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Items: 27


Hepcidin and the BMP-SMAD pathway: An unexpected liaison.

Silvestri L, Nai A, Dulja A, Pagani A.

Vitam Horm. 2019;110:71-99. doi: 10.1016/bs.vh.2019.01.004. Epub 2019 Feb 10.


Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice.

Artuso I, Pettinato M, Nai A, Pagani A, Sardo U, Billoré B, Lidonnici MR, Bennett C, Mandelli G, Pasricha SR, Ferrari G, Camaschella C, Kautz L, Silvestri L.

Haematologica. 2019 Mar;104(3):e87-e90. doi: 10.3324/haematol.2018.199810. Epub 2018 Sep 28. No abstract available.


Transferrin receptor 2 is a potential novel therapeutic target for β-thalassemia: evidence from a murine model.

Artuso I, Lidonnici MR, Altamura S, Mandelli G, Pettinato M, Muckenthaler MU, Silvestri L, Ferrari G, Camaschella C, Nai A.

Blood. 2018 Nov 22;132(21):2286-2297. doi: 10.1182/blood-2018-05-852277. Epub 2018 Sep 12.


The immunophilin FKBP12 inhibits hepcidin expression by binding the BMP type I receptor ALK2 in hepatocytes.

Colucci S, Pagani A, Pettinato M, Artuso I, Nai A, Camaschella C, Silvestri L.

Blood. 2017 Nov 9;130(19):2111-2120. doi: 10.1182/blood-2017-04-780692. Epub 2017 Sep 1.


The mutual control of iron and erythropoiesis.

Camaschella C, Pagani A, Nai A, Silvestri L.

Int J Lab Hematol. 2016 May;38 Suppl 1:20-6. doi: 10.1111/ijlh.12505. Epub 2016 May 9. Review.


Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.

Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D.

Blood. 2016 May 12;127(19):2327-36. doi: 10.1182/blood-2015-11-681494. Epub 2016 Jan 11.


Ineffective erythropoiesis and regulation of iron status in iron loading anaemias.

Camaschella C, Nai A.

Br J Haematol. 2016 Feb;172(4):512-23. doi: 10.1111/bjh.13820. Epub 2015 Oct 22. Review.


Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?

Pagani A, Ladli M, Nai A, Verdier F, Camaschella C, Silvestri L.

Haematologica. 2015 Sep;100(9):e380. doi: 10.3324/haematol.2015.128348. No abstract available.


Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?

Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L.

PLoS One. 2015 Apr 10;10(4):e0122696. doi: 10.1371/journal.pone.0122696. eCollection 2015.


Identification of TMPRSS6 cleavage sites of hemojuvelin.

Rausa M, Ghitti M, Pagani A, Nai A, Campanella A, Musco G, Camaschella C, Silvestri L.

J Cell Mol Med. 2015 Apr;19(4):879-88. doi: 10.1111/jcmm.12462. Epub 2015 Feb 22.


Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form.

Pagani A, Vieillevoye M, Nai A, Rausa M, Ladli M, Lacombe C, Mayeux P, Verdier F, Camaschella C, Silvestri L.

Haematologica. 2015 Apr;100(4):458-65. doi: 10.3324/haematol.2014.118521. Epub 2015 Jan 30.


The second transferrin receptor regulates red blood cell production in mice.

Nai A, Lidonnici MR, Rausa M, Mandelli G, Pagani A, Silvestri L, Ferrari G, Camaschella C.

Blood. 2015 Feb 12;125(7):1170-9. doi: 10.1182/blood-2014-08-596254. Epub 2014 Dec 11.


The extrahepatic role of TFR2 in iron homeostasis.

Silvestri L, Nai A, Pagani A, Camaschella C.

Front Pharmacol. 2014 May 7;5:93. doi: 10.3389/fphar.2014.00093. eCollection 2014. Review.


The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.

Nai A, Pellegrino RM, Rausa M, Pagani A, Boero M, Silvestri L, Saglio G, Roetto A, Camaschella C.

Haematologica. 2014 Jun;99(6):1016-21. doi: 10.3324/haematol.2013.103143. Epub 2014 Mar 21.


A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice.

Riba M, Rausa M, Sorosina M, Cittaro D, Garcia Manteiga JM, Nai A, Pagani A, Martinelli-Boneschi F, Stupka E, Camaschella C, Silvestri L.

PLoS One. 2013 Jul 29;8(7):e69694. doi: 10.1371/journal.pone.0069694. Print 2013.


How to assess causality of TMPRSS6 mutations?

Silvestri L, Rausa M, Pagani A, Nai A, Camaschella C.

Hum Mutat. 2013 Jul;34(7):1043-5. doi: 10.1002/humu.22321. Epub 2013 Apr 17. No abstract available.


Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.

Nai A, Pagani A, Mandelli G, Lidonnici MR, Silvestri L, Ferrari G, Camaschella C.

Blood. 2012 May 24;119(21):5021-9. doi: 10.1182/blood-2012-01-401885. Epub 2012 Apr 6.


TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals.

Nai A, Pagani A, Silvestri L, Campostrini N, Corbella M, Girelli D, Traglia M, Toniolo D, Camaschella C.

Blood. 2011 Oct 20;118(16):4459-62. doi: 10.1182/blood-2011-06-364034. Epub 2011 Aug 26.


Low hepcidin accounts for the proinflammatory status associated with iron deficiency.

Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L.

Blood. 2011 Jul 21;118(3):736-46. doi: 10.1182/blood-2011-02-337212. Epub 2011 May 31.


Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo.

Poli M, Girelli D, Campostrini N, Maccarinelli F, Finazzi D, Luscieti S, Nai A, Arosio P.

Blood. 2011 Jan 20;117(3):997-1004. doi: 10.1182/blood-2010-06-289082. Epub 2010 Nov 12.


Increased susceptibility to iron deficiency of Tmprss6-haploinsufficient mice.

Nai A, Pagani A, Silvestri L, Camaschella C.

Blood. 2010 Aug 5;116(5):851-2. doi: 10.1182/blood-2010-04-278655. No abstract available.


Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA).

De Falco L, Totaro F, Nai A, Pagani A, Girelli D, Silvestri L, Piscopo C, Campostrini N, Dufour C, Al Manjomi F, Minkov M, Van Vuurden DG, Feliu A, Kattamis A, Camaschella C, Iolascon A.

Hum Mutat. 2010 May;31(5):E1390-405. doi: 10.1002/humu.21243.


Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia.

Silvestri L, Guillem F, Pagani A, Nai A, Oudin C, Silva M, Toutain F, Kannengiesser C, Beaumont C, Camaschella C, Grandchamp B.

Blood. 2009 May 28;113(22):5605-8. doi: 10.1182/blood-2008-12-195594. Epub 2009 Apr 8.


The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C.

Cell Metab. 2008 Dec;8(6):502-11. doi: 10.1016/j.cmet.2008.09.012. Epub 2008 Oct 30.


Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response.

Pagani A, Silvestri L, Nai A, Camaschella C.

Haematologica. 2008 Oct;93(10):1466-72. doi: 10.3324/haematol.12508.


[Statistical review of juvenile osteochondritis].


Minerva Ortop. 1955 Mar;6(3):116-23. Italian. No abstract available.


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