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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.

Mosaheb MM, Dobrikova EY, Brown MC, Yang Y, Cable J, Okada H, Nair SK, Bigner DD, Ashley DM, Gromeier M.

Nat Commun. 2020 Jan 27;11(1):524. doi: 10.1038/s41467-019-13939-z.


Triphala: A phytomedicine for local drug delivery - A strategic intervention.

Shivaprasad BM, Patil P, Nair SK, Singh N, Shivanand S, Sameera U.

Ayu. 2019 Jan-Mar;40(1):53-57. doi: 10.4103/ayu.AYU_40_17.


Natural product biosynthesis: What's next? An introduction to the JBC Reviews Thematic Series.

Nair SK, Jez JM.

J Biol Chem. 2020 Jan 10;295(2):335-336. doi: 10.1074/jbc.REV119.011586. Epub 2019 Dec 5. Review.


Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis.

Chekan JR, Ongpipattanakul C, Nair SK.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24049-24055. doi: 10.1073/pnas.1908364116. Epub 2019 Nov 12.


Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses.

Huang MN, Nicholson LT, Batich KA, Swartz AM, Kopin D, Wellford S, Prabhakar VK, Woroniecka K, Nair SK, Fecci PE, Sampson JH, Gunn MD.

J Clin Invest. 2020 Feb 3;130(2):774-788. doi: 10.1172/JCI128267.


A 12-week, multicenter, normal-use evaluation of a manual toothbrush with angled bristle design.

Kakar AM, Nair SK, Saraf S.

J Indian Soc Periodontol. 2019 Sep-Oct;23(5):469-474. doi: 10.4103/jisp.jisp_529_18.


Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae.

Huo L, Zhao X, Acedo JZ, Estrada P, Nair SK, van der Donk WA.

Chembiochem. 2020 Jan 15;21(1-2):190-199. doi: 10.1002/cbic.201900483. Epub 2019 Nov 4.


Examining Peripheral and Tumor Cellular Immunome in Patients With Cancer.

Holl EK, Frazier VN, Landa K, Beasley GM, Hwang ES, Nair SK.

Front Immunol. 2019 Jul 31;10:1767. doi: 10.3389/fimmu.2019.01767. eCollection 2019.


Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics.

Bothwell IR, Cogan DP, Kim T, Reinhardt CJ, van der Donk WA, Nair SK.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17245-17250. doi: 10.1073/pnas.1905240116. Epub 2019 Aug 13.


Genome-wide association study to identify genomic regions influencing spontaneous fertility in maize haploids.

Chaikam V, Gowda M, Nair SK, Melchinger AE, Boddupalli PM.

Euphytica. 2019;215(8):138. doi: 10.1007/s10681-019-2459-5. Epub 2019 Jul 8.


Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants.

Chekan JR, Ongpipattanakul C, Wright TR, Zhang B, Bollinger JM Jr, Rajakovich LJ, Krebs C, Cicchillo RM, Nair SK.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13299-13304. doi: 10.1073/pnas.1900711116. Epub 2019 Jun 17.


Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

Chandramohan V, Bao X, Yu X, Parker S, McDowall C, Yu YR, Healy P, Desjardins A, Gunn MD, Gromeier M, Nair SK, Pastan IH, Bigner DD.

J Immunother Cancer. 2019 May 29;7(1):142. doi: 10.1186/s40425-019-0614-0.


Mechanistic Basis for Ribosomal Peptide Backbone Modifications.

Dong SH, Liu A, Mahanta N, Mitchell DA, Nair SK.

ACS Cent Sci. 2019 May 22;5(5):842-851. doi: 10.1021/acscentsci.9b00124. Epub 2019 Apr 16.


Can Exercise-Induced Modulation of the Tumor Physiologic Microenvironment Improve Antitumor Immunity?

Zhang X, Ashcraft KA, Betof Warner A, Nair SK, Dewhirst MW.

Cancer Res. 2019 May 15;79(10):2447-2456. doi: 10.1158/0008-5472.CAN-18-2468. Epub 2019 May 8. Review.


Corrigendum to "Drug delivery and tissue engineering applications of biocompatible pectin-chitin/nano CaCO3 composite scaffolds" [Colloids Surf. B: Biointerfaces 106 (2013) 109-116].

Sudheesh Kumar PT, Ramya C, Jayakumar R, Nair SKV, Lakshmanan VK.

Colloids Surf B Biointerfaces. 2019 Jul 1;179:517-518. doi: 10.1016/j.colsurfb.2019.04.025. Epub 2019 Apr 13. No abstract available.


Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor.

Zukher I, Pavlov M, Tsibulskaya D, Kulikovsky A, Zyubko T, Bikmetov D, Serebryakova M, Nair SK, Ehrenberg M, Dubiley S, Severinov K.

mBio. 2019 Apr 30;10(2). pii: e00768-19. doi: 10.1128/mBio.00768-19.


