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Items: 1 to 50 of 270

1.

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.

Ongpipattanakul C, Nair SK.

ACS Chem Biol. 2018 Sep 11. doi: 10.1021/acschembio.8b00668. [Epub ahead of print]

PMID:
30204409
2.

Substrate-assisted enzymatic formation of lysinoalanine in duramycin.

An L, Cogan DP, Navo CD, Jiménez-Osés G, Nair SK, van der Donk WA.

Nat Chem Biol. 2018 Oct;14(10):928-933. doi: 10.1038/s41589-018-0122-4. Epub 2018 Sep 3.

PMID:
30177849
3.

Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin.

Kapoor I, Nair SK.

Biochemistry. 2018 Sep 11;57(36):5282-5288. doi: 10.1021/acs.biochem.8b00576. Epub 2018 Aug 29.

PMID:
30125480
4.

Mini-Stern Trial: A randomized trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement.

Nair SK, Sudarshan CD, Thorpe BS, Singh J, Pillay T, Catarino P, Valchanov K, Codispoti M, Dunning J, Abu-Omar Y, Moorjani N, Matthews C, Freeman CJ, Fox-Rushby JA, Sharples LD.

J Thorac Cardiovasc Surg. 2018 Jun 4. pii: S0022-5223(18)31482-X. doi: 10.1016/j.jtcvs.2018.05.057. [Epub ahead of print]

PMID:
30075959
5.

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.

O'Reilly MC, Dong SH, Rossi FM, Karlen KM, Kumar RS, Nair SK, Blackwell HE.

Cell Chem Biol. 2018 Sep 20;25(9):1128-1139.e3. doi: 10.1016/j.chembiol.2018.06.007. Epub 2018 Jul 19.

PMID:
30033130
6.

A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.

Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK.

J Am Chem Soc. 2018 Jul 5;140(26):8124-8127. doi: 10.1021/jacs.8b05187. Epub 2018 Jun 26.

PMID:
29924593
7.

Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, in Rhodopseudomonas palustris.

Cogan DP, Baraquet C, Harwood CS, Nair SK.

J Biol Chem. 2018 Jul 27;293(30):11727-11735. doi: 10.1074/jbc.RA118.003561. Epub 2018 May 23.

PMID:
29794028
8.

The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.

Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW.

Methods Enzymol. 2018;604:113-163. doi: 10.1016/bs.mie.2018.03.002. Epub 2018 May 4.

PMID:
29779651
9.

mRNA expression of IFN-λs in the gingival tissue of patients with chronic or aggressive periodontitis: A polymerase chain reaction study.

Bilichodmath S, Nair SK, Bilichodmath R, Mangalekar SB.

J Periodontol. 2018 Jul;89(7):867-874. doi: 10.1002/JPER.17-0349.

PMID:
29717481
10.

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Morita M, Hao Y, Jokela JK, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW.

J Am Chem Soc. 2018 May 16;140(19):6044-6048. doi: 10.1021/jacs.8b03137. Epub 2018 May 1.

PMID:
29701961
11.

Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.

Force J, Howie LJ, Abbott SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK.

Clin Breast Cancer. 2018 Feb 24. pii: S1526-8209(17)30266-5. doi: 10.1016/j.clbc.2018.02.010. [Epub ahead of print]

PMID:
29615305
12.

Identification and validation of genomic regions influencing kernel zinc and iron in maize.

Hindu V, Palacios-Rojas N, Babu R, Suwarno WB, Rashid Z, Usha R, Saykhedkar GR, Nair SK.

Theor Appl Genet. 2018 Jul;131(7):1443-1457. doi: 10.1007/s00122-018-3089-3. Epub 2018 Mar 24.

13.

Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides.

Ongpipattanakul C, Nair SK.

Biochemistry. 2018 Jun 12;57(23):3201-3209. doi: 10.1021/acs.biochem.8b00114. Epub 2018 Mar 27.

PMID:
29553721
14.

Enzymatic reconstitution of ribosomal peptide backbone thioamidation.

Mahanta N, Liu A, Dong S, Nair SK, Mitchell DA.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3030-3035. doi: 10.1073/pnas.1722324115. Epub 2018 Mar 5.

15.

Recombinant Poliovirus for Cancer Immunotherapy.

Gromeier M, Nair SK.

Annu Rev Med. 2018 Jan 29;69:289-299. doi: 10.1146/annurev-med-050715-104655.

16.

Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.

Petronikolou N, Hollatz AJ, Schuler MA, Nair SK.

Chembiochem. 2018 Apr 16;19(8):784-788. doi: 10.1002/cbic.201700679. Epub 2018 Mar 8.

PMID:
29399933
17.

Genome-wide association study in Asia-adapted tropical maize reveals novel and explored genomic regions for sorghum downy mildew resistance.

Rashid Z, Singh PK, Vemuri H, Zaidi PH, Prasanna BM, Nair SK.

