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EXPRESS: Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder.

Tajima H, Kasai H, Tanabe N, Sugiura T, Miwa H, Naito A, Suda R, Nishimura R, Jujo TS, Sakao S, Tatsumi K.

Pulm Circ. 2019 Feb 19:2045894019836420. doi: 10.1177/2045894019836420. [Epub ahead of print] No abstract available.


[A Case of Disease Control Achieved with TACE Using Cisplatin for Liver-Limited Metastases of Colorectal Cancer].

Kagawa Y, Murata K, Naito A, Kawai K, Sakamoto T, Murakami K, Katsura Y, Ohmura Y, Masuzawa T, Takeno A, Yoshimura M, Takeda Y.

Gan To Kagaku Ryoho. 2019 Jan;46(1):163-165. Japanese.


Elevated levels of autoantibodies against EXD2 and PHAX in the sera of patients with chronic thromboembolic pulmonary hypertension.

Naito A, Hiwasa T, Tanabe N, Sanada TJ, Sugiura T, Shigeta A, Terada J, Takizawa H, Kashiwado K, Sakao S, Tatsumi K.

PLoS One. 2019 Feb 13;14(2):e0211377. doi: 10.1371/journal.pone.0211377. eCollection 2019.


Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs.

Sugiyama A, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Ando K, Naito AT, Izumi-Nakaseko H.

J Pharmacol Sci. 2019 Jan 24. pii: S1347-8613(19)30008-8. doi: 10.1016/j.jphs.2019.01.004. [Epub ahead of print]


Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions.

Tanikawa Y, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Kitta K, Hoshiai K, Izumi-Nakaseko H, Naito AT, Sugiyama A.

Cardiovasc Toxicol. 2019 Feb 8. doi: 10.1007/s12012-019-09509-w. [Epub ahead of print]


Measurement of J-Tpeakc along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals.

Goto A, Hagiwara-Nagasawa M, Kambayashi R, Chiba K, Izumi-Nakaseko H, Naito AT, Kanda Y, Sugiyama A.

Cardiovasc Toxicol. 2019 Feb 2. doi: 10.1007/s12012-019-09506-z. [Epub ahead of print]


[Treatment Outcomes of Gemcitabine and Cisplatin Combination Therapy for Unresectable and Recurrent Biliary Tract Cancer].

Sakamoto T, Takeda Y, Ohmura Y, Katsura Y, Mori R, Nose Y, Kawai K, Murakami K, Naito A, Inatome J, Kagawa Y, Masuzawa T, Takeno A, Egawa C, Murata K.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2414-2416. Japanese.


[A Case of Successful Drainage for Mediastinitis during Chemotherapy for Unresectable Advanced Esophageal Cancer].

Fukuyama K, Takeno A, Murakami K, Kawai K, Sakamoto T, Inatome J, Naito A, Katsura Y, Ohmura Y, Kagawa Y, Masuzawa T, Egawa C, Takeda Y, Murata K.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2402-2404. Japanese.


[Staging by TNM Classification of Two Cases of Advanced Appendiceal Carcinoma].

Murata K, Kagawa Y, Kawai K, Naito A, Sakamoto T, Murakami K, Katsura Y, Ohmura Y, Masuzawa T, Takeno A, Takeda Y.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2393-2395. Japanese.


[Resection for Peritoneal Dissemination of Colorectal Cancer].

Naito A, Murata K, Kagawa Y, Kawai K, Sakamoto T, Inatome J, Murakami K, Katsura Y, Ohmura Y, Masuzawa T, Takeno A, Egawa C, Takeda Y, Kato T, Tamura S.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2360-2362. Japanese.


[A Case of an Elderly Patient with Unresectable HER2-Positive Gastric Cancer Successfully Treated by Chemotherapy Combined with Trastuzumab over a Long Period].

Yukawa Y, Takeno A, Kawai K, Sakamoto T, Inatome J, Naito A, Murakami K, Katsura Y, Ohmura Y, Kagawa Y, Masuzawa T, Egawa C, Takeda Y, Murata K.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2273-2275. Japanese.


[A Case of Gastric Schwannoma with Regional Lymphadenopathy].

Nose Y, Takeno A, Masuzawa T, Toya K, Yukawa Y, Mori R, Kawai K, Sakamoto T, Murakami K, Naito A, Katsura Y, Ohmura Y, Kagawa Y, Takeda Y, Murata K.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1952-1954. Japanese.


