, Nakayama KI, Murphy KM, Loh DY, Reinherz EL, Alt FW.

J Immunol. 2019 Mar 1;202(5):1317-1320. No abstract available.

PMID:
30782850
9.

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.

Abe Y, Honsho M, Itoh R, Kawaguchi R, Fujitani M, Fujiwara K, Hirokane M, Matsuzaki T, Nakayama K, Ohgi R, Marutani T, Nakayama KI, Yamashita T, Fujiki Y.

Life Sci Alliance. 2018 Dec 3;1(6):e201800062. doi: 10.26508/lsa.201800062. eCollection 2018 Dec.

10.

Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches.

Hui K, Katayama Y, Nakayama KI, Nomura J, Sakurai T.

Neurosci Biobehav Rev. 2018 Nov 21. pii: S0149-7634(18)30121-0. doi: 10.1016/j.neubiorev.2018.08.001. [Epub ahead of print] Review.

PMID:
30470595
11.

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data.

Kawata K, Yugi K, Hatano A, Kokaji T, Tomizawa Y, Fujii M, Uda S, Kubota H, Matsumoto M, Nakayama KI, Kuroda S.

Genes Cells. 2019 Jan;24(1):82-93. doi: 10.1111/gtc.12655. Epub 2018 Dec 16.

12.

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16.

Hosokawa H, Romero-Wolf M, Yui MA, Ungerbäck J, Quiloan MLG, Matsumoto M, Nakayama KI, Tanaka T, Rothenberg EV.

Nat Immunol. 2018 Dec;19(12):1427-1440. doi: 10.1038/s41590-018-0238-4. Epub 2018 Oct 30.

13.

Brain-Derived Neurotrophic Factor Improves Limited Exercise Capacity in Mice With Heart Failure.

Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T.

Circulation. 2018 Oct 30;138(18):2064-2066. doi: 10.1161/CIRCULATIONAHA.118.035212. No abstract available.

PMID:
30372141
14.

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T, Rothenberg EV.

Immunity. 2018 Oct 16;49(4):782. doi: 10.1016/j.immuni.2018.09.019. No abstract available.

15.

A photochemical layer-by-layer solution process for preparing organic semiconducting thin films having the right material at the right place.

Suzuki M, Yamaguchi Y, Uchinaga K, Takahira K, Quinton C, Yamamoto S, Nagami N, Furukawa M, Nakayama KI, Yamada H.

Chem Sci. 2018 Jul 17;9(32):6614-6621. doi: 10.1039/c8sc01799a. eCollection 2018 Aug 28.

16.

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks.

Kawata K, Hatano A, Yugi K, Kubota H, Sano T, Fujii M, Tomizawa Y, Kokaji T, Tanaka KY, Uda S, Suzuki Y, Matsumoto M, Nakayama KI, Saitoh K, Kato K, Ueno A, Ohishi M, Hirayama A, Soga T, Kuroda S.

iScience. 2018 Sep 28;7:212-229. doi: 10.1016/j.isci.2018.07.022. Epub 2018 Sep 10.

17.

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

Watanabe S, Fujiyama H, Takafuji T, Kayama K, Matsumoto M, Nakayama KI, Yoshida K, Sugimoto N, Fujita M.

J Cell Sci. 2018 Aug 3;131(15). pii: jcs213009. doi: 10.1242/jcs.213009.

18.

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.

Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T, Rothenberg EV.

Immunity. 2018 Jun 19;48(6):1119-1134.e7. doi: 10.1016/j.immuni.2018.04.024. Erratum in: Immunity. 2018 Oct 16;49(4):782.

19.

Methylphenidate and Guanfacine Ameliorate ADHD-Like Phenotypes in Fez1-Deficient Mice.

Sumitomo A, Saka A, Ueta K, Horike K, Hirai K, Gamo NJ, Hikida T, Nakayama KI, Sawa A, Sakurai T, Tomoda T.

Mol Neuropsychiatry. 2018 May;3(4):223-233. doi: 10.1159/000488081. Epub 2018 Apr 26.

