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Items: 1 to 50 of 489

1.

Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds.

Kawata M, Mori D, Kanke K, Hojo H, Ohba S, Chung UI, Yano F, Masaki H, Otsu M, Nakauchi H, Tanaka S, Saito T.

Stem Cell Reports. 2019 Sep 10;13(3):530-544. doi: 10.1016/j.stemcr.2019.07.012. Epub 2019 Aug 8.

2.

Using the Inducible Caspase-9 Suicide-Safeguard System with iPSC and Bioluminescent Tracking.

Villanueva J, Nishimura T, Nakauchi H.

Methods Mol Biol. 2019;2048:259-264. doi: 10.1007/978-1-4939-9728-2_20.

PMID:
31396943
3.

Human iPSC Generation from Antigen-Specific T Cells.

Nishimura T, Murmann Y, Nakauchi H.

Methods Mol Biol. 2019;2048:53-57. doi: 10.1007/978-1-4939-9728-2_5.

PMID:
31396928
4.

Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes.

Ghosn E, Yoshimoto M, Nakauchi H, Weissman IL, Herzenberg LA.

Development. 2019 Aug 1;146(15). pii: dev170571. doi: 10.1242/dev.170571. Review.

PMID:
31371526
5.

Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.

Segal JM, Kent D, Wesche DJ, Ng SS, Serra M, Oulès B, Kar G, Emerton G, Blackford SJI, Darmanis S, Miquel R, Luong TV, Yamamoto R, Bonham A, Jassem W, Heaton N, Vigilante A, King A, Sancho R, Teichmann S, Quake SR, Nakauchi H, Rashid ST.

Nat Commun. 2019 Jul 26;10(1):3350. doi: 10.1038/s41467-019-11266-x.

6.

Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.

Haematologica. 2019 Jul 11. pii: haematol.2019.223511. doi: 10.3324/haematol.2019.223511. [Epub ahead of print]

7.

Author Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S.

Nature. 2019 Jul;571(7766):E12. doi: 10.1038/s41586-019-1395-9.

PMID:
31289376
8.

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Wilkinson AC, Ishida R, Kikuchi M, Sudo K, Morita M, Crisostomo RV, Yamamoto R, Loh KM, Nakamura Y, Watanabe M, Nakauchi H, Yamazaki S.

Nature. 2019 Jul;571(7763):117-121. doi: 10.1038/s41586-019-1244-x. Epub 2019 May 29. Erratum in: Nature. 2019 Jul;571(7766):E12.

PMID:
31142833
9.

Anephrogenic phenotype induced by SALL1 gene knockout in pigs.

Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H.

Sci Rep. 2019 May 29;9(1):8016. doi: 10.1038/s41598-019-44387-w.

10.

Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination.

Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, Laustsen A, Lesch BJ, Jakobsen MR, Sebastiano V, Nakauchi H, Porteus MH.

Cell Stem Cell. 2019 May 2;24(5):821-828.e5. doi: 10.1016/j.stem.2019.04.001.

PMID:
31051134
11.

Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium.

Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M.

J Hepatol. 2019 Jul;71(1):143-152. doi: 10.1016/j.jhep.2019.02.024. Epub 2019 Mar 19.

PMID:
30898581
12.

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.

Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M.

Sci Rep. 2019 Feb 14;9(1):2072. doi: 10.1038/s41598-018-37430-9.

13.

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.

Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M.

Nat Commun. 2019 Feb 5;10(1):451. doi: 10.1038/s41467-019-08394-9.

14.

Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells.

Nishimura T, Nakauchi H.

Methods Mol Biol. 2019;1899:25-40. doi: 10.1007/978-1-4939-8938-6_3.

PMID:
30649763
15.

Efficient scarless genome editing in human pluripotent stem cells.

Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH.

Nat Methods. 2018 Dec;15(12):1045-1047. doi: 10.1038/s41592-018-0212-y. Epub 2018 Nov 30.

PMID:
30504872
16.

Changing concepts in hematopoietic stem cells.

Yamamoto R, Wilkinson AC, Nakauchi H.

Science. 2018 Nov 23;362(6417):895-896. doi: 10.1126/science.aat7873. No abstract available.

PMID:
30467158
17.

Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector.

Mizuno N, Mizutani E, Sato H, Kasai M, Ogawa A, Suchy F, Yamaguchi T, Nakauchi H.

iScience. 2018 Nov 30;9:286-297. doi: 10.1016/j.isci.2018.10.030. Epub 2018 Nov 2.

18.

Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.

van Galen P, Mbong N, Kreso A, Schoof EM, Wagenblast E, Ng SWK, Krivdova G, Jin L, Nakauchi H, Dick JE.

