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In Memoriam: David C. Gadsby, PhD.

Andersen OS, Nairn AC, Palmer LG, Shapley RM.

J Gen Physiol. 2019 Aug 5;151(8):967-969. doi: 10.1085/jgp.201912400. Epub 2019 Jul 16. No abstract available.


Editorial for Special Issue: Neuroproteomics.

Williams KR, Nairn AC.

Proteomes. 2019 May 31;7(2). pii: E24. doi: 10.3390/proteomes7020024.


Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD).

Wilson RS, Rauniyar N, Sakaue F, Lam TT, Williams KR, Nairn AC.

Proteomes. 2019 Apr 2;7(2). pii: E12. doi: 10.3390/proteomes7020012.


Cell-Type-Specific Proteomics: A Neuroscience Perspective.

Wilson RS, Nairn AC.

Proteomes. 2018 Dec 9;6(4). pii: E51. doi: 10.3390/proteomes6040051. Review.


ProteomicsBrowser: MS/proteomics data visualization and investigation.

Peng G, Wilson R, Tang Y, Lam TT, Nairn AC, Williams K, Zhao H.

Bioinformatics. 2019 Jul 1;35(13):2313-2314. doi: 10.1093/bioinformatics/bty958.


Phosphoproteomic analysis of cocaine memory extinction and reconsolidation in the nucleus accumbens.

Torregrossa MM, MacDonald M, Stone KL, Lam TT, Nairn AC, Taylor JR.

Psychopharmacology (Berl). 2019 Jan;236(1):531-543. doi: 10.1007/s00213-018-5071-9. Epub 2018 Nov 8.


cAMP regulation of protein phosphatases PP1 and PP2A in brain.

Leslie SN, Nairn AC.

Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):64-73. doi: 10.1016/j.bbamcr.2018.09.006. Epub 2018 Sep 18. Review.


Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo.

Miller MB, Wilson RS, Lam TT, Nairn AC, Picciotto MR.

Proteomes. 2018 Oct 15;6(4). pii: E42. doi: 10.3390/proteomes6040042.


Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol.

Bertholomey ML, Stone K, Lam TT, Bang S, Wu W, Nairn AC, Taylor JR, Torregrossa MM.

Proteomes. 2018 Oct 12;6(4). pii: E41. doi: 10.3390/proteomes6040041.


Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology.

Rapanelli M, Frick L, Jindachomthong K, Xu J, Ohtsu H, Nairn AC, Pittenger C.

Neuroscience. 2018 Nov 10;392:172-179. doi: 10.1016/j.neuroscience.2018.09.035. Epub 2018 Sep 29.


The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction.

Chang AN, Gao N, Liu Z, Huang J, Nairn AC, Kamm KE, Stull JT.

J Biol Chem. 2018 Oct 26;293(43):16677-16686. doi: 10.1074/jbc.RA118.003083. Epub 2018 Sep 5.


Isoform-Level Interpretation of High-Throughput Proteomics Data Enabled by Deep Integration with RNA-seq.

Carlyle BC, Kitchen RR, Zhang J, Wilson RS, Lam TT, Rozowsky JS, Williams KR, Sestan N, Gerstein MB, Nairn AC.

J Proteome Res. 2018 Oct 5;17(10):3431-3444. doi: 10.1021/acs.jproteome.8b00310. Epub 2018 Sep 6.


Correction: The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in Xenopus oocytes (doi:10.1242/jcs.126599).

Dupré A, Buffin E, Roustan C, Nairn AC, Jessus C, Haccard O.

J Cell Sci. 2018 Jul 30;131(14). pii: jcs222182. doi: 10.1242/jcs.222182. No abstract available.


Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons.

Li D, Musante V, Zhou W, Picciotto MR, Nairn AC.

J Biol Chem. 2018 Jul 13;293(28):11179-11194. doi: 10.1074/jbc.RA117.001519. Epub 2018 May 25.


The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.

Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J.

Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22.


Making brain proteomics true to type.

Wilson RS, Nairn AC.

Nat Biotechnol. 2018 Feb 6;36(2):149-150. doi: 10.1038/nbt.4077. No abstract available.


Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.


Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.

Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA.

ACS Cent Sci. 2017 Dec 27;3(12):1322-1328. doi: 10.1021/acscentsci.7b00486. Epub 2017 Dec 6.


