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Mutagenesis of a Quintuple Mutant Impaired in Environmental Responses Reveals Roles for CHROMATIN REMODELING4 in the Arabidopsis Floral Transition.

Sang Q, Pajoro A, Sun H, Song B, Yang X, Stolze SC, Andr S F, Schneeberger K, Nakagami H, Coupland G.

Plant Cell. 2020 Mar 4. pii: tpc.00992.2019. doi: 10.1105/tpc.19.00992. [Epub ahead of print]


AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine.

Tenma A, Nakagami H, Tomioka H, Sakaguchi M, Ide R, Koriyama H, Hayashi H, Shimamura M, Rakugi H, Morishita R.

FASEB Bioadv. 2019 Nov 22;1(12):760-772. doi: 10.1096/fba.2019-00056. eCollection 2019 Dec.


Development of an IL-17A DNA Vaccine to Treat Systemic Lupus Erythematosus in Mice.

Koriyama H, Ikeda Y, Nakagami H, Shimamura M, Yoshida S, Rakugi H, Morishita R.

Vaccines (Basel). 2020 Feb 12;8(1). pii: E83. doi: 10.3390/vaccines8010083.


CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.

Kimura S, Hunter K, Vaahtera L, Tran HC, Citterico M, Vaattovaara A, Rokka A, Stolze SC, Harzen A, Meissner L, Wilkens MMT, Hamann T, Toyota M, Nakagami H, Wrzaczek M.

Plant Cell. 2020 Feb 7. pii: tpc.00525.2019. doi: 10.1105/tpc.19.00525. [Epub ahead of print]


Novel properties of myoferlin in glucose metabolism via pathways involving modulation of adipose functions.

Nozato Y, Takami Y, Yamamoto K, Nagasawa M, Nozato S, Imaizumi Y, Takeshita H, Wang C, Ito Y, Takeda S, Takeya Y, Sugimoto K, Nakagami H, Hanayama R, Rakugi H.

FASEB J. 2020 Feb;34(2):2792-2811. doi: 10.1096/fj.201901539RR. Epub 2020 Jan 7.


Cyanidioschyzon merolae aurora kinase phosphorylates evolutionarily conserved sites on its target to regulate mitochondrial division.

Kato S, Okamura E, Matsunaga TM, Nakayama M, Kawanishi Y, Ichinose T, Iwane AH, Sakamoto T, Imoto Y, Ohnuma M, Nomura Y, Nakagami H, Kuroiwa H, Kuroiwa T, Matsunaga S.

Commun Biol. 2019 Dec 20;2:477. doi: 10.1038/s42003-019-0714-x. eCollection 2019.


Regulation of Photosynthetic Carbohydrate Metabolism by a Raf-Like Kinase in the Liverwort Marchantia polymorpha.

Koide E, Suetsugu N, Iwano M, Gotoh E, Nomura Y, Stolze SC, Nakagami H, Kohchi T, Nishihama R.

Plant Cell Physiol. 2020 Mar 1;61(3):631-643. doi: 10.1093/pcp/pcz232.


Cellular senescence and senescence-associated T cells as a potential therapeutic target.

Nakagami H.

Geriatr Gerontol Int. 2020 Feb;20(2):97-100. doi: 10.1111/ggi.13851. Epub 2019 Dec 14. Review.


Stable Immune Response Induced by Intradermal DNA Vaccination by a Novel Needleless Pyro-Drive Jet Injector.

Chang C, Sun J, Hayashi H, Suzuki A, Sakaguchi Y, Miyazaki H, Nishikawa T, Nakagami H, Yamashita K, Kaneda Y.

AAPS PharmSciTech. 2019 Dec 9;21(1):19. doi: 10.1208/s12249-019-1564-z.


Isolation of Natural Fungal Pathogens from Marchantia polymorpha Reveals Antagonism between Salicylic Acid and Jasmonate during Liverwort-Fungus Interactions.

Matsui H, Iwakawa H, Hyon GS, Yotsui I, Katou S, Monte I, Nishihama R, Franzen R, Solano R, Nakagami H.

