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Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme.

Ge Y, Czekster CM, Miller OK, Botting CH, Schwarz-Linek U, Naismith JH.

Biochemistry. 2019 Apr 23;58(16):2125-2132. doi: 10.1021/acs.biochem.9b00084. Epub 2019 Apr 5.


Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase.

Harrison PJ, Gable K, Somashekarappa N, Kelly V, Clarke DJ, Naismith JH, Dunn TM, Campopiano DJ.

J Lipid Res. 2019 May;60(5):953-962. doi: 10.1194/jlr.M089367. Epub 2019 Feb 21.


Complexes formed by the siderophore-based monosulfactam antibiotic BAL30072 and their interaction with the outer membrane receptor PiuA of P. aeruginosa.

Scorciapino MA, Malloci G, Serra I, Milenkovic S, Moynié L, Naismith JH, Desarbre E, Page MGP, Ceccarelli M.

Biometals. 2019 Feb;32(1):155-170. doi: 10.1007/s10534-018-00166-0. Epub 2019 Jan 11.


Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii.

Moynié L, Serra I, Scorciapino MA, Oueis E, Page MG, Ceccarelli M, Naismith JH.

Elife. 2018 Dec 18;7. pii: e42270. doi: 10.7554/eLife.42270.


Oxidation of the Cyanobactin Precursor Peptide Is Independent of the Leader Peptide and Operates in a Defined Order.

Gao S, Ge Y, Bent AF, Schwarz-Linek U, Naismith JH.

Biochemistry. 2018 Oct 16;57(41):5996-6002. doi: 10.1021/acs.biochem.8b00835. Epub 2018 Sep 28.


A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds.

Song H, van der Velden NS, Shiran SL, Bleiziffer P, Zach C, Sieber R, Imani AS, Krausbeck F, Aebi M, Freeman MF, Riniker S, Künzler M, Naismith JH.

Sci Adv. 2018 Aug 24;4(8):eaat2720. doi: 10.1126/sciadv.aat2720. eCollection 2018 Aug.


A Key Role for the Periplasmic PfeE Esterase in Iron Acquisition via the Siderophore Enterobactin in Pseudomonas aeruginosa.

Perraud Q, Moynié L, Gasser V, Munier M, Godet J, Hoegy F, Mély Y, Mislin GLA, Naismith JH, Schalk IJ.

ACS Chem Biol. 2018 Sep 21;13(9):2603-2614. doi: 10.1021/acschembio.8b00543. Epub 2018 Aug 22.


Getting Drugs into Gram-Negative Bacteria: Rational Rules for Permeation through General Porins.

Acosta-Gutiérrez S, Ferrara L, Pathania M, Masi M, Wang J, Bodrenko I, Zahn M, Winterhalter M, Stavenger RA, Pagès JM, Naismith JH, van den Berg B, Page MGP, Ceccarelli M.

ACS Infect Dis. 2018 Oct 12;4(10):1487-1498. doi: 10.1021/acsinfecdis.8b00108. Epub 2018 Aug 17.


Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides.

Liston SD, McMahon SA, Le Bas A, Suits MDL, Naismith JH, Whitfield C.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4870-E4879. doi: 10.1073/pnas.1801336115. Epub 2018 May 7.


Desferrioxamine biosynthesis: diverse hydroxamate assembly by substrate-tolerant acyl transferase DesC.

Ronan JL, Kadi N, McMahon SA, Naismith JH, Alkhalaf LM, Challis GL.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170068. doi: 10.1098/rstb.2017.0068.


TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates.

Luscher A, Moynié L, Auguste PS, Bumann D, Mazza L, Pletzer D, Naismith JH, Köhler T.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00097-18. doi: 10.1128/AAC.00097-18. Print 2018 Jun.


Characterization of the Fast and Promiscuous Macrocyclase from Plant PCY1 Enables the Use of Simple Substrates.

Ludewig H, Czekster CM, Oueis E, Munday ES, Arshad M, Synowsky SA, Bent AF, Naismith JH.

