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Items: 1 to 50 of 324

1.

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice.

Chen J, Huang Z, Wu X, Kang J, Ren Y, Gao W, Lu X, Wang J, Ding W, Nakabeppu Y, Fan Y, Wang Y.

Free Radic Biol Med. 2019 Nov 1;143:482-493. doi: 10.1016/j.freeradbiomed.2019.09.005. Epub 2019 Sep 7.

PMID:
31505270
2.

Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer's Disease Brain.

Nakabeppu Y.

Adv Exp Med Biol. 2019;1128:27-44. doi: 10.1007/978-981-13-3540-2_3. Review.

PMID:
31062324
3.

Origins of Brain Insulin and Its Function.

Nakabeppu Y.

Adv Exp Med Biol. 2019;1128:1-11. doi: 10.1007/978-981-13-3540-2_1. Review.

PMID:
31062322
4.

8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes.

Haruyama N, Sakumi K, Katogi A, Tsuchimoto D, De Luca G, Bignami M, Nakabeppu Y.

Prog Neurobiol. 2019 Sep;180:101613. doi: 10.1016/j.pneurobio.2019.04.002. Epub 2019 Apr 23.

PMID:
31026482
5.

A Pilot Study of Texture Analysis of Primary Tumor [18F]FDG Uptake to Predict Recurrence in Surgically Treated Patients with Non-small Cell Lung Cancer.

Nakajo M, Jinguji M, Shinaji T, Aoki M, Tani A, Nakabeppu Y, Nakajo M, Sato M, Yoshiura T.

Mol Imaging Biol. 2019 Aug;21(4):771-780. doi: 10.1007/s11307-018-1290-z.

PMID:
30397859
6.

18F-FDG-PET/CT features of primary tumours for predicting the risk of recurrence in thyroid cancer after total thyroidectomy: potential usefulness of combination of the SUV-related, volumetric, and heterogeneous texture parameters.

Nakajo M, Jinguji M, Shinaji T, Tani A, Nakabeppu Y, Nakajo M, Nakajo A, Natsugoe S, Yoshiura T.

Br J Radiol. 2019 Feb;92(1094):20180620. doi: 10.1259/bjr.20180620. Epub 2018 Nov 7.

PMID:
30273012
7.

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma.

Sakurada A, Miyanishi K, Tanaka S, Sato M, Sakamoto H, Kawano Y, Takada K, Nakabeppu Y, Kobune M, Kato J.

Free Radic Biol Med. 2018 Dec;129:88-96. doi: 10.1016/j.freeradbiomed.2018.09.010. Epub 2018 Sep 13.

PMID:
30218772
8.

Correlation between clinical and radiologic features of patients with Gerstmann-Sträussler-Scheinker syndrome (Pro102Leu).

Yoshimura M, Yuan JH, Higashi K, Yoshimura A, Arata H, Okubo R, Nakabeppu Y, Yoshiura T, Takashima H.

J Neurol Sci. 2018 Aug 15;391:15-21. doi: 10.1016/j.jns.2018.05.012. Epub 2018 May 17.

9.

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.

Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI.

Ann Neurol. 2018 Aug;84(2):208-224. doi: 10.1002/ana.25279. Epub 2018 Sep 3.

PMID:
30014510
10.

Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.

Hommyo R, Suzuki SO, Abolhassani N, Hamasaki H, Shijo M, Maeda N, Honda H, Nakabeppu Y, Iwaki T.

Neuropathology. 2018 Jun;38(3):247-259. doi: 10.1111/neup.12466. Epub 2018 Mar 30.

PMID:
29603402
11.

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.

Neuroscience. 2018 May 1;377:87-97. doi: 10.1016/j.neuroscience.2018.02.031. Epub 2018 Mar 3.

PMID:
29510211
12.

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.

Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y.

Sci Rep. 2017 Dec 19;7(1):17762. doi: 10.1038/s41598-017-17999-3.

13.

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.

