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Fibrodysplasia Ossificans Progressiva: Review and Research Activities in Japan.

Haga N, Nakashima Y, Kitoh H, Kamizono J, Katagiri T, Saijo H, Tsukamoto S, Shinoda Y, Sawada R, Nakahara Y.

Pediatr Int. 2019 Nov 27. doi: 10.1111/ped.14065. [Epub ahead of print] Review.


In vitro pharmacological effects of peficitinib on lymphocyte activation: a potential treatment for systemic sclerosis with JAK inhibitors.

Kitanaga Y, Imamura E, Nakahara Y, Fukahori H, Fujii Y, Kubo S, Nakayamada S, Tanaka Y.

Rheumatology (Oxford). 2019 Nov 25. pii: kez526. doi: 10.1093/rheumatology/kez526. [Epub ahead of print]


A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient.

Fujioka Y, Hata N, Hatae R, Suzuki SO, Sangatsuda Y, Nakahara Y, Mizoguchi M, Iihara K.

Neuropathology. 2019 Nov 24. doi: 10.1111/neup.12609. [Epub ahead of print]


Bi-directional regulation between NDRG1 and GSK3β controls tumor growth and is targeted by differentiation inducing factor-1 in glioblastoma.

Ito H, Watari K, Shibata T, Miyamoto T, Murakami Y, Nakahara Y, Izumi H, Wakimoto H, Kuwano M, Abe T, Ono M.

Cancer Res. 2019 Nov 13. pii: canres.0438.2019. doi: 10.1158/0008-5472.CAN-19-0438. [Epub ahead of print]


Metachronous rectal metastasis from pulmonary adenocarcinoma after 11 years of chemo-, immuno-, and radiotherapy for recurrent lesions: a case report.

Suzuki Y, Imasato M, Nakahara Y, Naito A, Mikamori M, Ohtsuka M, Furukawa K, Moon JH, Asaoka T, Kishi K, Yasuoka H, Komuta K, Akamatsu H.

Surg Case Rep. 2019 Oct 24;5(1):151. doi: 10.1186/s40792-019-0722-6.


Multicenter study of zoledronic acid administration in non-small-cell lung cancer patients with bone metastasis: Thoracic Oncology Research Group (TORG) 1017.

Nakahara Y, Hosomi Y, Shibuya M, Mitsufuji H, Katagiri M, Naoki K, Soejima K, Nogami N, Nagase S, Nishikawa M, Minato K, Takiguchi Y, Seki N, Yamada K, Seto T, Okamoto H.

Mol Clin Oncol. 2019 Oct;11(4):349-353. doi: 10.3892/mco.2019.1903. Epub 2019 Jul 23.


A phase II study of low starting dose of afatinib as first-line treatment in patients with EGFR mutation-positive non-small-cell lung cancer (KTORG1402).

Yokoyama T, Yoshioka H, Fujimoto D, Demura Y, Hirano K, Kawai T, Kagami R, Washio Y, Ishida T, Kogo M, Tomii K, Okuno T, Akai M, Hirabayashi M, Nishimura T, Nakahara Y, Kim YH, Miyakoshi C, Yoshimura K, Hirai T; Kyoto Thoracic Oncology Research Group (KTORG).

Lung Cancer. 2019 Sep;135:175-180. doi: 10.1016/j.lungcan.2019.03.030. Epub 2019 Mar 28.


Left ventricular outflow tract obstruction by transatrial left ventricular cannulation.

Nakahara Y, Kanemura T, Shioya M, Yamana K.

Interact Cardiovasc Thorac Surg. 2019 Dec 1;29(6):981-982. doi: 10.1093/icvts/ivz190.


[Effectiveness of an Early Enteral Nutrition Flowchart after Open Heart Surgery].

Fukuse M, Nakahara Y, Ishikawa O.

Kyobu Geka. 2019 May;72(5):338-343. Japanese.


Prospects for a personalized peptide vaccine against lung cancer.

