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Items: 1 to 50 of 223

1.

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.

Ohata H, Shiokawa D, Obata Y, Sato A, Sakai H, Fukami M, Hara W, Taniguchi H, Ono M, Nakagama H, Okamoto K.

Cell Rep. 2019 Jul 30;28(5):1282-1295.e8. doi: 10.1016/j.celrep.2019.06.085.

2.

Chemoprevention of colorectal cancer: Past, present, and future.

Umezawa S, Higurashi T, Komiya Y, Arimoto J, Horita N, Kaneko T, Iwasaki M, Nakagama H, Nakajima A.

Cancer Sci. 2019 Jul 30. doi: 10.1111/cas.14149. [Epub ahead of print] Review.

3.

MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells.

Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Kato T, Nakagama H, Ochiya T.

Cell Death Dis. 2019 Jul 18;10(8):553. doi: 10.1038/s41419-019-1788-6.

4.

DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China.

Totsuka Y, Lin Y, He Y, Ishino K, Sato H, Kato M, Nagai M, Elzawahry A, Totoki Y, Nakamura H, Hosoda F, Shibata T, Matsuda T, Matsushima Y, Song G, Meng F, Li D, Liu J, Qiao Y, Wei W, Inoue M, Kikuchi S, Nakagama H, Shan B.

Chem Res Toxicol. 2019 Aug 19;32(8):1515-1527. doi: 10.1021/acs.chemrestox.9b00017. Epub 2019 Jul 9.

PMID:
31286759
5.

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles.

Mimaki S, Watanabe M, Kinoshita M, Yamashita R, Haeno H, Takemura S, Tanaka S, Marubashi S, Totsuka Y, Shibata T, Nakagama H, Ochiai A, Nakamori S, Kubo S, Tsuchihara K.

Carcinogenesis. 2019 Jun 20. pii: bgz120. doi: 10.1093/carcin/bgz120. [Epub ahead of print]

PMID:
31228243
6.

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

Yachida S, Mizutani S, Shiroma H, Shiba S, Nakajima T, Sakamoto T, Watanabe H, Masuda K, Nishimoto Y, Kubo M, Hosoda F, Rokutan H, Matsumoto M, Takamaru H, Yamada M, Matsuda T, Iwasaki M, Yamaji T, Yachida T, Soga T, Kurokawa K, Toyoda A, Ogura Y, Hayashi T, Hatakeyama M, Nakagama H, Saito Y, Fukuda S, Shibata T, Yamada T.

Nat Med. 2019 Jun;25(6):968-976. doi: 10.1038/s41591-019-0458-7. Epub 2019 Jun 6.

PMID:
31171880
7.
8.

[A Multi-Stakeholder Dialogue on Universal Health Coverage for Cancer in Asia - Seeking an Approach to Asia Health and Wellbeing Initiative].

Akaza H, Kawahara N, Nakagama H, Noda T.

Gan To Kagaku Ryoho. 2018 Sep;45(9):1259-1277. Japanese.

PMID:
30237367
9.

Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans.

Takahashi M, Hori M, Ishigamori R, Mutoh M, Imai T, Nakagama H.

Cancer Sci. 2018 Oct;109(10):3013-3023. doi: 10.1111/cas.13766. Epub 2018 Sep 5. Review.

10.

The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas.

Miyazaki M, Otomo R, Matsushima-Hibiya Y, Suzuki H, Nakajima A, Abe N, Tomiyama A, Ichimura K, Matsuda K, Watanabe T, Ochiya T, Nakagama H, Sakai R, Enari M.

Cell Death Discov. 2018 May 10;4:56. doi: 10.1038/s41420-018-0059-0. eCollection 2018.

11.

Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells.

Gailhouste L, Liew LC, Yasukawa K, Hatada I, Tanaka Y, Nakagama H, Ochiya T.

Mol Ther. 2018 Jul 5;26(7):1840-1854. doi: 10.1016/j.ymthe.2018.04.018. Epub 2018 Apr 26.

12.

Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells.

Gailhouste L, Liew LC, Hatada I, Nakagama H, Ochiya T.