The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.

Paspalas CD, Carlyle BC, Leslie S, Preuss TM, Crimins JL, Huttner AJ, van Dyck CH, Rosene DL, Nairn AC, Arnsten AFT.

Alzheimers Dement. 2018 May;14(5):680-691. doi: 10.1016/j.jalz.2017.11.005. Epub 2017 Dec 11.


A multiregional proteomic survey of the postnatal human brain.

Carlyle BC, Kitchen RR, Kanyo JE, Voss EZ, Pletikos M, Sousa AMM, Lam TT, Gerstein MB, Sestan N, Nairn AC.

Nat Neurosci. 2017 Dec;20(12):1787-1795. doi: 10.1038/s41593-017-0011-2. Epub 2017 Nov 13.


X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA.

J Med Chem. 2017 Nov 22;60(22):9299-9319. doi: 10.1021/acs.jmedchem.7b01292. Epub 2017 Nov 8.


Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.

Lombroso PJ, Ogren M, Kurup P, Nairn AC.

F1000Res. 2016 Dec 29;5. pii: F1000 Faculty Rev-2932. doi: 10.12688/f1000research.8571.1. eCollection 2016. Review.


Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1.

Chiba K, Chien KY, Sobu Y, Hata S, Kato S, Nakaya T, Okada Y, Nairn AC, Kinjo M, Taru H, Wang R, Suzuki T.

Mol Biol Cell. 2017 Dec 15;28(26):3857-3869. doi: 10.1091/mbc.E17-05-0303. Epub 2017 Nov 1.


Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo.

Sobu Y, Furukori K, Chiba K, Nairn AC, Kinjo M, Hata S, Suzuki T.

Mol Biol Cell. 2017 Dec 15;28(26):3844-3856. doi: 10.1091/mbc.E17-05-0301. Epub 2017 Nov 1. Erratum in: Mol Biol Cell. 2018 Feb 1;29(3):376.


The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

Pradhan S, Khatlani T, Nairn AC, Vijayan KV.

J Biol Chem. 2017 Aug 11;292(32):13133-13142. doi: 10.1074/jbc.M117.796656. Epub 2017 Jun 14.


Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition.

Musante V, Li L, Kanyo J, Lam TT, Colangelo CM, Cheng SK, Brody AH, Greengard P, Le Novère N, Nairn AC.

Elife. 2017 Jun 14;6. pii: e24998. doi: 10.7554/eLife.24998.


Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61.

Xu J, Kurup P, Nairn AC, Lombroso PJ.

Mol Neurobiol. 2018 Apr;55(4):3096-3111. doi: 10.1007/s12035-017-0555-x. Epub 2017 May 2.


ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).

Andrade EC, Musante V, Horiuchi A, Matsuzaki H, Brody AH, Wu T, Greengard P, Taylor JR, Nairn AC.

J Neurosci. 2017 Mar 8;37(10):2709-2722. doi: 10.1523/JNEUROSCI.4559-15.2017. Epub 2017 Feb 6.


WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.

Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23.


Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.

Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC.

J Biol Chem. 2017 Jan 27;292(4):1462-1476. doi: 10.1074/jbc.M116.752402. Epub 2016 Dec 20.


Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ.

Mol Psychiatry. 2018 Feb;23(2):271-281. doi: 10.1038/mp.2016.163. Epub 2016 Oct 18.


The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons.

Rapanelli M, Frick LR, Horn KD, Schwarcz RC, Pogorelov V, Nairn AC, Pittenger C.

J Biol Chem. 2016 Sep 30;291(40):21042-21052. Epub 2016 Aug 10.


Phosphoproteomic Analysis Reveals a Novel Mechanism of CaMKIIα Regulation Inversely Induced by Cocaine Memory Extinction versus Reconsolidation.

Rich MT, Abbott TB, Chung L, Gulcicek EE, Stone KL, Colangelo CM, Lam TT, Nairn AC, Taylor JR, Torregrossa MM.

J Neurosci. 2016 Jul 20;36(29):7613-27. doi: 10.1523/JNEUROSCI.1108-16.2016.


Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function.

Kamceva M, Benedict J, Nairn AC, Lombroso PJ.