Nakahara Y, Kouro T, Igarashi Y, Kawahara M, Sasada T.

Expert Rev Vaccines. 2019 Jul;18(7):703-709. doi: 10.1080/14760584.2019.1635461. Epub 2019 Jun 28.


BK virus-associated viruria and viremia in a patient with lymphangioleiomyomatosis after lung re-transplantation: A case report and review of the literature on BK virus infection post-lung transplantation.

Okumura J, Nakahara Y, Nakaguro M, Shindo Y, Hase T, Wakahara K, Hashimoto N, Hasegawa Y.

J Infect Chemother. 2019 Oct;25(10):820-824. doi: 10.1016/j.jiac.2019.04.002. Epub 2019 Apr 23.


Repressive role of stabilized hypoxia inducible factor 1α expression on transforming growth factor β-induced extracellular matrix production in lung cancer cells.

Ando A, Hashimoto N, Sakamoto K, Omote N, Miyazaki S, Nakahara Y, Imaizumi K, Kawabe T, Hasegawa Y.

Cancer Sci. 2019 Jun;110(6):1959-1973. doi: 10.1111/cas.14027. Epub 2019 May 13.


Association between extracranial internal carotid artery tortuosity and thromboembolic complications during coil embolization of anterior circulation ruptured aneurysms.

Ogata A, Suzuyama K, Ebashi R, Takase Y, Inoue K, Masuoka J, Yoshioka F, Nakahara Y, Abe T.

Acta Neurochir (Wien). 2019 Jun;161(6):1175-1181. doi: 10.1007/s00701-019-03903-7. Epub 2019 Apr 15.


Crystallite Size Increase of Silver Nanoparticles by Ligand Exchange and Subsequent Washing Process with Antisolvent.

Okada S, Nakahara Y, Watanabe M, Tamai T, Yajima S.

J Nanosci Nanotechnol. 2019 Aug 1;19(8):4565-4570. doi: 10.1166/jnn.2019.16361.


Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model.

Le TD, Nakahara Y, Ueda M, Okumura K, Hirai J, Sato Y, Takemoto D, Tomimori N, Ono Y, Nakai M, Shibata H, Inoue YH.

Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1826-1839. doi: 10.26355/eurrev_201902_17146.


Efficacy and risk of cytotoxic chemotherapy in extensive disease-small cell lung cancer patients with interstitial pneumonia.

Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Nakahara Y, Nishinarita N, Igawa S, Naoki K.

BMC Cancer. 2019 Feb 20;19(1):163. doi: 10.1186/s12885-019-5367-0.


[A Case of Complete Response to Lower Rectal Cancer after Preoperative Chemotherapy with CapeOX Therapy].

Tsujimura N, Takemoto H, Nakahara Y, Wakasugi M, Hirota M, Matsumoto T, Takachi K, Nishioka K, Oshima S.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1928-1930. Japanese.


Status epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report.

Koguchi M, Nakahara Y, Ebashi R, Ogata A, Shimokawa S, Masuoka J, Abe T.

J Med Case Rep. 2019 Jan 20;13(1):18. doi: 10.1186/s13256-018-1939-x.


Questionnaire survey on patient awareness of invasive rebiopsy in advanced non-small cell lung cancer.

Fukui T, Ishihara M, Kasajima M, Hiyoshi Y, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Naoki K.

Thorac Cancer. 2019 Mar;10(3):501-507. doi: 10.1111/1759-7714.12964. Epub 2019 Jan 16.


Efficacy of Single-incision Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair for Overweight or Obese Patients.

Wakasugi M, Nakahara Y, Hirota M, Matsumoto T, Kusu T, Takemoto H, Takachi K, Oshima S.

Surg Laparosc Endosc Percutan Tech. 2019 Jun;29(3):200-202. doi: 10.1097/SLE.0000000000000628.


Real-world evaluation of carboplatin plus a weekly dose of nab-paclitaxel for patients with advanced non-small-cell lung cancer with interstitial lung disease.