Cell Death Dis. 2018 May 1;9(5):468. doi: 10.1038/s41419-018-0487-z.

13.

Prognostic importance of pretransplant disease status for posttransplant outcomes in patients with adult T cell leukemia/lymphoma.

Inoue Y, Fuji S, Tanosaki R, Inamoto Y, Tanaka T, Ito A, Okinaka K, Kurosawa S, Kim SW, Nakagama H, Fukuda T.

Bone Marrow Transplant. 2018 Sep;53(9):1105-1115. doi: 10.1038/s41409-018-0139-z. Epub 2018 Mar 9.

PMID:
29523883
14.

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells.

Shiokawa D, Sato A, Ohata H, Mutoh M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K.

Cell Rep. 2017 May 2;19(5):981-994. doi: 10.1016/j.celrep.2017.04.017.

15.

Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.

Yoshimatsu Y, Nakahara T, Tanaka K, Inagawa Y, Narisawa-Saito M, Yugawa T, Ohno SI, Fujita M, Nakagama H, Kiyono T.

Cancer Sci. 2017 Jul;108(7):1303-1309. doi: 10.1111/cas.13264. Epub 2017 Jun 5.

16.

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease.

Liew LC, Katsuda T, Gailhouste L, Nakagama H, Ochiya T.

Int Immunol. 2017 Jan 1;29(1):11-19. doi: 10.1093/intimm/dxx002. Review.

PMID:
28184439
17.

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

Kanemoto K, Fukuta K, Kawai N, Tozawa K, Ochiai M, Okamoto K, Ohnami S, Sakamoto H, Yoshida T, Kanai Y, Katoh M, Yasui T, Kohri K, Kakizoe T, Nakagama H.

PLoS One. 2016 Nov 30;11(11):e0167374. doi: 10.1371/journal.pone.0167374. eCollection 2016.

18.

Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments.

Hori M, Onaya H, Hiraoka N, Yamaji T, Kobayashi H, Takahashi M, Mutoh M, Shimada K, Nakagama H.

Jpn J Radiol. 2016 Oct;34(10):667-676. Epub 2016 Aug 31.

PMID:
27581428
19.

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes.

Mimaki S, Totsuka Y, Suzuki Y, Nakai C, Goto M, Kojima M, Arakawa H, Takemura S, Tanaka S, Marubashi S, Kinoshita M, Matsuda T, Shibata T, Nakagama H, Ochiai A, Kubo S, Nakamori S, Esumi H, Tsuchihara K.

Carcinogenesis. 2016 Aug;37(8):817-826. doi: 10.1093/carcin/bgw066. Epub 2016 Jun 7.

20.

Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report.

Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.

Cancer Sci. 2016 Mar;107(3):369-71. doi: 10.1111/cas.12889. Review.

21.

Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells.

Ezawa I, Sawai Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Kobayashi Y, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.

Cancer Sci. 2016 Jun;107(6):734-45. doi: 10.1111/cas.12933. Epub 2016 May 16.

22.

Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on Diabetes and Cancer, Second Report.

Goto A, Noto H, Noda M, Ueki K, Kasuga M, Tajima N, Ohashi K, Sakai R, Tsugane S, Hamajima N, Tajima K, Imai K, Nakagama H.

Diabetol Int. 2016 Mar 7;7(1):12-15. doi: 10.1007/s13340-016-0257-z. eCollection 2016 Mar. Review.

23.

Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma.

Yachida S, Wood LD, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss MJ, Wolfgang CL, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban RH, Shibata T.

Cancer Cell. 2016 Feb 8;29(2):229-40. doi: 10.1016/j.ccell.2015.12.012. Epub 2016 Jan 21.

24.

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R.

Sci Rep. 2016 Jan 12;6:19174. doi: 10.1038/srep19174.

25.

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation.

Atsumi Y, Minakawa Y, Ono M, Dobashi S, Shinohe K, Shinohara A, Takeda S, Takagi M, Takamatsu N, Nakagama H, Teraoka H, Yoshioka K.

Cell Rep. 2015 Dec 29;13(12):2728-40. doi: 10.1016/j.celrep.2015.11.054. Epub 2015 Dec 17.

26.

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.