[Tracheo-Bronchial Airway Stenting for Airway Stenosis Due to Inoperable Advanced Esophageal Cancers].

Takeno A, Masuzawa T, Murakami K, Iwata T, Yamamoto A, Kawai K, Sakamoto T, Inadome J, Naito A, Katsura Y, Ohmura Y, Kagawa Y, Egawa C, Takeda Y, Murata K.

Gan To Kagaku Ryoho. 2018 Dec;45(13):2241-2243. Japanese.


Fibrillation mechanism of glucagon in the presence of phospholipid bilayers as revealed by 13C solid-state NMR spectroscopy.

Yamane I, Momose A, Fujita H, Yoshimoto E, Kikuchi-Kinoshita A, Kawamura I, Naito A.

Chem Phys Lipids. 2019 Jan 25;219:36-44. doi: 10.1016/j.chemphyslip.2019.01.008. [Epub ahead of print]


Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes.

Ito M, Hara H, Takeda N, Naito AT, Nomura S, Kondo M, Hata Y, Uchiyama M, Morita H, Komuro I.

J Mol Cell Cardiol. 2019 Jan 23;128:90-95. doi: 10.1016/j.yjmcc.2019.01.020. [Epub ahead of print]


Effects of genetic background on responses to superovulation in Japanese Black cattle.

Hirayama H, Naito A, Fujii T, Sugimoto M, Takedomi T, Moriyasu S, Sakai H, Kageyama S.

J Vet Med Sci. 2019 Jan 15. doi: 10.1292/jvms.18-0537. [Epub ahead of print]


High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.

Satoh M, Nomura S, Harada M, Yamaguchi T, Ko T, Sumida T, Toko H, Naito AT, Takeda N, Tobita T, Fujita T, Ito M, Fujita K, Ishizuka M, Kariya T, Akazawa H, Kobayashi Y, Morita H, Takimoto E, Aburatani H, Komuro I.

J Mol Cell Cardiol. 2019 Jan 3;128:77-89. doi: 10.1016/j.yjmcc.2018.12.018. [Epub ahead of print]


Endothelial cells from pulmonary endarterectomy specimens possess a high angiogenic potential and express high levels of hepatocyte growth factor.

Naito A, Sakao S, Lang IM, Voelkel NF, Jujo T, Ishida K, Sugiura T, Matsumiya G, Yoshino I, Tanabe N, Tatsumi K.

BMC Pulm Med. 2018 Dec 29;18(1):197. doi: 10.1186/s12890-018-0769-3.


Relationship between amikacin blood concentration and ototoxicity in low birth weight infants.

Endo A, Nemoto A, Hanawa K, Maebayashi Y, Hasebe Y, Kobayashi M, Naito A, Kobayashi Y, Yamamoto S, Isobe K.

J Infect Chemother. 2019 Jan;25(1):17-21. doi: 10.1016/j.jiac.2018.10.001. Epub 2018 Oct 24.


Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice.

Nakatani K, Masuda D, Kobayashi T, Sairyo M, Zhu Y, Okada T, Naito AT, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Yamashita S.

Int Heart J. 2019 Jan 25;60(1):159-167. doi: 10.1536/ihj.18-114. Epub 2018 Dec 5.


Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection.

Fukao K, Noshi T, Yamamoto A, Kitano M, Ando Y, Noda T, Baba K, Matsumoto K, Higuchi N, Ikeda M, Shishido T, Naito A.

J Antimicrob Chemother. 2019 Mar 1;74(3):654-662. doi: 10.1093/jac/dky462.


Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.

Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.

JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653. doi: 10.1016/j.jacbts.2018.07.005. eCollection 2018 Oct.


Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death.

Goto A, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Kitta K, Hoshiai K, Chiba K, Ando K, Akie Y, Naito AT, Sugiyama A.

J Pharmacol Sci. 2018 Nov;138(3):198-202. doi: 10.1016/j.jphs.2018.10.003. Epub 2018 Oct 17.


Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.

Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.

Nat Commun. 2018 Oct 30;9(1):4435. doi: 10.1038/s41467-018-06639-7.


Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.

Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA.

Nat Immunol. 2018 Dec;19(12):1391-1402. doi: 10.1038/s41590-018-0236-6. Epub 2018 Oct 29.


Author Correction: Activation of endothelial β-catenin signaling induces heart failure.

Nakagawa A, Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I.

