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Effects of In-Hospital Exercise on Sarcopenia in Hepatoma Patients Who Underwent Transcatheter Arterial Chemoembolization.

Koya S, Kawaguchi T, Hashida R, Hirota K, Bekki M, Goto E, Yamada M, Sugimoto M, Hayashi S, Goshima N, Yoshiyama T, Otsuka T, Nozoe R, Nagamatsu A, Nakano D, Shirono T, Shimose S, Iwamoto H, Niizeki T, Matsuse H, Koga H, Miura H, Shiba N, Torimura T.

J Gastroenterol Hepatol. 2018 Nov 7. doi: 10.1111/jgh.14538. [Epub ahead of print]


Cardiac Glutathione Levels Increase in Response to Glucose in Diabetic Rats.

Thorwald MA, Godoy-Lugo JA, Rodriguez GJ, Rodriguez MA, Jamal M, Kinoshita H, Nakano D, Nishiyama A, Forman HJ, Ortiz RM.

Free Radic Biol Med. 2018 Oct 11. pii: S0891-5849(18)31281-4. doi: 10.1016/j.freeradbiomed.2018.10.405. [Epub ahead of print]


A novel role of renin inhibitor in the complement cascade.

Nakano D, Nishiyama A.

Kidney Int. 2018 Oct;94(4):650-652. doi: 10.1016/j.kint.2018.05.025.


Spontaneous regression of hepatocellular carcinoma with reduction in angiogenesis-related cytokines after treatment with sodium-glucose cotransporter 2 inhibitor in a cirrhotic patient with diabetes mellitus.

Kawaguchi T, Nakano D, Okamura S, Shimose S, Hayakawa M, Niizeki T, Koga H, Torimura T.

Hepatol Res. 2018 Sep 4. doi: 10.1111/hepr.13247. [Epub ahead of print]


Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice.

Ansary TM, Urushihara M, Fujisawa Y, Nagata S, Urata H, Nakano D, Hirofumi H, Kitamura K, Kagami S, Nishiyama A.

Exp Physiol. 2018 Nov;103(11):1524-1531. doi: 10.1113/EP087209. Epub 2018 Sep 14.


A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice.

Zhang Y, Nakano D, Guan Y, Hitomi H, Uemura A, Masaki T, Kobara H, Sugaya T, Nishiyama A.

Kidney Int. 2018 Sep;94(3):524-535. doi: 10.1016/j.kint.2018.05.002. Epub 2018 Jul 23.


Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats.

Rodriguez R, Lee A, Mathis KW, Broome HJ, Thorwald M, Martinez B, Nakano D, Nishiyama A, Ryan MJ, Ortiz RM.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1081-F1090. doi: 10.1152/ajprenal.00156.2018. Epub 2018 Jul 11.


Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats.

Rodriguez R, Moreno M, Lee AY, Godoy-Lugo JA, Nakano D, Nishiyama A, Parkes D, Awayda MS, Ortiz RM.

Hypertens Res. 2018 Oct;41(10):798-808. doi: 10.1038/s41440-018-0070-0. Epub 2018 Jul 9.


Effect of a SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats.

Li L, Konishi Y, Morikawa T, Zhang Y, Kitabayashi C, Kobara H, Masaki T, Nakano D, Hitomi H, Kobori H, Nishiyama A.

J Pharmacol Sci. 2018 Jun;137(2):220-223. doi: 10.1016/j.jphs.2017.10.006. Epub 2017 Oct 28.


Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis.

Kawaguchi T, Nakano D, Oriishi T, Torimura T.

Mol Med Rep. 2018 Aug;18(2):2033-2042. doi: 10.3892/mmr.2018.9223. Epub 2018 Jun 26.


Clinicopathological and molecular differences between right-sided and left-sided colorectal cancer in Japanese patients.

Natsume S, Yamaguchi T, Takao M, Iijima T, Wakaume R, Takahashi K, Matsumoto H, Nakano D, Horiguchi SI, Koizumi K, Miyaki M.

Jpn J Clin Oncol. 2018 Jul 1;48(7):609-618. doi: 10.1093/jjco/hyy069.


[Treatment for sarcopenia in patients with chronic liver disease].

Kawaguchi T, Nakano D, Torimura T.