Igawa S, Nishinarita N, Takakura A, Ozawa T, Harada S, Kusuhara S, Niwa H, Hosotani S, Sone H, Nakahara Y, Fukui T, Mitsufuji H, Yokoba M, Kubota M, Katagiri M, Sasaki J, Naoki K.

Cancer Manag Res. 2018 Dec 14;10:7013-7019. doi: 10.2147/CMAR.S189556. eCollection 2018.


Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer.

Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Ishihara M, Kasajima M, Nakahara Y, Otani S, Igawa S, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Naoki K.

Cancer Manag Res. 2018 Nov 21;10:6039-6047. doi: 10.2147/CMAR.S181789. eCollection 2018.


High-Affinity K+ Transporters from a Halophyte, Sporobolus virginicus, Mediate Both K+ and Na+ Transport in Transgenic Arabidopsis, X. laevis Oocytes and Yeast.

Tada Y, Endo C, Katsuhara M, Horie T, Shibasaka M, Nakahara Y, Kurusu T.

Plant Cell Physiol. 2019 Jan 1;60(1):176-187. doi: 10.1093/pcp/pcy202.


Single-incision laparoscopic preperitoneal mesh repair of supra-pubic incisional hernia: A case report.

Wakasugi M, Nakahara Y, Hirota M, Matsumoto T, Kusu T, Takemoto H, Takachi K, Oshima S.

Ann Med Surg (Lond). 2018 Sep 12;34:54-57. doi: 10.1016/j.amsu.2018.07.014. eCollection 2018 Oct.


Learning curve for single-incision laparoscopic totally extraperitoneal inguinal hernia repair.

Wakasugi M, Nakahara Y, Hirota M, Matsumoto T, Kusu T, Takemoto H, Takachi K, Oshima S.

Asian J Endosc Surg. 2019 Jul;12(3):301-305. doi: 10.1111/ases.12639. Epub 2018 Aug 21.


A Cyclic Nucleotide-Gated Channel, HvCNGC2-3, Is Activated by the Co-Presence of Na⁺ and K⁺ and Permeable to Na⁺ and K⁺ Non-Selectively.

Mori IC, Nobukiyo Y, Nakahara Y, Shibasaka M, Furuichi T, Katsuhara M.

Plants (Basel). 2018 Jul 26;7(3). pii: E61. doi: 10.3390/plants7030061.


Extensive spinal epidural immature teratoma in an infant: case report.

Yoshioka F, Shimokawa S, Masuoka J, Izaki T, Nakahara Y, Kawashima M, Sakata S, Abe T.

J Neurosurg Pediatr. 2018 Oct;22(4):411-415. doi: 10.3171/2018.4.PEDS17676. Epub 2018 Jul 6.


Possible involvement of pericytes in intraplaque hemorrhage of carotid artery stenosis.

Tanaka T, Ogata A, Masuoka J, Mizokami T, Wakamiya T, Nakahara Y, Inoue K, Shimokawa S, Yoshioka F, Momozaki N, Sakata S, Abe T.

J Neurosurg. 2018 Jun 1:1-7. doi: 10.3171/2018.1.JNS171942. [Epub ahead of print]


Systemic Staphylococcus pseudintermedius infection in an arctic fox (Vulpes lagopus) with severe multifocal suppurative meningoencephalitis and nephritis.

Iwata K, Kasuya K, Takayama K, Nakahara Y, Kobayashi Y, Kato A, Senba H, Yanagisawa M, Shibahara T.

J Vet Med Sci. 2018 Aug 10;80(8):1219-1222. doi: 10.1292/jvms.18-0061. Epub 2018 Jun 11.


Intracranial Response to Nivolumab in a Patient with PD-L1-negative Lung Adenocarcinoma.

Nakahara Y, Fukui T, Shirasawa M, Harada S, Kusuhara S, Takakura A, Yokoba M, Mitsufuji H, Kubota M, Katagiri M, Sasaki J, Masuda N, Inukai M, Sekiguchi T, Naoki K.

