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Items: 1 to 50 of 210

1.

Aging and APOE-ε4 are determinative factors of plasma Aβ42 levels.

Nakamura T, Kawarabayashi T, Seino Y, Hirohata M, Nakahata N, Narita S, Itoh K, Nakaji S, Shoji M.

Ann Clin Transl Neurol. 2018 Sep 7;5(10):1184-1191. doi: 10.1002/acn3.635. eCollection 2018 Oct.

2.

Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity.

Okuda-Tanino A, Sugawara D, Tashiro T, Iwashita M, Obara Y, Moriya T, Tsushima C, Saigusa D, Tomioka Y, Ishii K, Nakahata N.

PLoS One. 2017 Mar 10;12(3):e0173628. doi: 10.1371/journal.pone.0173628. eCollection 2017.

3.

Validity of a food frequency questionnaire in a population with high alcohol consumption in Japan.

Nakahata NT, Takada AN, Imaeda N, Goto C, Kuwabara KH, Niimura H, Arai Y, Yoshita K, Takezaki T.

Asia Pac J Clin Nutr. 2016;25(1):195-201. doi: 10.6133/apjcn.2016.25.1.10.

4.

Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population.

Mantjoro EM, Toyota K, Kanouchi H, Kheradmand M, Niimura H, Kuwabara K, Nakahata N, Ogawa S, Shimatani K, Kairupan TS, Nindita Y, Ibusuki R, Nerome Y, Owaki T, Maenohara S, Takezaki T.

J Atheroscler Thromb. 2016 Jun 1;23(6):681-91. doi: 10.5551/jat.32243. Epub 2016 Jan 21.

5.

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.

Obara Y, Nagasawa R, Nemoto W, Pellegrino MJ, Takahashi M, Habecker BA, Stork PJS, Ichiyanagi O, Ito H, Tomita Y, Ishii K, Nakahata N.

Cell Signal. 2016 Mar;28(3):177-189. doi: 10.1016/j.cellsig.2015.12.016. Epub 2015 Dec 29.

6.

Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.

Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K, Hamajima N, Hishida A, Kawai S, Oze I, Shinchi K, Takashima N, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

J Diabetes. 2016 Sep;8(5):667-76. doi: 10.1111/1753-0407.12344. Epub 2015 Dec 1.

PMID:
26374515
7.

Phosphorylation of ERK5 on Thr732 is associated with ERK5 nuclear localization and ERK5-dependent transcription.

Honda T, Obara Y, Yamauchi A, Couvillon AD, Mason JJ, Ishii K, Nakahata N.

PLoS One. 2015 Feb 17;10(2):e0117914. doi: 10.1371/journal.pone.0117914. eCollection 2015.

8.

Novel inhibitory effects of cardamonin on thromboxane A2-induced scratching response: Blocking of Gh/transglutaminase-2 binding to thromboxane A2 receptor.

Park MK, Choi JK, Kim HJ, Nakahata N, Lim KM, Kim SY, Lee CH.

Pharmacol Biochem Behav. 2014 Nov;126:131-5. doi: 10.1016/j.pbb.2014.09.011. Epub 2014 Oct 5.

PMID:
25285619
9.

GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study.

Hishida A, Takashima N, Turin TC, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y.

J Nephrol. 2014 Apr;27(2):143-9. doi: 10.1007/s40620-013-0025-0. Epub 2013 Dec 17.

PMID:
24535998
10.

Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age.

Kheradmand M, Niimura H, Kuwabara K, Nakahata N, Nakamura A, Ogawa S, Mantjoro EM, Shimatani K, Nerome Y, Owaki T, Kusano K, Takezaki T.

J Epidemiol. 2013;23(6):457-65. Epub 2013 Sep 28.

11.

Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization.

Ando K, Fukuhara S, Moriya T, Obara Y, Nakahata N, Mochizuki N.

J Cell Biol. 2013 Sep 16;202(6):901-16. doi: 10.1083/jcb.201301115. Epub 2013 Sep 9.

12.

Genome-wide association study of genetic factors related to confectionery intake: potential roles of the ADIPOQ gene.

Wakai K, Matsuo K, Matsuda F, Yamada R, Takahashi M, Kawaguchi T, Yatabe Y, Ito H, Hosono S, Tajima K, Naito M, Morita E, Yin G, Sakamoto T, Takashima N, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Watanabe Y, Arisawa K, Kubo M, Hamajima N, Tanaka H; J-MICC Study Group.

Obesity (Silver Spring). 2013 Nov;21(11):2413-9. doi: 10.1002/oby.20316. Epub 2013 May 29.

13.

Suppression of adenylyl cyclase-mediated cAMP production by plasma membrane associated cytoskeletal protein 4.1G.

Goto T, Chiba A, Sukegawa J, Yanagisawa T, Saito M, Nakahata N.

Cell Signal. 2013 Mar;25(3):690-7. doi: 10.1016/j.cellsig.2012.11.020. Epub 2012 Nov 29.