Immune expression in children with Wilms tumor: a pilot study.

Holl EK, Routh JC, Johnston AW, Frazier V, Rice HE, Tracy ET, Nair SK.

J Pediatr Urol. 2019 Oct;15(5):441.e1-441.e8. doi: 10.1016/j.jpurol.2019.03.011. Epub 2019 Mar 20.


Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor.

Dong SH, Kulikovsky A, Zukher I, Estrada P, Dubiley S, Severinov K, Nair SK.

Chem Sci. 2018 Dec 26;10(8):2391-2395. doi: 10.1039/c8sc03173h. eCollection 2019 Feb 28.


Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin.

Petronikolou N, Ortega MA, Borisova SA, Nair SK, Metcalf WW.

ACS Chem Biol. 2019 Apr 19;14(4):742-750. doi: 10.1021/acschembio.9b00030. Epub 2019 Mar 13.


Objective assessment of clinical benefit with ministernotomy more important than anecdotal clinical experience of surgeons.

Nair SK.

J Thorac Cardiovasc Surg. 2019 Apr;157(4):e132-e133. doi: 10.1016/j.jtcvs.2018.11.083. Epub 2019 Feb 13. No abstract available.


Colloidal Gels with Tunable Mechanomorphology Regulate Endothelial Morphogenesis.

Nair SK, Basu S, Sen B, Lin MH, Kumar AN, Yuan Y, Cullen PJ, Sarkar D.

Sci Rep. 2019 Jan 31;9(1):1072. doi: 10.1038/s41598-018-37788-w.


Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098.

Nguyen K, DeSieno MA, Bae B, Johannes TW, Cobb RE, Zhao H, Nair SK.

Org Biomol Chem. 2019 Feb 6;17(6):1506-1518. doi: 10.1039/c8ob02840k.


Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease.

Bobeica SC, Dong SH, Huo L, Mazo N, McLaughlin MI, Jiménez-Osés G, Nair SK, van der Donk WA.

Elife. 2019 Jan 14;8. pii: e42305. doi: 10.7554/eLife.42305.


Marker-Assisted Breeding of Improved Maternal Haploid Inducers in Maize for the Tropical/Subtropical Regions.

Chaikam V, Nair SK, Martinez L, Lopez LA, Utz HF, Melchinger AE, Boddupalli PM.

Front Plant Sci. 2018 Oct 18;9:1527. doi: 10.3389/fpls.2018.01527. eCollection 2018.


Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis.

Ongpipattanakul C, Nair SK.

ACS Chem Biol. 2018 Oct 19;13(10):2989-2999. doi: 10.1021/acschembio.8b00668. Epub 2018 Sep 25.


Substrate-assisted enzymatic formation of lysinoalanine in duramycin.

An L, Cogan DP, Navo CD, Jiménez-Osés G, Nair SK, van der Donk WA.

Nat Chem Biol. 2018 Oct;14(10):928-933. doi: 10.1038/s41589-018-0122-4. Epub 2018 Sep 3.


Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin.

Kapoor I, Nair SK.

Biochemistry. 2018 Sep 11;57(36):5282-5288. doi: 10.1021/acs.biochem.8b00576. Epub 2018 Aug 29.


Mini-Stern Trial: A randomized trial comparing mini-sternotomy to full median sternotomy for aortic valve replacement.

Nair SK, Sudarshan CD, Thorpe BS, Singh J, Pillay T, Catarino P, Valchanov K, Codispoti M, Dunning J, Abu-Omar Y, Moorjani N, Matthews C, Freeman CJ, Fox-Rushby JA, Sharples LD.

J Thorac Cardiovasc Surg. 2018 Dec;156(6):2124-2132.e31. doi: 10.1016/j.jtcvs.2018.05.057. Epub 2018 Jun 4.


Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.

O'Reilly MC, Dong SH, Rossi FM, Karlen KM, Kumar RS, Nair SK, Blackwell HE.

Cell Chem Biol. 2018 Sep 20;25(9):1128-1139.e3. doi: 10.1016/j.chembiol.2018.06.007. Epub 2018 Jul 19.


Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters.

Petronikolou N, Nair SK.

ACS Catal. 2018 Jul 6;8(7):6334-6344. doi: 10.1021/acscatal.8b00787. Epub 2018 Jun 1.


A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases.

Estrada P, Morita M, Hao Y, Schmidt EW, Nair SK.

J Am Chem Soc. 2018 Jul 5;140(26):8124-8127. doi: 10.1021/jacs.8b05187. Epub 2018 Jun 26.


Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, in Rhodopseudomonas palustris.

Cogan DP, Baraquet C, Harwood CS, Nair SK.

J Biol Chem. 2018 Jul 27;293(30):11727-11735. doi: 10.1074/jbc.RA118.003561. Epub 2018 May 23.


The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.