Sci Rep. 2018 Jan 10;8(1):366. doi: 10.1038/s41598-017-18690-3.

18.

Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12928-12933. doi: 10.1073/pnas.1716035114. Epub 2017 Nov 20.

19.

Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A.

J Control Release. 2018 Jan 10;269:364-373. doi: 10.1016/j.jconrel.2017.11.021. Epub 2017 Nov 13.

PMID:
29146246
20.

Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Reap EA, Suryadevara CM, Batich KA, Sanchez-Perez L, Archer GE, Schmittling RJ, Norberg PK, Herndon JE 2nd, Healy P, Congdon KL, Gedeon PC, Campbell OC, Swartz AM, Riccione KA, Yi JS, Hossain-Ibrahim MK, Saraswathula A, Nair SK, Dunn-Pirio AM, Broome TM, Weinhold KJ, Desjardins A, Vlahovic G, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Fecci PE, Mitchell DA, Sampson JH.

Cancer Res. 2018 Jan 1;78(1):256-264. doi: 10.1158/0008-5472.CAN-17-0469. Epub 2017 Nov 1.

PMID:
29093005
21.

Modeling the effects of thiamethoxam on Midwestern farm ponds and emergent wetlands.

Bartell SM, Nair SK, Grant S, Brain RA.

Environ Toxicol Chem. 2018 Mar;37(3):738-754. doi: 10.1002/etc.4010. Epub 2017 Dec 11.

PMID:
29044673
22.

Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

Brown MC, Holl EK, Boczkowski D, Dobrikova E, Mosaheb M, Chandramohan V, Bigner DD, Gromeier M, Nair SK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan4220. doi: 10.1126/scitranslmed.aan4220.

23.

Molecular basis for the substrate specificity of quorum signal synthases.

Dong SH, Frane ND, Christensen QH, Greenberg EP, Nagarajan R, Nair SK.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9092-9097. doi: 10.1073/pnas.1705400114. Epub 2017 Aug 7.

24.

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.

Chekan JR, Estrada P, Covello PS, Nair SK.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6551-6556. doi: 10.1073/pnas.1620499114. Epub 2017 Jun 5.

25.

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes.

Estrada P, Manandhar M, Dong SH, Deveryshetty J, Agarwal V, Cronan JE, Nair SK.

Nat Chem Biol. 2017 Jun;13(6):668-674. doi: 10.1038/nchembio.2359. Epub 2017 Apr 17.

PMID:
28414711
26.

Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.

Batich KA, Reap EA, Archer GE, Sanchez-Perez L, Nair SK, Schmittling RJ, Norberg P, Xie W, Herndon JE 2nd, Healy P, McLendon RE, Friedman AH, Friedman HS, Bigner D, Vlahovic G, Mitchell DA, Sampson JH.

Clin Cancer Res. 2017 Apr 15;23(8):1898-1909. doi: 10.1158/1078-0432.CCR-16-2057.

27.

Dissection of a major QTL qhir1 conferring maternal haploid induction ability in maize.

Nair SK, Molenaar W, Melchinger AE, Boddupalli PM, Martinez L, Lopez LA, Chaikam V.

Theor Appl Genet. 2017 Jun;130(6):1113-1122. doi: 10.1007/s00122-017-2873-9. Epub 2017 Mar 18.

28.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J.

J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29.

PMID:
28287730
29.

Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products.

Sardar D, Hao Y, Lin Z, Morita M, Nair SK, Schmidt EW.

J Am Chem Soc. 2017 Mar 1;139(8):2884-2887. doi: 10.1021/jacs.6b12872. Epub 2017 Feb 15.

30.

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

Repka LM, Chekan JR, Nair SK, van der Donk WA.

Chem Rev. 2017 Apr 26;117(8):5457-5520. doi: 10.1021/acs.chemrev.6b00591. Epub 2017 Jan 30. Review.

31.

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli SI, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA.

ACS Chem Biol. 2017 Feb 17;12(2):548-557. doi: 10.1021/acschembio.6b01031. Epub 2017 Jan 13.

32.

Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates.

Chekan JR, Koos JD, Zong C, Maksimov MO, Link AJ, Nair SK.

J Am Chem Soc. 2016 Dec 21;138(50):16452-16458. doi: 10.1021/jacs.6b10389. Epub 2016 Dec 7.

33.

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

Olivares P, Ulrich EC, Chekan JR, van der Donk WA, Nair SK.

ACS Chem Biol. 2017 Feb 17;12(2):456-463. doi: 10.1021/acschembio.6b00939. Epub 2016 Dec 27.

34.

ArfGAP Domain-Containing Protein 2 (ADAP2) Integrates Upstream and Downstream Modules of RIG-I Signaling and Facilitates Type I Interferon Production.

Bist P, Kim SS, Pulloor NK, McCaffrey K, Nair SK, Liu Y, Lin R, Krishnan MN.

