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Items: 26

1.

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J.

Cell Death Differ. 2018 Oct 19. doi: 10.1038/s41418-018-0215-3. [Epub ahead of print]

PMID:
30341420
2.

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer.

Najafov A, Zervantonakis IK, Mookhtiar AK, Greninger P, March RJ, Egan RK, Luu HS, Stover DG, Matulonis UA, Benes CH, Yuan J.

PLoS Biol. 2018 Aug 29;16(8):e2005756. doi: 10.1371/journal.pbio.2005756. eCollection 2018 Aug.

3.

GECO: gene expression correlation analysis after genetic algorithm-driven deconvolution.

Najafov J, Najafov A.

Bioinformatics. 2018 Jul 13. doi: 10.1093/bioinformatics/bty623. [Epub ahead of print]

PMID:
30010797
4.

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.

Amin P, Florez M, Najafov A, Pan H, Geng J, Ofengeim D, Dziedzic SA, Wang H, Barrett VJ, Ito Y, LaVoie MJ, Yuan J.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5944-E5953. doi: 10.1073/pnas.1806973115. Epub 2018 Jun 11.

PMID:
29891719
5.

Necroptosis in development and diseases.

Shan B, Pan H, Najafov A, Yuan J.

Genes Dev. 2018 Mar 1;32(5-6):327-340. doi: 10.1101/gad.312561.118. Review.

6.

Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.

Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J.

Cell Death Dis. 2018 Jan 26;9(2):138. doi: 10.1038/s41419-017-0170-9.

7.

ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.

Dziedzic SA, Su Z, Jean Barrett V, Najafov A, Mookhtiar AK, Amin P, Pan H, Sun L, Zhu H, Ma A, Abbott DW, Yuan J.

Nat Cell Biol. 2018 Jan;20(1):58-68. doi: 10.1038/s41556-017-0003-1. Epub 2017 Dec 4.

8.

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.

Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J.

Nat Commun. 2017 Aug 25;8(1):359. doi: 10.1038/s41467-017-00406-w.

9.

CrossCheck: an open-source web tool for high-throughput screen data analysis.

Najafov J, Najafov A.

Sci Rep. 2017 Jul 19;7(1):5855. doi: 10.1038/s41598-017-05960-3.

10.

Necroptosis and Cancer.

Najafov A, Chen H, Yuan J.

Trends Cancer. 2017 Apr;3(4):294-301. doi: 10.1016/j.trecan.2017.03.002.

11.

Roles of Caspases in Necrotic Cell Death.

Yuan J, Najafov A, Py BF.

Cell. 2016 Dec 15;167(7):1693-1704. doi: 10.1016/j.cell.2016.11.047. Review.

12.

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.

Science. 2016 Aug 5;353(6299):603-8. doi: 10.1126/science.aaf6803.

13.

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.

Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C.

Elife. 2016 Apr 22;5. pii: e12278. doi: 10.7554/eLife.12278.

14.

Correction: Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H.

J Cell Biol. 2016 Mar 28;212(7):881-2. doi: 10.1083/jcb.20150304403082016c. Epub 2016 Mar 21. No abstract available.

15.

Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.

Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H.

J Cell Biol. 2015 Aug 31;210(5):705-16. doi: 10.1083/jcb.201503044. Erratum in: J Cell Biol. 2016 Mar 28;212(7):881-2.

16.

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.

Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J.

Elife. 2015 Mar 30;4:e06734. doi: 10.7554/eLife.06734.

17.

Activation of necroptosis in multiple sclerosis.

Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Berlink Lima J, Qi C, Yu Q, Trapp B, Yuan J.

Cell Rep. 2015 Mar 24;10(11):1836-49.

18.

PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development.

Venigalla RK, McGuire VA, Clarke R, Patterson-Kane JC, Najafov A, Toth R, McCarthy PC, Simeons F, Stojanovski L, Arthur JS.

EMBO J. 2013 Apr 3;32(7):1008-22. doi: 10.1038/emboj.2013.40. Epub 2013 Mar 5.

19.

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.

Najafov A, Shpiro N, Alessi DR.

Biochem J. 2012 Dec 1;448(2):285-95. doi: 10.1042/BJ20121287.

PMID:
23030823
20.

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C.

J Cell Sci. 2012 Oct 1;125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13.

21.

MENA is a transcriptional target of the Wnt/beta-catenin pathway.

Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N.

PLoS One. 2012;7(5):e37013. doi: 10.1371/journal.pone.0037013. Epub 2012 May 17.

22.

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR.

Biochem J. 2011 Jan 15;433(2):357-69. doi: 10.1042/BJ20101732.

PMID:
21087210
23.

Uncoupling the Warburg effect from cancer.

Najafov A, Alessi DR.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19135-6. doi: 10.1073/pnas.1014047107. Epub 2010 Nov 1. No abstract available.

24.

Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.

Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A.

Cell Signal. 2010 Oct;22(10):1523-35. doi: 10.1016/j.cellsig.2010.05.021. Epub 2010 Jun 9.

PMID:
20538055
25.

The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans.

Landsverk ML, Li S, Hutagalung AH, Najafov A, Hoppe T, Barral JM, Epstein HF.

J Cell Biol. 2007 Apr 23;177(2):205-10. Epub 2007 Apr 16.

26.

Clinicopathological and genetic study of early-onset demyelinating neuropathy.

Parman Y, Battaloglu E, Baris I, Bilir B, Poyraz M, Bissar-Tadmouri N, Williams A, Ammar N, Nelis E, Timmerman V, De Jonghe P, Najafov A, Deymeer F, Serdaroglu P, Brophy PJ, Said G.

Brain. 2004 Nov;127(Pt 11):2540-50. Epub 2004 Oct 6. Erratum in: Brain. 2007 Jul;130(7):1972. Necefov, Ayaz [corrected to Najafov, Ayaz].

PMID:
15469949

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