Cell Rep. 2018 Oct 30;25(5):1109-1117.e5. doi: 10.1016/j.celrep.2018.10.021.

19.

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate.

Taoka K, Arai S, Kataoka K, Hosoi M, Miyauchi M, Yamazaki S, Honda A, Aixinjueluo W, Kobayashi T, Kumano K, Yoshimi A, Otsu M, Niwa A, Nakahata T, Nakauchi H, Kurokawa M.

Sci Rep. 2018 Oct 26;8(1):15855. doi: 10.1038/s41598-018-34193-1.

20.

An interspecies barrier to tetraploid complementation and chimera formation.

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H.

Sci Rep. 2018 Oct 16;8(1):15289. doi: 10.1038/s41598-018-33690-7.

21.

Mosaicism diminishes the value of pre-implantation embryo biopsies for detecting CRISPR/Cas9 induced mutations in sheep.

Vilarino M, Suchy FP, Rashid ST, Lindsay H, Reyes J, McNabb BR, van der Meulen T, Huising MO, Nakauchi H, Ross PJ.

Transgenic Res. 2018 Dec;27(6):525-537. doi: 10.1007/s11248-018-0094-x. Epub 2018 Oct 3.

PMID:
30284144
22.

Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.

Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.

Stem Cell Reports. 2018 Oct 9;11(4):988-997. doi: 10.1016/j.stemcr.2018.08.015. Epub 2018 Sep 20.

23.

Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold.

Ng SS, Saeb-Parsy K, Blackford SJI, Segal JM, Serra MP, Horcas-Lopez M, No DY, Mastoridis S, Jassem W, Frank CW, Cho NJ, Nakauchi H, Glenn JS, Rashid ST.

Biomaterials. 2018 Nov;182:299-311. doi: 10.1016/j.biomaterials.2018.07.043. Epub 2018 Jul 27.

24.

Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA.

Higaki K, Hirao M, Kawana-Tachikawa A, Iriguchi S, Kumagai A, Ueda N, Bo W, Kamibayashi S, Watanabe A, Nakauchi H, Suzuki K, Kaneko S.

Mol Ther Nucleic Acids. 2018 Sep 7;12:793-804. doi: 10.1016/j.omtn.2018.07.017. Epub 2018 Aug 4.

25.

[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].

Ando M, Nakauchi H, Komatsu N.

Rinsho Ketsueki. 2018;59(7):932-938. doi: 10.11406/rinketsu.59.932. Japanese.

PMID:
30078805
26.

Chimeric liver transplantation reveals interspecific graft remodelling.

Oldani G, Peloso A, Vijgen S, Wilson EM, Slits F, Gex Q, Morel P, Delaune V, Orci LA, Yamaguchi T, Kobayashi T, Rubbia-Brandt L, Nakauchi H, Lacotte S, Toso C.

J Hepatol. 2018 Nov;69(5):1025-1036. doi: 10.1016/j.jhep.2018.07.008. Epub 2018 Jul 20.

PMID:
30031887
27.

Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

Ishizuka S, Lai CY, Otsu M, Nakauchi H, Nagamune T, Kawahara M.

ACS Synth Biol. 2018 Jul 20;7(7):1709-1714. doi: 10.1021/acssynbio.8b00163. Epub 2018 Jun 21.

PMID:
29920201
28.

Author Correction: Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.

Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.

Sci Rep. 2018 Jun 7;8(1):8946. doi: 10.1038/s41598-018-27041-9.

29.

Interspecies chimeras.

Suchy F, Nakauchi H.

Curr Opin Genet Dev. 2018 Oct;52:36-41. doi: 10.1016/j.gde.2018.05.007. Epub 2018 May 30. Review.

PMID:
29859382
30.

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.

Cell Stem Cell. 2018 May 3;22(5):713-725.e8. doi: 10.1016/j.stem.2018.04.002. Epub 2018 Apr 26.

31.

Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.

Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.

Exp Hematol. 2018 Jul;63:12-16.e1. doi: 10.1016/j.exphem.2018.04.004. Epub 2018 Apr 26.

32.

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.

Cell Stem Cell. 2018 Apr 5;22(4):600-607.e4. doi: 10.1016/j.stem.2018.03.013.

33.

In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects.

Yoshida A, Lee JK, Tomoyama S, Miwa K, Shirakawa K, Hamanaka S, Yamaguchi T, Nakauchi H, Miyagawa S, Sawa Y, Komuro I, Sakata Y.

Europace. 2018 Sep 1;20(9):1553-1560. doi: 10.1093/europace/eux379.

PMID:
29554331
34.

Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications.

Ong J, Serra MP, Segal J, Cujba AM, Ng SS, Butler R, Millar V, Hatch S, Zimri S, Koike H, Chan K, Bonham A, Walk M, Voss T, Heaton N, Mitry R, Dhawan A, Ebner D, Danovi D, Nakauchi H, Rashid ST.