Sci Rep. 2018 Oct 29;8(1):15858. doi: 10.1038/s41598-018-34062-x.


Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters.

Okada Y, Okubo K, Ikeda K, Yano Y, Hoshino M, Hayashi Y, Kiso Y, Itoh-Watanabe H, Naito A, Matsuzaki K.

ACS Chem Neurosci. 2018 Oct 11. doi: 10.1021/acschemneuro.8b00424. [Epub ahead of print]


In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.

Noshi T, Kitano M, Taniguchi K, Yamamoto A, Omoto S, Baba K, Hashimoto T, Ishida K, Kushima Y, Hattori K, Kawai M, Yoshida R, Kobayashi M, Yoshinaga T, Sato A, Okamatsu M, Sakoda Y, Kida H, Shishido T, Naito A.

Antiviral Res. 2018 Dec;160:109-117. doi: 10.1016/j.antiviral.2018.10.008. Epub 2018 Oct 11.


Structural Analyses of Alanine Trimer and Tetramer Crystals with Antiparallel and Parallel β-Sheet Structures Using Solid-State 1H Spin-Diffusion 2D Correlation NMR Spectroscopy.

Naito A, Kametani S, Aoki A, Asakura T.

J Phys Chem B. 2018 Oct 11;122(40):9373-9381. doi: 10.1021/acs.jpcb.8b07859. Epub 2018 Sep 28.


Expression and localization of aromatase in human gastric mucosa : Immunohistochemical study using biopsy materials.

Kobayashi H, Yoshida S, Shirasawa N, Maeda K, Naito A.

Histochem Cell Biol. 2019 Jan;151(1):21-28. doi: 10.1007/s00418-018-1708-3. Epub 2018 Aug 28.


Reply To: Detection of Alpha-Synuclein in Saliva: The Importance of Preanalytical Assessment.

Kang UJ, Taylor P, Naito A, Goldman JG; BioFIND investigators.

Mov Disord. 2018 Jul;33(6):1031. doi: 10.1002/mds.27424. No abstract available.


Contributions of yap1 Mutation and Subsequent atrF Upregulation to Voriconazole Resistance in Aspergillus flavus.

Ukai Y, Kuroiwa M, Kurihara N, Naruse H, Homma T, Maki H, Naito A.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01216-18. doi: 10.1128/AAC.01216-18. Print 2018 Nov.


Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.

Izumi-Nakaseko H, Hagiwara-Nagasawa M, Naito AT, Goto A, Chiba K, Sekino Y, Kanda Y, Sugiyama A.

J Pharmacol Sci. 2018 Aug;137(4):372-378. doi: 10.1016/j.jphs.2018.07.011. Epub 2018 Aug 4.


Finding useful biomarkers for Parkinson's disease.

Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, Gwinn K, Huang X, Kopil C, Kremer T, Lasch S, Marek K, Marto JA, Merchant K, Mollenhauer B, Naito A, Potashkin J, Reimer A, Rosenthal LS, Saunders-Pullman R, Scherzer CR, Sherer T, Singleton A, Sutherland M, Thiele I, van der Brug M, Van Keuren-Jensen K, Vaillancourt D, Walt D, West A, Zhang J.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaam6003. doi: 10.1126/scitranslmed.aam6003. Review.


Partial anomalous pulmonary venous return with dual drainage to the superior vena cava and left atrium with pulmonary hypertension.

Tanaka N, Jujo T, Sugiura T, Matsuura K, Kobayashi T, Naito A, Shimazu K, Kasai H, Suda R, Nishimura R, Ikari J, Sakao S, Tanabe N, Matsumiya G, Tatsumi K.

Respir Med Case Rep. 2018 Aug 7;25:112-115. doi: 10.1016/j.rmcr.2018.08.003. eCollection 2018.


Benefits of using a self-expandable metallic stent as a bridge to surgery for right- and left-sided obstructive colorectal cancers.

Morita S, Yamamoto K, Ogawa A, Naito A, Mizuno H, Yoshioka S, Matsumura T, Ohta K, Suzuki R, Matsuda C, Hata T, Nishimura J, Mizushima T, Doki Y, Mori M; Clinical Study Group of Osaka University (CSGO), Colorectal Group.

Surg Today. 2019 Jan;49(1):32-37. doi: 10.1007/s00595-018-1701-4. Epub 2018 Aug 13.


Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.

Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I.

