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Items: 1 to 50 of 325

1.
2.

Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.

Rosethorne EM, Nahorski SR, Challiss RA.

Biochem Pharmacol. 2008 Feb 15;75(4):942-55. Epub 2007 Oct 22.

3.

The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons.

Willets JM, Nelson CP, Nahorski SR, Challiss RA.

J Neurochem. 2007 Dec;103(6):2268-80. Epub 2007 Oct 1.

4.

Modulation of Gq-protein-coupled inositol trisphosphate and Ca2+ signaling by the membrane potential.

Billups D, Billups B, Challiss RA, Nahorski SR.

J Neurosci. 2006 Sep 27;26(39):9983-95.

5.

A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.

Dowling MR, Willets JM, Budd DC, Charlton SJ, Nahorski SR, Challiss RA.

J Pharmacol Exp Ther. 2006 Jun;317(3):1134-42. Epub 2006 Feb 17.

PMID:
16489127
6.

Pharmacology of intracellular signalling pathways.

Nahorski SR.

Br J Pharmacol. 2006 Jan;147 Suppl 1:S38-45. Review.

7.

Altered expression of G(q/11alpha) protein shapes mGlu1 and mGlu5 receptor-mediated single cell inositol 1,4,5-trisphosphate and Ca(2+) signaling.

Atkinson PJ, Young KW, Ennion SJ, Kew JN, Nahorski SR, Challiss RA.

Mol Pharmacol. 2006 Jan;69(1):174-84. Epub 2005 Oct 18.

PMID:
16234485
8.

Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.

Nelson CP, Nahorski SR, Challiss RA.

J Pharmacol Exp Ther. 2006 Jan;316(1):279-88. Epub 2005 Sep 27.

PMID:
16188951
9.

Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion.

Young KW, Billups D, Nelson CP, Johnston N, Willets JM, Schell MJ, Challiss RA, Nahorski SR.

Mol Cell Neurosci. 2005 Sep;30(1):48-57.

PMID:
15996483
10.
13.

Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to facilitate Ca2+ release in hippocampal neurons.

Nash MS, Willets JM, Billups B, John Challiss RA, Nahorski SR.

J Biol Chem. 2004 Nov 19;279(47):49036-44. Epub 2004 Sep 1.

16.

Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea pig urinary bladder and submandibular salivary gland.

Nelson CP, Gupta P, Napier CM, Nahorski SR, Challiss RA.

J Pharmacol Exp Ther. 2004 Sep;310(3):1255-65. Epub 2004 May 12.

PMID:
15140916
18.

Non-visual GRKs: are we seeing the whole picture?

Willets JM, Challiss RA, Nahorski SR.

Trends Pharmacol Sci. 2003 Dec;24(12):626-33. Review.

PMID:
14654303
19.
20.

Visualizing phosphoinositide signalling in single neurons gets a green light.

Nahorski SR, Young KW, John Challiss RA, Nash MS.

Trends Neurosci. 2003 Aug;26(8):444-52. Review.

PMID:
12900176
21.

Role of Ca2+ feedback on single cell inositol 1,4,5-trisphosphate oscillations mediated by G-protein-coupled receptors.

Young KW, Nash MS, Challiss RA, Nahorski SR.

J Biol Chem. 2003 Jun 6;278(23):20753-60. Epub 2003 Apr 1.

22.

Sphingosine 1-phosphate: a Ca2+ release mediator in the balance.

Young KW, Nahorski SR.

Cell Calcium. 2002 Nov-Dec;32(5-6):335-41. Review.

PMID:
12543093
23.

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

Young KW, Willets JM, Parkinson MJ, Bartlett P, Spiegel S, Nahorski SR, Challiss RA.

Cell Calcium. 2003 Feb;33(2):119-28.

PMID:
12531188
24.

Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration.

Nash MS, Schell MJ, Atkinson PJ, Johnston NR, Nahorski SR, Challiss RA.

J Biol Chem. 2002 Sep 27;277(39):35947-60. Epub 2002 Jul 15.

25.
26.

Intracellular signalling. Receptor-specific messenger oscillations.

Nash MS, Young KW, Challiss RA, Nahorski SR.

Nature. 2001 Sep 27;413(6854):381-2. No abstract available.

PMID:
11574876
28.
29.
30.

Enhanced inducible mGlu1alpha receptor expression in Chinese hamster ovary cells.

Nash MS, Selkirk JV, Gaymer CE, Challiss RA, Nahorski SR.

J Neurochem. 2001 Jun;77(6):1664-7.

31.

Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.

Nash MS, Young KW, Willars GB, Challiss RA, Nahorski SR.

Biochem J. 2001 May 15;356(Pt 1):137-42.

32.

Cell type-specific differences in the coupling of recombinant mGlu1alpha receptors to endogenous G protein sub-populations.

Selkirk JV, Price GW, Nahorski SR, Challiss RA.

Neuropharmacology. 2001 Apr;40(5):645-56.

PMID:
11311892
33.
35.
36.

Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release.

Young KW, Nahorski SR.

Semin Cell Dev Biol. 2001 Feb;12(1):19-25. Review.

PMID:
11162743
37.

Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropes.

Willars GB, Royall JE, Nahorski SR, El-Gehani F, Everest H, McArdle CA.

J Biol Chem. 2001 Feb 2;276(5):3123-9. Epub 2000 Nov 7.

38.

Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.

Young KW, Bootman MD, Channing DR, Lipp P, Maycox PR, Meakin J, Challiss RA, Nahorski SR.

J Biol Chem. 2000 Dec 8;275(49):38532-9.

39.

Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells.

Young KW, Channing DR, Nahorski SR.

Eur J Pharmacol. 2000 Aug 18;402(1-2):55-9.

PMID:
10940357
40.

Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1alpha metabotropic glutamate receptor signaling in baby hamster kidney cells.

Hermans E, Saunders R, Selkirk JV, Mistry R, Nahorski SR, Challiss RA.

Mol Pharmacol. 2000 Aug;58(2):352-60.

PMID:
10908303
41.

The muscarinic M(5) receptor: a silent or emerging subtype?

Eglen RM, Nahorski SR.

Br J Pharmacol. 2000 May;130(1):13-21. Review. No abstract available.

42.

Intracellular Ca2+ stores regulate muscarinic receptor stimulation of phospholipase C in cerebellar granule cells.

Masgrau R, Servitja JM, Sarri E, Young KW, Nahorski SR, Picatoste F.

J Neurochem. 2000 Feb;74(2):818-26.

43.

Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.

Willars GB, Müller-Esterl W, Nahorski SR.

Am J Physiol. 1999 Nov;277(5):C859-69. doi: 10.1152/ajpcell.1999.277.5.C859.

PMID:
10564078
44.
45.

Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization.

Willars GB, Heding A, Vrecl M, Sellar R, Blomenröhr M, Nahorski SR, Eidne KA.

J Biol Chem. 1999 Oct 15;274(42):30146-53.

47.

Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain.

Shockley MS, Tolbert LM, Tobin AB, Nahorski SR, Sadée W, Lameh J.

Eur J Pharmacol. 1999 Jul 14;377(1):137-46.

PMID:
10448936
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