20.

Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1.

Nakatsumi H, Oka T, Higa T, Shirane M, Nakayama KI.

Genes Cells. 2018 Jul;23(7):599-605. doi: 10.1111/gtc.12597. Epub 2018 May 29.

21.

Impact of helical organization on the photovoltaic properties of oligothiophene supramolecular polymers.

Ouchi H, Kizaki T, Yamato M, Lin X, Hoshi N, Silly F, Kajitani T, Fukushima T, Nakayama KI, Yagai S.

Chem Sci. 2018 Mar 12;9(15):3638-3643. doi: 10.1039/c7sc05093c. eCollection 2018 Apr 21.

22.

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis.

Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, Ohkawa Y, Miyata K, Oike Y, Shirane M, Nishiyama M, Nakayama KI.

Cell Rep. 2018 May 15;23(7):1988-2000. doi: 10.1016/j.celrep.2018.04.050.

23.

TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.

Hashimoto Y, Shirane M, Nakayama KI.

Genes Cells. 2018 Jun;23(6):418-434. doi: 10.1111/gtc.12583. Epub 2018 Apr 27.

24.

Hidden Peptides Encoded by Putative Noncoding RNAs.

Matsumoto A, Nakayama KI.

Cell Struct Funct. 2018 May 18;43(1):75-83. doi: 10.1247/csf.18005. Epub 2018 Apr 11. Review.

25.

The promise of targeted proteomics for quantitative network biology.

Matsumoto M, Nakayama KI.

Curr Opin Biotechnol. 2018 Dec;54:88-97. doi: 10.1016/j.copbio.2018.02.014. Epub 2018 Mar 15. Review.

PMID:
29550704
26.

Correction for Matsunuma et al., "UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation To Regulate Cell Proliferation".

Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M.

Mol Cell Biol. 2018 Mar 15;38(7). pii: e00572-17. doi: 10.1128/MCB.00572-17. Print 2018 Apr 1. No abstract available.

27.

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.

Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.

Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004.

28.

Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.

Nakayama S, Yumimoto K, Kawamura A, Nakayama KI.

J Biol Chem. 2018 Apr 13;293(15):5705-5714. doi: 10.1074/jbc.RA117.000741. Epub 2018 Feb 22.

29.

Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis.

Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, Niida H, Suzuki S, Nakayama KI, Inui N, Suda T, Kitagawa M.

Int J Mol Sci. 2018 Feb 6;19(2). pii: E474. doi: 10.3390/ijms19020474.

30.

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.

Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Mimori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M.

Cancer Res. 2018 Mar 1;78(5):1334-1346. doi: 10.1158/0008-5472.CAN-17-3303. Epub 2017 Dec 27.

31.

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages.

Nakatsumi H, Matsumoto M, Nakayama KI.

Cell Rep. 2017 Nov 28;21(9):2471-2486. doi: 10.1016/j.celrep.2017.11.014.

32.

Structural basis for the assembly of the Ragulator-Rag GTPase complex.

Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M.

Nat Commun. 2017 Nov 20;8(1):1625. doi: 10.1038/s41467-017-01762-3.

33.

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.

Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H.

Mol Cell. 2017 Nov 16;68(4):645-658.e5. doi: 10.1016/j.molcel.2017.10.018.

34.

Sez6l2 regulates phosphorylation of ADD and neuritogenesis.

Yaguchi H, Yabe I, Takahashi H, Watanabe M, Nomura T, Kano T, Matsumoto M, Nakayama KI, Watanabe M, Hatakeyama S.

Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):234-241. doi: 10.1016/j.bbrc.2017.10.047. Epub 2017 Oct 12.

PMID:
29032200
35.

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders.

Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, Miyakawa T.

Neuropsychopharmacology. 2018 Feb;43(3):459-468. doi: 10.1038/npp.2017.167. Epub 2017 Aug 4.

36.

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.

Muto Y, Nishiyama M, Nita A, Moroishi T, Nakayama KI.

