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Items: 1 to 50 of 3253

1.

Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies.

Kita Y, Hamada A, Saito R, Teramoto Y, Tanaka R, Takano K, Nakayama K, Murakami K, Matsumoto K, Akamatsu S, Yamasaki T, Inoue T, Tabata Y, Okuno Y, Ogawa O, Kobayashi T.

Br J Cancer. 2019 Nov 1. doi: 10.1038/s41416-019-0609-0. [Epub ahead of print]

PMID:
31673101
2.

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment.

Takii R, Fujimoto M, Matsumoto M, Srivastava P, Katiyar A, Nakayama KI, Nakai A.

EMBO J. 2019 Oct 28:e102566. doi: 10.15252/embj.2019102566. [Epub ahead of print]

PMID:
31657478
3.

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with In Vivo Anti-Tumor Activity.

Kawai J, Toki T, Ota M, Inoue H, Takata Y, Asahi T, Suzuki M, Shimada T, Ono K, Suzuki K, Takaishi S, Ohki H, Matsui S, Tsutsumi S, Hirota Y, Nakayama K.

J Med Chem. 2019 Oct 22. doi: 10.1021/acs.jmedchem.9b01113. [Epub ahead of print]

PMID:
31638799
5.

Relationship between Microsatellite Instability, Immune Cells Infiltration, and Expression of Immune Checkpoint Molecules in Ovarian Carcinoma: Immunotherapeutic Strategies for the Future.

Yamashita H, Nakayama K, Ishikawa M, Ishibashi T, Nakamura K, Sawada K, Yoshimura Y, Tatsumi N, Kurose S, Minamoto T, Iida K, Razia S, Ishikawa N, Kyo S.

Int J Mol Sci. 2019 Oct 16;20(20). pii: E5129. doi: 10.3390/ijms20205129.

6.

Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis.

Numata T, Nakayama K, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Minagawa S, Ishikawa T, Hara H, Araya J, Kuwano K.

BMC Pulm Med. 2019 Oct 12;19(1):176. doi: 10.1186/s12890-019-0952-1.

7.

Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression.

Eguchi K, Nakayama K.

Biochem Biophys Res Commun. 2019 Nov 26;520(1):128-135. doi: 10.1016/j.bbrc.2019.09.109. Epub 2019 Sep 30.

PMID:
31582221
8.

Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1.

Kuriki R, Hata T, Nakayama K, Ito Y, Misawa K, Ito S, Tatematsu M, Kaneda N.

Nagoya J Med Sci. 2019 Aug;81(3):415-425. doi: 10.18999/nagjms.81.3.415.

9.

Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.

Yu Y, Nakagawa T, Morohoshi A, Nakagawa M, Ishida N, Suzuki N, Aoki M, Nakayama K.

Hum Mol Genet. 2019 Sep 30. pii: ddz119. doi: 10.1093/hmg/ddz119. [Epub ahead of print]

PMID:
31577344
10.

ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.

Tone T, Nakayama K, Takatsu H, Shin HW.

FEBS Lett. 2019 Sep 30. doi: 10.1002/1873-3468.13629. [Epub ahead of print]

PMID:
31571211
11.

PTPN3 expressed in activated T lymphocytes is a candidate for a non-antibody-type immune checkpoint inhibitor.

Fujimura A, Nakayama K, Imaizumi A, Kawamoto M, Oyama Y, Ichimiya S, Umebayashi M, Koya N, Morisaki T, Nakagawa T, Onishi H.

Cancer Immunol Immunother. 2019 Sep 27. doi: 10.1007/s00262-019-02403-y. [Epub ahead of print]

PMID:
31562536
12.

Nylon mesh cryodevice for bovine mature oocytes, easily removable excess vitrification solution.

Chinen S, Yamanaka T, Nakayama K, Watanabe H, Akiyama Y, Hirabayashi M, Hochi S.

Cryobiology. 2019 Oct;90:96-99. doi: 10.1016/j.cryobiol.2019.09.010. Epub 2019 Sep 21.

PMID:
31550455
13.

Increase of body mass index is a useful predictor of childhood obesity.