Li GH, Akatsuka S, Chew SH, Jiang L, Nishiyama T, Sakamoto A, Takahashi T, Futakuchi M, Suzuki H, Sakumi K, Nakabeppu Y, Toyokuni S.

Pathol Int. 2017 Nov;67(11):564-574. doi: 10.1111/pin.12598. Epub 2017 Oct 13.

PMID:
29027306
14.

Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse.

Chikama K, Yamada H, Tsukamoto T, Kajitani K, Nakabeppu Y, Uchimura N.

Brain Res. 2017 Dec 1;1676:77-82. doi: 10.1016/j.brainres.2017.09.006. Epub 2017 Sep 9.

PMID:
28899760
15.

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B.

DNA Repair (Amst). 2017 Oct;58:13-20. doi: 10.1016/j.dnarep.2017.08.005. Epub 2017 Aug 12.

PMID:
28843610
16.

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway.

Asada S, Ohta E, Akimoto Y, Abolhassani N, Tsuchimoto D, Nakabeppu Y.

Sci Rep. 2017 Jul 26;7(1):6528. doi: 10.1038/s41598-017-06636-8.

17.

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.

Vartanian V, Tumova J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd RS, Sampath H.

PLoS One. 2017 Jul 20;12(7):e0181687. doi: 10.1371/journal.pone.0181687. eCollection 2017.

18.

Increase in the Regional Cerebral Blood Flow following Waon Therapy in Patients with Chronic Fatigue Syndrome: A Pilot Study.

Munemoto T, Soejima Y, Masuda A, Nakabeppu Y, Tei C.

Intern Med. 2017;56(14):1817-1824. doi: 10.2169/internalmedicine.56.8001. Epub 2017 Jul 15.

19.

Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation.

Kajitani K, Yanagimoto K, Nakabeppu Y.

Psychopharmacology (Berl). 2017 Oct;234(19):2919-2927. doi: 10.1007/s00213-017-4683-9. Epub 2017 Jul 11.

PMID:
28698921
20.

Texture analysis of FDG PET/CT for differentiating between FDG-avid benign and metastatic adrenal tumors: efficacy of combining SUV and texture parameters.

Nakajo M, Jinguji M, Nakajo M, Shinaji T, Nakabeppu Y, Fukukura Y, Yoshiura T.

Abdom Radiol (NY). 2017 Dec;42(12):2882-2889. doi: 10.1007/s00261-017-1207-3.

PMID:
28612161
21.

Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer.

Fujishita T, Okamoto T, Akamine T, Takamori S, Takada K, Katsura M, Toyokawa G, Shoji F, Shimokawa M, Oda Y, Nakabeppu Y, Maehara Y.

Lung Cancer. 2017 Jul;109:52-57. doi: 10.1016/j.lungcan.2017.04.012. Epub 2017 Apr 24.

PMID:
28577950
22.

Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice.

Yoshii Y, Inoue T, Uemura Y, Iwasaki Y, Yada T, Nakabeppu Y, Noda M.

Neurochem Res. 2017 Sep;42(9):2658-2665. doi: 10.1007/s11064-017-2281-1. Epub 2017 May 2.

PMID:
28462451
23.

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.

Waz S, Nakamura T, Hirata K, Koga-Ogawa Y, Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y, Yamagata Y.

J Biol Chem. 2017 Feb 17;292(7):2785-2794. doi: 10.1074/jbc.M116.749713. Epub 2016 Dec 29.

24.

Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi.

Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T.

Brain Pathol. 2018 Jan;28(1):58-71. doi: 10.1111/bpa.12475. Epub 2017 Feb 8.

PMID:
27997051
25.

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.

Akiyama S, Saeki H, Nakashima Y, Iimori M, Kitao H, Oki E, Oda Y, Nakabeppu Y, Kakeji Y, Maehara Y.

Cancer Med. 2017 Jan;6(1):258-266. doi: 10.1002/cam4.979. Epub 2016 Dec 5.