PMID:
23201780
14.

Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.

Obara Y, Yanagihata Y, Abe T, Dafik L, Ishii K, Nakahata N.

Cell Signal. 2013 Mar;25(3):589-97. doi: 10.1016/j.cellsig.2012.11.021. Epub 2012 Nov 29.

PMID:
23200849
15.

Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A₂ receptor: dependency on receptor isoforms and downstream signaling types.

Goto S, Saito M, Obara Y, Moriya T, Nakahata N.

Eur J Pharmacol. 2012 Oct 15;693(1-3):15-24. doi: 10.1016/j.ejphar.2012.07.046. Epub 2012 Aug 21.

PMID:
22963705
16.

Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells.

Nusuetrong P, Saito M, Kikuchi H, Oshima Y, Moriya T, Nakahata N.

J Toxicol Sci. 2012;37(4):803-12.

17.

[Functional Assessment Staging (FAST)].

Watanabe M, Nakahata N, Shoji M.

Nihon Rinsho. 2011 Oct;69 Suppl 8:450-4. Japanese. No abstract available.

PMID:
22787832
18.

Hetero-oligomerization between adenosine A₁ and thromboxane A₂ receptors and cellular signal transduction on stimulation with high and low concentrations of agonists for both receptors.

Mizuno N, Suzuki T, Hirasawa N, Nakahata N.

Eur J Pharmacol. 2012 Feb 29;677(1-3):5-14. doi: 10.1016/j.ejphar.2011.12.006. Epub 2011 Dec 16.

PMID:
22200626
19.

Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function.

Suzuki T, Obara Y, Moriya T, Nakata H, Nakahata N.

FEBS Lett. 2011 Dec 15;585(24):3978-84. doi: 10.1016/j.febslet.2011.10.050. Epub 2011 Nov 10.

20.

Lysophosphatidylinositol causes neurite retraction via GPR55, G13 and RhoA in PC12 cells.

Obara Y, Ueno S, Yanagihata Y, Nakahata N.

PLoS One. 2011;6(8):e24284. doi: 10.1371/journal.pone.0024284. Epub 2011 Aug 31.

21.

Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations.

Nishino S, Ohtomo K, Numata Y, Sato T, Nakahata N, Kurita M.

Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):17-22. doi: 10.1016/j.pnpbp.2011.07.008. Epub 2011 Jul 22.

PMID:
21803112
22.

A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells.

Chiba T, Ueno S, Obara Y, Nakahata N.

J Pharm Pharmacol. 2011 May;63(5):636-47. doi: 10.1111/j.2042-7158.2011.01250.x. Epub 2011 Mar 28.

PMID:
21492165
23.

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.

Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N.

Biomed Res. 2011 Feb;32(1):67-72.

24.
25.

Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum.

Ishiuchi K, Kubota T, Ishiyama H, Hayashi S, Shibata T, Mori K, Obara Y, Nakahata N, Kobayashi J.

Bioorg Med Chem. 2011 Jan 15;19(2):749-53. doi: 10.1016/j.bmc.2010.12.025. Epub 2010 Dec 13.

PMID:
21215644
26.

Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells.

Obara Y, Nemoto W, Kohno S, Murata T, Kaneda N, Nakahata N.

Cell Signal. 2011 Apr;23(4):666-72. doi: 10.1016/j.cellsig.2010.11.020. Epub 2010 Dec 2.

PMID:
21130871
27.

[Novel method for the measurement of intracellular cAMP levels by using a fusion gene of PKA and firefly luciferase].

Obara Y, Nakahata N.

Nihon Yakurigaku Zasshi. 2010 Nov;136(5):285-9. Japanese. No abstract available.

PMID:
21079368
28.

[Brain-derived neurotrophic factor (BDNF)].

Kurita M, Nishino S, Nakahata N.

Nihon Rinsho. 2010 Jul;68 Suppl 7:131-3. Japanese. No abstract available.

PMID:
20960761
29.

[Pharmacological activity of mastoparan: its contribution to signal transduction].

Nakahata N, Sugama J.

Nihon Yakurigaku Zasshi. 2010 Sep;136(3):145-9. Review. Japanese. No abstract available.

PMID:
20838016
30.

The uterus sustains stable biological clock during pregnancy.

Akiyama S, Ohta H, Watanabe S, Moriya T, Hariu A, Nakahata N, Chisaka H, Matsuda T, Kimura Y, Tsuchiya S, Tei H, Okamura K, Yaegashi N.

Tohoku J Exp Med. 2010 Aug;221(4):287-98.

31.

Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.

Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata N.

Phytomedicine. 2010 Dec 1;17(14):1082-5. doi: 10.1016/j.phymed.2010.05.004. Epub 2010 Jul 16.

PMID:
20637576
32.

P2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells.

Ando K, Obara Y, Sugama J, Kotani A, Koike N, Ohkubo S, Nakahata N.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):809-19. doi: 10.1124/jpet.110.167528. Epub 2010 May 28.