Intern Med. 2018 Nov 1;57(21):3149-3152. doi: 10.2169/internalmedicine.9884-17. Epub 2018 Jun 6.


A promising response to osimertinib in a patient with erlotinib-resistant lung adenocarcinoma with an uncommon EGFR mutation.

Niwa H, Nakahara Y, Sasaki J, Masuda N.

BMJ Case Rep. 2018 Jun 4;2018. pii: bcr-2017-219770. doi: 10.1136/bcr-2017-219770.


Activity of Nivolumab and Utility of Neutrophil-to-Lymphocyte Ratio as a Predictive Biomarker for Advanced Non-Small-Cell Lung Cancer: A Prospective Observational Study.

Fukui T, Okuma Y, Nakahara Y, Otani S, Igawa S, Katagiri M, Mitsufuji H, Kubota M, Hiyoshi Y, Ishihara M, Kasajima M, Sasaki J, Naoki K.

Clin Lung Cancer. 2019 May;20(3):208-214.e2. doi: 10.1016/j.cllc.2018.04.021. Epub 2018 May 5.


Overexpression of the protein disulfide isomerase AtCYO1 in chloroplasts slows dark-induced senescence in Arabidopsis.

Tominaga J, Nakahara Y, Horikawa D, Tanaka A, Kondo M, Kamei Y, Takami T, Sakamoto W, Unno K, Sakamoto A, Shimada H.

BMC Plant Biol. 2018 May 4;18(1):80. doi: 10.1186/s12870-018-1294-5.


Efficacy of single-incision laparoscopic totally extraperitoneal repair for irreducible or incarcerated inguinal hernia.

Wakasugi M, Nakahara Y, Hirota M, Matsumoto T, Takemoto H, Takachi K, Nishioka K, Oshima S.

Asian J Endosc Surg. 2019 Jan;12(1):95-100. doi: 10.1111/ases.12488. Epub 2018 Apr 25.



Nakahara Y, Kanemura T.

Ann Thorac Surg. 2018 Jul;106(1):311. doi: 10.1016/j.athoracsur.2018.03.031. Epub 2018 Apr 16. No abstract available.


Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat.

Okizaki A, Nakayama M, Nakajima K, Fujimoto O, Oshikiri S, Koike-Satake M, Nakahara Y.

J Nucl Cardiol. 2018 Apr 13. doi: 10.1007/s12350-018-1274-z. [Epub ahead of print]


A Japanese trial to monitor methicillin-resistant Staphylococcus aureus (MRSA) in imported swine during the quarantine period.

Furuno M, Uchiyama M, Nakahara Y, Uenoyama K, Fukuhara H, Morino S, Kijima M.

J Glob Antimicrob Resist. 2018 Sep;14:182-184. doi: 10.1016/j.jgar.2018.03.012. Epub 2018 Apr 3.


Reflux after esophagectomy with gastric conduit reconstruction in the posterior mediastinum for esophageal cancer: original questionnaire and EORTC QLQ-C30 survey.

Nakahara Y, Yamasaki M, Miyazaki Y, Tanaka K, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.

Dis Esophagus. 2018 Jul 1;31(7). doi: 10.1093/dote/doy001.


Intraabdominal actinomycosis resulting in a difficult to diagnose intraperitoneal mass: A case report.

Tsujimura N, Takemoto H, Nakahara Y, Wakasugi M, Matsumoto T, Nishioka K, Takachi K, Oshima S, Yoshida K.

Int J Surg Case Rep. 2018;45:101-103. doi: 10.1016/j.ijscr.2018.03.024. Epub 2018 Mar 21.


A resected case of medullary carcinoma of the ascending colon followed by infarction of the greater omentum mimicking anastomotic leakage.

Wakasugi M, Kono H, Yasuhara Y, Tsujimura N, Nakahara Y, Matsumoto T, Takemoto H, Takachi K, Nishioka K, Yoshida K, Oshima S.

Int J Surg Case Rep. 2017 Nov 21;41:456-460. doi: 10.1016/j.ijscr.2017.11.027. eCollection 2017.


