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Items: 1 to 50 of 56

1.

Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.

Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G.

MBio. 2019 Feb 5;10(1). pii: e02624-18. doi: 10.1128/mBio.02624-18.

2.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

PMID:
30700910
3.

Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.

Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK.

J Exp Med. 2019 Feb 4;216(2):369-383. doi: 10.1084/jem.20180722. Epub 2019 Jan 22.

PMID:
30670465
4.

Iron in the Tumor Microenvironment-Connecting the Dots.

Pfeifhofer-Obermair C, Tymoszuk P, Petzer V, Weiss G, Nairz M.

Front Oncol. 2018 Nov 26;8:549. doi: 10.3389/fonc.2018.00549. eCollection 2018. Review.

5.

Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.

Sonnweber T, Pizzini A, Nairz M, Weiss G, Tancevski I.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3285. doi: 10.3390/ijms19113285. Review.

6.

The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension.

Sonnweber T, Nairz M, Theurl I, Petzer V, Tymoszuk P, Haschka D, Rieger E, Kaessmann B, Deri M, Watzinger K, Steringer-Mascherbauer R, Tancevski I, Weiss G, Löffler-Ragg J.

PLoS One. 2018 Aug 30;13(8):e0203396. doi: 10.1371/journal.pone.0203396. eCollection 2018.

7.

Iron and innate antimicrobial immunity-Depriving the pathogen, defending the host.

Nairz M, Dichtl S, Schroll A, Haschka D, Tymoszuk P, Theurl I, Weiss G.

J Trace Elem Med Biol. 2018 Jul;48:118-133. doi: 10.1016/j.jtemb.2018.03.007. Epub 2018 Mar 10. Review.

PMID:
29773170
8.

Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages.

Dichtl S, Haschka D, Nairz M, Seifert M, Volani C, Lutz O, Weiss G.

Biochem Pharmacol. 2018 Feb;148:193-201. doi: 10.1016/j.bcp.2017.12.001. Epub 2017 Dec 5.

9.

Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.

Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G.

Sci Rep. 2017 Oct 12;7(1):13012. doi: 10.1038/s41598-017-13046-3.

10.

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK.

J Exp Med. 2017 Nov 6;214(11):3293-3310. doi: 10.1084/jem.20170689. Epub 2017 Oct 4.

11.

Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection.

Nairz M, Schroll A, Haschka D, Dichtl S, Tymoszuk P, Demetz E, Moser P, Haas H, Fang FC, Theurl I, Weiss G.

Front Cell Infect Microbiol. 2017 Apr 11;7:110. doi: 10.3389/fcimb.2017.00110. eCollection 2017.

12.

"Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels.

Nairz M, Theurl I, Swirski FK, Weiss G.

Pflugers Arch. 2017 Apr;469(3-4):397-418. doi: 10.1007/s00424-017-1944-8. Epub 2017 Mar 1. Review.

13.

Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

Asshoff M, Petzer V, Warr MR, Haschka D, Tymoszuk P, Demetz E, Seifert M, Posch W, Nairz M, Maciejewski P, Fowles P, Burns CJ, Smith G, Wagner KU, Weiss G, Whitney JA, Theurl I.

Blood. 2017 Mar 30;129(13):1823-1830. doi: 10.1182/blood-2016-09-740092. Epub 2017 Feb 10.

14.

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL.

Blood. 2017 Jan 26;129(4):405-414. doi: 10.1182/blood-2016-06-721571. Epub 2016 Nov 18.

15.

Iron deficiency or anemia of inflammation? : Differential diagnosis and mechanisms of anemia of inflammation.

Nairz M, Theurl I, Wolf D, Weiss G.

Wien Med Wochenschr. 2016 Oct;166(13-14):411-423. Epub 2016 Aug 24. Review.

16.

Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.

Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G.

Cell Commun Signal. 2016 Jul 28;14(1):14. doi: 10.1186/s12964-016-0137-y.

17.

On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK.

Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18.

18.

Heme oxygenase 1 controls early innate immune response of macrophages to Salmonella Typhimurium infection.

Mitterstiller AM, Haschka D, Dichtl S, Nairz M, Demetz E, Talasz H, Soares MP, Einwallner E, Esterbauer H, Fang FC, Geley S, Weiss G.

Cell Microbiol. 2016 Oct;18(10):1374-89. doi: 10.1111/cmi.12578. Epub 2016 Mar 18.

PMID:
26866925
19.

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen.

Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J.

Cell Rep. 2015 Dec 15;13(10):2048-55. doi: 10.1016/j.celrep.2015.11.005. Epub 2015 Nov 25.

20.

Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response.

Nairz M, Schroll A, Haschka D, Dichtl S, Sonnweber T, Theurl I, Theurl M, Lindner E, Demetz E, Aßhoff M, Bellmann-Weiler R, Müller R, Gerner RR, Moschen AR, Baumgartner N, Moser PL, Talasz H, Tilg H, Fang FC, Weiss G.

