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Items: 1 to 50 of 164

1.

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats.

Hojo M, Sakamoto Y, Maeno A, Tayama K, Tada Y, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Tanaka K, Yano N, Kaihoko F, Hasegawa Y, Suzuki T, Inomata A, Moriyasu T, Miyajima K, Nakae D.

J Toxicol Pathol. 2020 Jan;33(1):47-55. doi: 10.1293/tox.2019-0064. Epub 2019 Nov 22.

2.

Establishment of the Global SEND Alliance (G-SEND) in Japan and efficient creation of electronic SEND datasets between CROs.

Anzai T, Matsuyama T, Wasko M, Hatakeyama H, Horikawa SI, Anzai R, Iwata H, Imai N, Mizuhashi F, Tsuboi M, Okuzono T, Takagi H, Cho H, Rong BTS, Masaki F, Nakae D.

J Toxicol Pathol. 2019 Apr;32(2):119-126. doi: 10.1293/tox.2018-0066. Epub 2019 Mar 2.

3.

Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model.

Saito T, Toriniwa Y, Ishii Y, Uemura A, Miyajima K, Uno K, Shirai Y, Nakae D, Ohta T.

J Toxicol Pathol. 2018 Oct;31(4):283-291. doi: 10.1293/tox.2018-0016. Epub 2018 Sep 2.

4.

Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats.

Sakamoto Y, Hojo M, Kosugi Y, Watanabe K, Hirose A, Inomata A, Suzuki T, Nakae D.

J Toxicol Sci. 2018;43(10):587-600. doi: 10.2131/jts.43.587.

5.

Effect of dosing frequency of teriparatide (PTH 1-34) on bone formation in rats: comparison of bone metabolism marker levels.

Watanabe A, Tsurui K, Yoneyama S, Iwata H, Anzai T, Jerome C, Nakae D.

J Toxicol Sci. 2018;43(7):435-442. doi: 10.2131/jts.43.435.

6.

Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes.

Fukai E, Sato H, Watanabe M, Nakae D, Totsuka Y.

Cancer Sci. 2018 Apr;109(4):1024-1031. doi: 10.1111/cas.13534. Epub 2018 Apr 1.

7.

Extracts of black and brown rice powders improve hepatic lipid accumulation via the activation of PPARα in obese and diabetic model mice.

Felix AD, Takahashi N, Takahashi M, Katsumata-Tsuboi R, Satoh R, Soon Hui T, Miyajima K, Nakae D, Inoue H, Uehara M.

Biosci Biotechnol Biochem. 2017 Nov;81(11):2209-2211. doi: 10.1080/09168451.2017.1372178. Epub 2017 Sep 22.

PMID:
28934910
8.

Specific pathologist responses for Standard for Exchange of Nonclinical Data (SEND).

Watanabe A, Kusuoka O, Sato N, Nakazono O, Wasko M, Potenta D, Nakae D, Hatakeyama H, Iwata H, Naota M, Anzai T.

J Toxicol Pathol. 2017 Jul;30(3):201-207. doi: 10.1293/tox.2017-0019. Epub 2017 May 30. Review.

9.

Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats.

Horibata K, Ukai A, Ogata A, Nakae D, Ando H, Kubo Y, Nagasawa A, Yuzawa K, Honma M.

Genes Environ. 2017 Jan 6;39:4. doi: 10.1186/s41021-016-0065-5. eCollection 2017.

10.

Effects Induced by Organic Acids in a Human Lung Alveolar Carcinoma Cell Line A549.

Okubo T, Suzuki T, Hosaka M, Nakae D.

Yakugaku Zasshi. 2016;136(10):1433-1438. Japanese.

11.

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.

Suzuki-Kemuriyama N, Matsuzaka T, Kuba M, Ohno H, Han SI, Takeuchi Y, Isaka M, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Miyajima K, Nakae D, Yahagi N, Nakagawa Y, Sone H, Yamada N, Shimano H.

PLoS One. 2016 Jun 22;11(6):e0157580. doi: 10.1371/journal.pone.0157580. eCollection 2016.

12.

Comparison of fetal toxicity of various multi-wall carbon nanotubes in mice.