Plant Cell Physiol. 2020 Feb 1;61(2):442. doi: 10.1093/pcp/pcz214. No abstract available.


Investigator-initiated clinical study of a functional peptide, SR-0379, for limb ulcers of patients with Werner syndrome as a pilot study.

Nakagami H, Sugimoto K, Ishikawa T, Koshizaka M, Fujimoto T, Kiyohara E, Hayashi M, Nakagawa Y, Ando H, Terabe Y, Takami Y, Yamamoto K, Takeya Y, Takemoto M, Ebihara T, Nakamura A, Nishikawa M, Yao XJ, Hanaoka H, Yokote K, Rakugi H.

Geriatr Gerontol Int. 2019 Nov;19(11):1118-1123. doi: 10.1111/ggi.13782.


[Development of therapeutic vaccine for life style-related diseases].

Nakagami H.

Nihon Yakurigaku Zasshi. 2019;154(5):270-274. doi: 10.1254/fpj.154.270. Review. Japanese.


Preventative effects of the partial RANKL peptide MHP1-AcN in a mouse model of imiquimod-induced psoriasis.

Ju N, Shimamura M, Hayashi H, Ikeda Y, Yoshida S, Nakamura A, Morishita R, Rakugi H, Nakagami H.

Sci Rep. 2019 Oct 28;9(1):15434. doi: 10.1038/s41598-019-51681-0.


Isolation of Natural Fungal Pathogens from Marchantia polymorpha Reveals Antagonism between Salicylic Acid and Jasmonate during Liverwort-Fungus Interactions.

Matsui H, Iwakawa H, Hyon GS, Yotsui I, Katou S, Monte I, Nishihama R, Franzen R, Solano R, Nakagami H.

Plant Cell Physiol. 2020 Feb 1;61(2):265-275. doi: 10.1093/pcp/pcz187. Erratum in: Plant Cell Physiol. 2020 Feb 1;61(2):442.


The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.

Yang C, Sofroni K, Wijnker E, Hamamura Y, Carstens L, Harashima H, Stolze SC, Vezon D, Chelysheva L, Orban-Nemeth Z, Pochon G, Nakagami H, Schlögelhofer P, Grelon M, Schnittger A.

EMBO J. 2020 Feb 3;39(3):e101625. doi: 10.15252/embj.2019101625. Epub 2019 Sep 26.


Comparative Phosphoproteomic Analysis Reveals a Decay of ABA Signaling in Barley Embryos during After-Ripening.

Ishikawa S, Barrero JM, Takahashi F, Nakagami H, Peck SC, Gubler F, Shinozaki K, Umezawa T.

Plant Cell Physiol. 2019 Dec 1;60(12):2758-2768. doi: 10.1093/pcp/pcz163.


Shotgun Proteomic Analysis Highlights the Roles of Long-Lived mRNAs and De Novo Transcribed mRNAs in Rice Seeds upon Imbibition.

Sano N, Takebayashi Y, To A, Mhiri C, Rajjou LC, Nakagami H, Kanekatsu M.

Plant Cell Physiol. 2019 Nov 1;60(11):2584-2596. doi: 10.1093/pcp/pcz152.


Direct evidence on the efficacy of GnRH agonist in recurrent steroid cell tumor-not otherwise specified.

Nakasone T, Nakamoto T, Matsuzaki A, Nakagami H, Aoki Y.

Gynecol Oncol Rep. 2019 Jul 16;29:73-75. doi: 10.1016/j.gore.2019.07.006. eCollection 2019 Aug.


Conserved Biochemical Defenses Underpin Host Responses to Oomycete Infection in an Early-Divergent Land Plant Lineage.

Carella P, Gogleva A, Hoey DJ, Bridgen AJ, Stolze SC, Nakagami H, Schornack S.

Curr Biol. 2019 Jul 22;29(14):2282-2294.e5. doi: 10.1016/j.cub.2019.05.078. Epub 2019 Jul 11.


Gene modification by fast-track recombineering for cellular localization and isolation of components of plant protein complexes.

Hu Z, Ghosh A, Stolze SC, Horváth M, Bai B, Schaefer S, Zündorf S, Liu S, Harzen A, Hajheidari M, Sarnowski TJ, Nakagami H, Koncz Z, Koncz C.