Stem Cell Reports. 2018 Mar 13;10(3):693-702. doi: 10.1016/j.stemcr.2018.01.025. Epub 2018 Mar 1.

35.

Modeling lethal X-linked genetic disorders in pigs with ensured fertility.

Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakauchi H, Nagashima H.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):708-713. doi: 10.1073/pnas.1715940115. Epub 2018 Jan 8.

36.

iPSC-Derived Organs In Vivo: Challenges and Promise.

Suchy F, Yamaguchi T, Nakauchi H.

Cell Stem Cell. 2018 Jan 4;22(1):21-24. doi: 10.1016/j.stem.2017.12.003.

37.

Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells.

Aihara A, Koike T, Abe N, Nakamura S, Sawaguchi A, Nakamura T, Sugimoto N, Nakauchi H, Nishino T, Eto K.

Blood Adv. 2017 Feb 28;1(7):468-476. doi: 10.1182/bloodadvances.2016000844. eCollection 2017 Feb 28.

38.

CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep.

Vilarino M, Rashid ST, Suchy FP, McNabb BR, van der Meulen T, Fine EJ, Ahsan S, Mursaliyev N, Sebastiano V, Diab SS, Huising MO, Nakauchi H, Ross PJ.

Sci Rep. 2017 Dec 12;7(1):17472. doi: 10.1038/s41598-017-17805-0.

39.

Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.

Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S.

Blood. 2018 Feb 8;131(6):621-635. doi: 10.1182/blood-2017-01-762393. Epub 2017 Nov 16.

40.

Mammalian Transcription Factor Networks: Recent Advances in Interrogating Biological Complexity.

Wilkinson AC, Nakauchi H, Göttgens B.

Cell Syst. 2017 Oct 25;5(4):319-331. doi: 10.1016/j.cels.2017.07.004. Review.

41.

Establishment of mouse expanded potential stem cells.

Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P.

Nature. 2017 Oct 19;550(7676):393-397. doi: 10.1038/nature24052. Epub 2017 Oct 11.

42.

A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.

Ren Y, Sekine-Kondo E, Shibata R, Kato-Itoh M, Umino A, Yanagida A, Satoh M, Inoue K, Yamaguchi T, Mochida K, Nakae S, Van Kaer L, Iwabuchi K, Nakauchi H, Watarai H.

Sci Rep. 2017 Oct 6;7(1):12765. doi: 10.1038/s41598-017-12475-4.

43.

Dissection of Signaling Events Downstream of the c-Mpl Receptor in Murine Hematopoietic Stem Cells Via Motif-Engineered Chimeric Receptors.

Saka K, Lai CY, Nojima M, Kawahara M, Otsu M, Nakauchi H, Nagamune T.

Stem Cell Rev Rep. 2018 Feb;14(1):101-109. doi: 10.1007/s12015-017-9768-7.

44.

In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.

Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.

Stem Cell Reports. 2017 Oct 10;9(4):1024-1033. doi: 10.1016/j.stemcr.2017.08.010. Epub 2017 Sep 21.

45.

Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells.

Tachikawa S, Nishimura T, Nakauchi H, Ohnuma K.

In Vitro Cell Dev Biol Anim. 2017 Oct;53(9):841-851. doi: 10.1007/s11626-017-0192-8. Epub 2017 Aug 28.

PMID:
28849348
46.

Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts.

Hirabayashi M, Hara H, Goto T, Takizawa A, Dwinell MR, Yamanaka T, Hochi S, Nakauchi H.

J Reprod Dev. 2017 Dec 15;63(6):611-616. doi: 10.1262/jrd.2017-074. Epub 2017 Aug 19.

47.

Lessons from Interspecies Mammalian Chimeras.

Suchy F, Nakauchi H.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:203-217. doi: 10.1146/annurev-cellbio-100616-060654. Epub 2017 Aug 14. Review.

PMID:
28806099
48.

Interspecies chimeras for human stem cell research.

Masaki H, Nakauchi H.

Development. 2017 Jul 15;144(14):2544-2547. doi: 10.1242/dev.151183.

49.

Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse.

Ueno K, Iwagawa T, Ochiai G, Koso H, Nakauchi H, Nagasaki M, Suzuki Y, Watanabe S.

Sci Rep. 2017 Jun 15;7(1):3578. doi: 10.1038/s41598-017-03874-8. Erratum in: Sci Rep. 2018 Jun 7;8(1):8946.

50.

Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome.

Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.

Blood. 2017 Jul 6;130(1):59-72. doi: 10.1182/blood-2016-09-738096. Epub 2017 Mar 21.

PMID:
28325863

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