Nihon Shokakibyo Gakkai Zasshi. 2018;115(5):439-448. doi: 10.11405/nisshoshi.115.439. Japanese. No abstract available.


Characteristics and Prognostic Factors of Bone Metastasis in Patients With Colorectal Cancer.

Kawamura H, Yamaguchi T, Yano Y, Hozumi T, Takaki Y, Matsumoto H, Nakano D, Takahashi K.

Dis Colon Rectum. 2018 Jun;61(6):673-678. doi: 10.1097/DCR.0000000000001071.


Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response.

Strausser SA, Nakano D, Souma T.

Curr Opin Nephrol Hypertens. 2018 Jul;27(4):314-322. doi: 10.1097/MNH.0000000000000424.


Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.

Rodriguez R, Minas JN, Vazquez-Medina JP, Nakano D, Parkes DG, Nishiyama A, Ortiz RM.

J Endocrinol. 2018 Jun;237(3):271-284. doi: 10.1530/JOE-17-0678. Epub 2018 Apr 11.


Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models.

Kitamura H, Nakano D, Sawanobori Y, Asaga T, Yokoi H, Yanagita M, Mukoyama M, Tokudome T, Kangawa K, Shirakami G, Nishiyama A.

Anesthesiology. 2018 Aug;129(2):296-310. doi: 10.1097/ALN.0000000000002214.


Effects of water turbidity and different temperatures on oxidative stress in caddisfly (Stenopsyche marmorata) larvae.

Suzuki J, Imamura M, Nakano D, Yamamoto R, Fujita M.

Sci Total Environ. 2018 Jul 15;630:1078-1085. doi: 10.1016/j.scitotenv.2018.02.286. Epub 2018 Mar 7.


Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle.

Kawanishi N, Takagi K, Lee HC, Nakano D, Okuno T, Yokomizo T, Machida S.

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1;314(6):R892-R901. doi: 10.1152/ajpregu.00371.2017. Epub 2018 Feb 14.


A novel approach to adenine-induced chronic kidney disease associated anemia in rodents.

Rahman A, Yamazaki D, Sufiun A, Kitada K, Hitomi H, Nakano D, Nishiyama A.

PLoS One. 2018 Feb 7;13(2):e0192531. doi: 10.1371/journal.pone.0192531. eCollection 2018.


Combined therapy with gas gangrene antitoxin and recombinant human soluble thrombomodulin for Clostridium perfringens sepsis in a rat model.

Hifumi T, Nakano D, Chiba J, Takahashi M, Yamamoto A, Fujisawa Y, Kawakita K, Kuroda Y, Nishiyama A.

Toxicon. 2018 Jan;141:112-117. doi: 10.1016/j.toxicon.2017.12.043. Epub 2017 Dec 12.


New cyclic sulfides extracted from Allium sativum: garlicnins P, J2, and Q.

Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.

J Nat Med. 2018 Jan;72(1):335-341. doi: 10.1007/s11418-017-1151-0. Epub 2017 Nov 20.


A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy.

Guan Y, Nakano D, Zhang Y, Li L, Liu W, Nishida M, Kuwabara T, Morishita A, Hitomi H, Mori K, Mukoyama M, Masaki T, Hirano K, Nishiyama A.

J Pharmacol Sci. 2017 Sep 14. pii: S1347-8613(17)30128-7. doi: 10.1016/j.jphs.2017.09.002. [Epub ahead of print]


New cyclic sulfides, garlicnins I2, M, N, and O, from Allium sativum.

Nohara T, Ono M, Nishioka N, Masuda F, Fujiwara Y, Ikeda T, Nakano D, Kinjo J.

J Nat Med. 2018 Jan;72(1):326-331. doi: 10.1007/s11418-017-1133-2. Epub 2017 Oct 30.


Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats.

Thorwald M, Rodriguez R, Lee A, Martinez B, Peti-Peterdi J, Nakano D, Nishiyama A, Ortiz RM.

Redox Biol. 2018 Apr;14:371-378. doi: 10.1016/j.redox.2017.10.005. Epub 2017 Oct 7.


Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.

Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaaj2300. doi: 10.1126/scitranslmed.aaj2300.


Responses of renal hemodynamics and tubular functions to acute sodium-glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats.

Ansary TM, Fujisawa Y, Rahman A, Nakano D, Hitomi H, Kobara H, Masaki T, Titze JM, Kitada K, Nishiyama A.