Plant J. 2019 Oct;100(2):411-429. doi: 10.1111/tpj.14450. Epub 2019 Jul 26.


Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice.

Kawano T, Shimamura M, Nakagami H, Kanki H, Sasaki T, Mochizuki H.

PLoS One. 2019 May 2;14(5):e0215482. doi: 10.1371/journal.pone.0215482. eCollection 2019.


SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis.

Yang C, Hamamura Y, Sofroni K, Böwer F, Stolze SC, Nakagami H, Schnittger A.

Nat Commun. 2019 Apr 15;10(1):1755. doi: 10.1038/s41467-019-09759-w.


A vaccine targeting blood clot formation: what is the potential?

Shimamura M, Nakagami H.

Expert Rev Vaccines. 2019 May;18(5):419-421. doi: 10.1080/14760584.2019.1588114. Epub 2019 Mar 20. No abstract available.


Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity.

Yoshida Y, Shimizu I, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagami H, Morishita R, Minamino T.

Sci Rep. 2019 Mar 7;9(1):3858. doi: 10.1038/s41598-019-40325-y.


Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.

Shih CM, Lin FY, Yeh JS, Lin YW, Loh SH, Tsao NW, Nakagami H, Morishita R, Sawamura T, Li CY, Lin CY, Huang CY.

Transl Res. 2019 Mar;205:17-32. doi: 10.1016/j.trsl.2018.09.005. Epub 2018 Oct 9.


Algal Protein Kinase, Triacylglycerol Accumulation Regulator 1, Modulates Cell Viability and Gametogenesis in Carbon/Nitrogen-Imbalanced Conditions.

Shinkawa H, Kajikawa M, Nomura Y, Ogura M, Sawaragi Y, Yamano T, Nakagami H, Sugiyama N, Ishihama Y, Kanesaki Y, Yoshikawa H, Fukuzawa H.

Plant Cell Physiol. 2019 Apr 1;60(4):916-930. doi: 10.1093/pcp/pcz010.


Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice.

Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H.

Hypertension. 2018 Dec;72(6):1355-1364. doi: 10.1161/HYPERTENSIONAHA.118.11316.


Pathophysiological significance of cylindromatosis in the vascular endothelium and macrophages for the initiation of age-related atherogenesis.

Imaizumi Y, Takami Y, Yamamoto K, Nagasawa M, Nozato Y, Nozato S, Takeshita H, Wang C, Yokoyama S, Hayashi H, Hongyo K, Akasaka H, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.

Biochem Biophys Res Commun. 2019 Jan 22;508(4):1168-1174. doi: 10.1016/j.bbrc.2018.12.025. Epub 2018 Dec 13.


A Golgi-Released Subpopulation of the Trans-Golgi Network Mediates Protein Secretion in Arabidopsis.

Uemura T, Nakano RT, Takagi J, Wang Y, Kramer K, Finkemeier I, Nakagami H, Tsuda K, Ueda T, Schulze-Lefert P, Nakano A.

Plant Physiol. 2019 Feb;179(2):519-532. doi: 10.1104/pp.18.01228. Epub 2018 Dec 13.


Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.

Shimamura M, Nakagami H, Shimizu H, Mukai H, Watanabe R, Okuzono T, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Ju N, Mochizuki H, Morishita R.

Sci Rep. 2018 Dec 11;8(1):17770. doi: 10.1038/s41598-018-35898-z.


Recent Advances in Therapeutic Vaccines to Treat Hypertension.

Nakagami H, Morishita R.

Hypertension. 2018 Nov;72(5):1031-1036. doi: 10.1161/HYPERTENSIONAHA.118.11084. Review. No abstract available.


Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.

Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.

J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):975-986. doi: 10.1002/jcsm.12334. Epub 2018 Sep 11.


Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.

Shimamura M, Nakagami H, Shimizu H, Wakayama K, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Mochizuki H, Morishita R.

Biomed Res Int. 2018 Jul 30;2018:4637084. doi: 10.1155/2018/4637084. eCollection 2018.