Fujitani T, Inomata A, Ogata A, Sakamoto Y, Hirose A, Nishimura T, Ikeda R, Nakae D.

Toxicol Rep. 2015 Jul 19;2:1404-1408. doi: 10.1016/j.toxrep.2015.07.014. eCollection 2015.

13.

Expression of MAS1 in breast cancer.

Luo Y, Tanabe E, Kitayoshi M, Nishiguchi Y, Fujiwara R, Matsushima S, Sasaki T, Sasahira T, Chihara Y, Nakae D, Fujii K, Ohmori H, Kuniyasu H.

Cancer Sci. 2015 Sep;106(9):1240-8. doi: 10.1111/cas.12719. Epub 2015 Jul 20.

14.

Responses to the Standard for Exchange of Nonclinical Data (SEND) in non-US countries.

Anzai T, Kaminishi M, Sato K, Kaufman L, Iwata H, Nakae D.

J Toxicol Pathol. 2015 Apr;28(2):57-64. doi: 10.1293/tox.2015-0007. Epub 2015 Apr 1. Review. Erratum in: J Toxicol Pathol. 2016 Jan;29(1):74.

15.

In vitro effects induced by diesel exhaust at an air-liquid interface in a human lung alveolar carcinoma cell line A549.

Okubo T, Hosaka M, Nakae D.

Exp Toxicol Pathol. 2015 Jul-Aug;67(7-8):383-8. doi: 10.1016/j.etp.2015.03.004. Epub 2015 May 14.

PMID:
25983017
16.

Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study.

Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori T, Nakae D, Hirose A, Kanno J, Tsuda H.

Cancer Sci. 2015 Jul;106(7):825-32. doi: 10.1111/cas.12687. Epub 2015 Jun 5.

17.

Comparative effects of sulfhydryl compounds on target organellae, nuclei and mitochondria, of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes.

Nakagawa Y, Inomata A, Ogata A, Nakae D.

J Appl Toxicol. 2015 Dec;35(12):1465-72. doi: 10.1002/jat.3137. Epub 2015 Mar 23.

PMID:
25809591
18.

Pancreatic Ductal Adenocarcinoma in a Wistar Hannover GALAS Rat.

Kuroda Y, Hayashi S, Hagio S, Abe M, Furukawa S, Nakae D.

J Toxicol Pathol. 2014 Jul;27(2):147-51. doi: 10.1293/tox.2013-0068. Epub 2013 Dec 29.

19.

Effects of different types of bedding materials on behavioral development in laboratory CD1 mice (Mus musculus).

Tanaka T, Ogata A, Inomata A, Nakae D.

Birth Defects Res B Dev Reprod Toxicol. 2014 Oct;101(5):393-401. doi: 10.1002/bdrb.21129. Epub 2014 Oct 3.

PMID:
25283888
20.

Occurrence and behavior of the chiral anti-inflammatory drug naproxen in an aquatic environment.

Suzuki T, Kosugi Y, Hosaka M, Nishimura T, Nakae D.

Environ Toxicol Chem. 2014 Dec;33(12):2671-8. doi: 10.1002/etc.2741. Epub 2014 Oct 8.

PMID:
25234664
21.

High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1β secretion.

Cui H, Wu W, Okuhira K, Miyazawa K, Hattori T, Sai K, Naito M, Suzuki K, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Hirose A, Nishimaki-Mogami T.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):593-9. doi: 10.1016/j.bbrc.2014.08.118. Epub 2014 Aug 30.

PMID:
25181346
22.

Rapid identification of a narcotic plant Papaver bracteatum using flow cytometry.

Aragane M, Watanabe D, Nakajima J, Yoshida M, Yoshizawa M, Abe T, Nishiyama R, Suzuki J, Moriyasu T, Nakae D, Sudo H, Sato H, Hishida A, Kawahara N, Makabe S, Nakamura I, Mii M.

J Nat Med. 2014 Oct;68(4):677-85. doi: 10.1007/s11418-014-0850-z. Epub 2014 Jun 22.

23.

Teratogenicity of asbestos in mice.

Fujitani T, Hojo M, Inomata A, Ogata A, Hirose A, Nishimura T, Nakae D.

J Toxicol Sci. 2014 Apr;39(2):363-70.

24.

Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response.