ACS Chem Biol. 2018 Mar 16;13(3):801-811. doi: 10.1021/acschembio.8b00050. Epub 2018 Feb 12.


Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics.

Ojo OS, Nardone B, Musolino SF, Neal AR, Wilson L, Lebl T, Slawin AMZ, Cordes DB, Taylor JE, Naismith JH, Smith AD, Westwood NJ.

Org Biomol Chem. 2018 Jan 3;16(2):266-273. doi: 10.1039/c7ob02697h.


Sparse Labeling PELDOR Spectroscopy on Multimeric Mechanosensitive Membrane Channels.

Ackermann K, Pliotas C, Valera S, Naismith JH, Bode BE.

Biophys J. 2017 Nov 7;113(9):1968-1978. doi: 10.1016/j.bpj.2017.09.005.


Bypassing the proline/thiazoline requirement of the macrocyclase PatG.

Oueis E, Stevenson H, Jaspars M, Westwood NJ, Naismith JH.

Chem Commun (Camb). 2017 Nov 14;53(91):12274-12277. doi: 10.1039/c7cc06550g.


Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates.

Czekster CM, Ludewig H, McMahon SA, Naismith JH.

Nat Commun. 2017 Oct 19;8(1):1045. doi: 10.1038/s41467-017-00862-4.


Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments.

Barski M, Brennan B, Miller OK, Potter JA, Vijayakrishnan S, Bhella D, Naismith JH, Elliott RM, Schwarz-Linek U.

Elife. 2017 Sep 15;6. pii: e29236. doi: 10.7554/eLife.29236.


Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Michailidou F, Chung CW, Brown MJB, Bent AF, Naismith JH, Leavens WJ, Lynn SM, Sharma SV, Goss RJM.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12492-12497. doi: 10.1002/anie.201705639. Epub 2017 Aug 30.


Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System.

Pliotas C, Grayer SC, Ekkerman S, Chan AKN, Healy J, Marius P, Bartlett W, Khan A, Cortopassi WA, Chandler SA, Rasmussen T, Benesch JLP, Paton RS, Claridge TDW, Miller S, Booth IR, Naismith JH, Conway SJ.

Biochemistry. 2017 Aug 15;56(32):4219-4234. doi: 10.1021/acs.biochem.7b00300. Epub 2017 Aug 4.


Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.

Wang M, Moynié L, Harrison PJ, Kelly V, Piper A, Naismith JH, Campopiano DJ.

Nat Chem Biol. 2017 Jun;13(6):660-667. doi: 10.1038/nchembio.2361. Epub 2017 Apr 17.


Kinetic Landscape of a Peptide Bond-Forming Prolyl Oligopeptidase.

Czekster CM, Naismith JH.

Biochemistry. 2017 Apr 18;56(15):2086-2095. doi: 10.1021/acs.biochem.7b00012. Epub 2017 Apr 7.


YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Burkhart BJ, Schwalen CJ, Mann G, Naismith JH, Mitchell DA.

Chem Rev. 2017 Apr 26;117(8):5389-5456. doi: 10.1021/acs.chemrev.6b00623. Epub 2017 Mar 3. Review.


Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization.

Oueis E, Nardone B, Jaspars M, Westwood NJ, Naismith JH.

ChemistryOpen. 2016 Dec 13;6(1):11-14. doi: 10.1002/open.201600134. eCollection 2017 Feb.


Structure and Function of the PiuA and PirA Siderophore-Drug Receptors from Pseudomonas aeruginosa and Acinetobacter baumannii.

Moynié L, Luscher A, Rolo D, Pletzer D, Tortajada A, Weingart H, Braun Y, Page MG, Naismith JH, Köhler T.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02531-16. doi: 10.1128/AAC.02531-16. Print 2017 Apr.


Kinetics and Structure of a Cold-Adapted Hetero-Octameric ATP Phosphoribosyltransferase.

Stroek R, Ge Y, Talbot PD, Glok MK, Bernaś KE, Thomson CM, Gould ER, Alphey MS, Liu H, Florence GJ, Naismith JH, da Silva RG.