Int Heart J. 2018 Sep 26;59(5):1096-1105. doi: 10.1536/ihj.17-730. Epub 2018 Aug 11.


Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir.

Lubna NJ, Nakamura Y, Hagiwara-Nagasawa M, Goto A, Chiba K, Kitta K, Izumi-Nakaseko H, Ando K, Naito AT, Akie Y, Sugiyama A.

J Toxicol Sci. 2018;43(8):507-512. doi: 10.2131/jts.43.507.


Generation of Fabry cardiomyopathy model for drug screening using induced pluripotent stem cell-derived cardiomyocytes from a female Fabry patient.

Kuramoto Y, Naito AT, Tojo H, Sakai T, Ito M, Shibamoto M, Nakagawa A, Higo T, Okada K, Yamaguchi T, Lee JK, Miyagawa S, Sawa Y, Sakata Y, Komuro I.

J Mol Cell Cardiol. 2018 Aug;121:256-265. doi: 10.1016/j.yjmcc.2018.07.246. Epub 2018 Jul 23.


Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects.

Goto A, Izumi-Nakaseko H, Hagiwara-Nagasawa M, Chiba K, Ando K, Naito AT, Sugiyama A.

J Pharmacol Sci. 2018 Jun;137(2):237-240. doi: 10.1016/j.jphs.2018.06.005. Epub 2018 Jun 18.


Retinal Configuration of ppR Intermediates Revealed by Photoirradiation Solid-State NMR and DFT.

Makino Y, Kawamura I, Okitsu T, Wada A, Kamo N, Sudo Y, Ueda K, Naito A.

Biophys J. 2018 Jul 3;115(1):72-83. doi: 10.1016/j.bpj.2018.05.030.


Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

Omoto S, Speranzini V, Hashimoto T, Noshi T, Yamaguchi H, Kawai M, Kawaguchi K, Uehara T, Shishido T, Naito A, Cusack S.

Sci Rep. 2018 Jun 25;8(1):9633. doi: 10.1038/s41598-018-27890-4.


Fat infiltration in the gluteus minimus muscle in older adults.

Takano Y, Kobayashi H, Yuri T, Yoshida S, Naito A, Kiyoshige Y.

Clin Interv Aging. 2018 May 23;13:1011-1017. doi: 10.2147/CIA.S157402. eCollection 2018.


Prognostic significance of neutrophil-to-lymphocyte ratio in collecting duct carcinoma.

Taguchi S, Fukuhara H, Miyakawa J, Morikawa T, Naito A, Kawai T, Fujimura T, Kume H.

Jpn J Clin Oncol. 2018 Jul 1;48(7):692-694. doi: 10.1093/jjco/hyy076.


Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.

Goto A, Nakamura Y, Lubna NJ, Chiba K, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Naito AT, Sugiyama A.

Cardiovasc Toxicol. 2018 Dec;18(6):530-536. doi: 10.1007/s12012-018-9464-0.


Expression and localization of aquaporins 3 and 7 in bull spermatozoa and their relevance to sperm motility after cryopreservation.

Fujii T, Hirayama H, Fukuda S, Kageyama S, Naito A, Yoshino H, Moriyasu S, Yamazaki T, Sakamoto K, Hayakawa H, Takahashi K, Takahashi Y, Sawai K.

J Reprod Dev. 2018 Aug 20;64(4):327-335. doi: 10.1262/jrd.2017-166. Epub 2018 May 24.


Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction.

Wada T, Ando K, Naito AT, Nakamura Y, Goto A, Chiba K, Lubna NJ, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Nakazato Y, Sugiyama A.

Cancer Chemother Pharmacol. 2018 Jul;82(1):65-75. doi: 10.1007/s00280-018-3593-9. Epub 2018 May 2.


Giant umbilical cord and hypoglycemia in an infant with Proteus syndrome.

Saito T, Nakane T, Narusawa M, Yagasaki H, Nemoto A, Naito A, Sugita K.

Am J Med Genet A. 2018 May;176(5):1222-1224. doi: 10.1002/ajmg.a.38674.


Oligosynaptic inhibition mediated by group Ia afferents from flexor digitorum superficialis to wrist flexors in humans.

Nito M, Hashizume W, Jimenji M, Suzuki K, Sato T, Fujii H, Miyasaka T, Shindo M, Naito A.

Exp Brain Res. 2018 Jul;236(7):1849-1860. doi: 10.1007/s00221-018-5268-5. Epub 2018 Apr 20.


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