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Items: 1 to 50 of 93

1.

A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection.

Zhang W, Yi Z, Keung KL, Shang H, Wei C, Cravedi P, Sun Z, Xi C, Woytovich C, Farouk S, Huang W, Banu K, Gallon L, Magee CN, Najafian N, Samaniego M, Djamali A, Alexander SI, Rosales IA, Smith RN, Xiang J, Lerut E, Kuypers D, Naesens M, O'Connell PJ, Colvin R, Menon MC, Murphy B.

J Am Soc Nephrol. 2019 Aug;30(8):1481-1494. doi: 10.1681/ASN.2018111098. Epub 2019 Jul 5.

PMID:
31278196
2.

Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.

Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV.

Circulation. 2019 Sep 9;140(10):846-863. doi: 10.1161/CIRCULATIONAHA.119.040563. Epub 2019 Jul 3.

PMID:
31266349
3.

Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection.

Zhang W, Yi Z, Wei C, Keung KL, Sun Z, Xi C, Woytovich C, Farouk S, Gallon L, Menon MC, Magee C, Najafian N, Samaniego MD, Djamali A, Alexander SI, Rosales IA, Smith RN, O'Connell PJ, Colvin R, Cravedi P, Murphy B.

JCI Insight. 2019 Jun 6;4(11). pii: 127543. doi: 10.1172/jci.insight.127543. eCollection 2019 Jun 6.

4.

Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible.

Sack J, Najafian N, DeLisle A, Jakab S.

World J Hepatol. 2019 Apr 27;11(4):370-378. doi: 10.4254/wjh.v11.i4.370.

5.

Advance Care Planning for Patients with Cirrhosis in a Structured Inpatient/Outpatient Hepatology Program.

Najafian N, Sack JS, DeLisle AM, Jakab S.

J Palliat Med. 2019 Apr 9. doi: 10.1089/jpm.2018.0261. [Epub ahead of print]

PMID:
30964375
6.

Bariatric Surgery and Hepatocellular Carcinoma: a Propensity Score-Matched Analysis.

Njei B, McCarty TR, Sharma P, Lange A, Najafian N, Ngu JN, Ngomba VE, Echouffo-Tcheugui JB.

Obes Surg. 2018 Dec;28(12):3880-3889. doi: 10.1007/s11695-018-3431-5.

PMID:
30069863
7.

IL-6 production by monocytes is associated with graft function decline in patients with borderline changes suspicious for acute T-cell-mediated rejection: a pilot study.

Désy O, Béland S, Vallin P, Riopel J, Latulippe E, Najafian N, Chandraker A, Agharazii M, Batal I, De Serres SA.

Transpl Int. 2018 Jan;31(1):92-101. doi: 10.1111/tri.13070. Epub 2017 Sep 28.

8.

Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report.

Echenique IA, Beltran D, Ramirez-Ruiz L, Najafian N, Agrawal N.

Transplant Proc. 2017 Sep;49(7):1560-1564. doi: 10.1016/j.transproceed.2017.02.046.

PMID:
28838440
9.

Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans.

Schütte-Nütgen K, Boenisch O, Harrach H, Casey A, Guleria I, Najafian N, Sayegh MH, Gerard CJ, Subramaniam M.

Am J Pathol. 2017 Jun;187(6):1368-1379. doi: 10.1016/j.ajpath.2017.02.007. Epub 2017 Apr 17.

10.

Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study.

O'Connell PJ, Zhang W, Menon MC, Yi Z, Schröppel B, Gallon L, Luan Y, Rosales IA, Ge Y, Losic B, Xi C, Woytovich C, Keung KL, Wei C, Greene I, Overbey J, Bagiella E, Najafian N, Samaniego M, Djamali A, Alexander SI, Nankivell BJ, Chapman JR, Smith RN, Colvin R, Murphy B.