26.

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y.

Sci Rep. 2016 Nov 29;6:37889. doi: 10.1038/srep37889.

27.

The effects of olanzapine treatment on brain regional glucose metabolism in neuroleptic-naive first-episode schizophrenic patients.

Yoshimuta H, Nakamura M, Kanda E, Fujita S, Takeuchi K, Fujimoto T, Nakabeppu Y, Akasaki Y, Sano A.

Hum Psychopharmacol. 2016 Nov;31(6):419-426. doi: 10.1002/hup.2558.

PMID:
27859668
28.

MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?

Nakabeppu Y, Ohta E, Abolhassani N.

Free Radic Biol Med. 2017 Jun;107:151-158. doi: 10.1016/j.freeradbiomed.2016.11.002. Epub 2016 Nov 7. Review.

PMID:
27833032
29.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Massaad MJ, Zhou J, Tsuchimoto D, Chou J, Jabara H, Janssen E, Glauzy S, Olson BG, Morbach H, Ohsumi TK, Schmitz K, Kyriacos M, Kane J, Torisu K, Nakabeppu Y, Notarangelo LD, Chouery E, Megarbane A, Kang PB, Al-Idrissi E, Aldhekri H, Meffre E, Mizui M, Tsokos GC, Manis JP, Al-Herz W, Wallace SS, Geha RS.

J Clin Invest. 2016 Nov 1;126(11):4219-4236. doi: 10.1172/JCI85647. Epub 2016 Oct 17.

30.

Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis.

Takemori C, Kunisada M, Yogianti F, Oka S, Sakumi K, Ono R, Nakabeppu Y, Nishigori C.

J Dermatol Sci. 2017 Feb;85(2):140-143. doi: 10.1016/j.jdermsci.2016.10.011. Epub 2016 Oct 20. No abstract available.

PMID:
27789198
31.

Current clinical status of 18F-FLT PET or PET/CT in digestive and abdominal organ oncology.

Nakajo M, Kajiya Y, Jinguji M, Nakabeppu Y, Nakajo M, Nihara T, Yoshiura T.

Abdom Radiol (NY). 2017 Mar;42(3):951-961. doi: 10.1007/s00261-016-0947-9. Review.

PMID:
27770160
32.

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

Evans MD, Mistry V, Singh R, Gackowski D, Różalski R, Siomek-Gorecka A, Phillips DH, Zuo J, Mullenders L, Pines A, Nakabeppu Y, Sakumi K, Sekiguchi M, Tsuzuki T, Bignami M, Oliński R, Cooke MS.

Free Radic Biol Med. 2016 Oct;99:385-391. doi: 10.1016/j.freeradbiomed.2016.08.018. Epub 2016 Aug 30.

PMID:
27585947
33.

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway.

Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T.

Cancer Sci. 2017 Jan;108(1):108-115. doi: 10.1111/cas.13106. Epub 2016 Dec 1.

34.

MUTYH promotes oxidative microglial activation and inherited retinal degeneration.

Nakatake S, Murakami Y, Ikeda Y, Morioka N, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Nakabeppu Y, Sonoda KH.

JCI Insight. 2016 Sep 22;1(15):e87781. doi: 10.1172/jci.insight.87781.

35.

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells.

Yoneshima Y, Abolhassani N, Iyama T, Sakumi K, Shiomi N, Mori M, Shiomi T, Noda T, Tsuchimoto D, Nakabeppu Y.

Sci Rep. 2016 Sep 13;6:32849. doi: 10.1038/srep32849.

36.

Texture analysis of 18F-FDG PET/CT to predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy.

Nakajo M, Jinguji M, Nakabeppu Y, Nakajo M, Higashi R, Fukukura Y, Sasaki K, Uchikado Y, Natsugoe S, Yoshiura T.

Eur J Nucl Med Mol Imaging. 2017 Feb;44(2):206-214. doi: 10.1007/s00259-016-3506-2. Epub 2016 Sep 10.