Neural Plast. 2016;2016:8136925. doi: 10.1155/2016/8136925. Epub 2016 Apr 12. Review.


DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons.

Engmann O, Giralt A, Gervasi N, Marion-Poll L, Gasmi L, Filhol O, Picciotto MR, Gilligan D, Greengard P, Nairn AC, Hervé D, Girault JA.

Nat Commun. 2015 Dec 7;6:10099. doi: 10.1038/ncomms10099.


The PsychENCODE project.

PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N.

Nat Neurosci. 2015 Dec;18(12):1707-12. doi: 10.1038/nn.4156. Review. No abstract available.


Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor.

Yang H, Hou H, Pahng A, Gu H, Nairn AC, Tang YP, Colombo PJ, Xia H.

J Neurosci. 2015 Nov 11;35(45):15082-7. doi: 10.1523/JNEUROSCI.1865-15.2015.


Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.

Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ.

Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8.


Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.

Liu R, Correll RN, Davis J, Vagnozzi RJ, York AJ, Sargent MA, Nairn AC, Molkentin JD.

J Mol Cell Cardiol. 2015 Oct;87:204-13. doi: 10.1016/j.yjmcc.2015.08.018. Epub 2015 Aug 31.


Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ.

J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17.


APP intracellular domain-WAVE1 pathway reduces amyloid-β production.

Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y.

Nat Med. 2015 Sep;21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17.


The role of ventral striatal cAMP signaling in stress-induced behaviors.

Plattner F, Hayashi K, Hernández A, Benavides DR, Tassin TC, Tan C, Day J, Fina MW, Yuen EY, Yan Z, Goldberg MS, Nairn AC, Greengard P, Nestler EJ, Taussig R, Nishi A, Houslay MD, Bibb JA.

Nat Neurosci. 2015 Aug;18(8):1094-100. doi: 10.1038/nn.4066. Epub 2015 Jul 20.


YPED: an integrated bioinformatics suite and database for mass spectrometry-based proteomics research.

Colangelo CM, Shifman M, Cheung KH, Stone KL, Carriero NJ, Gulcicek EE, Lam TT, Wu T, Bjornson RD, Bruce C, Nairn AC, Rinehart J, Miller PL, Williams KR.

Genomics Proteomics Bioinformatics. 2015 Feb;13(1):25-35. doi: 10.1016/j.gpb.2014.11.002. Epub 2015 Feb 21.


Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF.

Spellman DS, Wildsmith KR, Honigberg LA, Tuefferd M, Baker D, Raghavan N, Nairn AC, Croteau P, Schirm M, Allard R, Lamontagne J, Chelsky D, Hoffmann S, Potter WZ; Alzheimer's Disease Neuroimaging Initiative; Foundation for NIH (FNIH) Biomarkers Consortium CSF Proteomics Project Team.

Proteomics Clin Appl. 2015 Aug;9(7-8):715-31. doi: 10.1002/prca.201400178. Epub 2015 Apr 24.


Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.

Baguley TD, Nairn AC, Lombroso PJ, Ellman JA.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. doi: 10.1016/j.bmcl.2015.01.020. Epub 2015 Jan 20.


STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.

Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1202-7. doi: 10.1073/pnas.1417423112. Epub 2015 Jan 12.


Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins.

Colangelo CM, Ivosev G, Chung L, Abbott T, Shifman M, Sakaue F, Cox D, Kitchen RR, Burton L, Tate SA, Gulcicek E, Bonner R, Rinehart J, Nairn AC, Williams KR.

Proteomics. 2015 Apr;15(7):1202-14. doi: 10.1002/pmic.201400353. Epub 2015 Feb 12.


Decoding neuroproteomics: integrating the genome, translatome and functional anatomy.

Kitchen RR, Rozowsky JS, Gerstein MB, Nairn AC.

Nat Neurosci. 2014 Nov;17(11):1491-9. doi: 10.1038/nn.3829. Epub 2014 Oct 28. Review.


Activation of exchange protein activated by cAMP in the rat basolateral amygdala impairs reconsolidation of a memory associated with self-administered cocaine.

Wan X, Torregrossa MM, Sanchez H, Nairn AC, Taylor JR.

PLoS One. 2014 Sep 26;9(9):e107359. doi: 10.1371/journal.pone.0107359. eCollection 2014.

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