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Items: 1 to 50 of 186

1.

Cysteinylprolyl imide (CPI) peptide: a highly reactive and easily accessible crypto-thioester for chemical protein synthesis.

Yanase M, Nakatsu K, Cardos CJ, Konda Y, Hayashi G, Okamoto A.

Chem Sci. 2019 May 9;10(23):5967-5975. doi: 10.1039/c9sc00646j. eCollection 2019 Jun 21.

2.

Structural Insights into Azole-based Inhibitors of Heme Oxygenase-1: Development of Selective Compounds for Therapeutic Applications.

Rahman MN, Vukomanovic D, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z.

Curr Med Chem. 2018;25(42):5803-5821. doi: 10.2174/0929867325666180606082512. Review.

PMID:
30674243
3.

TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses.

Abd El-Hafeez AA, Hosoi T, Nakatsu K, Thon M, Shimamoto A, Tahara H, Ozawa K.

Biotechnol Lett. 2018 Jun;40(6):915-922. doi: 10.1007/s10529-018-2544-1. Epub 2018 Apr 5.

PMID:
29619746
4.

Differential inhibition of rat and mouse microsome heme oxygenase by derivatives of imidazole and benzimidazole.

Hum M, McLaughlin BE, Kong X, Vlahakis JZ, Vukomanovic D, Szarek WA, Nakatsu K.

Can J Physiol Pharmacol. 2017 Dec;95(12):1454-1461. doi: 10.1139/cjpp-2017-0236. Epub 2017 Aug 9.

PMID:
28793202
5.

Drug-enhanced carbon monoxide production from heme by cytochrome P450 reductase.

Vukomanovic D, Rahman MN, Jia Z, Nakatsu K.

Med Gas Res. 2017 Mar 30;7(1):37-44. doi: 10.4103/2045-9912.202908. eCollection 2017 Jan-Mar.

6.

Cysteine-independent activation/inhibition of heme oxygenase-2.

Vukomanovic D, Rahman MN, Maines MD, Ozolinš TR, Szarek WA, Jia Z, Nakatsu K.

Med Gas Res. 2016 Apr 4;6(1):10-13. eCollection 2016 Mar.

7.

Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death.

Hosoi T, Nakatsu K, Shimamoto A, Tahara H, Ozawa K.

Neurosci Lett. 2016 Aug 26;629:241-244. doi: 10.1016/j.neulet.2016.07.027. Epub 2016 Jul 18.

PMID:
27443785
8.

Sinus Node Dysfunction After Acute Lithium Treatment at Therapeutic Levels.

Nakamura M, Nakatsu K, Nagamine T.

Innov Clin Neurosci. 2015 Nov-Dec;12(11-12):18-20.

9.

Structure-Activity Relationships of 1,2-Disubstituted Benzimidazoles: Selective Inhibition of Heme Oxygenase-2 Activity.

Kong X, Vukomanovic D, Nakatsu K, Szarek WA.

ChemMedChem. 2015 Aug;10(8):1435-41. doi: 10.1002/cmdc.201500128. Epub 2015 Jun 17.

PMID:
26083133
10.

Erratum to: "A novel role for ezrin in breast cancer angio/lymphangiogenesis".

Ghaffari A, Hoskin V, Szeto A, Hum M, Liaghati N, Nakatsu K, LeBrun D, Madarnas Y, SenGupta S, Elliott BE.

Breast Cancer Res. 2015 Jan 23;17:9. doi: 10.1186/s13058-014-0511-x. No abstract available.

11.

Synthesis of a peptide that can translocate to the endoplasmic reticulum.

Nakatsu K, Hosoi T, Toyoda K, Ozawa K.

Biochem Biophys Res Commun. 2015 May 8;460(3):628-32. doi: 10.1016/j.bbrc.2015.03.080. Epub 2015 Mar 21.

PMID:
25804636
12.

A novel role for ezrin in breast cancer angio/lymphangiogenesis.

Ghaffari A, Hoskin V, Szeto A, Hum M, Liaghati N, Nakatsu K, LeBrun D, Madarnas Y, Sengupta S, Elliott BE.

Breast Cancer Res. 2014 Sep 18;16(5):438. doi: 10.1186/s13058-014-0438-2. Erratum in: Breast Cancer Res. 2015;17:9. LeBrun, David [added].

13.

TERT attenuated ER stress-induced cell death.

Hosoi T, Inoue Y, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, Tahara H, Ozawa K.

Biochem Biophys Res Commun. 2014 May 2;447(2):378-82. doi: 10.1016/j.bbrc.2014.04.034. Epub 2014 Apr 16.

PMID:
24746472
14.

Caffeine attenuated ER stress-induced leptin resistance in neurons.

Hosoi T, Toyoda K, Nakatsu K, Ozawa K.