Nat Commun. 2017 Jul 17;8:16114. doi: 10.1038/ncomms16114.

37.

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.

Zhang S, Chen Q, Liu Q, Li Y, Sun X, Hong L, Ji S, Liu C, Geng J, Zhang W, Lu Z, Yin ZY, Zeng Y, Lin KH, Wu Q, Li Q, Nakayama K, Nakayama KI, Deng X, Johnson RL, Zhu L, Gao D, Chen L, Zhou D.

Cancer Cell. 2017 May 8;31(5):669-684.e7. doi: 10.1016/j.ccell.2017.04.004.

38.

A large-scale targeted proteomics assay resource based on an in vitro human proteome.

Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI.

Nat Methods. 2017 Mar;14(3):251-258. doi: 10.1038/nmeth.4116. Epub 2016 Dec 26.

PMID:
28267743
39.

High-fidelity self-assembly pathways for hydrogen-bonding molecular semiconductors.

Lin X, Suzuki M, Gushiken M, Yamauchi M, Karatsu T, Kizaki T, Tani Y, Nakayama KI, Suzuki M, Yamada H, Kajitani T, Fukushima T, Kikkawa Y, Yagai S.

Sci Rep. 2017 Feb 22;7:43098. doi: 10.1038/srep43098.

40.

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.

Ohnishi T, Shirane M, Nakayama KI.

Sci Rep. 2017 Jan 20;7:41130. doi: 10.1038/srep41130.

41.

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.

Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00470-16. doi: 10.1128/MCB.00470-16. Print 2017 Apr 15.

42.

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.

43.

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto A, Pasut A, Matsumoto M, Yamashita R, Fung J, Monteleone E, Saghatelian A, Nakayama KI, Clohessy JG, Pandolfi PP.

Nature. 2017 Jan 12;541(7636):228-232. doi: 10.1038/nature21034. Epub 2016 Dec 26.

PMID:
28024296
44.

GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.

Kayama K, Watanabe S, Takafuji T, Tsuji T, Hironaka K, Matsumoto M, Nakayama KI, Enari M, Kohno T, Shiraishi K, Kiyono T, Yoshida K, Sugimoto N, Fujita M.

EMBO Rep. 2017 Jan;18(1):123-137. doi: 10.15252/embr.201642444. Epub 2016 Nov 17.

45.

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors.

Kitade S, Onoyama I, Kobayashi H, Yagi H, Yoshida S, Kato M, Tsunematsu R, Asanoma K, Sonoda K, Wake N, Hata K, Nakayama KI, Kato K.

Cancer Sci. 2016 Oct;107(10):1399-1405. doi: 10.1111/cas.13026. Epub 2016 Sep 24.

46.

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.

Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S.

J Mol Cell Cardiol. 2016 Nov;100:43-53. doi: 10.1016/j.yjmcc.2016.09.013. Epub 2016 Sep 25.

47.

CHD8 haploinsufficiency results in autistic-like phenotypes in mice.

Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI.

Nature. 2016 Sep 29;537(7622):675-679. doi: 10.1038/nature19357. Epub 2016 Sep 7.

PMID:
27602517
48.

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling.

Hatano A, Matsumoto M, Nakayama KI.

Genes Cells. 2016 Oct;21(10):1095-1112. doi: 10.1111/gtc.12406. Epub 2016 Sep 7.

49.

Induction of Glycosphingolipid GM3 Expression by Valproic Acid Suppresses Cancer Cell Growth.

Kawashima N, Nishimiya Y, Takahata S, Nakayama KI.

J Biol Chem. 2016 Oct 7;291(41):21424-21433. Epub 2016 Aug 18.

50.

Development of N- and O-linked oligosaccharide engineered Saccharomyces cerevisiae strain.

Abe H, Tomimoto K, Fujita Y, Iwaki T, Chiba Y, Nakayama KI, Nakajima Y.

Glycobiology. 2016 Nov;26(11):1248-1256. doi: 10.1093/glycob/cww071. Epub 2016 Jul 12.

PMID:
27496768

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