Eur J Immunol. 2015 Nov;45(11):3073-86. doi: 10.1002/eji.201545569. Epub 2015 Sep 30.

21.

Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.

He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK.

Circ Heart Fail. 2015 Sep;8(5):980-7. doi: 10.1161/CIRCHEARTFAILURE.115.002334. Epub 2015 Jul 31.

22.

Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.

Nairz M, Ferring-Appel D, Casarrubea D, Sonnweber T, Viatte L, Schroll A, Haschka D, Fang FC, Hentze MW, Weiss G, Galy B.

Cell Host Microbe. 2015 Aug 12;18(2):254-61. doi: 10.1016/j.chom.2015.06.017. Epub 2015 Jul 16.

23.

Contrasting regulation of macrophage iron homeostasis in response to infection with Listeria monocytogenes depending on localization of bacteria.

Haschka D, Nairz M, Demetz E, Wienerroither S, Decker T, Weiss G.

Metallomics. 2015 Jun;7(6):1036-45. doi: 10.1039/c4mt00328d.

PMID:
25869778
24.

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis.

Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK.

Science. 2015 Mar 13;347(6227):1260-5. doi: 10.1126/science.aaa4268.

25.

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-798. doi: 10.1016/j.cmet.2014.09.004.

26.

'Ride on the ferrous wheel'--the cycle of iron in macrophages in health and disease.

Nairz M, Schroll A, Demetz E, Tancevski I, Theurl I, Weiss G.

Immunobiology. 2015 Feb;220(2):280-94. doi: 10.1016/j.imbio.2014.09.010. Epub 2014 Sep 16. Review.

PMID:
25240631
27.

Iron at the interface of immunity and infection.

Nairz M, Haschka D, Demetz E, Weiss G.

Front Pharmacol. 2014 Jul 16;5:152. doi: 10.3389/fphar.2014.00152. eCollection 2014. Review.

28.

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.

Theurl M, Nairz M, Schroll A, Sonnweber T, Asshoff M, Haschka D, Seifert M, Willenbacher W, Wilflingseder D, Posch W, Murphy AT, Witcher DR, Theurl I, Weiss G.

Haematologica. 2014 Sep;99(9):1516-24. doi: 10.3324/haematol.2013.099481. Epub 2014 Jun 3.

29.

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2.

Tancevski I, Nairz M, Duwensee K, Auer K, Schroll A, Heim C, Feistritzer C, Hoefer J, Gerner RR, Moschen AR, Heller I, Pallweber P, Li X, Theurl M, Demetz E, Wolf AM, Wolf D, Eller P, Ritsch A, Weiss G.

EMBO Mol Med. 2014 Jun;6(6):810-20. doi: 10.1002/emmm.201303415. Epub 2014 Apr 6.

30.

Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.

Sonnweber T, Nachbaur D, Schroll A, Nairz M, Seifert M, Demetz E, Haschka D, Mitterstiller AM, Kleinsasser A, Burtscher M, Trübsbach S, Murphy AT, Wroblewski V, Witcher DR, Mleczko-Sanecka K, Vecchi C, Muckenthaler MU, Pietrangelo A, Theurl I, Weiss G.

Gut. 2014 Dec;63(12):1951-9. doi: 10.1136/gutjnl-2013-305317. Epub 2014 Mar 5.

PMID:
24598129
31.

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.

Warszawska JM, Gawish R, Sharif O, Sigel S, Doninger B, Lakovits K, Mesteri I, Nairz M, Boon L, Spiel A, Fuhrmann V, Strobl B, Müller M, Schenk P, Weiss G, Knapp S.

J Clin Invest. 2013 Aug;123(8):3363-72. doi: 10.1172/JCI67911. Epub 2013 Jul 1.

32.

Lipocalin-2 expressed in innate immune cells is an endogenous inhibitor of inflammation in murine nephrotoxic serum nephritis.

Eller K, Schroll A, Banas M, Kirsch AH, Huber JM, Nairz M, Skvortsov S, Weiss G, Rosenkranz AR, Theurl I.

PLoS One. 2013 Jul 4;8(7):e67693. doi: 10.1371/journal.pone.0067693. Print 2013.

33.

Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection.

Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G.

J Exp Med. 2013 May 6;210(5):855-73. doi: 10.1084/jem.20121946. Epub 2013 Apr 29.

34.

Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis.

Bellmann-Weiler R, Schroll A, Engl S, Nairz M, Talasz H, Seifert M, Weiss G.

Immunobiology. 2013 Jul;218(7):969-78. doi: 10.1016/j.imbio.2012.11.004. Epub 2012 Nov 21.

35.

Lipocalin-2 ameliorates granulocyte functionality.

Schroll A, Eller K, Feistritzer C, Nairz M, Sonnweber T, Moser PA, Rosenkranz AR, Theurl I, Weiss G.