Neurosci Lett. 2014 May 21;569:23-6. doi: 10.1016/j.neulet.2014.03.053. Epub 2014 Mar 31.

PMID:
24699176
15.

In vitro Activation of heme oxygenase-2 by menadione and its analogs.

Vukomanovic D, Rahman MN, Bilokin Y, Golub AG, Brien JF, Szarek WA, Jia Z, Nakatsu K.

Med Gas Res. 2014 Feb 18;4(1):4. doi: 10.1186/2045-9912-4-4.

16.

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position.

Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA.

Bioorg Med Chem. 2013 Nov 1;21(21):6788-95. doi: 10.1016/j.bmc.2013.07.050. Epub 2013 Aug 8.

PMID:
24021581
17.

Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds.

Rahman MN, Vukomanovic D, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z.

J R Soc Interface. 2013 Jan 6;10(78):20120697. doi: 10.1098/rsif.2012.0697. Epub 2012 Nov 8.

18.

Glancing angle deposition of copper iodide nanocrystals for efficient organic photovoltaics.

Zhou Y, Taima T, Miyadera T, Yamanari T, Kitamura M, Nakatsu K, Yoshida Y.

Nano Lett. 2012 Aug 8;12(8):4146-52. doi: 10.1021/nl301709x. Epub 2012 Jul 24.

PMID:
22800302
19.

Heme oxygenase inhibition by α-(1H-imidazol-1-yl)-ω-phenylalkanes: effect of introduction of heteroatoms in the alkyl linker.

Vlahakis JZ, Lazar C, Roman G, Vukomanovic D, Nakatsu K, Szarek WA.

ChemMedChem. 2012 May;7(5):897-902. doi: 10.1002/cmdc.201100602. Epub 2012 Mar 16.

PMID:
22431362
20.

A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition.

Rahman MN, Vlahakis JZ, Vukomanovic D, Lee W, Szarek WA, Nakatsu K, Jia Z.

PLoS One. 2012;7(1):e29514. doi: 10.1371/journal.pone.0029514. Epub 2012 Jan 19.

21.

Perinatal iron deficiency combined with a high-fat diet causes obesity and cardiovascular dysregulation.

Bourque SL, Komolova M, McCabe K, Adams MA, Nakatsu K.

Endocrinology. 2012 Mar;153(3):1174-82. doi: 10.1210/en.2011-1700. Epub 2011 Dec 30.

PMID:
22210741
22.

Selective activation of heme oxygenase-2 by menadione.

Vukomanovic D, McLaughlin BE, Rahman MN, Szarek WA, Brien JF, Jia Z, Nakatsu K.

Can J Physiol Pharmacol. 2011 Nov;89(11):861-4. doi: 10.1139/y11-091. Epub 2011 Nov 1.

PMID:
22039914
23.
24.

Heme oxygenase inhibition by 1-aryl-2-(1h-imidazol-1-yl/1h-1,2,4-triazol-1-yl)ethanones and their derivatives.

Roman G, Vlahakis JZ, Vukomanovic D, Nakatsu K, Szarek WA.

ChemMedChem. 2010 Sep 3;5(9):1541-55. doi: 10.1002/cmdc.201000120.

PMID:
20652928
25.

Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition.

Vlahakis JZ, Rahman MN, Roman G, Jia Z, Nakatsu K, Szarek WA.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):79-88. doi: 10.1016/j.vascn.2010.05.015. Epub 2010 Jun 4.

PMID:
20561893
26.

Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.

Vukomanovic D, McLaughlin B, Rahman MN, Vlahakis JZ, Roman G, Dercho RA, Kinobe RT, Hum M, Brien JF, Jia Z, Szarek WA, Nakatsu K.

Can J Physiol Pharmacol. 2010 Apr;88(4):480-6. doi: 10.1139/y10-004.

PMID:
20555417
27.

The effects of azole-based heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2 and human cytochromes P450 3A4 and 2D6.

Hum M, McLaughlin BE, Roman G, Vlahakis JZ, Szarek WA, Nakatsu K.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):981-7. doi: 10.1124/jpet.110.168492. Epub 2010 May 25.

PMID:
20501634
28.

Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.

Bourque SL, Benjamin CD, Adams MA, Nakatsu K.

J Pharmacol Exp Ther. 2010 Apr;333(1):290-6. doi: 10.1124/jpet.109.162966. Epub 2010 Jan 13.

PMID:
20071481
29.
30.

Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors.

Rahman MN, Vlahakis JZ, Roman G, Vukomanovic D, Szarek WA, Nakatsu K, Jia Z.

J Inorg Biochem. 2010 Mar;104(3):324-30. doi: 10.1016/j.jinorgbio.2009.10.011. Epub 2009 Oct 24. Review.

PMID:
19917515
31.
32.

Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.

Vlahakis JZ, Hum M, Rahman MN, Jia Z, Nakatsu K, Szarek WA.