Lancet. 2016 Sep 3;388(10048):983-93. doi: 10.1016/S0140-6736(16)30826-1. Epub 2016 Jul 22.

11.

An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.

Liebow A, Li X, Racie T, Hettinger J, Bettencourt BR, Najafian N, Haslett P, Fitzgerald K, Holmes RP, Erbe D, Querbes W, Knight J.

J Am Soc Nephrol. 2017 Feb;28(2):494-503. doi: 10.1681/ASN.2016030338. Epub 2016 Jul 18.

12.

Codominant Role of Interferon-γ- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients.

Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV.

Am J Transplant. 2016 Jul;16(7):2158-71. doi: 10.1111/ajt.13705. Epub 2016 Apr 7.

13.

Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility.

Escobar-Hoyos LF, Shah R, Roa-Peña L, Vanner EA, Najafian N, Banach A, Nielsen E, Al-Khalil R, Akalin A, Talmage D, Shroyer KR.

Cancer Res. 2015 Sep 1;75(17):3650-62. doi: 10.1158/0008-5472.CAN-15-0293. Epub 2015 Jun 24.

14.

Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival.

Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A.

J Am Soc Nephrol. 2015 Dec;26(12):3102-13. doi: 10.1681/ASN.2014080804. Epub 2015 Apr 8.

15.

TIM-1 signaling is required for maintenance and induction of regulatory B cells.

Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM.

Am J Transplant. 2015 Apr;15(4):942-53. doi: 10.1111/ajt.13087. Epub 2015 Feb 2.

16.

Tregitope: Immunomodulation powerhouse.

Cousens L, Najafian N, Martin WD, De Groot AS.

Hum Immunol. 2014 Dec;75(12):1139-46. doi: 10.1016/j.humimm.2014.10.012. Epub 2014 Oct 22.

17.

Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus.

Gallon L, Traitanon O, Sustento-Reodica N, Leventhal J, Ansari MJ, Gehrau RC, Ariyamuthu V, De Serres SA, Alvarado A, Chhabra D, Mathew JM, Najafian N, Mas V.

Kidney Int. 2015 Apr;87(4):828-38. doi: 10.1038/ki.2014.350. Epub 2014 Oct 29.

18.
19.

Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

Grafals M, Smith B, Murakami N, Trabucco A, Hamill K, Marangos E, Gilligan H, Pomfret EA, Pomposelli JJ, Simpson MA, Azzi J, Najafian N, Riella LV.

PLoS One. 2014 Aug 11;9(8):e104408. doi: 10.1371/journal.pone.0104408. eCollection 2014.

20.

Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch.

Riella LV, Safa K, Yagan J, Lee B, Azzi J, Najafian N, Abdi R, Milford E, Mah H, Gabardi S, Malek S, Tullius SG, Magee C, Chandraker A.

Transplantation. 2014 Jun 27;97(12):1247-52. doi: 10.1097/01.TP.0000442782.98131.7c.

PMID:
24854670
21.

Serum matrix metalloproteinase levels in patients exposed to sulfur mustard.

Shohrati M, Haji Hosseini R, Esfandiari MA, Najafian N, Najafian B, Golbedagh A.

Iran Red Crescent Med J. 2014 Mar;16(3):e15129. doi: 10.5812/ircmj.15129. Epub 2014 Mar 5.

22.

Evaluation of Aggregometery Parameters and Efficacy of Plavix versus Clopidex in Patients Suffering from Ischemic Heart Disease: A Randomized Double Blind Clinical Trial.

Shohrati M, Moshkani M, Pishgoo B, Ahmadinejad M, Najafian N, Najafian B, Kazemisaleh D.

Iran Red Crescent Med J. 2014 Feb;16(2):e15277. doi: 10.5812/ircmj.15277. Epub 2014 Feb 7.

23.

Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1β secretion in the peripheral blood.

Batal I, De Serres SA, Mfarrej BG, Grafals M, Pinkus GS, Kalra A, Weins A, Bijol V, Rennke HG, Guleria I, Abdi R, Chandraker A, Najafian N.