Ishiguro T, Sato A, Ohata H, Ikarashi Y, Takahashi RU, Ochiya T, Yoshida M, Tsuda H, Onda T, Kato T, Kasamatsu T, Enomoto T, Tanaka K, Nakagama H, Okamoto K.

Cancer Res. 2016 Jan 1;76(1):150-60. doi: 10.1158/0008-5472.CAN-15-0361. Epub 2015 Dec 15.

27.

Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer.

Takai E, Totoki Y, Nakamura H, Morizane C, Nara S, Hama N, Suzuki M, Furukawa E, Kato M, Hayashi H, Kohno T, Ueno H, Shimada K, Okusaka T, Nakagama H, Shibata T, Yachida S.

Sci Rep. 2015 Dec 16;5:18425. doi: 10.1038/srep18425.

28.

[A roadmap toward total elimination of cancer].

Okamoto K, Nakagama H.

Nihon Rinsho. 2015 May;73(5):860-5. Japanese.

PMID:
25985644
29.

Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo.

Suzuki M, Chiwaki F, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y, Sasaki H.

PLoS One. 2015 Apr 8;10(4):e0123407. doi: 10.1371/journal.pone.0123407. eCollection 2015.

30.

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Tominaga N, Kosaka N, Ono M, Katsuda T, Yoshioka Y, Tamura K, Lötvall J, Nakagama H, Ochiya T.

Nat Commun. 2015 Apr 1;6:6716. doi: 10.1038/ncomms7716.

31.

Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.

Sakamaki A, Katsuragi Y, Otsuka K, Tomita M, Obata M, Iwasaki T, Abe M, Sato T, Ochiai M, Sakuraba Y, Aoyagi Y, Gondo Y, Sakimura K, Nakagama H, Mishima Y, Kominami R.

Carcinogenesis. 2015 Jun;36(6):622-31. doi: 10.1093/carcin/bgv044. Epub 2015 Mar 31.

PMID:
25827435
32.

Development of cancer-initiating cells and immortalized cells with genomic instability.

Yoshioka K, Atsumi Y, Nakagama H, Teraoka H.

World J Stem Cells. 2015 Mar 26;7(2):483-9. doi: 10.4252/wjsc.v7.i2.483. Review.

33.

Comprehensive DNA adduct analysis reveals pulmonary inflammatory response contributes to genotoxic action of magnetite nanoparticles.

Ishino K, Kato T, Kato M, Shibata T, Watanabe M, Wakabayashi K, Nakagama H, Totsuka Y.

Int J Mol Sci. 2015 Feb 4;16(2):3474-92. doi: 10.3390/ijms16023474.

34.

TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion.

Otomo R, Otsubo C, Matsushima-Hibiya Y, Miyazaki M, Tashiro F, Ichikawa H, Kohno T, Ochiya T, Yokota J, Nakagama H, Taya Y, Enari M.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18691-6. doi: 10.1073/pnas.1412062112. Epub 2014 Dec 15.

35.

Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts.

Goto M, Shinmura K, Matsushima Y, Ishino K, Yamada H, Totsuka Y, Matsuda T, Nakagama H, Sugimura H.

Free Radic Biol Med. 2014 Nov;76:136-46. doi: 10.1016/j.freeradbiomed.2014.07.044. Epub 2014 Aug 20.

PMID:
25151120
36.

NEK9-dependent proliferation of cancer cells lacking functional p53.

Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N.

Sci Rep. 2014 Aug 18;4:6111. doi: 10.1038/srep06111.

37.

Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice.

Higurashi T, Endo H, Uchiyama T, Uchiyama S, Yamada E, Ohkubo H, Sakai E, Takahashi H, Maeda S, Wada K, Natsumeda Y, Hippo Y, Nakajima A, Nakagama H.

Carcinogenesis. 2014 Sep;35(9):2134-41. doi: 10.1093/carcin/bgu135. Epub 2014 Jun 23.

PMID:
24958593
38.

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors.