Sci Rep. 2017 Aug 25;7(1):9555. doi: 10.1038/s41598-017-09352-5.


Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice.

Tomita T, Arai S, Kitada K, Mizuno M, Suzuki Y, Sakata F, Nakano D, Hiramoto E, Takei Y, Maruyama S, Nishiyama A, Matsuo S, Miyazaki T, Ito Y.

Sci Rep. 2017 Jul 25;7(1):6450. doi: 10.1038/s41598-017-06824-6.


IBMX protects human proximal tubular epithelial cells from hypoxic stress through suppressing hypoxia-inducible factor-1α expression.

Hasan AU, Kittikulsuth W, Yamaguchi F, Musarrat Ansary T, Rahman A, Shibayama Y, Nakano D, Hitomi H, Tokuda M, Nishiyama A.

Exp Cell Res. 2017 Sep 15;358(2):343-351. doi: 10.1016/j.yexcr.2017.07.007. Epub 2017 Jul 6.


High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.

Kitada K, Daub S, Zhang Y, Klein JD, Nakano D, Pedchenko T, Lantier L, LaRocque LM, Marton A, Neubert P, Schröder A, Rakova N, Jantsch J, Dikalova AE, Dikalov SI, Harrison DG, Müller DN, Nishiyama A, Rauh M, Harris RC, Luft FC, Wassermann DH, Sands JM, Titze J.

J Clin Invest. 2017 May 1;127(5):1944-1959. doi: 10.1172/JCI88532. Epub 2017 Apr 17.


Antitumor Allium Sulfides.

Nohara T, Fujiwara Y, El-Aasr M, Ikeda T, Ono M, Nakano D, Kinjo J.

Chem Pharm Bull (Tokyo). 2017;65(3):209-217. doi: 10.1248/cpb.c16-00844. Review.


Effect of a selective SGLT2 inhibitor, luseogliflozin, on circadian rhythm of sympathetic nervous function and locomotor activities in metabolic syndrome rats.

Rahman A, Fujisawa Y, Nakano D, Hitomi H, Nishiyama A.

Clin Exp Pharmacol Physiol. 2017 Apr;44(4):522-525. doi: 10.1111/1440-1681.12725.


Atypical Cyclic Sulfides, Garlicnins G, I, and J, Extracted from Allium sativum.

Ono M, Fujiwara Y, Ikeda T, Pan C, El-Aasr M, Lee JH, Nakano D, Kinjo J, Nohara T.

Chem Pharm Bull (Tokyo). 2017;65(1):102-106. doi: 10.1248/cpb.c16-00648.


Exogenous thyroxine improves glucose intolerance in insulin-resistant rats.

Vazquez-Anaya G, Martinez B, Soñanez-Organis JG, Nakano D, Nishiyama A, Ortiz RM.

J Endocrinol. 2017 Mar;232(3):501-511. doi: 10.1530/JOE-16-0428. Epub 2016 Dec 15.


Erythropoietin-producing cells.

Nakano D.

Nihon Yakurigaku Zasshi. 2016;148(5):281. doi: 10.1254/fpj.148.281. Japanese. No abstract available.


Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens.

Nakano D, Ishitsuka K, Matsuda N, Kouguchi A, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J.

J Nat Med. 2017 Jan;71(1):170-180. doi: 10.1007/s11418-016-1046-5. Epub 2016 Oct 13.


Experimental models for acute kidney injury.

Nakano D.

Nihon Yakurigaku Zasshi. 2016 Sep;148(3):163. doi: 10.1254/fpj.148.163. Japanese. No abstract available.


Multiphoton imaging of kidney pathophysiology.

Nakano D, Nishiyama A.

J Pharmacol Sci. 2016 Sep;132(1):1-5. doi: 10.1016/j.jphs.2016.08.001. Epub 2016 Aug 12. Review.


Screening of promising chemotherapeutic candidates from plants extracts.

Kinjo J, Nakano D, Fujioka T, Okabe H.

J Nat Med. 2016 Jul;70(3):335-60. doi: 10.1007/s11418-016-0992-2. Epub 2016 Apr 16. Review.


Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome.

Rahman A, Kittikulsuth W, Fujisawa Y, Sufiun A, Rafiq K, Hitomi H, Nakano D, Sohara E, Uchida S, Nishiyama A.