Transplantation. 2014 May 27;97(10):1034-42. doi: 10.1097/01.TP.0000441096.22471.36.

PMID:
24406453
24.

Targeting CD28 to prevent transplant rejection.

Yeung MY, Najafian N, Sayegh MH.

Expert Opin Ther Targets. 2014 Feb;18(2):225-42. doi: 10.1517/14728222.2014.863875. Epub 2013 Dec 12. Review.

PMID:
24329604
25.

Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.

Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N.

J Immunol. 2013 Oct 15;191(8):4447-55. doi: 10.4049/jimmunol.1300992. Epub 2013 Sep 13.

26.

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.

Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR.

Blood. 2013 Oct 24;122(17):3062-73. doi: 10.1182/blood-2013-05-500801. Epub 2013 Sep 12.

27.

Impact of calcineurin-inhibitor conversion to mTOR inhibitor on renal allograft function in a prednisone-free regimen.

Chhabra D, Alvarado A, Dalal P, Leventhal J, Wang C, Sustento-Reodica N, Najafian N, Skaro A, Levitsky J, Mas V, Gallon L.

Am J Transplant. 2013 Nov;13(11):2902-11. doi: 10.1111/ajt.12437. Epub 2013 Sep 5.

28.

Standardization and cross validation of alloreactive IFNγ ELISPOT assays within the clinical trials in organ transplantation consortium.

Ashoor I, Najafian N, Korin Y, Reed EF, Mohanakumar T, Ikle D, Heeger PS, Lin M.

Am J Transplant. 2013 Jul;13(7):1871-9. doi: 10.1111/ajt.12286. Epub 2013 May 24.

29.

Jagged2-signaling promotes IL-6-dependent transplant rejection.

Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A.

Eur J Immunol. 2013 Jun;43(6):1449-58. doi: 10.1002/eji.201243151. Epub 2013 May 2.

30.

Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model.

D'Addio F, Boenisch O, Magee CN, Yeung MY, Yuan X, Mfarrej B, Vergani A, Ansari MJ, Fiorina P, Najafian N.

PLoS One. 2013;8(1):e53797. doi: 10.1371/journal.pone.0053797. Epub 2013 Jan 10.

31.

TIM-3 regulates innate immune cells to induce fetomaternal tolerance.

Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I.

J Immunol. 2013 Jan 1;190(1):88-96. doi: 10.4049/jimmunol.1202176. Epub 2012 Nov 23.

32.

In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity.

Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS.

J Clin Immunol. 2013 Jan;33 Suppl 1:S43-9. doi: 10.1007/s10875-012-9762-4. Epub 2012 Sep 2. Review.

33.

The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells.

Magee CN, Boenisch O, Najafian N.

Am J Transplant. 2012 Oct;12(10):2588-600. doi: 10.1111/j.1600-6143.2012.04180.x. Epub 2012 Jul 3. Review.

34.

Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses.

Ueno T, Yeung MY, McGrath M, Yang S, Zaman N, Snawder B, Padera RF, Magee CN, Gorbatov R, Hashiguchi M, Azuma M, Freeman GJ, Sayegh MH, Najafian N.

Eur J Immunol. 2012 Sep;42(9):2343-53. doi: 10.1002/eji.201242501.

35.

The role of coinhibitory signaling pathways in transplantation and tolerance.

McGrath MM, Najafian N.

Front Immunol. 2012 Mar 19;3:47. doi: 10.3389/fimmu.2012.00047. eCollection 2012.

36.

Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients.

De Serres SA, Mfarrej BG, Grafals M, Riella LV, Magee CN, Yeung MY, Dyer C, Ahmad U, Chandraker A, Najafian N.

Clin J Am Soc Nephrol. 2012 Jun;7(6):1018-25. doi: 10.2215/CJN.11051011. Epub 2012 Apr 12.