Bioorg Med Chem. 2009 Mar 15;17(6):2461-75. doi: 10.1016/j.bmc.2009.01.078. Epub 2009 Feb 12.

PMID:
19268600
33.

X-ray crystal structure of human heme oxygenase-1 in complex with 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone: a common binding mode for imidazole-based heme oxygenase-1 inhibitors.

Rahman MN, Vlahakis JZ, Szarek WA, Nakatsu K, Jia Z.

J Med Chem. 2008 Oct 9;51(19):5943-52. doi: 10.1021/jm800505m. Epub 2008 Sep 18.

PMID:
18798608
34.

Acute depletion of heme by succinylacetone alters vascular responses but does not induce hypertension.

Soong J, Adams MA, Nakatsu K.

Can J Physiol Pharmacol. 2008 Sep;86(9):613-9. doi: 10.1139/y08-064.

PMID:
18758510
35.

Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic?

Kinobe RT, Dercho RA, Nakatsu K.

Can J Physiol Pharmacol. 2008 Sep;86(9):577-99. doi: 10.1139/y08-066. Review.

PMID:
18758507
36.

Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats.

Komolova M, Bourque SL, Nakatsu K, Adams MA.

Int J Obes (Lond). 2008 Sep;32(9):1441-4. doi: 10.1038/ijo.2008.97. Epub 2008 Jul 8.

PMID:
18607379
37.

Perinatal iron deficiency affects locomotor behavior and water maze performance in adult male and female rats.

Bourque SL, Iqbal U, Reynolds JN, Adams MA, Nakatsu K.

J Nutr. 2008 May;138(5):931-7.

PMID:
18424604
38.

Long-term circulatory consequences of perinatal iron deficiency in male Wistar rats.

Bourque SL, Komolova M, Nakatsu K, Adams MA.

Hypertension. 2008 Jan;51(1):154-9. Epub 2007 Oct 29. Erratum in: Hypertension. 2008 May;51(5):e44.

PMID:
17967999
39.

Effectiveness of novel imidazole-dioxolane heme oxygenase inhibitors in renal proximal tubule epithelial cells.

Kinobe RT, Ji Y, Vlahakis JZ, Motterlini R, Brien JF, Szarek WA, Nakatsu K.

J Pharmacol Exp Ther. 2007 Dec;323(3):763-70. Epub 2007 Aug 30.

PMID:
17761847
40.

Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.

Roman G, Riley JG, Vlahakis JZ, Kinobe RT, Brien JF, Nakatsu K, Szarek WA.

Bioorg Med Chem. 2007 May 1;15(9):3225-34. Epub 2007 Feb 22.

PMID:
17339115
41.

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia.

Kinobe RT, Vlahakis JZ, Soong JM, Szarek WA, Brien JF, Longo LD, Nakatsu K.

Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):893-901.

PMID:
17111034
42.

Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.

Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA.

J Med Chem. 2006 Jul 13;49(14):4437-41.

PMID:
16821802
43.

Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.

Kinobe RT, Dercho RA, Vlahakis JZ, Brien JF, Szarek WA, Nakatsu K.

J Pharmacol Exp Ther. 2006 Oct;319(1):277-84. Epub 2006 Jun 28.

PMID:
16807364
44.

Determination of in vivo carbon monoxide production in laboratory animals via exhaled air.

Dercho RA, Nakatsu K, Wong RJ, Stevenson DK, Vreman HJ.

J Pharmacol Toxicol Methods. 2006 Nov-Dec;54(3):288-95. Epub 2006 Mar 15.

PMID:
16540352
45.

Anti-Plasmodium activity of imidazole-dioxolane compounds.

Vlahakis JZ, Kinobe RT, Nakatsu K, Szarek WA, Crandall IE.

Bioorg Med Chem Lett. 2006 May 1;16(9):2396-406. Epub 2006 Feb 21.

PMID:
16495054
46.

Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms.

Kinobe RT, Vlahakis JZ, Vreman HJ, Stevenson DK, Brien JF, Szarek WA, Nakatsu K.

Br J Pharmacol. 2006 Feb;147(3):307-15.

47.

The source of endogenous carbon monoxide formation in human placental chorionic villi.

Ahmed H, McLaughlin BE, Soong J, Marks GS, Brien JF, Nakatsu K.

Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):447-51.

PMID:
16309566
48.

Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats.

Suits MD, Pal GP, Nakatsu K, Matte A, Cygler M, Jia Z.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16955-60. Epub 2005 Nov 7.

49.

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1457-61.

PMID:
15713406
50.

Peroxynitrite-mediated inactivation of heme oxygenases.

Kinobe R, Ji Y, Nakatsu K.

BMC Pharmacol. 2004 Oct 21;4:26. doi: 10.1186/1471-2210-4-26.

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