PMID:
20511347
33.

15-Deoxy-delta 12,14-prostaglandin J2 biphasically regulates the proliferation of mouse hippocampal neural progenitor cells by modulating the redox state.

Katura T, Moriya T, Nakahata N.

Mol Pharmacol. 2010 Apr;77(4):601-11. doi: 10.1124/mol.109.061010. Epub 2010 Jan 19.

PMID:
20086036
34.

[The regulation of thromboxane A(2)-receptor function by dimerization and receptor-associated protein].

Nakahata N.

Nihon Yakurigaku Zasshi. 2009 Nov;134(5):259-63. Review. Japanese. No abstract available.

PMID:
19915285
35.

The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects.

Obara Y, Nakahata N.

Mol Pharmacol. 2010 Jan;77(1):10-6. doi: 10.1124/mol.109.060236. Epub 2009 Oct 26. Review.

PMID:
19858097
36.

Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands.

Uchiyama K, Saito M, Sasaki M, Obara Y, Higashiyama S, Nakahata N.

Eur J Pharm Sci. 2009 Dec 8;38(5):504-11. doi: 10.1016/j.ejps.2009.09.016. Epub 2009 Oct 3.

PMID:
19804825
37.

Involvement of aquaporin in thromboxane A2 receptor-mediated, G 12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells.

Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N.

Cell Signal. 2010 Jan;22(1):41-6. doi: 10.1016/j.cellsig.2009.09.006. Epub 2009 Sep 20.

PMID:
19772916
38.

Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model.

Tsutakawa S, Kobayashi D, Kusama M, Moriya T, Nakahata N.

Br J Dermatol. 2009 Nov;161(5):1020-7. doi: 10.1111/j.1365-2133.2009.09349.x. Epub 2009 Jun 11.

PMID:
19673871
39.

An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.

Wakasaya Y, Watanabe M, Tomiyama M, Suzuki C, Jackson M, Fujimuro M, Kimura T, Seino Y, Kawarabayashi T, Yamamoto-Watanabe Y, Matsubara E, Shirahama I, Takamura A, Nakahata N, Shoji M.

Intern Med. 2009;48(15):1311-3. Epub 2009 Aug 3.

40.

ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.

Obara Y, Yamauchi A, Takehara S, Nemoto W, Takahashi M, Stork PJ, Nakahata N.

J Biol Chem. 2009 Aug 28;284(35):23564-73. doi: 10.1074/jbc.M109.027821. Epub 2009 Jul 6.

41.

A reduction of epidermal growth factor receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells.

Honma S, Saito M, Kikuchi H, Saito Y, Oshima Y, Nakahata N, Yoshida M.

Eur J Pharmacol. 2009 Aug 15;616(1-3):38-42. doi: 10.1016/j.ejphar.2009.06.030. Epub 2009 Jun 23.

PMID:
19559020
42.

The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice.

Moriya T, Aida R, Kudo T, Akiyama M, Doi M, Hayasaka N, Nakahata N, Mistlberger R, Okamura H, Shibata S.

Eur J Neurosci. 2009 Apr;29(7):1447-60. doi: 10.1111/j.1460-9568.2009.06697.x. Epub 2009 Mar 23.

PMID:
19519629
43.

Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor.

Tokue S, Sasaki M, Nakahata N.

Prostaglandins Other Lipid Mediat. 2009 Jun;89(1-2):8-15. doi: 10.1016/j.prostaglandins.2009.02.001. Epub 2009 Feb 13.

PMID:
19464661
44.
45.

[cAMP signaling for ERK activation in neuronal cells].

Obara Y, Nakahata N, Stork PJ.

Nihon Yakurigaku Zasshi. 2009 Feb;133(2):63-8. Review. Japanese. No abstract available.

PMID:
19218743
46.
47.

Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.

Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N.

Biol Pharm Bull. 2008 Sep;31(9):1727-32.

48.

Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus.

Bastos GN, Moriya T, Inui F, Katura T, Nakahata N.

Neuroscience. 2008 Aug 13;155(2):454-62. doi: 10.1016/j.neuroscience.2008.06.020. Epub 2008 Jun 17.

PMID:
18616986
49.

Maternal feeding controls fetal biological clock.

Ohta H, Xu S, Moriya T, Iigo M, Watanabe T, Nakahata N, Chisaka H, Hanita T, Matsuda T, Ohura T, Kimura Y, Yaegashi N, Tsuchiya S, Tei H, Okamura K.

PLoS One. 2008 Jul 2;3(7):e2601. doi: 10.1371/journal.pone.0002601.

50.

Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells.

Nusuetrong P, Pengsuparp T, Meksuriyen D, Tanitsu M, Kikuchi H, Mizugaki M, Shimazu K, Oshima Y, Nakahata N, Yoshida M.

Biol Pharm Bull. 2008 Jun;31(6):1115-20.

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