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Building the health workforce: Saudi Arabia's challenges in achieving Vision 2030.

Albejaidi F, Nair KS.

Int J Health Plann Manage. 2019 Aug 12. doi: 10.1002/hpm.2861. [Epub ahead of print] Review.


TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle.

Koh JH, Johnson ML, Dasari S, LeBrasseur NK, Vuckovic I, Henderson GC, Cooper SA, Manjunatha S, Ruegsegger GN, Shulman GI, Lanza IR, Nair KS.

Diabetes. 2019 Aug;68(8):1552-1564. doi: 10.2337/db19-0088. Epub 2019 May 14.


AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle.

Koh JH, Hancock CR, Han DH, Holloszy JO, Nair KS, Dasari S.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E931-E939. doi: 10.1152/ajpendo.00460.2018. Epub 2019 Mar 19.


Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction.

Chaanine AH, Joyce LD, Stulak JM, Maltais S, Joyce DL, Dearani JA, Klaus K, Nair KS, Hajjar RJ, Redfield MM.

Circ Heart Fail. 2019 Feb;12(2):e005131. doi: 10.1161/CIRCHEARTFAILURE.118.005131.


Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes.

Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS.

FASEB J. 2019 Mar;33(3):4458-4472. doi: 10.1096/fj.201802043R. Epub 2019 Jan 24.


FoxO Transcription Factors Are Critical Regulators of Diabetes-Related Muscle Atrophy.

O'Neill BT, Bhardwaj G, Penniman CM, Krumpoch MT, Suarez Beltran PA, Klaus K, Poro K, Li M, Pan H, Dreyfuss JM, Nair KS, Kahn CR.

Diabetes. 2019 Mar;68(3):556-570. doi: 10.2337/db18-0416. Epub 2018 Dec 6.


Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.

Jankowski CM, Wolfe P, Schmiege SJ, Nair KS, Khosla S, Jensen M, von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R, Weiss EP, Villareal DT, Kohrt WM.

Clin Endocrinol (Oxf). 2019 Feb;90(2):293-300. doi: 10.1111/cen.13901. Epub 2018 Dec 9.


Altered mitochondrial function in insulin-deficient and insulin-resistant states.

Ruegsegger GN, Creo AL, Cortes TM, Dasari S, Nair KS.

J Clin Invest. 2018 Aug 31;128(9):3671-3681. doi: 10.1172/JCI120843. Epub 2018 Aug 31. Review.


A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E.

Nat Commun. 2018 Jun 11;9(1):2278. doi: 10.1038/s41467-018-04555-4.


A novel triple-tracer approach to assess postprandial protein turnover.

Moran A, Toffolo G, Schiavon M, Vella A, Klaus K, Cobelli C, Nair KS.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E469-E477. doi: 10.1152/ajpendo.00012.2018. Epub 2018 Jun 5.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2018 May 22;23(8):2532. doi: 10.1016/j.celrep.2018.05.027. No abstract available.


Müller glia-derived PRSS56 is required to sustain ocular axial growth and prevent refractive error.

Paylakhi S, Labelle-Dumais C, Tolman NG, Sellarole MA, Seymens Y, Saunders J, Lakosha H, deVries WN, Orr AC, Topilko P, John SW, Nair KS.

PLoS Genet. 2018 Mar 12;14(3):e1007244. doi: 10.1371/journal.pgen.1007244. eCollection 2018 Mar.


First and second trimester urinary metabolic profiles and fetal growth restriction: an exploratory nested case-control study within the infant development and environment study.

Luthra G, Vuckovic I, Bangdiwala A, Gray H, Redmon JB, Barrett ES, Sathyanarayana S, Nguyen RHN, Swan SH, Zhang S, Dzeja P, Macura SI, Nair KS.

BMC Pregnancy Childbirth. 2018 Feb 8;18(1):48. doi: 10.1186/s12884-018-1674-8.


Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies.

Gonsalves WI, Ramakrishnan V, Hitosugi T, Ghosh T, Jevremovic D, Dutta T, Sakrikar D, Petterson XM, Wellik L, Kumar SK, Nair KS.

JCI Insight. 2018 Jan 11;3(1). pii: 94543. doi: 10.1172/jci.insight.94543. eCollection 2018 Jan 11.


A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.

Choquet H, Thai KK, Yin J, Hoffmann TJ, Kvale MN, Banda Y, Schaefer C, Risch N, Nair KS, Melles R, Jorgenson E.

Nat Commun. 2017 Dec 13;8(1):2108. doi: 10.1038/s41467-017-01913-6.


Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults.

Robinson MM, Lowe VJ, Nair KS.

J Clin Endocrinol Metab. 2018 Jan 1;103(1):221-227. doi: 10.1210/jc.2017-01571.


Extended Follow-up of Patients Treated With Bendamustine for Lymphoid Malignancies.

Penne M, Sarraf Yazdy M, Nair KS, Cheson BD.

Clin Lymphoma Myeloma Leuk. 2017 Oct;17(10):637-644. doi: 10.1016/j.clml.2017.06.033. Epub 2017 Jun 30.


Insulin Regulation of Proteostasis and Clinical Implications.

James HA, O'Neill BT, Nair KS.

Cell Metab. 2017 Aug 1;26(2):310-323. doi: 10.1016/j.cmet.2017.06.010. Epub 2017 Jul 14. Review.


Combining a nontargeted and targeted metabolomics approach to identify metabolic pathways significantly altered in polycystic ovary syndrome.

Chang AY, Lalia AZ, Jenkins GD, Dutta T, Carter RE, Singh RJ, Nair KS.

Metabolism. 2017 Jun;71:52-63. doi: 10.1016/j.metabol.2017.03.002. Epub 2017 Mar 8.


Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.

Robinson MM, Dasari S, Konopka AR, Johnson ML, Manjunatha S, Esponda RR, Carter RE, Lanza IR, Nair KS.

Cell Metab. 2017 Mar 7;25(3):581-592. doi: 10.1016/j.cmet.2017.02.009.


Reflections on Diabetes Editorship (2012-2016).

Nair KS.

Diabetes. 2017 Jan;66(1):5-6. doi: 10.2337/db16-1331. No abstract available.


FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress.

Chaanine AH, Kohlbrenner E, Gamb SI, Guenzel AJ, Klaus K, Fayyaz AU, Nair KS, Hajjar RJ, Redfield MM.

Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1540-H1559. doi: 10.1152/ajpheart.00549.2016. Epub 2016 Sep 30.


Eulogy for the Metabolic Clinical Investigator?

Vella A, Jensen MD, Nair KS.

Diabetes. 2016 Oct;65(10):2821-3. doi: 10.2337/db16-0923. No abstract available.


Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15.


Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus.

Manjunatha S, Distelmaier K, Dasari S, Carter RE, Kudva YC, Nair KS.

Metabolism. 2016 Sep;65(9):1421-31. doi: 10.1016/j.metabol.2016.06.008. Epub 2016 Jun 29.


YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.

Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW.

Dis Model Mech. 2016 Aug 1;9(8):863-71. doi: 10.1242/dmm.024307. Epub 2016 Jun 9.


Release of skeletal muscle peptide fragments identifies individual proteins degraded during insulin deprivation in type 1 diabetic humans and mice.

Robinson MM, Dasari S, Karakelides H, Bergen HR 3rd, Nair KS.

Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E628-37. doi: 10.1152/ajpendo.00175.2016. Epub 2016 Jul 19.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2016 May 17;15(7):1394-1400. doi: 10.1016/j.celrep.2016.04.024. Epub 2016 May 5. Erratum in: Cell Rep. 2018 May 22;23(8):2532.


Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.

Conover CA, Bale LK, Nair KS.

Exp Gerontol. 2016 Jul;80:36-42. doi: 10.1016/j.exger.2016.04.005. Epub 2016 Apr 13.


The role of idelalisib in the treatment of relapsed and refractory chronic lymphocytic leukemia.

Nair KS, Cheson B.

Ther Adv Hematol. 2016 Apr;7(2):69-84. doi: 10.1177/2040620715625966. Epub 2016 Feb 3. Review.


Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis.

Espinosa De Ycaza AE, Rizza RA, Nair KS, Jensen MD.

J Clin Endocrinol Metab. 2016 Apr;101(4):1719-28. doi: 10.1210/jc.2015-4062. Epub 2016 Feb 17.


Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic People.

Dutta T, Kudva YC, Persson XM, Schenck LA, Ford GC, Singh RJ, Carter R, Nair KS.

J Clin Endocrinol Metab. 2016 Mar;101(3):1023-33. doi: 10.1210/jc.2015-2640. Epub 2016 Jan 21.


Altered Skeletal Muscle Mitochondrial Proteome As the Basis of Disruption of Mitochondrial Function in Diabetic Mice.

Zabielski P, Lanza IR, Gopala S, Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS.

Diabetes. 2016 Mar;65(3):561-73. doi: 10.2337/db15-0823. Epub 2015 Dec 30.


Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans.

Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR.

J Clin Endocrinol Metab. 2016 Feb;101(2):626-34. doi: 10.1210/jc.2015-2892. Epub 2015 Dec 28.


1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells.

Ryan ZC, Craig TA, Folmes CD, Wang X, Lanza IR, Schaible NS, Salisbury JL, Nair KS, Terzic A, Sieck GC, Kumar R.

J Biol Chem. 2016 Jan 15;291(3):1514-28. doi: 10.1074/jbc.M115.684399. Epub 2015 Nov 24.


Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools.

Sud M, Fahy E, Cotter D, Azam K, Vadivelu I, Burant C, Edison A, Fiehn O, Higashi R, Nair KS, Sumner S, Subramaniam S.

Nucleic Acids Res. 2016 Jan 4;44(D1):D463-70. doi: 10.1093/nar/gkv1042. Epub 2015 Oct 13.


Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.

Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS.

Diabetes. 2016 Jan;65(1):74-84. doi: 10.2337/db15-0675. Epub 2015 Aug 31.


Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women.

Hebert SL, Marquet-de Rougé P, Lanza IR, McCrady-Spitzer SK, Levine JA, Middha S, Carter RE, Klaus KA, Therneau TM, Highsmith EW, Nair KS.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1409-17. doi: 10.1093/gerona/glv086. Epub 2015 Aug 22.


Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM.

Cell Metab. 2015 Oct 6;22(4):734-740. doi: 10.1016/j.cmet.2015.08.001. Epub 2015 Aug 13.


Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT.

Exp Eye Res. 2015 Dec;141:42-56. doi: 10.1016/j.exer.2015.06.019. Epub 2015 Jun 24. Review.


Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins.

Hines KM, Ford GC, Klaus KA, Irving BA, Ford BL, Johnson KL, Lanza IR, Nair KS.

Anal Bioanal Chem. 2015 May;407(14):4045-52. doi: 10.1007/s00216-015-8641-2. Epub 2015 Apr 2.


Association of UCP-3 rs1626521 with obesity and stomach functions in humans.

Acosta A, Camilleri M, Shin A, Vazquez-Roque MI, Iturrino J, Lanza IR, Nair KS, Burton D, O'Neill J, Eckert D, Carlson P, Vella A, Zinsmeister AR.

Obesity (Silver Spring). 2015 Apr;23(4):898-906. doi: 10.1002/oby.21039. Epub 2015 Mar 7.


Effect of insulin sensitizer therapy on amino acids and their metabolites.

Irving BA, Carter RE, Soop M, Weymiller A, Syed H, Karakelides H, Bhagra S, Short KR, Tatpati L, Barazzoni R, Nair KS.

Metabolism. 2015 Jun;64(6):720-8. doi: 10.1016/j.metabol.2015.01.008. Epub 2015 Jan 22.


Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training.

Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS.

Diabetes. 2015 Jun;64(6):2104-15. doi: 10.2337/db14-1701. Epub 2015 Jan 20.


Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS.

J Clin Endocrinol Metab. 2015 Apr;100(4):1654-63. doi: 10.1210/jc.2014-3081. Epub 2015 Jan 19.


Chronically endurance-trained individuals preserve skeletal muscle mitochondrial gene expression with age but differences within age groups remain.

Johnson ML, Lanza IR, Short DK, Asmann YW, Nair KS.

Physiol Rep. 2014 Dec 18;2(12). pii: e12239. doi: 10.14814/phy2.12239. Print 2014 Dec 1.


Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.

Johnson ML, Irving BA, Lanza IR, Vendelbo MH, Konopka AR, Robinson MM, Henderson GC, Klaus KA, Morse DM, Heppelmann C, Bergen HR 3rd, Dasari S, Schimke JM, Jakaitis DR, Nair KS.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1386-93. doi: 10.1093/gerona/glu221. Epub 2014 Dec 10.


Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

Horm Cancer. 2015 Feb;6(1):1. doi: 10.1007/s12672-014-0206-x. No abstract available.


Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

Endocr Rev. 2014 Dec;35(6):850. doi: 10.1210/er.2014-1089. Epub 2014 Nov 3. No abstract available.


Statement of principle.

Cefalu WT, Nair KS, Seaquist ER, Zierath J, Boulton AJ, LeRoith D, Harrell RM, Grunberger G, Wartofsky L, Gore AC, Wierman ME, Hammes SR, Lange CA, Santen RJ.

J Clin Endocrinol Metab. 2014 Dec;99(12):4376. doi: 10.1210/jc.2014-3958. No abstract available.


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