Ichikawa G, Arisaka O, Nakayama K, Koyama S, Yoshihara S.

J Pediatr. 2019 Sep 18. pii: S0022-3476(19)30995-3. doi: 10.1016/j.jpeds.2019.08.011. [Epub ahead of print] No abstract available.

PMID:
31542155
14.

Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis.

Tsubouchi K, Araya J, Yoshida M, Sakamoto T, Koumura T, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Kurita Y, Kobayashi K, Ito S, Fujita Y, Utsumi H, Hashimoto M, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Matsudaira H, Ohtsuka T, Nakayama K, Nakanishi Y, Imai H, Kuwano K.

J Immunol. 2019 Oct 15;203(8):2076-2087. doi: 10.4049/jimmunol.1801232. Epub 2019 Sep 18.

PMID:
31534007
15.

Erratum: Author Correction: Bcl11b controls odorant receptor class choice in mice.

Enomoto T, Nishida H, Iwata T, Fujita A, Nakayama K, Kashiwagi T, Hatanaka Y, Kondo H, Kajitani R, Itoh T, Ohmoto M, Matsumoto I, Hirota J.

Commun Biol. 2019 Sep 12;2:343. doi: 10.1038/s42003-019-0592-2. eCollection 2019.

16.

Japanese adaptation of the Bad Sobernheim Stress Questionnaire-Brace for patients with adolescent idiopathic scoliosis.

Asada T, Kotani T, Nakayama K, Sasaki T, Fujii K, Sunami T, Sakuma T, Iijima Y, Akazawa T, Minami S, Ohtori S, Koda M, Yamazaki M.

J Orthop Sci. 2019 Nov;24(6):1010-1014. doi: 10.1016/j.jos.2019.08.003. Epub 2019 Sep 10.

PMID:
31515118
17.

Correction: Synergistic anti-AML effects of the LSD1 inhibitor T-3775440 and the NEDD8-activating enzyme inhibitor pevonedistat via transdifferentiation and DNA rereplication.

Ishikawa Y, Nakayama K, Morimoto M, Mizutani A, Nakayama A, Toyoshima K, Hayashi A, Takagi S, Dairiki R, Miyashita H, Matsumoto S, Gamo K, Nomura T, Nakamura K.

Oncogenesis. 2019 Sep 11;8(9):51. doi: 10.1038/s41389-019-0160-0.

18.

Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis.

Ozeki M, Aoki Y, Nozawa A, Yasue S, Endo S, Hori Y, Matsuoka K, Niihori T, Funayama R, Shirota M, Nakayama K, Fukao T.

Orphanet J Rare Dis. 2019 Sep 11;14(1):215. doi: 10.1186/s13023-019-1191-5.

19.

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases.

Honda H, Matsumoto M, Shijo M, Hamasaki H, Sadashima S, Suzuki SO, Aishima S, Kai K, Nakayama KI, Sasagasako N, Iwaki T.

J Neuropathol Exp Neurol. 2019 Oct 1;78(10):922-929. doi: 10.1093/jnen/nlz075.

PMID:
31504701
20.

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective.

Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, Sugawara J, Tamiya G, Hozawa A, Nakaya N, Tsuchiya N, Nakamura T, Narita A, Kogure M, Hirata T, Tsuji I, Nagami F, Fuse N, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Suzuki Y, Osumi N, Nakayama K, Ito K, Egawa S, Chida K, Kodama E, Kiyomoto H, Ishii T, Tsuboi A, Tomita H, Taki Y, Kawame H, Suzuki K, Ishii N, Ogishima S, Mizuno S, Takai-Igarashi T, Minegishi N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Tanabe O, Koshiba S, Hashizume H, Motohashi H, Tominaga T, Ito S, Tanno K, Sakata K, Shimizu A, Hitomi J, Sasaki M, Kinoshita K, Tanaka H, Kobayashi T, Kure S, Yaegashi N, Yamamoto M; Tohoku Medical Megabank Project Study Group .

Int J Epidemiol. 2019 Aug 25. pii: dyz169. doi: 10.1093/ije/dyz169. [Epub ahead of print] No abstract available.