PMID:
27613542
37.

PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.

Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, Sakumi K, Torisu T, Chida K, Sueishi K, Kubo M, Hata J, Kitazono T, Kiyohara Y, Nakabeppu Y.

Genes Cells. 2016 Oct;21(10):1030-1048. doi: 10.1111/gtc.12402. Epub 2016 Aug 22.

38.

Corrigendum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.

Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.

Sci Rep. 2016 Jun 10;6:27164. doi: 10.1038/srep27164. No abstract available.

39.

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.

Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y.

Mech Ageing Dev. 2017 Jan;161(Pt A):95-104. doi: 10.1016/j.mad.2016.05.005. Epub 2016 May 24. Review.

PMID:
27233446
40.

Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.

Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y.

Sci Rep. 2016 Apr 29;6:24696. doi: 10.1038/srep24696. No abstract available.

41.

Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice.

Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T.

Sci Rep. 2016 Mar 10;6:22991. doi: 10.1038/srep22991. Erratum in: Sci Rep. 2016 Jun 10;6:27164.

42.

Vasovagal-related stress immediately before FDG injection may increase bilateral adrenal FDG uptake.

Jinguji M, Nakajo M, Nakajo M, Nakabeppu Y, Yoshiura T.

Br J Radiol. 2016;89(1061):20150950. doi: 10.1259/bjr.20150950. Epub 2016 Mar 24.

43.
44.

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M.

Cell Rep. 2015 Dec 29;13(12):2671-8. doi: 10.1016/j.celrep.2015.12.001. Epub 2015 Dec 17.

45.

Dexamethasone Suppression FDG PET/CT for Differentiating between True- and False-Positive Pulmonary and Mediastinal Lymph Node Metastases in Non-Small Cell Lung Cancer: A Pilot Study of FDG PET/CT after Oral Administration of Dexamethasone.

Nakajo M, Nakajo M, Nakayama H, Jinguji M, Nakabeppu Y, Higashi M, Nakamura Y, Sato M, Yoshiura T.

Radiology. 2016 Apr;279(1):246-53. doi: 10.1148/radiol.2015150883. Epub 2015 Nov 16.

PMID:
26579562
46.

The value of intratumoral heterogeneity of (18)F-FDG uptake to differentiate between primary benign and malignant musculoskeletal tumours on PET/CT.

Nakajo M, Nakajo M, Jinguji M, Fukukura Y, Nakabeppu Y, Tani A, Yoshiura T.

Br J Radiol. 2015;88(1055):20150552. doi: 10.1259/bjr.20150552. Epub 2015 Sep 4.

47.

FDG-PET/CT and FLT-PET/CT for differentiating between lipid-poor benign and malignant adrenal tumours.

Nakajo M, Jinguji M, Fukukura Y, Kajiya Y, Tani A, Nakajo M, Nakabeppu Y, Arimura H, Nishio Y, Nakamura F, Yoshiura T.

Eur Radiol. 2015 Dec;25(12):3696-705. doi: 10.1007/s00330-015-3787-z. Epub 2015 Apr 30.

PMID:
25925356
48.

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.

Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T.

J Pharmacol Sci. 2015 Apr;127(4):446-55. doi: 10.1016/j.jphs.2015.03.005. Epub 2015 Mar 24.

49.

Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome.

Behmanesh M, Sakumi K, Tsuchimoto D, Torisu K, Ohnishi-Honda Y, Rancourt DE, Nakabeppu Y.

DNA Res. 2015 Apr;22(2):181. doi: 10.1093/dnares/dsv006. No abstract available.

50.

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria.

Ohtsubo T, Nishioka K, Imaiso Y, Iwai S, Shimokawa H, Oda H, Fujiwara T, Nakabeppu Y.

Nucleic Acids Res. 2015 Apr 20;43(7):3870-1. doi: 10.1093/nar/gkv264. Epub 2015 Mar 23. No abstract available.

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