Totsuka Y, Ishino K, Kato T, Goto S, Tada Y, Nakae D, Watanabe M, Wakabayashi K.

Nanomaterials (Basel). 2014 Mar 18;4(1):175-188. doi: 10.3390/nano4010175.

25.

Long-term Pulmonary Responses to Quadweekly Intermittent Intratracheal Spray Instillations of Magnetite (Fe3O4) Nanoparticles for 52 Weeks in Fischer 344 Rats.

Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Inomata A, Ogata A, Nakae D.

J Toxicol Pathol. 2013 Dec;26(4):393-403. doi: 10.1293/tox.2013-0036. Epub 2013 Dec 26.

26.

Multi-step lung carcinogenesis model induced by oral administration of N-nitrosobis(2-hydroxypropyl)amine in rats.

Tsujiuchi T, Nakae D, Konishi Y.

Exp Toxicol Pathol. 2014 Mar;66(2-3):81-8. doi: 10.1016/j.etp.2013.11.006. Epub 2013 Dec 27. Review.

PMID:
24377951
27.

Effects of maternal exposure to imazalil on behavioral development in F₁-generation mice.

Tanaka T, Ogata A, Inomata A, Nakae D.

Birth Defects Res B Dev Reprod Toxicol. 2013 Aug;98(4):334-42. doi: 10.1002/bdrb.21070. Epub 2013 Aug 26.

PMID:
24039133
28.

Effects of N-acetyl-L-cysteine on target sites of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes.

Nakagawa Y, Suzuki T, Nakajima K, Inomata A, Ogata A, Nakae D.

Arch Toxicol. 2014 Jan;88(1):115-26. doi: 10.1007/s00204-013-1096-3. Epub 2013 Jul 23.

PMID:
23877122
29.

Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice.

Nakajima J, Nakae D, Yasukawa K.

J Pharm Pharmacol. 2013 Aug;65(8):1223-30. doi: 10.1111/jphp.12082. Epub 2013 May 21.

PMID:
23837590
30.

Acute phase pulmonary responses to a single intratracheal spray instillation of magnetite (fe(3)o(4)) nanoparticles in Fischer 344 rats.

Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Ogata A, Nakae D.

J Toxicol Pathol. 2012 Dec;25(4):233-9. doi: 10.1293/tox.25.233. Epub 2012 Dec 20.

31.

Reproductive and neurobehavioral effects of brilliant blue FCF in mice.

Tanaka T, Takahashi O, Inomata A, Ogata A, Nakae D.

Birth Defects Res B Dev Reprod Toxicol. 2012 Dec;95(6):395-409. doi: 10.1002/bdrb.21029. Epub 2012 Dec 3.

PMID:
23208798
32.

Multi-walled carbon nanotubes translocate into the pleural cavity and induce visceral mesothelial proliferation in rats.

Xu J, Futakuchi M, Shimizu H, Alexander DB, Yanagihara K, Fukamachi K, Suzui M, Kanno J, Hirose A, Ogata A, Sakamoto Y, Nakae D, Omori T, Tsuda H.

Cancer Sci. 2012 Dec;103(12):2045-50. doi: 10.1111/cas.12005. Epub 2012 Oct 10.

33.

Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia.

Abe M, Hayashi S, Usuda K, Hagio S, Furukawa S, Nakae D.

J Toxicol Pathol. 2012 Mar;25(1):11-7. doi: 10.1293/tox.25.11.

34.

Genotoxicity of multi-walled carbon nanotubes in both in vitro and in vivo assay systems.

Kato T, Totsuka Y, Ishino K, Matsumoto Y, Tada Y, Nakae D, Goto S, Masuda S, Ogo S, Kawanishi M, Yagi T, Matsuda T, Watanabe M, Wakabayashi K.

Nanotoxicology. 2013 Jun;7(4):452-61. doi: 10.3109/17435390.2012.674571. Epub 2012 Apr 4.

PMID:
22397533
35.

Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice.

Yamaguchi A, Fujitani T, Ohyama K, Nakae D, Hirose A, Nishimura T, Ogata A.

J Toxicol Sci. 2012 Feb;37(1):177-89.

36.

Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice.

Fujitani T, Ohyama K, Hirose A, Nishimura T, Nakae D, Ogata A.