PMID:
31504573
21.

Pleural Fluid Eosinophilia: A Possible Adverse Event of Interleukin-17 Inhibition.

Hayashi W, Osada SI, Toyoshima A, Yamada K, Sudo K, Nakayama K, Manabe M.

Acta Derm Venereol. 2019 Sep 10. doi: 10.2340/00015555-3311. [Epub ahead of print] No abstract available.

22.

Shiga toxin 2eB-transgenic lettuce vaccine is effective in protecting weaned piglets from edema disease caused by Shiga toxin-producing Escherichia coli infection.

Hamabata T, Sato T, Takita E, Matsui T, Imaoka T, Nakanishi N, Nakayama K, Tsukahara T, Sawada K.

Anim Sci J. 2019 Nov;90(11):1460-1467. doi: 10.1111/asj.13292. Epub 2019 Sep 10.

PMID:
31502390
23.

Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.

Nozaki S, Castro Araya RF, Katoh Y, Nakayama K.

Biol Open. 2019 Sep 17;8(9). pii: bio043786. doi: 10.1242/bio.043786.

24.

Cancer-associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer.

Aizawa T, Karasawa H, Funayama R, Shirota M, Suzuki T, Maeda S, Suzuki H, Yamamura A, Naitoh T, Nakayama K, Unno M.

Cancer Med. 2019 Oct;8(14):6370-6382. doi: 10.1002/cam4.2523. Epub 2019 Aug 29.

25.

Assessment of distributed hydrological model performance for simulation of multi-heavy-metal transport in Harrach River, Algeria.

Bouragba S, Komai K, Nakayama K.

Water Sci Technol. 2019 Jul;80(1):11-24. doi: 10.2166/wst.2019.250.

PMID:
31461418
26.

Rapid Progression of Scoliosis Requiring Re-Instrumentation after Implant Removal Due to Infection Following Posterior Spinal Fusion and Instrumentation.

Nakayama K, Kotani T, Sakuma T, Kishida S, Muramatsu Y, Sasaki Y, Ueno K, Iijima Y, Akazawa T, Yamazaki M, Minami S.

Spine Surg Relat Res. 2018 Oct 19;3(1):102-105. doi: 10.22603/ssrr.2018-0039. eCollection 2019 Jan 25. No abstract available.

27.

Enhancement of swallowing motor activity by the ACE inhibitor imidapril in an arterially perfused rat preparation.

Moriya T, Nakayama K, Nakamura S, Mochizuki A, Ofuji T, Shirota T, Inoue T.

Eur J Pharmacol. 2019 Oct 15;861:172601. doi: 10.1016/j.ejphar.2019.172601. Epub 2019 Aug 14.

PMID:
31421086
28.

Data processing on a comparative evaluation of the extraction and analysis procedures for urinary phospholipid and lysophospholipid using MALDI-TOF/MS.

Li X, Nakayama K, Goto T, Akamatsu S, Shimizu K, Ogawa O, Inoue T.

Data Brief. 2019 Jul 15;25:104275. doi: 10.1016/j.dib.2019.104275. eCollection 2019 Aug.

29.

Clinicopathological and biological analysis of PIK3CA mutation and amplification in cervical carcinomas.

Razia S, Nakayama K, Nakamura K, Ishibashi T, Ishikawa M, Minamoto T, Iida K, Otsuki Y, Nakayama S, Ishikawa N, Kyo S.

Exp Ther Med. 2019 Sep;18(3):2278-2284. doi: 10.3892/etm.2019.7771. Epub 2019 Jul 12.

30.

Bcl11b controls odorant receptor class choice in mice.

Enomoto T, Nishida H, Iwata T, Fujita A, Nakayama K, Kashiwagi T, Hatanaka Y, Kondo H, Kajitani R, Itoh T, Ohmoto M, Matsumoto I, Hirota J.

Commun Biol. 2019 Aug 7;2:296. doi: 10.1038/s42003-019-0536-x. eCollection 2019. Erratum in: Commun Biol. 2019 Sep 12;2:343.