Phase II study of bevacizumab, cisplatin, and docetaxel plus maintenance bevacizumab as first-line treatment for patients with advanced non-squamous non-small-cell lung cancer combined with exploratory analysis of circulating endothelial cells: Thoracic Oncology Research Group (TORG)1016.

Ikeda S, Kato T, Ogura T, Sekine A, Oda T, Masuda N, Igawa S, Katono K, Otani S, Yamada K, Saito H, Kondo T, Hosomi Y, Nakahara Y, Nishikawa M, Utumi K, Misumi Y, Yamanaka T, Sakamaki K, Okamoto H.

BMC Cancer. 2018 Mar 2;18(1):241. doi: 10.1186/s12885-018-4150-y.


Early Rehabilitation and In-Hospital Mortality in Intensive Care Patients With Community-Acquired Pneumonia.

Sawada Y, Sasabuchi Y, Nakahara Y, Matsui H, Fushimi K, Haga N, Yasunaga H.

Am J Crit Care. 2018 Mar;27(2):97-103. doi: 10.4037/ajcc2018911.


Primary splenic malignant lymphoma mimicking metastasis of rectosigmoid cancer: A case report.

Wakasugi M, Yasuhara Y, Nakahara Y, Matsumoto T, Takemoto H, Takachi K, Nishioka K, Yoshida K, Oshima S.

Int J Surg Case Rep. 2018;44:11-15. doi: 10.1016/j.ijscr.2018.01.022. Epub 2018 Feb 9.


Effect of Protective Agents on Silver Nanoparticle Preparation by Vacuum Evaporation on Running Hydrocarbon Solution.

Ienaga T, Nakahara Y, Yajima S, Kimura K.

J Nanosci Nanotechnol. 2018 Apr 1;18(4):2547-2554. doi: 10.1166/jnn.2018.14392.


[Eight Cases of Esophagus and Tracheobronchial Stenting for Advanced Esophageal Cancer].

Nakahara Y, Takachi K, Tsujimura N, Wakasugi M, Hirota M, Matsumoto T, Takemoto H, Nishioka K, Oshima S.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1161-1163. Japanese.


Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy.

Omote N, Hashimoto N, Morise M, Sakamoto K, Miyazaki S, Ando A, Nakahara Y, Hasegawa Y.

Int J Chron Obstruct Pulmon Dis. 2017 Dec 11;12:3541-3547. doi: 10.2147/COPD.S149456. eCollection 2017.


Longitudinal study of the activities of daily living and quality of life in Japanese patients with fibrodysplasia ossificans progressiva.

Nakahara Y, Kitoh H, Nakashima Y, Toguchida J, Haga N.

Disabil Rehabil. 2019 Mar;41(6):699-704. doi: 10.1080/09638288.2017.1405083. Epub 2017 Nov 16.


Protic NNN and NCN Pincer-Type Ruthenium Complexes Featuring (Trifluoromethyl)pyrazole Arms: Synthesis and Application to Catalytic Hydrogen Evolution from Formic Acid.

Nakahara Y, Toda T, Matsunami A, Kayaki Y, Kuwata S.

Chem Asian J. 2018 Jan 4;13(1):73-80. doi: 10.1002/asia.201701474. Epub 2017 Dec 5.


The role of prophylactic cranial irradiation for patients with small-cell lung cancer.

Nakahara Y, Sasaki J, Fukui T, Otani S, Igawa S, Hayakawa K, Masuda N.

Jpn J Clin Oncol. 2018 Jan 1;48(1):26-30. doi: 10.1093/jjco/hyx146. Review.


Long-term Hyperglycemia Naturally Induces Dental Caries but Not Periodontal Disease in Type 1 and Type 2 Diabetic Rodents.

Nakahara Y, Ozaki K, Matsuura T.

Diabetes. 2017 Nov;66(11):2868-2874. doi: 10.2337/db17-0291. Epub 2017 Aug 9.

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