Ohki R, Saito K, Chen Y, Kawase T, Hiraoka N, Saigawa R, Minegishi M, Aita Y, Yanai G, Shimizu H, Yachida S, Sakata N, Doi R, Kosuge T, Shimada K, Tycko B, Tsukada T, Kanai Y, Sumi S, Namiki H, Taya Y, Shibata T, Nakagama H.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2404-13. doi: 10.1073/pnas.1319962111. Epub 2014 May 27.

39.

RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.

Tominaga N, Hagiwara K, Kosaka N, Honma K, Nakagama H, Ochiya T.

Mol Cancer. 2014 May 31;13:134. doi: 10.1186/1476-4598-13-134.

40.

A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability.

Yamamoto Y, Miyamoto M, Tatsuda D, Kubo M, Nakagama H, Nakamura Y, Satoh H, Matsuda K, Watanabe T, Ohta T.

Cancer Res. 2014 Jul 15;74(14):3707-15. doi: 10.1158/0008-5472.CAN-13-3037. Epub 2014 May 15.

41.

Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon.

Ochiai M, Hippo Y, Izumiya M, Watanabe M, Nakagama H.

Cancer Sci. 2014 Aug;105(8):943-50. doi: 10.1111/cas.12446. Epub 2014 Jul 12.

42.

A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice.

Kochi T, Shimizu M, Totsuka Y, Shirakami Y, Nakanishi T, Watanabe T, Tanaka T, Nakagama H, Wakabayashi K, Moriwaki H.

Toxicol Rep. 2014 Apr 30;1:69-73. doi: 10.1016/j.toxrep.2014.04.006. eCollection 2014.

43.

TSPAN2 is involved in cell invasion and motility during lung cancer progression.

Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J, Enari M.

Cell Rep. 2014 Apr 24;7(2):527-538. doi: 10.1016/j.celrep.2014.03.027. Epub 2014 Apr 13.

44.

Circulating exosomal microRNAs as biomarkers of colon cancer.

Ogata-Kawata H, Izumiya M, Kurioka D, Honma Y, Yamada Y, Furuta K, Gunji T, Ohta H, Okamoto H, Sonoda H, Watanabe M, Nakagama H, Yokota J, Kohno T, Tsuchiya N.

PLoS One. 2014 Apr 4;9(4):e92921. doi: 10.1371/journal.pone.0092921. eCollection 2014.

45.

Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma.

Hori M, Takahashi M, Hiraoka N, Yamaji T, Mutoh M, Ishigamori R, Furuta K, Okusaka T, Shimada K, Kosuge T, Kanai Y, Nakagama H.

Clin Transl Gastroenterol. 2014 Mar 13;5:e53. doi: 10.1038/ctg.2014.5.

46.

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.

Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart ME, Tsusaka T, Hori K, Murakami I, Izumi T, Takaori-Kondo A, Yokode M, Peters G, Beach D, Kondoh H.

J Cell Biol. 2014 Mar 3;204(5):729-45. doi: 10.1083/jcb.201306149. Epub 2014 Feb 24.

47.

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.

Sakai H, Sato A, Aihara Y, Ikarashi Y, Midorikawa Y, Kracht M, Nakagama H, Okamoto K.

Cancer Sci. 2014 Apr;105(4):425-30. doi: 10.1111/cas.12380. Epub 2014 Mar 24.

48.

AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.

Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):852-7. doi: 10.1016/j.bbrc.2013.12.059. Epub 2013 Dec 14.

PMID:
24342614
49.

In vivo genotoxicity of a novel heterocyclic amine, aminobenzoazepinoquinolinone-derivative (ABAQ), produced by the Maillard reaction between glucose and l-tryptophan.

Totsuka Y, Watanabe T, Coulibaly S, Kobayashi S, Nishizaki M, Okazaki M, Hasei T, Wakabayashi K, Nakagama H.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15;760:48-55. doi: 10.1016/j.mrgentox.2013.12.002. Epub 2013 Dec 12.

PMID:
24333690
50.

Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate: nano-surface and molecular-orientation limited proteolysis.

Iwamoto N, Shimada T, Umino Y, Aoki C, Aoki Y, Sato TA, Hamada A, Nakagama H.

Analyst. 2014 Feb 7;139(3):576-80. doi: 10.1039/c3an02104a.

PMID:
24326404

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