Biochemistry. 2017 Feb 7;56(5):793-803. doi: 10.1021/acs.biochem.6b01138. Epub 2017 Jan 24.


Spectator no more, the role of the membrane in regulating ion channel function.

Pliotas C, Naismith JH.

Curr Opin Struct Biol. 2017 Aug;45:59-66. doi: 10.1016/ Epub 2016 Dec 7. Review.


Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD.

Bent AF, Mann G, Houssen WE, Mykhaylyk V, Duman R, Thomas L, Jaspars M, Wagner A, Naismith JH.

Acta Crystallogr D Struct Biol. 2016 Nov 1;72(Pt 11):1174-1180. Epub 2016 Oct 28.


MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca2+ Ion Bound at the Constriction Zone.

Ferrara LGM, Wallat GD, Moynié L, Dhanasekar NN, Aliouane S, Acosta-Gutiérrez S, Pagès JM, Bolla JM, Winterhalter M, Ceccarelli M, Naismith JH.

J Mol Biol. 2016 Nov 6;428(22):4528-4543. doi: 10.1016/j.jmb.2016.09.021. Epub 2016 Sep 30.


Mechanisms of cyanobactin biosynthesis.

Czekster CM, Ge Y, Naismith JH.

Curr Opin Chem Biol. 2016 Dec;35:80-88. doi: 10.1016/j.cbpa.2016.08.029. Epub 2016 Sep 14. Review.


Bacterial polysaccharide synthesis and export.

Woodward L, Naismith JH.

Curr Opin Struct Biol. 2016 Oct;40:81-88. doi: 10.1016/ Epub 2016 Aug 19. Review.


Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Oueis E, Jaspars M, Westwood NJ, Naismith JH.

Angew Chem Weinheim Bergstr Ger. 2016 May 4;128(19):5936-5939. Epub 2016 Apr 5.


The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac.

Brás NF, Ferreira P, Calixto AR, Jaspars M, Houssen W, Naismith JH, Fernandes PA, Ramos MJ.

Chemistry. 2016 Sep 5;22(37):13089-97. doi: 10.1002/chem.201601670. Epub 2016 Jul 8.


Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule.

Yang J, Wang Y, Wang T, Jiang J, Botting CH, Liu H, Chen Q, Yang J, Naismith JH, Zhu X, Chen L.

Nat Commun. 2016 Jun 30;7:12103. doi: 10.1038/ncomms12103.


Enzymatic Macrocyclization of 1,2,3-Triazole Peptide Mimetics.

Oueis E, Jaspars M, Westwood NJ, Naismith JH.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5842-5. doi: 10.1002/anie.201601564. Epub 2016 Apr 5.


Mechanism of DNA loading by the DNA repair helicase XPD.

Constantinescu-Aruxandei D, Petrovic-Stojanovska B, Penedo JC, White MF, Naismith JH.

Nucleic Acids Res. 2016 Apr 7;44(6):2806-15. doi: 10.1093/nar/gkw102. Epub 2016 Feb 20.


Accurate Extraction of Nanometer Distances in Multimers by Pulse EPR.

Valera S, Ackermann K, Pliotas C, Huang H, Naismith JH, Bode BE.

Chemistry. 2016 Mar 24;22(14):4700-3. doi: 10.1002/chem.201505143. Epub 2016 Feb 25.


Taking a molecular motor for a spin: helicase mechanism studied by spin labeling and PELDOR.

Constantinescu-Aruxandei D, Petrovic-Stojanovska B, Schiemann O, Naismith JH, White MF.

Nucleic Acids Res. 2016 Jan 29;44(2):954-68. doi: 10.1093/nar/gkv1373. Epub 2015 Dec 10.


Molecular Basis of Filtering Carbapenems by Porins from β-Lactam-resistant Clinical Strains of Escherichia coli.

Bajaj H, Scorciapino MA, Moynié L, Page MG, Naismith JH, Ceccarelli M, Winterhalter M.