31.

Publisher Correction: Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes.

Itoh M, Mukae Y, Kitsuka T, Arai K, Nakamura A, Uchihashi K, Toda S, Matsubayashi K, Oyama JI, Node K, Kami D, Gojo S, Morita S, Nishida T, Nakayama K, Kobayashi E.

Nat Commun. 2019 Aug 6;10(1):3625. doi: 10.1038/s41467-019-11555-5.

32.

The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.

Takayama M, Takatsu H, Hamamoto A, Inoue H, Naito T, Nakayama K, Shin HW.

J Cell Sci. 2019 Sep 2;132(17). pii: jcs231720. doi: 10.1242/jcs.231720.

PMID:
31371488
33.

Dedifferentiated Endometrial Carcinoma Could be A Target for Immune Checkpoint Inhibitors (Anti PD-1/PD-L1 Antibodies).

Ono R, Nakayama K, Nakamura K, Yamashita H, Ishibashi T, Ishikawa M, Minamoto T, Razia S, Ishikawa N, Otsuki Y, Nakayama S, Onuma H, Kurioka H, Kyo S.

Int J Mol Sci. 2019 Jul 31;20(15). pii: E3744. doi: 10.3390/ijms20153744.

34.

A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients.

Shimizu H, Nakayama KI.

EBioMedicine. 2019 Aug;46:150-159. doi: 10.1016/j.ebiom.2019.07.046. Epub 2019 Jul 26.

35.

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.

Yoshida M, Minagawa S, Araya J, Sakamoto T, Hara H, Tsubouchi K, Hosaka Y, Ichikawa A, Saito N, Kadota T, Sato N, Kurita Y, Kobayashi K, Ito S, Utsumi H, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Iwamoto T, Imai H, Kuwano K.

Nat Commun. 2019 Jul 17;10(1):3145. doi: 10.1038/s41467-019-10991-7.

36.

Genetic variants influencing obesity-related traits in Japanese population.

Nakayama K, Inaba Y.

Ann Hum Biol. 2019 Jun;46(4):298-304. doi: 10.1080/03014460.2019.1644373. Epub 2019 Aug 9.

PMID:
31307227
37.

2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids.

Kitsuka T, Itoh M, Amamoto S, Arai KI, Oyama J, Node K, Toda S, Morita S, Nishida T, Nakayama K.

PLoS One. 2019 Jul 11;14(7):e0213114. doi: 10.1371/journal.pone.0213114. eCollection 2019.

38.

Transition-Metal Distribution in Brownmillerite Ca2FeCoO5.

Nakayama K, Ishikawa R, Kuwabara A, Kobayashi S, Motohashi T, Shibata N, Ikuhara Y.

Inorg Chem. 2019 Aug 5;58(15):10209-10216. doi: 10.1021/acs.inorgchem.9b01356. Epub 2019 Jul 11.

PMID:
31294550
39.

Advanced monoenergetic reconstruction technique in dual-energy computed tomography for evaluation of vascular anatomy before adrenal vein sampling.

Nakayama K, Shimohira M, Nakagawa M, Ozawa Y, Sawada Y, Ohta K, Ohashi K, Shibamoto Y.

Acta Radiol. 2019 Jul 7:284185119860226. doi: 10.1177/0284185119860226. [Epub ahead of print] No abstract available.

PMID:
31280588
40.

Regulation of Gene Expression under Hypoxic Conditions.

Nakayama K, Kataoka N.

Int J Mol Sci. 2019 Jul 3;20(13). pii: E3278. doi: 10.3390/ijms20133278. Review.

41.

Additional validation of Osaka method (0.01 mol/L dithiothreitol) for negating the daratumumab interference.

Hosokawa M, Kashiwagi H, Nakayama K, Sakuragi M, Nakao M, Morikawa T, Kiyokawa T, Aochi H, Nagamine K, Shibayama H, Tomiyama Y.

Transfusion. 2019 Jul;59(7):2479-2480. doi: 10.1111/trf.15305. No abstract available.

PMID:
31268593
42.