Eur J Immunol. 2012 Dec;42(12):3346-57. doi: 10.1002/eji.201142351. Epub 2012 Nov 7.

36.

Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.

Fritsche G, Nairz M, Libby SJ, Fang FC, Weiss G.

J Leukoc Biol. 2012 Aug;92(2):353-9. doi: 10.1189/jlb.1111554. Epub 2012 Jun 15.

37.

High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption.

Sonnweber T, Ress C, Nairz M, Theurl I, Schroll A, Murphy AT, Wroblewski V, Witcher DR, Moser P, Ebenbichler CF, Kaser S, Weiss G.

J Nutr Biochem. 2012 Dec;23(12):1600-8. doi: 10.1016/j.jnutbio.2011.10.013. Epub 2012 Mar 23.

PMID:
22444869
38.

The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection.

Taub N, Nairz M, Hilber D, Hess MW, Weiss G, Huber LA.

J Cell Sci. 2012 Jun 1;125(Pt 11):2698-708. doi: 10.1242/jcs.100073. Epub 2012 Mar 16.

39.

The pleiotropic effects of erythropoietin in infection and inflammation.

Nairz M, Sonnweber T, Schroll A, Theurl I, Weiss G.

Microbes Infect. 2012 Mar;14(3):238-46. doi: 10.1016/j.micinf.2011.10.005. Epub 2011 Nov 4. Review.

40.

Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.

Theurl I, Schroll A, Nairz M, Seifert M, Theurl M, Sonnweber T, Kulaksiz H, Weiss G.

Haematologica. 2011 Dec;96(12):1761-9. doi: 10.3324/haematol.2011.048926. Epub 2011 Aug 22.

41.

Nifedipine affects the course of Salmonella enterica serovar Typhimurium infection by modulating macrophage iron homeostasis.

Mair SM, Nairz M, Bellmann-Weiler R, Muehlbacher T, Schroll A, Theurl I, Moser PL, Talasz H, Fang FC, Weiss G.

J Infect Dis. 2011 Sep 1;204(5):685-94. doi: 10.1093/infdis/jir395.

42.

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G.

Blood. 2011 Nov 3;118(18):4977-84. doi: 10.1182/blood-2011-03-345066. Epub 2011 Jul 5.

43.

Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways.

Nairz M, Schroll A, Moschen AR, Sonnweber T, Theurl M, Theurl I, Taub N, Jamnig C, Neurauter D, Huber LA, Tilg H, Moser PL, Weiss G.

Immunity. 2011 Jan 28;34(1):61-74. doi: 10.1016/j.immuni.2011.01.002. Epub 2011 Jan 20.

44.

The struggle for iron - a metal at the host-pathogen interface.

Nairz M, Schroll A, Sonnweber T, Weiss G.

Cell Microbiol. 2010 Dec;12(12):1691-702. doi: 10.1111/j.1462-5822.2010.01529.x. Epub 2010 Oct 21. Review.

PMID:
20964797
45.

Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia.

Theurl I, Finkenstedt A, Schroll A, Nairz M, Sonnweber T, Bellmann-Weiler R, Theurl M, Seifert M, Wroblewski VJ, Murphy AT, Witcher D, Zoller H, Weiss G.

Br J Haematol. 2010 Feb;148(3):449-55. doi: 10.1111/j.1365-2141.2009.07961.x. Epub 2009 Oct 15.

PMID:
19863534
46.

Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.

Nairz M, Theurl I, Schroll A, Theurl M, Fritsche G, Lindner E, Seifert M, Crouch ML, Hantke K, Akira S, Fang FC, Weiss G.

Blood. 2009 Oct 22;114(17):3642-51. doi: 10.1182/blood-2009-05-223354. Epub 2009 Aug 21.

47.

Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition.

Nairz M, Fritsche G, Crouch ML, Barton HC, Fang FC, Weiss G.

Cell Microbiol. 2009 Sep;11(9):1365-81. doi: 10.1111/j.1462-5822.2009.01337.x. Epub 2009 Jun 2.

48.

Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications.

Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, Sonnweber T, Eberwein L, Witcher DR, Murphy AT, Wroblewski VJ, Wurz E, Datz C, Weiss G.

Blood. 2009 May 21;113(21):5277-86. doi: 10.1182/blood-2008-12-195651. Epub 2009 Mar 17.

49.

Nramp1-functionality increases iNOS expression via repression of IL-10 formation.

Fritsche G, Nairz M, Werner ER, Barton HC, Weiss G.

Eur J Immunol. 2008 Nov;38(11):3060-7. doi: 10.1002/eji.200838449.

50.

Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis.

Seifert M, Nairz M, Schroll A, Schrettl M, Haas H, Weiss G.

Immunobiology. 2008;213(9-10):767-78. doi: 10.1016/j.imbio.2008.07.010. Epub 2008 Sep 7.

PMID:
18926292

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