J Biol Chem. 2016 Feb 5;291(6):2837-47. doi: 10.1074/jbc.M115.690156. Epub 2015 Dec 8.


Exploration of a potential difluoromethyl-nucleoside substrate with the fluorinase enzyme.

Thompson S, McMahon SA, Naismith JH, O'Hagan D.

Bioorg Chem. 2016 Feb;64:37-41. doi: 10.1016/j.bioorg.2015.11.003. Epub 2015 Nov 18.


A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

Moynié L, Hope AG, Finzel K, Schmidberger J, Leckie SM, Schneider G, Burkart MD, Smith AD, Gray DW, Naismith JH.

J Mol Biol. 2016 Jan 16;428(1):108-120. doi: 10.1016/j.jmb.2015.10.027. Epub 2015 Nov 10.


The role of lipids in mechanosensation.

Pliotas C, Dahl AC, Rasmussen T, Mahendran KR, Smith TK, Marius P, Gault J, Banda T, Rasmussen A, Miller S, Robinson CV, Bayley H, Sansom MS, Booth IR, Naismith JH.

Nat Struct Mol Biol. 2015 Dec;22(12):991-8. doi: 10.1038/nsmb.3120. Epub 2015 Nov 9.


Derivatisable Cyanobactin Analogues: A Semisynthetic Approach.

Oueis E, Adamson C, Mann G, Ludewig H, Redpath P, Migaud M, Westwood NJ, Naismith JH.

Chembiochem. 2015 Dec;16(18):2646-50. doi: 10.1002/cbic.201500494. Epub 2015 Nov 10.


Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Branigan E, Plechanovová A, Jaffray EG, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2015 Aug;22(8):597-602. doi: 10.1038/nsmb.3052. Epub 2015 Jul 6.


Structural analysis of leader peptide binding enables leader-free cyanobactin processing.

Koehnke J, Mann G, Bent AF, Ludewig H, Shirran S, Botting C, Lebl T, Houssen W, Jaspars M, Naismith JH.

Nat Chem Biol. 2015 Aug;11(8):558-563. doi: 10.1038/nchembio.1841. Epub 2015 Jun 22.


Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate.

Juárez JF, Liu H, Zamarro MT, McMahon S, Liu H, Naismith JH, Eberlein C, Boll M, Carmona M, Díaz E.

J Biol Chem. 2015 May 8;290(19):12165-83. doi: 10.1074/jbc.M115.637074. Epub 2015 Mar 20.


A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide.

Hagelueken G, Clarke BR, Huang H, Tuukkanen A, Danciu I, Svergun DI, Hussain R, Liu H, Whitfield C, Naismith JH.

Nat Struct Mol Biol. 2015 Jan;22(1):50-56. doi: 10.1038/nsmb.2935. Epub 2014 Dec 15.


The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.

Mann G, Koehnke J, Bent AF, Graham R, Houssen W, Jaspars M, Schwarz-Linek U, Naismith JH.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1597-603. doi: 10.1107/S2053230X1402425X. Epub 2014 Nov 14.


Editorial overview: Catalysis and regulation: enzyme catalysis, biosynthetic pathways and regulation.

Naismith JH, Parker EJ.

Curr Opin Struct Biol. 2014 Dec;29:iv-v. doi: 10.1016/ Epub 2014 Dec 2. No abstract available.


The structural biology of patellamide biosynthesis.

Koehnke J, Bent AF, Houssen WE, Mann G, Jaspars M, Naismith JH.

Curr Opin Struct Biol. 2014 Dec;29:112-121. doi: 10.1016/ Epub 2014 Nov 25. Review.


An efficient method for the in vitro production of azol(in)e-based cyclic peptides.

Houssen WE, Bent AF, McEwan AR, Pieiller N, Tabudravu J, Koehnke J, Mann G, Adaba RI, Thomas L, Hawas UW, Liu H, Schwarz-Linek U, Smith MC, Naismith JH, Jaspars M.

Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14171-4. doi: 10.1002/anie.201408082. Epub 2014 Oct 21.

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