SELENOPROTEIN O is a chloroplast protein involved in ROS scavenging and its absence increases dehydration tolerance in Arabidopsis thaliana.

Fichman Y, Koncz Z, Reznik N, Miller G, Szabados L, Kramer K, Nakagami H, Fromm H, Koncz C, Zilberstein A.

Plant Sci. 2018 May;270:278-291. doi: 10.1016/j.plantsci.2018.02.023. Epub 2018 Mar 3.


Therapeutic Vaccines for Hypertension: a New Option for Clinical Practice.

Nakagami H, Morishita R.

Curr Hypertens Rep. 2018 Mar 19;20(3):22. doi: 10.1007/s11906-018-0820-z. Review.


Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial.

Nakagami H, Sugimoto K, Ishikawa T, Fujimoto T, Yamaoka T, Hayashi M, Kiyohara E, Ando H, Terabe Y, Takami Y, Yamamoto K, Takeya Y, Takemoto M, Koshizaka M, Ebihara T, Nakamura A, Nishikawa M, Yao XJ, Hanaoka H, Katayama I, Yokote K, Rakugi H.

NPJ Aging Mech Dis. 2018 Feb 13;4:2. doi: 10.1038/s41514-018-0021-7. eCollection 2018.


Development of vaccine for dyslipidemia targeted to a proprotein convertase subtilisin/kexin type 9 (PCSK9) epitope in mice.

Kawakami R, Nozato Y, Nakagami H, Ikeda Y, Shimamura M, Yoshida S, Sun J, Kawano T, Takami Y, Noma T, Rakugi H, Minamino T, Morishita R.

PLoS One. 2018 Feb 13;13(2):e0191895. doi: 10.1371/journal.pone.0191895. eCollection 2018.


Stable Accumulation of Photosystem II Requires ONE-HELIX PROTEIN1 (OHP1) of the Light Harvesting-Like Family.

Myouga F, Takahashi K, Tanaka R, Nagata N, Kiss AZ, Funk C, Nomura Y, Nakagami H, Jansson S, Shinozaki K.

Plant Physiol. 2018 Mar;176(3):2277-2291. doi: 10.1104/pp.17.01782. Epub 2018 Feb 1.


Comparative analysis of plant isochorismate synthases reveals structural mechanisms underlying their distinct biochemical properties.

Yokoo S, Inoue S, Suzuki N, Amakawa N, Matsui H, Nakagami H, Takahashi A, Arai R, Katou S.

Biosci Rep. 2018 Mar 9;38(2). pii: BSR20171457. doi: 10.1042/BSR20171457. Print 2018 Apr 27.


Pathophysiology of cardiovascular disease in diabetes mellitus.

Rodriguez-Araujo G, Nakagami H.

Cardiovasc Endocrinol Metab. 2018 Feb 14;7(1):4-9. doi: 10.1097/XCE.0000000000000141. eCollection 2018 Mar. Review.


Blue light-excited LOV1 and LOV2 domains cooperatively regulate the kinase activity of full-length phototropin2 from Arabidopsis.

Oide M, Okajima K, Nakagami H, Kato T, Sekiguchi Y, Oroguchi T, Hikima T, Yamamoto M, Nakasako M.

J Biol Chem. 2018 Jan 19;293(3):963-972. doi: 10.1074/jbc.RA117.000324. Epub 2017 Dec 1.


Association between renin-angiotensin-aldosterone system blockade and future osteoporotic fracture risk in hypertensive population: A population-based cohort study in Taiwan.

Chen CI, Yeh JS, Tsao NW, Lin FY, Shih CM, Chiang KH, Kao YT, Fang YA, Tsai LW, Liu WC, Nakagami H, Morishita R, Kuo YJ, Huang CY.

Medicine (Baltimore). 2017 Nov;96(46):e8331. doi: 10.1097/MD.0000000000008331.


The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions.

Matsui H, Nomura Y, Egusa M, Hamada T, Hyon GS, Kaminaka H, Watanabe Y, Ueda T, Trujillo M, Shirasu K, Nakagami H.