J Hypertens. 2016 May;34(5):893-906. doi: 10.1097/HJH.0000000000000871.


On the Origin of Urinary Renin: A Translational Approach.

Roksnoer LC, Heijnen BF, Nakano D, Peti-Peterdi J, Walsh SB, Garrelds IM, van Gool JM, Zietse R, Struijker-Boudier HA, Hoorn EJ, Danser AH.

Hypertension. 2016 May;67(5):927-33. doi: 10.1161/HYPERTENSIONAHA.115.07012. Epub 2016 Feb 29.


A sodium-glucose co-transporter 2 inhibitor empagliflozin prevents abnormality of circadian rhythm of blood pressure in salt-treated obese rats.

Takeshige Y, Fujisawa Y, Rahman A, Kittikulsuth W, Nakano D, Mori H, Masaki T, Ohmori K, Kohno M, Ogata H, Nishiyama A.

Hypertens Res. 2016 Jun;39(6):415-22. doi: 10.1038/hr.2016.2. Epub 2016 Jan 28.


Totally laparoscopic gastrectomy for early gastric cancer accompanied by huge hiatal hernia: A case report.

Hagiwara C, Yajima K, Iwasaki Y, Oohinata R, Yuu K, Ishiyama S, Amaki M, Nakano D, Yamaguchi T, Matsumoto H, Takahashi K.

Asian J Endosc Surg. 2016 Feb;9(1):61-4. doi: 10.1111/ases.12218.


Two new bicyclic sulfoxides from Welsh onion.

Nohara T, Fujiwara Y, Ikeda T, Murakami K, Ono M, El-Aasr M, Nakano D, Kinjo J.

J Nat Med. 2016 Apr;70(2):260-5. doi: 10.1007/s11418-015-0947-z. Epub 2015 Dec 16.


Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease.

Kuwahara S, Hosojima M, Kaneko R, Aoki H, Nakano D, Sasagawa T, Kabasawa H, Kaseda R, Yasukawa R, Ishikawa T, Suzuki A, Sato H, Kageyama S, Tanaka T, Kitamura N, Narita I, Komatsu M, Nishiyama A, Saito A.

J Am Soc Nephrol. 2016 Jul;27(7):1996-2008. doi: 10.1681/ASN.2015020190. Epub 2015 Nov 3.


Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N.

J Am Soc Nephrol. 2016 Feb;27(2):428-38. doi: 10.1681/ASN.2014121184. Epub 2015 Jun 8.


Reduction of Tubular Flow Rate as a Mechanism of Oliguria in the Early Phase of Endotoxemia Revealed by Intravital Imaging.

Nakano D, Doi K, Kitamura H, Kuwabara T, Mori K, Mukoyama M, Nishiyama A.

J Am Soc Nephrol. 2015 Dec;26(12):3035-44. doi: 10.1681/ASN.2014060577. Epub 2015 Apr 8.


Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (IV): phenanthroindolizidine alkaloids from Tylophora tanakae leaves.

Nakano D, Ishitsuka K, Ikeda M, Tsuchihashi R, Okawa M, Okabe H, Tamura K, Kinjo J.

J Nat Med. 2015 Jul;69(3):397-401. doi: 10.1007/s11418-015-0906-8. Epub 2015 Apr 4.


Chelation of dietary iron prevents iron accumulation and macrophage infiltration in the type I diabetic kidney.

Morita T, Nakano D, Kitada K, Morimoto S, Ichihara A, Hitomi H, Kobori H, Shiojima I, Nishiyama A.

Eur J Pharmacol. 2015 Jun 5;756:85-91. doi: 10.1016/j.ejphar.2015.03.053. Epub 2015 Mar 26.


(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma.

Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S, Nishiyama A.

Sci Rep. 2015 Mar 9;5:8854. doi: 10.1038/srep08854.


Effect of dipeptidyl peptidase-4 inhibition on circadian blood pressure during the development of salt-dependent hypertension in rats.

Sufiun A, Rafiq K, Fujisawa Y, Rahman A, Mori H, Nakano D, Kobori H, Ohmori K, Masaki T, Kohno M, Nishiyama A.

Hypertens Res. 2015 Apr;38(4):237-43. doi: 10.1038/hr.2014.173. Epub 2015 Jan 15.

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