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Items: 39


Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.

Mennie AK, Moser BA, Hoyle A, Low RS, Tanaka K, Nakamura TM.

Commun Biol. 2019 Aug 7;2:297. doi: 10.1038/s42003-019-0546-8. eCollection 2019.


A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to Telomere Shortening in Fission Yeast.

Xu YJ, Khan S, Didier AC, Wozniak M, Liu Y, Singh A, Nakamura TM.

Mol Cell Biol. 2019 Sep 27;39(20). pii: e00175-19. doi: 10.1128/MCB.00175-19. Print 2019 Oct 15.


The NuA4 acetyltransferase and histone H4 acetylation promote replication recovery after topoisomerase I-poisoning.

Noguchi C, Singh T, Ziegler MA, Peake JD, Khair L, Aza A, Nakamura TM, Noguchi E.

Epigenetics Chromatin. 2019 Apr 16;12(1):24. doi: 10.1186/s13072-019-0271-z.


The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S, Vaurs M, Escandell JM, Maestroni L, Nakamura TM, Ferreira MG, Géli V, Coulon S.

Sci Adv. 2018 May 16;4(5):eaar2740. doi: 10.1126/sciadv.aar2740. eCollection 2018 May.


LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.

Mennie AK, Moser BA, Nakamura TM.

Nat Commun. 2018 Feb 8;9(1):586. doi: 10.1038/s41467-018-02874-0.


SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.

Nie M, Moser BA, Nakamura TM, Boddy MN.

PLoS Genet. 2017 May 5;13(5):e1006776. doi: 10.1371/journal.pgen.1006776. eCollection 2017 May.


Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Gadaleta MC, Das MM, Tanizawa H, Chang YT, Noma K, Nakamura TM, Noguchi E.

PLoS Genet. 2016 Mar 18;12(3):e1005943. doi: 10.1371/journal.pgen.1005943. eCollection 2016 Mar.


Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast.

Moser BA, Raguimova ON, Nakamura TM.

Mol Biol Cell. 2015 Nov 1;26(21):3857-66. doi: 10.1091/mbc.E15-07-0481. Epub 2015 Sep 9.


RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.

Audry J, Maestroni L, Delagoutte E, Gauthier T, Nakamura TM, Gachet Y, Saintomé C, Géli V, Coulon S.

EMBO J. 2015 Jul 14;34(14):1942-58. doi: 10.15252/embj.201490773. Epub 2015 Jun 3.


Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.

Harland JL, Chang YT, Moser BA, Nakamura TM.

PLoS Genet. 2014 Oct 16;10(10):e1004708. doi: 10.1371/journal.pgen.1004708. eCollection 2014 Oct.


Telomere regulation during the cell cycle in fission yeast.

Moser BA, Chang YT, Nakamura TM.

Methods Mol Biol. 2014;1170:411-24. doi: 10.1007/978-1-4939-0888-2_22.


SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.

Miyagawa K, Low RS, Santosa V, Tsuji H, Moser BA, Fujisawa S, Harland JL, Raguimova ON, Go A, Ueno M, Matsuyama A, Yoshida M, Nakamura TM, Tanaka K.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5950-5. doi: 10.1073/pnas.1401359111. Epub 2014 Apr 7.


Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.

Chang YT, Moser BA, Nakamura TM.

PLoS Genet. 2013 Nov;9(11):e1003936. doi: 10.1371/journal.pgen.1003936. Epub 2013 Nov 7.


Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

Moser BA, Chang YT, Kosti J, Nakamura TM.

Nat Struct Mol Biol. 2011 Nov 20;18(12):1408-13. doi: 10.1038/nsmb.2187.


The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.

Garabedian MV, Noguchi C, Ziegler MA, Das MM, Singh T, Harper LJ, Leman AR, Khair L, Moser BA, Nakamura TM, Noguchi E.

Genetics. 2012 Feb;190(2):487-500. doi: 10.1534/genetics.111.135459. Epub 2011 Nov 17.


Telomeres avoid end detection by severing the checkpoint signal transduction pathway.

Carneiro T, Khair L, Reis CC, Borges V, Moser BA, Nakamura TM, Ferreira MG.

Nature. 2010 Sep 9;467(7312):228-32. doi: 10.1038/nature09353.


HAATI survivors replace canonical telomeres with blocks of generic heterochromatin.

Jain D, Hebden AK, Nakamura TM, Miller KM, Cooper JP.

Nature. 2010 Sep 9;467(7312):223-7. doi: 10.1038/nature09374.


To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?

Subramanian L, Nakamura TM.

Front Biosci (Landmark Ed). 2010 Jun 1;15:1105-18. Review.


A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeast.

Subramanian L, Nakamura TM.

PLoS Genet. 2010 Feb 5;6(2):e1000839. doi: 10.1371/journal.pgen.1000839.


Roles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.

Khair L, Subramanian L, Moser BA, Nakamura TM.

J Biol Chem. 2010 Feb 19;285(8):5327-37. doi: 10.1074/jbc.M109.078840. Epub 2009 Dec 29.


Protection and replication of telomeres in fission yeast.

Moser BA, Nakamura TM.

Biochem Cell Biol. 2009 Oct;87(5):747-58. doi: 10.1139/O09-037. Review.


Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.

Moser BA, Subramanian L, Khair L, Chang YT, Nakamura TM.

PLoS Genet. 2009 Aug;5(8):e1000622. doi: 10.1371/journal.pgen.1000622. Epub 2009 Aug 28.


Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Moser BA, Subramanian L, Chang YT, Noguchi C, Noguchi E, Nakamura TM.

EMBO J. 2009 Apr 8;28(7):810-20. doi: 10.1038/emboj.2009.31. Epub 2009 Feb 12.


Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.

Coulon S, Noguchi E, Noguchi C, Du LL, Nakamura TM, Russell P.

Mol Biol Cell. 2006 Apr;17(4):2081-90. Epub 2006 Feb 8.


Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM, Du LL, Redon C, Russell P.

Mol Cell Biol. 2004 Jul;24(14):6215-30. Erratum in: Mol Cell Biol. 2004 Sep;24(17):7820.


The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.

Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N.

Mol Cell Biol. 2003 Sep;23(18):6564-73.


Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.

Du LL, Nakamura TM, Moser BA, Russell P.

Mol Cell Biol. 2003 Sep;23(17):6150-8.


Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.

Haering CH, Nakamura TM, Baumann P, Cech TR.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6367-72.


Two modes of survival of fission yeast without telomerase.

Nakamura TM, Cooper JP, Cech TR.

Science. 1998 Oct 16;282(5388):493-6.


Reversing time: origin of telomerase.

Nakamura TM, Cech TR.

Cell. 1998 Mar 6;92(5):587-90. Review. No abstract available.


Telomerase is a true reverse transcriptase. A review.

Cech TR, Nakamura TM, Lingner J.

Biochemistry (Mosc). 1997 Nov;62(11):1202-5. Review.


Telomerase catalytic subunit homologs from fission yeast and human.

Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR.

Science. 1997 Aug 15;277(5328):955-9.


Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.

Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR.

EMBO J. 1995 Oct 2;14(19):4849-59.

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