PLoS Genet. 2017 Oct 26;13(10):e1007037. doi: 10.1371/journal.pgen.1007037. eCollection 2017 Oct.


Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome.

Bowman JL, Kohchi T, Yamato KT, Jenkins J, Shu S, Ishizaki K, Yamaoka S, Nishihama R, Nakamura Y, Berger F, Adam C, Aki SS, Althoff F, Araki T, Arteaga-Vazquez MA, Balasubrmanian S, Barry K, Bauer D, Boehm CR, Briginshaw L, Caballero-Perez J, Catarino B, Chen F, Chiyoda S, Chovatia M, Davies KM, Delmans M, Demura T, Dierschke T, Dolan L, Dorantes-Acosta AE, Eklund DM, Florent SN, Flores-Sandoval E, Fujiyama A, Fukuzawa H, Galik B, Grimanelli D, Grimwood J, Grossniklaus U, Hamada T, Haseloff J, Hetherington AJ, Higo A, Hirakawa Y, Hundley HN, Ikeda Y, Inoue K, Inoue SI, Ishida S, Jia Q, Kakita M, Kanazawa T, Kawai Y, Kawashima T, Kennedy M, Kinose K, Kinoshita T, Kohara Y, Koide E, Komatsu K, Kopischke S, Kubo M, Kyozuka J, Lagercrantz U, Lin SS, Lindquist E, Lipzen AM, Lu CW, De Luna E, Martienssen RA, Minamino N, Mizutani M, Mizutani M, Mochizuki N, Monte I, Mosher R, Nagasaki H, Nakagami H, Naramoto S, Nishitani K, Ohtani M, Okamoto T, Okumura M, Phillips J, Pollak B, Reinders A, Rövekamp M, Sano R, Sawa S, Schmid MW, Shirakawa M, Solano R, Spunde A, Suetsugu N, Sugano S, Sugiyama A, Sun R, Suzuki Y, Takenaka M, Takezawa D, Tomogane H, Tsuzuki M, Ueda T, Umeda M, Ward JM, Watanabe Y, Yazaki K, Yokoyama R, Yoshitake Y, Yotsui I, Zachgo S, Schmutz J.

Cell. 2017 Oct 5;171(2):287-304.e15. doi: 10.1016/j.cell.2017.09.030.


Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.

Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.

FASEB J. 2017 Sep;31(9):4053-4063. doi: 10.1096/fj.201700110R. Epub 2017 May 25.


Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcers.

Nakagami H, Yamaoka T, Hayashi M, Tanemura A, Takeya Y, Kurinami H, Sugimoto K, Nakamura A, Tomono K, Tamai K, Katayama I, Rakugi H, Kaneda Y.

Geriatr Gerontol Int. 2017 Nov;17(11):2150-2156. doi: 10.1111/ggi.13051. Epub 2017 May 10.


Design of therapeutic vaccines as a novel antibody therapy for cardiovascular diseases.

Nakagami H.

J Cardiol. 2017 Sep;70(3):201-205. doi: 10.1016/j.jjcc.2017.01.010. Epub 2017 Apr 9. Review.


A novel lipoprotein (a) lowering drug, D-47, decreases neointima thickening after vascular injury.

Nakaya Y, Fukuda D, Oyamada T, Ogawa K, Harada N, Nakagami H, Morishita R, Sata M, Sakaue H.

J Med Invest. 2017;64(1.2):64-67. doi: 10.2152/jmi.64.64.


Angiotensin II Peptide Vaccine Protects Ischemic Brain Through Reducing Oxidative Stress.

Wakayama K, Shimamura M, Suzuki JI, Watanabe R, Koriyama H, Akazawa H, Nakagami H, Mochizuki H, Isobe M, Morishita R.

Stroke. 2017 May;48(5):1362-1368. doi: 10.1161/STROKEAHA.116.016269. Epub 2017 Mar 31.


Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response.

Furlan G, Nakagami H, Eschen-Lippold L, Jiang X, Majovsky P, Kowarschik K, Hoehenwarter W, Lee J, Trujillo M.

Plant Cell. 2017 Apr;29(4):726-745. doi: 10.1105/tpc.16.00654. Epub 2017 Mar 9.

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