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.

Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M.

EBioMedicine. 2019 Jul;45:362-378. doi: 10.1016/j.ebiom.2019.06.013. Epub 2019 Jun 29.

43.

Comparative evaluation of the extraction and analysis of urinary phospholipids and lysophospholipids using MALDI-TOF/MS.

Li X, Nakayama K, Goto T, Akamatsu S, Shimizu K, Ogawa O, Inoue T.

Chem Phys Lipids. 2019 Sep;223:104787. doi: 10.1016/j.chemphyslip.2019.104787. Epub 2019 Jun 27.

PMID:
31255592
44.

Patients majoring in a healthcare field after scoliosis surgery: Comparison with the national census in Japan.

Kotani T, Sakuma T, Nakayama K, Iijima Y, Watanabe K, Isogai N, Akazawa T, Sato K, Asada T, Kishida S, Muramatsu Y, Sasaki Y, Ueno K, Katogi T, Minami S, Inage K, Shiga Y, Ohtori S.

J Orthop Sci. 2019 Jun 25. pii: S0949-2658(19)30183-6. doi: 10.1016/j.jos.2019.06.002. [Epub ahead of print]

PMID:
31253389
45.

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.

Kawai J, Ota M, Ohki H, Toki T, Suzuki M, Shimada T, Matsui S, Inoue H, Sugihara C, Matsuhashi N, Matsui Y, Takaishi S, Nakayama K.

ACS Med Chem Lett. 2019 May 24;10(6):893-898. doi: 10.1021/acsmedchemlett.9b00069. eCollection 2019 Jun 13.

PMID:
31223444
46.

Voter model on networks and the multivariate beta distribution.

Mori S, Hisakado M, Nakayama K.

Phys Rev E. 2019 May;99(5-1):052307. doi: 10.1103/PhysRevE.99.052307.

PMID:
31212470
47.

Histological evaluation of tendon formation using a scaffold-free three-dimensional-bioprinted construct of human dermal fibroblasts under in vitro static tensile culture.

Nakanishi Y, Okada T, Takeuchi N, Kozono N, Senju T, Nakayama K, Nakashima Y.

Regen Ther. 2019 May 10;11:47-55. doi: 10.1016/j.reth.2019.02.002. eCollection 2019 Dec.

48.

The Efficacy of a Scaffold-free Bio 3D Conduit Developed from Autologous Dermal Fibroblasts on Peripheral Nerve Regeneration in a Canine Ulnar Nerve Injury Model: A Preclinical Proof-of-Concept Study.

Mitsuzawa S, Ikeguchi R, Aoyama T, Takeuchi H, Yurie H, Oda H, Ohta S, Ushimaru M, Ito T, Tanaka M, Kunitomi Y, Tsuji M, Akieda S, Nakayama K, Matsuda S.

Cell Transplant. 2019 Sep-Oct;28(9-10):1231-1241. doi: 10.1177/0963689719855346. Epub 2019 Jun 12.

49.

Germline-Activating RRAS2 Mutations Cause Noonan Syndrome.

Niihori T, Nagai K, Fujita A, Ohashi H, Okamoto N, Okada S, Harada A, Kihara H, Arbogast T, Funayama R, Shirota M, Nakayama K, Abe T, Inoue SI, Tsai IC, Matsumoto N, Davis EE, Katsanis N, Aoki Y.

Am J Hum Genet. 2019 Jun 6;104(6):1233-1240. doi: 10.1016/j.ajhg.2019.04.014. Epub 2019 May 23.

PMID:
31130285
50.

Development of an immunodeficient pig model allowing long-term accommodation of artificial human vascular tubes.

Itoh M, Mukae Y, Kitsuka T, Arai K, Nakamura A, Uchihashi K, Toda S, Matsubayashi K, Oyama JI, Node K, Kami D, Gojo S, Morita S, Nishida T, Nakayama K, Kobayashi E.

Nat Commun. 2019 May 21;10(1):2244. doi: 10.1038/s41467-019-10107-1. Erratum in: Nat Commun. 2019 Aug 6;10(1):3625.

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