J Toxicol Sci. 2012 Feb;37(1):81-9.

37.

Lack of chronic toxicity and carcinogenicity of dietary administrated catechin mixture in Wistar Hannover GALAS rats.

Yoshida M, Takahashi M, Inoue K, Nakae D, Nishikawa A.

J Toxicol Sci. 2011 Jun;36(3):297-311.

38.

Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction.

Nakagawa Y, Suzuki T, Ishii H, Nakae D, Ogata A.

Arch Toxicol. 2011 Nov;85(11):1429-40. doi: 10.1007/s00204-011-0688-z. Epub 2011 Mar 2.

PMID:
21365311
39.

[Importance of researches on chronic effects by manufactured nanomaterials].

Hirose A, Takagi A, Nishimura T, Tsuda H, Sakamoto Y, Ogata A, Nakae D, Hino O, Kanno J.

Yakugaku Zasshi. 2011 Feb;131(2):195-201. Review. Japanese.

40.

Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system.

Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, Nolte T, Malarkey DE, Kaufmann W, Küttler K, Deschl U, Nakae D, Gregson R, Vinlove MP, Brix AE, Singh B, Belpoggi F, Ward JM.

Toxicol Pathol. 2010 Dec;38(7 Suppl):5S-81S. doi: 10.1177/0192623310386499. Review.

PMID:
21191096
41.

Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip / WAF1).

Wei M, Wanibuchi H, Nakae D, Tsuda H, Takahashi S, Hirose M, Totsuka Y, Tatematsu M, Fukushima S.

Cancer Sci. 2011 Jan;102(1):88-94. doi: 10.1111/j.1349-7006.2010.01761.x. Epub 2010 Oct 21.

42.

Parenteral paradichlorobenzene exposure reduces sperm production, alters sperm morphology and exhibits an androgenic effect in rats and mice.

Takahashi O, Ohashi N, Nakae D, Ogata A.

Food Chem Toxicol. 2011 Jan;49(1):49-56. doi: 10.1016/j.fct.2010.09.029. Epub 2010 Oct 12.

PMID:
20932873
43.

Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes.

Nakagawa Y, Suzuki T, Ishii H, Ogata A, Nakae D.

Chem Biol Interact. 2010 Dec 5;188(3):393-403. doi: 10.1016/j.cbi.2010.09.004. Epub 2010 Sep 15.

PMID:
20833158
44.

Toxicological evaluation of L-proline in a 90-day feeding study with Fischer 344 rats.

Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Ohashi N, Ogata A, Nakae D.

Regul Toxicol Pharmacol. 2010 Oct;58(1):114-20. doi: 10.1016/j.yrtph.2010.04.011. Epub 2010 May 4.

PMID:
20447433
45.

A 90-day Feeding Toxicity Study of l-Serine in Male and Female Fischer 344 Rats.

Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Chin K, Kawamata Y, Sakai R, Ohashi N, Ogata A, Nakae D.

J Toxicol Pathol. 2010 Mar;23(1):39-47. doi: 10.1293/tox.23.39. Epub 2010 Apr 5.

47.

Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.

Igarashi M, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.

J Toxicol Sci. 2009 Apr;34(2):163-74.

48.

Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats.

Sakamoto Y, Nakae D, Fukumori N, Tayama K, Maekawa A, Imai K, Hirose A, Nishimura T, Ohashi N, Ogata A.

J Toxicol Sci. 2009 Feb;34(1):65-76.

49.

Toxic effects of l-aspartic acid at high dose levels on kidneys and salivary glands in Fischer 344 rats detected in a 90-day feeding study.

Tada Y, Yano N, Takahashi H, Yuzawa K, Ando H, Kubo Y, Nagasawa A, Uehara S, Ogata A, Nakae D.

Food Chem Toxicol. 2008 Aug;46(8):2789-95. doi: 10.1016/j.fct.2008.05.013. Epub 2008 May 22.

PMID:
18583012
50.

Points to consider on the non-clinical safety evaluation of anticancer drugs.

Nakae D, Onodera H, Fueki O, Urano T, Komiyama N, Sagami F, Kai S, Nishimura C, Inoue T.

J Toxicol Sci. 2008 May;33(2):123-6. Review.

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