Gu W, Dong SH, Sarkar S, Nair SK, Schmidt EW.

Methods Enzymol. 2018;604:113-163. doi: 10.1016/bs.mie.2018.03.002. Epub 2018 May 4. Review.


mRNA expression of IFN-λs in the gingival tissue of patients with chronic or aggressive periodontitis: A polymerase chain reaction study.

Bilichodmath S, Nair SK, Bilichodmath R, Mangalekar SB.

J Periodontol. 2018 Jul;89(7):867-874. doi: 10.1002/JPER.17-0349.


Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis.

Morita M, Hao Y, Jokela JK, Sardar D, Lin Z, Sivonen K, Nair SK, Schmidt EW.

J Am Chem Soc. 2018 May 16;140(19):6044-6048. doi: 10.1021/jacs.8b03137. Epub 2018 May 1.


Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.

Force J, Howie LJ, Abbott SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK.

Clin Breast Cancer. 2018 Oct;18(5):410-417. doi: 10.1016/j.clbc.2018.02.010. Epub 2018 Feb 24.


Identification and validation of genomic regions influencing kernel zinc and iron in maize.

Hindu V, Palacios-Rojas N, Babu R, Suwarno WB, Rashid Z, Usha R, Saykhedkar GR, Nair SK.

Theor Appl Genet. 2018 Jul;131(7):1443-1457. doi: 10.1007/s00122-018-3089-3. Epub 2018 Mar 24.


Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides.

Ongpipattanakul C, Nair SK.

Biochemistry. 2018 Jun 12;57(23):3201-3209. doi: 10.1021/acs.biochem.8b00114. Epub 2018 Mar 27. Review.


Enzymatic reconstitution of ribosomal peptide backbone thioamidation.

Mahanta N, Liu A, Dong S, Nair SK, Mitchell DA.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3030-3035. doi: 10.1073/pnas.1722324115. Epub 2018 Mar 5.


Recombinant Poliovirus for Cancer Immunotherapy.

Gromeier M, Nair SK.

Annu Rev Med. 2018 Jan 29;69:289-299. doi: 10.1146/annurev-med-050715-104655. Review.


Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside.

Petronikolou N, Hollatz AJ, Schuler MA, Nair SK.

Chembiochem. 2018 Apr 16;19(8):784-788. doi: 10.1002/cbic.201700679. Epub 2018 Mar 8.


Genome-wide association study in Asia-adapted tropical maize reveals novel and explored genomic regions for sorghum downy mildew resistance.

Rashid Z, Singh PK, Vemuri H, Zaidi PH, Prasanna BM, Nair SK.

Sci Rep. 2018 Jan 10;8(1):366. doi: 10.1038/s41598-017-18690-3.


Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12928-12933. doi: 10.1073/pnas.1716035114. Epub 2017 Nov 20.


Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.

Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A.

J Control Release. 2018 Jan 10;269:364-373. doi: 10.1016/j.jconrel.2017.11.021. Epub 2017 Nov 13.


Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.

Reap EA, Suryadevara CM, Batich KA, Sanchez-Perez L, Archer GE, Schmittling RJ, Norberg PK, Herndon JE 2nd, Healy P, Congdon KL, Gedeon PC, Campbell OC, Swartz AM, Riccione KA, Yi JS, Hossain-Ibrahim MK, Saraswathula A, Nair SK, Dunn-Pirio AM, Broome TM, Weinhold KJ, Desjardins A, Vlahovic G, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Fecci PE, Mitchell DA, Sampson JH.

Cancer Res. 2018 Jan 1;78(1):256-264. doi: 10.1158/0008-5472.CAN-17-0469. Epub 2017 Nov 1.


Modeling the effects of thiamethoxam on Midwestern farm ponds and emergent wetlands.

Bartell SM, Nair SK, Grant S, Brain RA.

Environ Toxicol Chem. 2018 Mar;37(3):738-754. doi: 10.1002/etc.4010. Epub 2017 Dec 11.


Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs.

Brown MC, Holl EK, Boczkowski D, Dobrikova E, Mosaheb M, Chandramohan V, Bigner DD, Gromeier M, Nair SK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaan4220. doi: 10.1126/scitranslmed.aan4220.


Molecular basis for the substrate specificity of quorum signal synthases.

Dong SH, Frane ND, Christensen QH, Greenberg EP, Nagarajan R, Nair SK.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9092-9097. doi: 10.1073/pnas.1705400114. Epub 2017 Aug 7.


Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.

Chekan JR, Estrada P, Covello PS, Nair SK.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6551-6556. doi: 10.1073/pnas.1620499114. Epub 2017 Jun 5.


The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes.

Estrada P, Manandhar M, Dong SH, Deveryshetty J, Agarwal V, Cronan JE, Nair SK.

Nat Chem Biol. 2017 Jun;13(6):668-674. doi: 10.1038/nchembio.2359. Epub 2017 Apr 17.


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