Mol Cell Biol. 2017 Mar 1;37(6). pii: e00537-16. doi: 10.1128/MCB.00537-16. Print 2017 Mar 15.

35.

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase.

Hao Y, Pierce E, Roe D, Morita M, McIntosh JA, Agarwal V, Cheatham TE 3rd, Schmidt EW, Nair SK.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14037-14042. Epub 2016 Nov 21.

36.

Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models.

Holl EK, Brown MC, Boczkowski D, McNamara MA, George DJ, Bigner DD, Gromeier M, Nair SK.

Oncotarget. 2016 Nov 29;7(48):79828-79841. doi: 10.18632/oncotarget.12975.

37.

Rare case of proximal coronary plaque regression after distal arterial grafting.

Valooran GJ, Nair SK, Chandrasekharan K.

Indian Heart J. 2016 Sep;68 Suppl 2:S47-S50. doi: 10.1016/j.ihj.2015.07.029. Epub 2016 Jan 14.

38.

The RNAissance period.

Boczkowski D, Nair SK.

Discov Med. 2016 Aug;22(119):67-72. Review.

39.

"Cryptic" mediastinal tuberculosis with myasthenia-thymoma complex.

Valooran GJ, Nair SK, Chandrasekharan K, Thomas S, John J.

Indian J Tuberc. 2016 Apr;63(2):133-5. doi: 10.1016/j.ijtb.2016.01.007. Epub 2016 Apr 15.

PMID:
27451826
40.

Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand-Myanmar Border.

Boullé M, Witkowski B, Duru V, Sriprawat K, Nair SK, McDew-White M, Anderson TJ, Phyo AP, Menard D, Nosten F.

Emerg Infect Dis. 2016 Aug;22(8):1503-5. doi: 10.3201/eid2208.160004. No abstract available.

41.

Transfecting Human Monocytes with RNA.

Dannull J, Nair SK.

Methods Mol Biol. 2016;1428:177-86. doi: 10.1007/978-1-4939-3625-0_12.

PMID:
27236800
42.

RNA Vaccination Therapy: Advances in an Emerging Field.

Kreiter S, Diken M, Pascolo S, Nair SK, Thielemans KM, Geall A.

J Immunol Res. 2016;2016:9703914. doi: 10.1155/2016/9703914. Epub 2016 Feb 25. No abstract available.

43.

Intranasal mRNA nanoparticle vaccination induces prophylactic and therapeutic anti-tumor immunity.

Phua KK, Staats HF, Nair SK, Leong KW.

J Control Release. 2015 Sep 10;213:e66-7. doi: 10.1016/j.jconrel.2015.05.110. Epub 2015 Aug 19. No abstract available.

PMID:
27005208
44.

Recent progress on third generation covalent EGFR inhibitors.

Cheng H, Nair SK, Murray BW.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1861-8. doi: 10.1016/j.bmcl.2016.02.067. Epub 2016 Feb 23. Review.

PMID:
26968253
45.

The Genetic Basis of Haploid Induction in Maize Identified with a Novel Genome-Wide Association Method.

Hu H, Schrag TA, Peis R, Unterseer S, Schipprack W, Chen S, Lai J, Yan J, Prasanna BM, Nair SK, Chaikam V, Rotarenco V, Shatskaya OA, Zavalishina A, Scholten S, Schön CC, Melchinger AE.

Genetics. 2016 Apr;202(4):1267-76. doi: 10.1534/genetics.115.184234. Epub 2016 Feb 19.

46.

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis.

Ortega MA, Hao Y, Walker MC, Donadio S, Sosio M, Nair SK, van der Donk WA.

Cell Chem Biol. 2016 Mar 17;23(3):370-380. doi: 10.1016/j.chembiol.2015.11.017. Epub 2016 Feb 11.

47.

Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides.

Chekan JR, Cogan DP, Nair SK.

Medchemcomm. 2016 Jan 1;7(1):28-36. Epub 2015 Oct 12.

48.

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna D, Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre RA, Gajiwala KS, Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S, Lafontaine J, Lunney B, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas MA, Orr ST, Pairish M, Planken S, Ren S, Richter D, Ryan K, Sach N, Shen H, Smeal T, Solowiej J, Sutton S, Tran K, Tseng E, Vernier W, Walls M, Wang S, Weinrich SL, Xin S, Xu H, Yin MJ, Zientek M, Zhou R, Kath JC.

J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.

PMID:
26756222
49.

RNA-Based Vaccines in Cancer Immunotherapy.

McNamara MA, Nair SK, Holl EK.

J Immunol Res. 2015;2015:794528. doi: 10.1155/2015/794528. Epub 2015 Nov 19. Review.

50.

Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy.

Dannull J, Tan C, Farrell C, Wang C, Pruitt S, Nair SK, Lee WT.

J Immunol Res. 2015;2015:789136. doi: 10.1155/2015/789136. Epub 2015 Oct 28.

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