37.

Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4⁺ T cells and requires the presence of monocytes.

Boenisch O, Lopez M, Elyaman W, Magee CN, Ahmad U, Najafian N.

Am J Transplant. 2012 Apr;12(4):856-66. doi: 10.1111/j.1600-6143.2011.03978.x. Epub 2012 Mar 5.

38.

Rejection and regulation: a tight balance.

Ashoor IF, Najafian N.

Curr Opin Organ Transplant. 2012 Feb;17(1):1-7. doi: 10.1097/MOT.0b013e32834ef52a. Review.

39.

Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates.

Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T.

Am J Transplant. 2012 Feb;12(2):330-40. doi: 10.1111/j.1600-6143.2011.03795.x. Epub 2011 Nov 4.

40.

Immune profile of pediatric renal transplant recipients following alemtuzumab induction.

De Serres SA, Mfarrej BG, Magee CN, Benitez F, Ashoor I, Sayegh MH, Harmon WE, Najafian N.

J Am Soc Nephrol. 2012 Jan;23(1):174-82. doi: 10.1681/ASN.2011040360. Epub 2011 Nov 3.

41.

Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation.

Riella LV, Ueno T, Batal I, De Serres SA, Bassil R, Elyaman W, Yagita H, Medina-Pestana JO, Chandraker A, Najafian N.

J Immunol. 2011 Nov 1;187(9):4629-38. doi: 10.4049/jimmunol.1004076. Epub 2011 Sep 26.

42.

The emerging role of the TIM molecules in transplantation.

Yeung MY, McGrath M, Najafian N.

Am J Transplant. 2011 Oct;11(10):2012-9. doi: 10.1111/j.1600-6143.2011.03727.x. Epub 2011 Sep 11. Review.

43.

Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection.

Ueno T, Yamada A, Ito T, Yeung MY, Gorbatov R, Shimizu T, Abdi R, Sayegh MH, Auchincloss H Jr, Najafian N.

Transplantation. 2011 Sep 15;92(5):e26-7. doi: 10.1097/TP.0b013e318228061c. No abstract available.

PMID:
21866037
44.

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice.

Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM.

J Clin Invest. 2011 Sep;121(9):3645-56. doi: 10.1172/JCI46274. Epub 2011 Aug 8.

45.

Effect of biologic agents on regulatory T cells.

De Serres SA, Yeung MY, Mfarrej BG, Najafian N.

Transplant Rev (Orlando). 2011 Jul;25(3):110-6. doi: 10.1016/j.trre.2010.11.002. Epub 2011 Apr 21. Review.

PMID:
21514136
46.

Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts.

Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N.

Am J Transplant. 2011 Apr;11(4):832-40. doi: 10.1111/j.1600-6143.2011.03451.x. Epub 2011 Mar 14.

47.

The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury.

Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, Haller H, Najafian N, Habicht A.

J Am Soc Nephrol. 2011 Mar;22(3):484-95. doi: 10.1681/ASN.2010030321. Epub 2011 Feb 25.

48.

Monocyte-secreted inflammatory cytokines are associated with transplant glomerulopathy in renal allograft recipients.

De Serres SA, Vadivel N, Mfarrej BG, Grafals M, DeJoseph M, Dyer C, Magee CN, Chandraker A, Gallon LG, Najafian N.

Transplantation. 2011 Mar 15;91(5):552-9. doi: 10.1097/TP.0b013e318205b3c1.

PMID:
21150704
49.

In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses.

Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N.

Am J Transplant. 2010 Oct;10(10):2355-62. doi: 10.1111/j.1600-6143.2010.03250.x. Epub 2010 Sep 14.

50.

TIM-3: a novel regulatory molecule of alloimmune activation.

Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N.

J Immunol. 2010 Nov 15;185(10):5806-19. doi: 10.4049/jimmunol.0903435. Epub 2010 Oct 18.

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